Antifolate Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S1236	Leucovorin Calcium Pentahydrate (Folinic acid)	Leucovorin (Folinic acid) Calcium Pentahydrate is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition.Solutions are unstable and should be fresh-prepared.	J Exp Clin Cancer Res, 2025, 44(1):13 iScience, 2024, 27(10):110862 Cell Rep Med, 2023, 4(10):101200
S3129	Trimethoprim	Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.	Cell Rep, 2024, 43(7):114500 Sci Rep, 2024, 14(1):9167 CHALMERS UNIVERSITY OF TECHNOLOGY, 2023,
S5790	Folinic acid (Leucovorin)	Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.	Nat Cell Biol, 2024, Nat Commun, 2022, 13(1):6308
S2588	Calcium Folinate	Calcium Folinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.Solutions are unstable and should be fresh-prepared.	Drug Resist Updat, 2023, 71:101005 Drug Resistance Updates, 2023, 101005
S3082	Proguanil HCl(Atovaquone)	Proguanil hydrochloride (Chloroguanil, Chlorguanide hydrochloride), also known as Atovaquone, is an antimalarial proagent that acts as an inhibitor of dihydrofolate reductase (DHFR). It functions as a biguanide to enhance the effect of Atovaquone.	Int J Med Sci, 2022 Jan 1, 233-241
E1003	Aminopterin	Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.	Molecular Cancer Research, January 02, 2024, 82-93 Mol Cancer Res, 2024, 22(1):82-93
E4837	Trimethoprim (lactate)	Trimethoprim (lactate) is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), an essential enzyme responsible for the production of tetrahydrofolic acid (THF). By blocking this enzyme, it prevents the synthesis of bacterial DNA, hindering bacterial survival. This compound is a standard antibiotic for treating urinary tract infections (UTIs).
S5200	Diaveridine	Diaveridine (AI3-23935, CCRIS-3784) is a coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.