Home Metabolism Carbohydrate Metabolism activator Dorzagliatin For research use only.

Dorzagliatin

Synonyms: HMS-5552, RO-5305552, Sinogliatin

Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.

Dorzagliatin Chemical Structure

Dorzagliatin Chemical Structure

CAS: 1191995-00-2

Selleck's Dorzagliatin has been cited by 1 publication

Purity & Quality Control

Batch: S692101 DMSO] 92 mg/mL] false] Ethanol] 92 mg/mL] false] Water] Insoluble] false Purity: 99.9%
99.9

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Biological Activity

Description Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.
Targets
glucokinase [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04324424 Completed
Type 2 Diabetes Mellitus
Hua Medicine Limited
 April 23 2019 Phase 1
NCT04426708 Completed
Type 2 Diabetes Mellitus
Hua Medicine Limited
 February 18 2019 Phase 1
NCT03790839 Completed
Patients
Hua Medicine Limited
 January 31 2019 Phase 1
NCT03158506 Completed
Healthy Subject
Hua Medicine Limited
 March 29 2017 Phase 1
NCT02597400 Completed
Type 2 Diabetes Mellitus
Hua Medicine Limited
 October 2015 Phase 1
NCT02077452 Completed
Type 2 Diabetes Mellitus
Hua Medicine Limited
 March 2014 Phase 1

Chemical Information & Solubility

Molecular Weight 462.93 Formula
C22H27ClN4O5
CAS No. 1191995-00-2 SDF --
Smiles CC(C)CC(N1CC(=CC1=O)OC2=CC=CC=C2Cl)C(=O)NC3=N[N](CC(O)CO)C=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 92 mg/mL ( (198.73 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 92 mg/mL

Water : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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