Home Endocrinology & Hormones ACE inhibitor DX600

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DX600 ACE inhibitor

Cat.No.S9666

DX600 is a specific inhibitor of angiotensin-converting enzyme 2 (ACE2) that does not cross-react with ACE.
DX600 ACE inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 3074.32

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Quality Control

Batch: S966601 Water]100 mg/mL]false]]]false]]]false Purity: 99.19%
99.19

Solubility

In vitro
Batch:

Water : 100 mg/mL

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 3074.32 Formula

C141H185N35O40S2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 478188-26-0 -- Storage of Stock Solutions

Synonyms N/A Smiles CC(C)CC1NC(=O)C2CCCN2C(=O)C(CO)NC(=O)C(CSSCC(NC(=O)C(CCCCN)NC(=O)C(CC3=C[NH]C4=C3C=CC=C4)NC(=O)C(CC5=C[NH]C6=C5C=CC=C6)NC(=O)C7CCCN7C(=O)C(CC8=CC=C(O)C=C8)NC(=O)C(CC9=CC=C(O)C=C9)NC(=O)C(CCCNC(N)=N)NC1=O)C(=O)NC(C(C)O)C(=O)NC(CC%10=CC=C(O)C=C%10)C(=O)N%11CCCC%11C(=O)NC(CC(O)=O)C(=O)N%12CCCC%12C(=O)NC(CCC(O)=O)C(=O)NCC(=O)NCC(=O)NCC(N)=O)NC(=O)C(CC%13=CN=C[NH]%13)NC(=O)C(CO)NC(=O)C(CC%14=CC=C(O)C=C%14)NC(=O)C(CC(O)=O)NC(=O)CNC(C)=O

Mechanism of Action

Targets/IC50/Ki
ACE2
In vitro

DX600 is an ACE2 specific inhibitor that does not cross-react with ACE. Three human cell lines (Calu-3, Caco-2, Huh-7) are evaluated for the cell surface expression of ACE2 by flow cytometry and Western blot. Subsequently, whole cell lysates, cell culture supernatant, and live cells are evaluated in the assay. Calu-3 has elevated levels of ACE2 compared to Caco-2 or Huh-7. Calu-3 also demonstrates elevated ACE2 enzymatic activity in all three sources and can be inhibited by this compound.
In vivo

Mouse ACE2-driven Ang-(1-7) formation from Ang II is blocked by MLN-4760 but not by either linear or cyclic this compound. This chemical only blocks human ACE2 activity.
References

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