Home Endocrinology & Hormones ACE inhibitor Perindopril L-Arginine

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Perindopril L-Arginine ACE inhibitor

Cat.No.E2435

Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors.
Perindopril L-Arginine ACE inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 542.67

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Quality Control

Batch: E243501 Water]100 mg/mL]false]Ethanol]25 mg/mL]false]DMSO]Insoluble]false Purity: 99.46%
99.46

Solubility

In vitro
Batch:

Water : 100 mg/mL

Ethanol : 25 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
% Tween 80
% ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 542.67 Formula

C19H32N2O5.C6H14N4O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 612548-45-5 -- Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
ACE
References

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