| S1733 |
Methylprednisolone
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Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. This compound activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. It markedly reduces autophagy and apoptosis.
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iScience, 2025, 114293
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Food Chem Toxicol, 2024, 188:114665
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Clinical Cancer Research, 2022, 4444-4455
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| S4104 |
Diminazene Aceturate
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Diminazene(Diminazene diaceturate) is a di-amidine also known as 4,4-(1-Triazene–1,3–diyl)bis(benzenecarboximidamide), used as an effective trypanocidal agent. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties.
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Scientific Reports, 2025, 18633
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Sci Rep, 2025, 15(1):18633
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Cell, 2024, 4095-4112.e21
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| S5973 |
Methylprednisolone Acetate
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Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
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Current Issues in Molecular Biology, 2022, 1046-1061
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