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Dorzagliatin Carbohydrate Metabolism activator

Name: Dorzagliatin
Brand: Selleck Chemicals
SKU: S6921
Availability: InStock
Rating: 5 (4 reviews)

Cat.No.S6921

Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.

Dorzagliatin Carbohydrate Metabolism activator Chemical Structure

Quality Control

Batch: S692101 DMSO]92 mg/mL]false]Ethanol]92 mg/mL]false]Water]Insoluble]false Purity: 99.9%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

99.9

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Mitochondrial Metabolism Casein Kinase
Other Carbohydrate Metabolism Inhibitors	2-DG (2-Deoxy-D-glucose) Bromopyruvic acid (3-BP) 1-Deoxynojirimycin LY2608204 Voglibose AZD1656 FBPase-1 inhibitor-1 4',7-Dimethoxy-5-Hydroxyflavone BI-9787 Eleutherol

Solubility

In vitro
Batch:

DMSO : 92 mg/mL (198.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 92 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.600mg/ml (9.94mM)	Taking the 1 mL working solution as an example, add 50 μL of 92 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.760mg/ml (1.64mM)	Taking the 1 mL working solution as an example, add 50 μL of 15.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	462.93	Formula	C₂₂H₂₇ClN₄O₅	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1191995-00-2	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	HMS-5552, RO-5305552, Sinogliatin			SMILES	CC(C)CC(N1CC(=CC1=O)OC2=CC=CC=C2Cl)C(=O)NC3=N[N](CC(O)CO)C=C3

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	glucokinase
References	[1] https://pubmed.ncbi.nlm.nih.gov/29707866/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-26)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07786571	NOT_YET_RECRUITING	Type 2 Diabetes Mellitus (T2DM); Chronic Renal Insufficiency; Chronic Kidney Disease (Stages 3b-5); Glucose Homeostasis	Sun Yat-sen University	2026-12-01
NCT06995651	RECRUITING	Pancreatic Insufficiency; Cystic Fibrosis-related Diabetes	Michael R. Rickels, MD, MS	2025-10-21	PHASE1
NCT06976658	RECRUITING	Diabetes Mellitus; Monogenic Diabetes	Chinese University of Hong Kong	2025-04-30	PHASE2
NCT06263348	COMPLETED	Type2diabetes	Hua Medicine Limited	2024-01-17	PHASE4
NCT06671340	NOT_YET_RECRUITING	Diabetes Mellitus; Prediabetes / Type 2 Diabetes	Elaine Chow	2025-04-02
NCT05098470	ACTIVE_NOT_RECRUITING	Type 2 Diabetes	University of Alabama at Birmingham	2022-03-07	PHASE3

Tech Support

Handling Instructions

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