Home Apoptosis Antifolate

Antifolate

Other Apoptosis Related Inhibitors

Caspase Bcl-2 p53 Ferroptosis PD-1/PD-L1 Survivin TNF-alpha MDM2/MDMX KRas IAP
Cat.No. Product Name Information Product Use Citations Product Validations
S1210 Methotrexate Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
Cancer Res, 2026, 86(7):1724-1738
J Clin Invest, 2025, e190215
Theranostics, 2025, 15(10):4526-4549
Verified customer review of Methotrexate
S5097 Methotrexate disodium Methotrexate sodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
Chin Med J (Engl), 2023, 10.1097/CM9.0000000000002816
Pharmaceutics, 2023, 15(2)576
Bioact Mater, 2022, 18:459-470
S1135 Pemetrexed Disodium (LY231514) Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Frontiers in Pharmacology, September 27, 2021, 718675
Cancer Research, November 2, 2022, 4079-4092
Frontiers in Oncology, August 18, 2021, 711043
Verified customer review of Pemetrexed Disodium (LY231514)
S5264 L-5-Methyltetrahydrofolate calcium Calcium L-5-methyltetrahydrofolate (L-5-MTHF-Ca) is a synthetic derivative of folic acid, the predominant, naturally occurring form of folate.
S7785 Pemetrexed Disodium Hydrate Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. This compound stimulates autophagy and apoptosis.
Translational Lung Cancer Research, April 2022, 543-559
iScience, 2024, 27(10):110862
Cell Rep, 2022, 38(9):110448
Verified customer review of Pemetrexed Disodium Hydrate
S5971 Pemetrexed Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. This compound induces autophagy and apoptosis.
Anticancer Research, 2026, 1323-1335
Nat Commun, 2025, 16(1):7853
Nat Commun, 2025, 16(1):8476
S1497 Pralatrexate Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. This compound induces tumor cell apoptosis.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Br J Haematol, 2024, 10.1111/bjh.19658
Discov Oncol, 2024, 15(1):709
Verified customer review of Pralatrexate
S1236 Leucovorin Calcium Pentahydrate (Folinic acid) Leucovorin (Folinic acid) Calcium Pentahydrate is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition.Solutions are unstable and should be fresh-prepared.
Journal of Hepatocellular Carcinoma, March 27, 2023, 483-495
Journal of Student Research, August 2024, nan
J Exp Clin Cancer Res, 2025, 44(1):13
S2006 Pyrimethamine Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.
Antimicrob Agents Chemother, 2025, e0047125.
Int J Parasitol Drugs Drug Resist, 2025, 29:100626
BMC Cancer, 2024, 24(1):116
S3129 Trimethoprim Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
Cell Rep, 2024, 43(7):114500
Sci Rep, 2024, 14(1):9167
CHALMERS UNIVERSITY OF TECHNOLOGY, 2023,