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Glucokinase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S7443 AP-III-a4 (ENOblock) AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.
Cell Death Dis, 2026, 17(1)288
International Journal of Molecular Sciences, 2025, 8340
Cell Division, 2025, 23
E1703 SF2312 SF2312 is a highly potent inhibitor of Enolase with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively, and also is a natural phosphonate antibiotic. SF2312 displays activity against bacteria under anaerobic conditions.
E1028 POMHEX POMHEX, is a potent ENO2 -specific inhibitor of enolase and a racemic mixture, a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX. It is also glycolysis inhibitor and can be used for the research of cancer.
S7289 PFK-015 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
Nature, 2025, 10.1038/s41586-025-09328-w
Adv Healthc Mater, 2025, e2501417.
Cell Commun Signal, 2025, 23(1):104
Verified customer review of PFK-015
S7639 3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
Atherosclerosis, 2025, 405:119223
bioRxiv, 2025, nan
J Transl Med, 2024, 22(1):954
S8807 PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
Cancer & Metabolism, September 23, 2021, 33
eLife, September 09, 2025, 107536
Frontiers in Cellular and Infection Microbiology, October 08, 2025, 1648576
S1830 Oxfendazole Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.
bioRxiv, 2023, 2023.07.12.548707
Nature Cell Biology, 2019, 203-213
Molecular Medicine Reports, 2019, 2921-2926
S0400 KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.
Current Issues in Molecular Biology, 2025, 892
Curr Issues Mol Biol, 2025, 47(11)892
Molecular & Cellular Proteomics, 2023, 100649
S6496 Genz-123346 free base Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.