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Antifolate Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2006 Pyrimethamine Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.
Antimicrob Agents Chemother, 2025, e0047125.
Int J Parasitol Drugs Drug Resist, 2025, 29:100626
BMC Cancer, 2024, 24(1):116
S3129 Trimethoprim Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
Cell Rep, 2024, 43(7):114500
Sci Rep, 2024, 14(1):9167
CHALMERS UNIVERSITY OF TECHNOLOGY, 2023,
S5790 Folinic acid (Leucovorin) Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.
Nat Cell Biol, 2024,
Nat Commun, 2022, 13(1):6308
S2588 Calcium Folinate Calcium Folinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.Solutions are unstable and should be fresh-prepared.
Drug Resist Updat, 2023, 71:101005
E1003 Aminopterin Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.
Mol Cancer Res, 2024, 22(1):82-93
E4837 Trimethoprim (lactate) Trimethoprim (lactate) is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), an essential enzyme responsible for the production of tetrahydrofolic acid (THF). By blocking this enzyme, it prevents the synthesis of bacterial DNA, hindering bacterial survival. This compound is a standard antibiotic for treating urinary tract infections (UTIs).
S3082 Proguanil HCl(Atovaquone) Proguanil hydrochloride (Chloroguanil, Chlorguanide hydrochloride), also known as Atovaquone, is an antimalarial proagent that acts as an inhibitor of dihydrofolate reductase (DHFR). It functions as a biguanide to enhance the effect of Atovaquone.
S5200 Diaveridine Diaveridine (AI3-23935, CCRIS-3784) is a coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.