Glucokinase Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S6921	Dorzagliatin	Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.	Pharmaceuticals (Basel), 2025, 18(6)927 bioRxiv, 2025, 2025.04.03.647023 bioRxiv, 2025, 2023.08.11.552890
S0400	KAN0438757	KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.	Mol Cell Proteomics, 2023, 22(11):100649 Mol Cell Proteomics, 2023, 10.1016/j.mcpro.2023.100649 Research Square, 2023, Version 1
S2155	LY2608204	LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.	Sci Rep, 2017, 7:44681 Nat Commun, 2016, 7:11463
S1830	Oxfendazole	Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.	Mol Med Rep, 2019, 19(4):2921-2926
E1353	AZD1656	AZD1656 is a potent, selective and orally active activator of glucokinase. This compound has the potential for type 2 diabetes research.	Liver Res-Prc, 2023, Volume 7, Issue 2 Pages 124-135
S3470	ML198	ML198 is a novel activator of glucocerebrosidase (GCase) with an IC50 of 0.4 μM and does not inhibit the enzyme's action, but can facilitate its translocation to the lysosome.
S6496	Genz-123346 free base	Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.
S3527	AM2394	AM-2394 is a structurally distinct glucokinase activator (GKA), activates glucokinase (GK) with an EC50 of 60 nM.
E2509	WAY-297848	WAY-297848 is a novel glucokinase activator with potential use as a drug for the prevention or treatment of hyperglycemia, diabetes, obesity, dyslipidemia, metabolic syndrome, etc.
S9112	Kaempferitrin	Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
E1252	MitoPQ	MitoPQ (MitoParaquat), a mitochondria-targeted redox cycler, enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo.