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Australia
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Austria
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Belgium
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Brazil
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Canada
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China
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Czech Republic
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Denmark
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Finland
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France
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Germany
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Greece
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Hong Kong
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India
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Ireland
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Israel
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Italy
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Japan
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Korea
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Netherlands
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New Zealand
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Norway
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Poland
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Spain
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Sweden
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Switzerland
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Taiwan
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Turkey
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United Kingdom
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United States
Cysteine Protease Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S7393 | Aloxistatin (E-64d) | Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%. |
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| S7396 | Calpeptin | Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. This compound attenuates apoptosis and intracellular inflammatory changes in muscle cells. |
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| S1115 | Odanacatib | Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3. |
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| S7379 | E-64 | E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM. This compound induces oxidative stress and apoptosis in Filarial Parasite. |
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| S7386 | MG-101 (ALLN) | MG-101 (ALLN, Calpain inhibitor-1, Ac-LLnL-CHO) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins. |
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| S3692 | N-Ethylmaleimide (NEM) | NEM (N-Ethylmaleimide) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria. |
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| S7391 | Z-FA-FMK | Z-FA-FMK ((1S)-Z-FA-FMK) is an irreversible cysteine protease inhibitor, and also inhibits effector caspases. |
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| S2847 | Cathepsin Inhibitor 1 | Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
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| S7424 | PD 151746 | PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. |
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| S7392 | Loxistatin Acid (E-64C) | Loxistatin Acid (E-64C, NSC 694279, EP 475), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. This compound inhibits cathepsin L, a cysteine protease required for SARS-CoV-2 viral entry. |
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| E2886 | LY3000328 | LY 3000328 (Z-FL-COCHO, Compound 5) is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for human Cat S and mouse Cat S, respectively. |
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| E2899 | MG132 SSS | MG132 SSS(Z-Leu-Leu-Leu-al, MG132) is a potent proteasome and calpain inhibitor with IC50 of 100 nM and 1.2 μM, respectively. |
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| S7395 | PD 150606 | PD150606 is a potent and selective inhibitor of calpainwith Ki values of 0.21 µM for µ-calpain and 0.37 µM for m-calpain. It exhibits neuroprotective effects by reducing hypoxic/hypoglycemic injury in cerebrocortical neurons and excitotoxic damage in cerebellar Purkinje cells. |
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| S0722 | Cruzain-IN-1 | Cruzain-IN-1 is a selective inhibitor of trypanosomal cysteine proteases and a covalent and reversible Cruzain inhibitor with IC50 of 10 nM. | ||
| P1157 | Z-FY-CHO | Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific inhibitor of Cathepsin L (CTSL) that ameliorates cell apoptosis and preserves effective autophagic degradation. | ||
| S0194 | Balicatib | Balicatib (AAE-581) is a potent and selective inhibitor of the osteoclastic enzyme cathepsin K. | ||
| S5611 | 2-cyano-Pyrimidine | 2-cyano-Pyrimidine is a cathepsin K inhibitor with an IC50 of 170 nM. | ||
| E4453 | Cathepsin G Inhibitor I | Cathepsin G Inhibitor I exhibits reversible, competitive cathepsin G inhibition with IC50 and Ki values of 53 nM and 63 nM respectively. It can be used in antigen-processing studies and for modulation of T cell response in situ and in vivo. | ||
| S1013 | Bortezomib | Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. This compound inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors. |
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| S7420 | CA-074 methyl ester (CA-074 Me) | CA-074 methyl ester (CA-074 Me, Cathepsin B Inhibitor IV) is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor. |
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| S7381 | Pepstatin A | Pepstatin A (Pepstatin) is a potent aspartic protease inhibitor, and also inhibits HIV replication. Pepstatin A is also an inhibitor of cathepsins D and cathepsins E. Pepstatin A inhibits autophagy by suppressing lysosomal proteases. |
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| S7380 | Leupeptin Hemisulfate | Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin. |
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| S3025 | PMSF | PMSF (Phenylmethylsulfonyl Fluoride, Benzylsulfonyl fluoride) is an irreversible serine/cysteine protease inhibitor. |
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| S7394 | MDL-28170 | MDL-28170 (Calpain Inhibitor III) is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration. This compound is also an inhibitor of γ-secretase. |
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| S4591 | Nitroxoline | Nitroxoline (8-Hydroxy-5-nitroquinoline, 5-nitroquinolin-8-ol, 5-Nitro-8-quinolinol, 5-Nitro-8-hydroxyquinoline) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. This compound impairs tumor progression in vitro and in vivo by inhibiting cathepsin B activity. |
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