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Glucokinase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S7443 AP-III-a4 (ENOblock) AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.
Cell Div, 2025, 20(1):23
J Exp Clin Cancer Res, 2023, 42(1):1
bioRxiv, 2023, 10.1101/2023.08.01.551011
E1703 SF2312 SF2312 is a highly potent inhibitor of Enolase with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively, and also is a natural phosphonate antibiotic. SF2312 displays activity against bacteria under anaerobic conditions.
E7903 Glucosylsphingosine Glucosylsphingosine (lyso-Gb1) is a deacylated form of glucosylceramide and is also degraded by the glucocerebrosidase. This compound is a very promising, reliable and specific biomarker for monitoring Gaucher disease.
E1028 POMHEX POMHEX, is a potent ENO2 -specific inhibitor of enolase and a racemic mixture, a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX. It is also glycolysis inhibitor and can be used for the research of cancer.
S7289 PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
Nature, 2025, 10.1038/s41586-025-09328-w
Adv Healthc Mater, 2025, e2501417.
Cell Commun Signal, 2025, 23(1):104
Verified customer review of PFK15
S7639 3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
Atherosclerosis, 2025, 405:119223
J Transl Med, 2024, 22(1):954
bioRxiv, 2023, 10.1101/2023.08.01.551011
S8807 PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
bioRxiv, 2025, 2025.05.25.655979
Life Med, 2023, 2(1):lnad006
Nat Metab, 2022, 4(10):1287-1305
S0400 KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.
Mol Cell Proteomics, 2023, 22(11):100649
Mol Cell Proteomics, 2023, 10.1016/j.mcpro.2023.100649
Research Square, 2023, Version 1
S1830 Oxfendazole Oxfendazole (RS-8858,Fenbendazole sulfoxide) is a broad spectrum benzimidazole anthelmintic.
Mol Med Rep, 2019, 19(4):2921-2926
S6496 Genz-123346 free base Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.