Retinoid Receptor

Isoform-selective Products

Retinoid Receptor Products

  • All (18)
  • Retinoid Receptor Inhibitor (1)
  • Retinoid Receptor Antagonists (2)
  • Retinoid Receptor Agonists (15)
  • New Retinoid Receptor Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1653 Retinoic acid (Tretinoin) Retinoic acid (Tretinoin), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Cell Res, 2023, 33(6):421-433
Cell Prolif, 2023, 56(5):e13434
Phytomedicine, 2023, 118:154942
S2098 Bexarotene Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
iScience, 2024, 27(2):108857
Oncotarget, 2024, 15:124-133
Nat Commun, 2022, 13(1):7322
S4627 TTNPB TTNPB is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.
Genes (Basel), 2023, 14(4)946
Nature, 2022, 10.1038/s41586-022-04967-9
Cell Biosci, 2022, 12(1):174
S2933 AM580 AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.
Cell Rep, 2023, 42(6):112566
Cell Res, 2022, 10.1038/s41422-022-00668-0
J Leukoc Biol, 2022, 111(5):1107-1121
S1276 Adapalene Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.
Int J Mol Sci, 2022, 23(16)9366
Cancer Discov, 2020, 10(7):1058-1077
PLoS Pathog, 2020, 16;16(3):e1008341
S1368 Acitretin Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
Int J Mol Sci, 2022, 23(16)9366
Antimicrob Agents Chemother, 2017, 61(11). pii: e01368-17
Saudi Pharm J, 2017, 25(4):620-624
S1569 Tazarotene Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.
Int J Mol Sci, 2022, 23(16)9366
Mol Pharm, 2015, 12(9):3399-407
J Clin Invest, 2013, 123(9):3941-51
S4260 Tamibarotene Tamibarotene(Am 80) is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.
Int J Mol Sci, 2022, 23(16)9366
PLoS One, 2019, 14(1):e0211071
S2833 UVI 3003 UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR) with IC50 of 0.24 μM against human RXR.
Cell Rep, 2023, 10.1016/j.celrep.2023.113369
Genes (Basel), 2023, 14(4)946
S5233 Fenretinide (NSC 374551) Fenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.
Acta Pharm Sin B, 2023, 13(1):142-156
Acta Pharm Sin B, 2023, 13(1):142-156
E2813 SR 11237 SR 11237, a retinoid X receptor (RXR)-specific agonist, can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
J Am Heart Assoc, 2023, 12(15):e029415
S4699 Etretinate Etretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato,Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.
Viruses, 2021, 13(8)1533
E1627New BMS493 BMS493 is an inverse agonist of pan retinoic acid receptor (RAR). It increases nuclear corepressor interaction with RARs and can be used as an inhibitor for the dietary and pharmacologic manipulation of retinoic acid (RA) activity in vivo and in vitro.
E1445New Palovarotene Palovarotene (R 667; Ro 3300074) is a nuclear retinoic acid receptor γ (RAR-γ) agonist. It reduces heterotopic ossification (HO) in cultures and in murine and rat fibrodysplasia ossificans progressiva (FOP) models.
S6605 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist.
S6132 All trans-Retinal All trans-Retinal (Retinaldehyde, Vitamin A aldehyde, Retinene), a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer.
S2520New CD437(AHPN) CD437(AHPN), a synthetic retinoid, is a selective Retinoic acid Receptor γ ( RARγ) agonist. It exhibits an antiproliferative effect and induces apoptosis via activation of AP-1 in vitro.
E1468New MSU-42011 MSU-42011 is an orally active agonist of retinoid X receptor (RXR). MSU-42011 inhibits the expression of iNOS and p-ERK protein. It exhibits immunomodulatory and antitumor activity. MSU-42011 can be used for cancer research.
S5233 Fenretinide (NSC 374551) Fenretinide (4-hydroxy(phenyl)retinamide, 4-HPR, MK-4016) is a synthetic derivative of retinoic acid that has a broad-spectrum of cytotoxic activity against primary tumor cells, cell lines, and/or xenografts of various cancers (including neuroblastoma). Fenretinide (4-hydroxy(phenyl)retinamide; 4-HPR) is a synthetic derivative of retinoic acid, fenretinide can bind to retinoic acid receptor (RAR) and retinoid X receptor (RXR) at concentrations necessary to induce cell death.
Acta Pharm Sin B, 2023, 13(1):142-156
Acta Pharm Sin B, 2023, 13(1):142-156
S2833 UVI 3003 UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR) with IC50 of 0.24 μM against human RXR.
