Tretinoin

Catalog No.S1653 Synonyms: All-trans Retinoic Acid

Tretinoin Chemical Structure

Molecular Weight(MW): 300.4

Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

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Purity & Quality Control

Choose Selective Retinoid Receptor Inhibitors

Biological Activity

Description Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Targets
RAR [1] RXR [1]
In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. [1] Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse F9 cells MY\GeY5kfGmxbjDhd5NigQ>? MWOzJIRigXN? Mnz5TY5lfWO2aX;uJI9nKHSncn3pcoFtKGSrZn\ldoVvfGmjdHnvckBqdiCvb4Xz[UBHQSClZXzsd{Bie3Onc4Pl[EBjgSCvZXHzeZJqdmdic3XjdoV1\WRicHzhd41qdm:pZX6gZYN1cX[jdH;yJIFkfGm4aYT5JIFnfGW{IEOg[IF6eyxiSVO1NF0xNjByMEGg{txO M1HQS|E4PDh7NUe5
COS7 cells NUPzcJBDTnWwY4Tpc44h[XO|YYm= NEjtO3oyPiCq MmPuRYN1cX[rdImgZZQhcHWvYX6gVmFT\2GvbXGgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDDU3M4KGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIghT2GuND3ERmQh[XO|ZYPz[YQh[XNidILhcpNkemmydHnvcoFtKGGldHn2ZZRqd25iYX\0[ZIhOTZiaILzJIJ6KEejbESgdoV{eG:wc3Wg[YxmdWWwdD3kdol3\W5ibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUCuNFAxOiEQvF2= NVjYVXRmOTlyNUi5OlU>
CV-1 cells MkLTSpVv[3Srb36gZZN{[Xl? NEXTS3hVemGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBqdiCFVj2xJINmdGy|IHX4dJJme3OrbnegVoV1cW6xaXOgZYNq\CC{ZXPldJRweiCUQWKg[4FudWFuIFXDOVA:OC5yMEC3JO69VQ>? MmH1O|Q6ODd{NR?=
human breast cancer cell SK-BR-3 MVPQdo9tcW[ncnH0bY9vKGG|c3H5 NFHueJRKdmirYnn0bY9vKG:oIFXSMY5m\2G2aY\lJIh2dWGwIHLy[YF{fCClYX7j[ZIh[2WubDDTT{1DWi1|IIDyc4xq\mW{YYTpc44tKEmFNUC9NE4xODF5IN88US=> MV6xNlM4OjV{MB?=
HL-60 cells NX7aXGlpTnWwY4Tpc44h[XO|YYm= M2TndWlv\HWldHnvckBw\iC2cnHud4dtfXSjbXnuZZNmKCiWR3Hz[Ukh[WO2aY\peJkhcW5iSFytOlAh[2WubIOsJGVEPTB;MD6wNFUh|ryP MUS4O|g1PDV2
human T47D cells MkPrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkjsOkBl[Xm| NFXlXJRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBVPDeGIHPlcIx{KGGodHXyJFYh\GG7czDifUBOXFRiYYPzZZktKEmFNUC9NE4xODZizszN NX3KfHVNOTV4MUW1NlE>
mouse NIH3T3 cells MmXsSpVv[3Srb36gZZN{[Xl? NILxeodC[3Srdnn0fUBifCCUQWLhcJBp[SCneIDy[ZN{\WRiaX6gcY92e2ViTlnIN3Q{KGOnbHzzJIJ6KFJvU1HUJIF{e2G7LDDFR|UxRTBwMEC2N|Eh|ryP MXixPVI{QTJ|MB?=
Raji cells NFTwSoJHfW6ldHnvckBie3OjeR?= MoLoOFghcA>? MnziTY5pcWKrdHnvckBw\iCWUFGtbY5lfWOnZDDFdJN1\WmwLVLhdpIhfmm{dYOg[YFzdHliYX70bYdmdiCjY4TpeoF1cW:wIHnuJHJicmliY3XscJMh[W[2ZYKgOFghcHK|LDDJR|UxRTBwMEG1OEDPxE1? MmjBNVc2ODN6NUC=
human MV-4-11 cell NIrEcYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIrPVFdKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB{MEm5JO69VQ>? M13IcXNCVkeHUh?=
human ATN-1 cell NF3KbG5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wN|A{KM7:TR?= MXjTRW5ITVJ?
HL-60 cells MXTGeY5kfGmxbjDhd5NigQ>? NXzBOmhzPCCmYYnz MUDJcoR2[3Srb36gc4YhUExvNkCgZ4VtdHNiZHnm[oVz\W62aXH0bY9vKG:4ZYKgOEBl[Xm|LDDFSFUxRTBwMUKg{txO Mnn3PVU4Ojh7Mx?=
human MC-IXC cell NHfpe2FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Moe5TY5pcWKrdHnvckBw\iCqdX3hckBOSy2LWFOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE2PDN4IN88US=> MXTTRW5ITVJ?
human HH cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYjJcohq[mm2aX;uJI9nKGi3bXHuJGhJKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5zOUW1OEDPxE1? NXTINos1W0GQR1XS
