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ACE Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S8940 MLN-4760 MLN-4760 (compound 16) is a potent and selective inhibitor of human angiotensin-converting enzyme 2 (ACE2) with IC50 of 0.44 nM. This compound also inhibits bovine carboxypeptidase A (CPDA) with IC50 of 27 μM.
International Journal of Biological Sciences, May 11, 2023, 2613-2629
Int J Biol Sci, 2023, 19(8):2613-2629
S9666 DX600 DX600 is a specific inhibitor of angiotensin-converting enzyme 2 (ACE2) that does not cross-react with ACE.
Commun Biol, 2023, 6(1):386
Communications Biology, 2023, 6(1)
E4900 Enalapril Enalapril(Eletriptan, Amprace, Vaseretic) is an inhibitor of angiotensin-converting enzyme (ACE), primarily used to treat hypertension, heart failure, and asymptomatic left ventricular dysfunction. It also attenuates frailty in aging mice.
Biochem Pharmacol, 2025, 240:117098
E2435 Perindopril L-Arginine Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors.
E6037 Perindopril Perindopril (S-9490) is a brain-penetrating inhibitor of angiotensin-converting enzyme (ACE) with an IC50 of 0.048 μM for ACE-1. It exhibits anti-hypertensive, anti-inflammatory, and anti-fibrotic properties.
S3562 Deserpidine Deserpidine (Harmonyl), an alkaloid isolated from the roots of Rauwolfia canescens, is a competitive angiotensin converting enzyme (ACE) inhibitor, also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.
E0863New Talfirastide acetate Talfirastide acetate (TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate) is an endogenous heptapeptide of the renin–angiotensin system (RAS) with a cardioprotective role due to its anti‑inflammatory and anti‑fibrotic activities in cardiac cells. It inhibits purified canine ACE activity with an IC50 of 0.65 μM and also acts as a local synergistic modulator of kinin‑induced vasodilation by inhibiting ACE and promoting nitric oxide release.
E4876 Lisinopril Lisinopril(MK-521) is a potent inhibitor of angiotensin-1 converting enzyme (sACE-1) with an IC50 of 1.9 nM. It demonstrates significant efficacy in the management of hypertension and heart failure, potentially improving cardiovascular outcomes.
S2051 Captopril Captopril (SQ 14225,Capoten) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.
Frontiers in Pharmacology, March 18, 2022, 837756
bioRxiv, January 29, 2024, nan
Molecular Medicine Reports, August 27, 2019, 4433-4448
S2099 Temocapril HCl Temocapril HCl (CS-622) is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
J Immunother Cancer, 2024, 12(11)e009805
Human Cell, 2024, 854-864
J Pers Med, 2022, 12(2)258
S1941 Enalapril Maleate Enalapril (MK-421) Maleate is an angiotensin-converting enzyme (ACE) inhibitor, used in the treatment of hypertension, diabetic nephropathy, and chronic heart failure.
bioRxiv, July 13, 2023, nan
ACS Omega, July 12, 2021, 18610-18622
J Immunother Cancer, 2024, 12(11)e009805
S1793 Ramipril Ramipril (HOE-498) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM.
Communications Medicine, 2025, 420
J Immunother Cancer, 2024, 12(11)e009805
S2076 Lisinopril dihydrate Lisinopril dihydrate(MK-521 dihydrate) is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.
bioRxiv, 2025, Preprint
J Immunother Cancer, 2024, 12(11)e009805
S3981 Sinapinic Acid Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.
Biochem Pharmacol, 2025, 241:117171
ROYAL SOCIETY OF CHEMISTRY, 2023, 7, 2953-2973
S2079 Moexipril HCl Moexipril HCl (RS-10085) is a potent orally active nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, used for the treatment of hypertension and congestive heart failure.
J Cell Biochem, 2022, 10.1002/jcb.30213
S2109 Imidapril HCl Imidapril HCl(TA-6366) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
J Immunother Cancer, 2024, 12(11)e009805
S6468 Trandolapril Trandolapril(RU44570) is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.
J Immunother Cancer, 2024, 12(11)e009805
S2095 Fosinopril Sodium Fosinopril Sodium (SQ28555) is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
J Immunother Cancer, 2024, 12(11)e009805
S9820 Angiotensin (1-7) Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. This compound is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
Int J Biol Sci, 2023, 19(8):2613-2629
S2100 Temocapril Temocapril (CS-622,temocaprilum) is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.
S5728 Delapril Hydrochloride Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.