Glucokinase Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
E1252	MitoPQ	MitoPQ (MitoParaquat), a mitochondria-targeted redox cycler, enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo.	Cell Reports, 2025, 116262 Immunity, 2022, 1370-1385.e8
E1353	AZD1656	AZD1656 is a potent, selective and orally active activator of glucokinase. This compound has the potential for type 2 diabetes research.	Liver Res-Prc, 2023, Volume 7, Issue 2 Pages 124-135
S9112	Kaempferitrin	Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.	Phytomedicine, 2026, 154:158034
S3470	ML198	ML198 is a novel activator of glucocerebrosidase (GCase) with an IC50 of 0.4 μM and does not inhibit the enzyme's action, but can facilitate its translocation to the lysosome.
S6496	Genz-123346 free base	Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.
S3527	AM2394	AM-2394 is a structurally distinct glucokinase activator (GKA), activates glucokinase (GK) with an EC50 of 60 nM.
E2509	WAY-297848	WAY-297848 is a novel glucokinase activator with potential use as a drug for the prevention or treatment of hyperglycemia, diabetes, obesity, dyslipidemia, metabolic syndrome, etc.