MLL

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7265 MM-102 100 mg/mL 100 mg/mL 100 mg/mL
S7816 MI-463 <1 mg/mL 96 mg/mL 22 mg/mL
S7817 MI-503 <1 mg/mL 100 mg/mL 15 mg/mL
S7619 MI-3 (Menin-MLL Inhibitor) <1 mg/mL 19 mg/mL 19 mg/mL
S7618 MI-2 (Menin-MLL Inhibitor) <1 mg/mL 75 mg/mL 75 mg/mL
S7815 MI-136 <1 mg/mL 94 mg/mL 94 mg/mL
Catalog No. Information Product Use Citations Product Validations
S7265

MM-102

MM-102 is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay.

S7816

MI-463

MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.

S7817

MI-503

MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.

S7619

MI-3 (Menin-MLL Inhibitor)

MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.

S7618

MI-2 (Menin-MLL Inhibitor)

MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.

S7815

MI-136

MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.

Tags: MLL inhibitor | MLL modulator | MLL regulation| MLL interaction | MLL inhibition