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Glucokinase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2155 LY2608204 LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.
Scientific Reports, 2017, 44681
Sci Rep, 2017, 7:44681
Nat Commun, 2016, 7:11463
Verified customer review of LY2608204
E1353 AZD1656 AZD1656 is a potent, selective and orally active activator of glucokinase. This compound has the potential for type 2 diabetes research.
Liver Res-Prc, 2023, Volume 7, Issue 2 Pages 124-135
S9112 Kaempferitrin Kaempferitrin (Lespenefril, Lespedin, Lespenephryl, Kaempferol 3,7-dirhamnoside), isolated from the leaves of Hedyotis verticillata and from Onychium japonicum, has antimicrobial, antioxidant, and anti-inflammatory activities.
Phytomedicine, 2026, 154:158034
S3470 ML198 ML198 is a novel activator of glucocerebrosidase (GCase) with an IC50 of 0.4 μM and does not inhibit the enzyme's action, but can facilitate its translocation to the lysosome.
S6496 Genz-123346 free base Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.
S3527 AM2394 AM-2394 is a structurally distinct glucokinase activator (GKA), activates glucokinase (GK) with an EC50 of 60 nM.
E2509 WAY-297848 WAY-297848 is a novel glucokinase activator with potential use as a drug for the prevention or treatment of hyperglycemia, diabetes, obesity, dyslipidemia, metabolic syndrome, etc.