Cell Rep, 2023, 10.1016/j.celrep.2023.113369
Genes (Basel), 2023, 14(4)946
S6605 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist.
S1653 Retinoic acid (Tretinoin) Retinoic acid (Tretinoin), which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Cell Res, 2023, 33(6):421-433
Cell Prolif, 2023, 56(5):e13434
Phytomedicine, 2023, 118:154942
S2098 Bexarotene Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
iScience, 2024, 27(2):108857
Oncotarget, 2024, 15:124-133
Nat Commun, 2022, 13(1):7322
S4627 TTNPB TTNPB is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.
Genes (Basel), 2023, 14(4)946
Nature, 2022, 10.1038/s41586-022-04967-9
Cell Biosci, 2022, 12(1):174
S2933 AM580 AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.
Cell Rep, 2023, 42(6):112566
Cell Res, 2022, 10.1038/s41422-022-00668-0
J Leukoc Biol, 2022, 111(5):1107-1121
S1276 Adapalene Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.
Int J Mol Sci, 2022, 23(16)9366
Cancer Discov, 2020, 10(7):1058-1077
PLoS Pathog, 2020, 16;16(3):e1008341
S1368 Acitretin Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
Int J Mol Sci, 2022, 23(16)9366
Antimicrob Agents Chemother, 2017, 61(11). pii: e01368-17
Saudi Pharm J, 2017, 25(4):620-624
S1569 Tazarotene Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.
Int J Mol Sci, 2022, 23(16)9366
Mol Pharm, 2015, 12(9):3399-407
J Clin Invest, 2013, 123(9):3941-51
S4260 Tamibarotene Tamibarotene(Am 80) is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.
Int J Mol Sci, 2022, 23(16)9366
PLoS One, 2019, 14(1):e0211071
E2813 SR 11237 SR 11237, a retinoid X receptor (RXR)-specific agonist, can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
J Am Heart Assoc, 2023, 12(15):e029415
S4699 Etretinate Etretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato,Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.
Viruses, 2021, 13(8)1533
E1627New BMS493 BMS493 is an inverse agonist of pan retinoic acid receptor (RAR). It increases nuclear corepressor interaction with RARs and can be used as an inhibitor for the dietary and pharmacologic manipulation of retinoic acid (RA) activity in vivo and in vitro.
E1445New Palovarotene Palovarotene (R 667; Ro 3300074) is a nuclear retinoic acid receptor γ (RAR-γ) agonist. It reduces heterotopic ossification (HO) in cultures and in murine and rat fibrodysplasia ossificans progressiva (FOP) models.
S6132 All trans-Retinal All trans-Retinal (Retinaldehyde, Vitamin A aldehyde, Retinene), a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer.
S2520New CD437(AHPN) CD437(AHPN), a synthetic retinoid, is a selective Retinoic acid Receptor γ ( RARγ) agonist. It exhibits an antiproliferative effect and induces apoptosis via activation of AP-1 in vitro.
E1468New MSU-42011 MSU-42011 is an orally active agonist of retinoid X receptor (RXR). MSU-42011 inhibits the expression of iNOS and p-ERK protein. It exhibits immunomodulatory and antitumor activity. MSU-42011 can be used for cancer research.
E1627New BMS493 BMS493 is an inverse agonist of pan retinoic acid receptor (RAR). It increases nuclear corepressor interaction with RARs and can be used as an inhibitor for the dietary and pharmacologic manipulation of retinoic acid (RA) activity in vivo and in vitro.
E1445New Palovarotene Palovarotene (R 667; Ro 3300074) is a nuclear retinoic acid receptor γ (RAR-γ) agonist. It reduces heterotopic ossification (HO) in cultures and in murine and rat fibrodysplasia ossificans progressiva (FOP) models.
S2520New CD437(AHPN) CD437(AHPN), a synthetic retinoid, is a selective Retinoic acid Receptor γ ( RARγ) agonist. It exhibits an antiproliferative effect and induces apoptosis via activation of AP-1 in vitro.
E1468New MSU-42011 MSU-42011 is an orally active agonist of retinoid X receptor (RXR). MSU-42011 inhibits the expression of iNOS and p-ERK protein. It exhibits immunomodulatory and antitumor activity. MSU-42011 can be used for cancer research.

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Tags: Retinoid Receptor inhibitor|Retinoid Receptor agonist|Retinoid Receptor activator|Retinoid Receptor inducer|Retinoid Receptor antagonist|Retinoid Receptor signaling pathway|Retinoid Receptor assay kit