MLL

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MLL Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S7265 MM-102 MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay.
Cell Rep, 2022, 39(7):110836
Cell Death Discov, 2022, 8(1):180
J Cell Mol Med, 2020, 10.1111/jcmm.16030
S7618 MI-2 (Menin-MLL Inhibitor) MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
Life Sci Alliance, 2022, 5(4)e202101187
J Immunol, 2021, ji1901348
Cell Rep, 2019, 26(2):415-428
S7619 MI-3 (Menin-MLL Inhibitor) MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
Nature, 2021, 10.1038/s41586-021-04116-8
Clin Epigenetics, 2019, 11(1):137
Cancer Res, 2018, 78(20):5731-5740
S7815 MI-136 MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.
J Med Chem, 2020, 31
S7816 MI-463 MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.
Front Oncol, 2020, 10:524922
S7817 MI-503 MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.
J Assoc Res Otolaryngol, 2021, 10.1007/s10162-021-00801-7
Johannes Gutenberg-Universität Mainz, 2021, 10.25358/openscience-5949
Cancers (Basel), 2020, 12(9)E2715
S8934 VTP50469 VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.
S8996New SNDX-5613 SNDX-5613 is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.
S7265 MM-102 MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM in a cell-free assay.
Cell Rep, 2022, 39(7):110836
Cell Death Discov, 2022, 8(1):180
J Cell Mol Med, 2020, 10.1111/jcmm.16030
S7618 MI-2 (Menin-MLL Inhibitor) MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
Life Sci Alliance, 2022, 5(4)e202101187
J Immunol, 2021, ji1901348
Cell Rep, 2019, 26(2):415-428
S7619 MI-3 (Menin-MLL Inhibitor) MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.
Nature, 2021, 10.1038/s41586-021-04116-8
Clin Epigenetics, 2019, 11(1):137
Cancer Res, 2018, 78(20):5731-5740
S7815 MI-136 MI-136 can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.
J Med Chem, 2020, 31
S7816 MI-463 MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.
Front Oncol, 2020, 10:524922
S7817 MI-503 MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.
J Assoc Res Otolaryngol, 2021, 10.1007/s10162-021-00801-7
Johannes Gutenberg-Universität Mainz, 2021, 10.25358/openscience-5949
Cancers (Basel), 2020, 12(9)E2715
S8934 VTP50469 VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.
S8996New SNDX-5613 SNDX-5613 is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.
S8996New SNDX-5613 SNDX-5613 is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.
Tags: MLL inhibitor | MLL modulator | MLL regulation| MLL interaction | MLL inhibition