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Glucokinase Activators

Cat.No. Product Name Information Product Use Citations Product Validations
E7659 RO-28-1675 RO-28-1675 is a potent allosteric glucokinase (GK) activator with an EC50 of 54 nM. This compound can be used for the research of type 2 diabetes.
S6921 Dorzagliatin Dorzagliatin (HMS-5552, RO-5305552, Sinogliatin) is a dual-acting glucokinase (GK) activator that improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes.
Pharmaceuticals (Basel), 2025, 18(6)927
bioRxiv, 2025, 2025.04.03.647023
bioRxiv, 2025, 2023.08.11.552890
E1353 AZD1656 AZD1656 is a potent, selective and orally active activator of glucokinase. This compound has the potential for type 2 diabetes research.
Liver Res-Prc, 2023, Volume 7, Issue 2 Pages 124-135
S3470 ML198 ML198 is a novel activator of glucocerebrosidase (GCase) with an IC50 of 0.4 μM and does not inhibit the enzyme's action, but can facilitate its translocation to the lysosome.
S3527 AM2394 AM-2394 is a structurally distinct glucokinase activator (GKA), activates glucokinase (GK) with an EC50 of 60 nM.
E2509 WAY-297848 WAY-297848 is a novel glucokinase activator with potential use as a drug for the prevention or treatment of hyperglycemia, diabetes, obesity, dyslipidemia, metabolic syndrome, etc.