- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S1653||Tretinoin||<1 mg/mL||60 mg/mL||6 mg/mL|
|S2098||Bexarotene||<1 mg/mL||8 mg/mL||<1 mg/mL|
|S1276||Adapalene||<1 mg/mL||8 mg/mL||<1 mg/mL|
|S1368||Acitretin||<1 mg/mL||20 mg/mL||<1 mg/mL|
|S1569||Tazarotene||<1 mg/mL||10 mg/mL||10 mg/mL|
|S4627||TTNPB (Arotinoid Acid)||<1 mg/mL||15 mg/mL||<1 mg/mL|
|S4260||Tamibarotene||<1 mg/mL||70 mg/mL||70 mg/mL|
|S4699||Etretinate||<1 mg/mL||70 mg/mL||70 mg/mL|
- Retinoid Receptor Inhibitors (8)
|Catalog No.||Information||Product Use Citations||Product Validations|
Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
Adapalene is a dual RAR and RXR agonist, used in the treatment of acne.
Acitretin is a second generation retinoid used for psoriasis.
Acitretin does not induce HIV reactivation in J-lat and ACH-2 cells. (a, b) HIV reactivation induced by acid retinoic (AR) derivative acitretin (25 – 1 μM) in J-Lat cells clone 8.4 (a) and 9.2(b). HDAC inhibitors (HDCAi) panobinostat (PNB, 0.16μM) and vorinostat (VOR, 4 – 0.16 μM) were used as controls. Reactivation was determined by the quantification of GFP+ cells (%) after culturing J-Lat with HDACi and acitretin for 24h. (c, d) HIV reactivation induced by acitretin and HDACi in ACH-2 cells. Reactivation was determined after 48h of incubation by quantification of CAp24 (c) and HIV RNA copy number (d) in the supernatant. Values represent mean±SD of at least three independent experiments performed in triplicate. UN, untreated. *P < 0.05; **P < 0.01; ***P < 0.001.
Tazarotene is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.
TTNPB (Arotinoid Acid) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.
Tamibarotene is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.
Etretinate is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.