T-47D cells MoHBVJJwdGmoZYLheIlwdiCjc4PhfS=> M1fK[WlvcGmkaYTpc44hd2ZiRWKgdI9{cXSrdnWgbJVu[W5iYoLlZZN1KGOjbnPldkBk\WyuIGStOFdFKHC{b3zp[oVz[XSrb36sJGlEPTB;MD6yJO69VQ>? M{\oW|EzOzd{NUKw
human NB13 cell MmD6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEnwZpNKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI2PjZ2IN88US=> NI\WWlZUSU6JRWK=
human D-283MED cell M3\zZmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3rWSWlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{OEPNSWQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjJ6Mk[yJO69VQ>? M3;u[nNCVkeHUh?=
human HL-60 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVz1fJBTUW6qaXLpeIlwdiCxZjDoeY1idiCKTD22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOjh2OUGg{txO NYm3dI5HW0GQR1XS
human EW-3 cell NInG[YdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3vHOWlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOFgxOjhizszN NETJcHBUSU6JRWK=
human LNCAP cells MVHQdo9tcW[ncnH0bY9vKGG|c3H5 NFj4bnk1QCCq NEjSNmtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFzOR2FRKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MD61JO69VQ>? MYWxPVM4PTh{NR?=
human KU812 cell MlPES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWDJcohq[mm2aX;uJI9nKGi3bXHuJGtWQDF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD61N|YxQSEQvF2= NI\NcphUSU6JRWK=
human MCF7 cells MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1HDc|Yh\GG7cx?= MonCS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOVgh|ryP MXGxOVYyPTV{MR?=
NB4 cell MmDCSpVv[3Srb36gZZN{[Xl? M1vObWlv\HWldHnvckBw\iCQQkSgZ4VtdCCmaX\m[ZJmdnSrYYTpc44tKEWGNUC9NE43OSEQvF2= MkC1PVU4Ojh7Mx?=
human SK-NEP-1 cell NX;VZpVNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGX0eo5KdmirYnn0bY9vKG:oIHj1cYFvKFONLV7FVE0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC54NkKzNUDPxE1? MYDTRW5ITVJ?
human HCC1806 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHvybYxKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{G4NFYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd{OUK5JO69VQ>? NEf6fWxUSU6JRWK=
human T47D cells NU\EfXp[S3m2b4TvfIlkyqCjc4PhfS=> NHfPRZQ1QCCq MX\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDUOFdFKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwQVAvQDJizszN NYfMbWVqOjV5MEGyOVE>
human HuO-3N1 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV;KXZh5UW6qaXLpeIlwdiCxZjDoeY1idiCKdV:tN24yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC56M{G2JO69VQ>? M{XHdHNCVkeHUh?=
human RPMI-8226 cell NX:0bpMzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYLJcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOEKyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTl|M{Sg{txO MYXTRW5ITVJ?
human LAMA-84 cell MXjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{[4OWlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTl4M{Wg{txO MYnTRW5ITVJ?
human NCI-H720 cell Ml[5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHjZSJVKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO|IxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yMk[yNUDPxE1? MU\TRW5ITVJ?
human MOLT-13 cell NHzKc25Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoDzTY5pcWKrdHnvckBw\iCqdX3hckBOV0yWLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPDVizszN NFLoNlFUSU6JRWK=
human JVM-2 cell M2jaNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXvJcohq[mm2aX;uJI9nKGi3bXHuJGpXVS1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MT6xO|MyPiEQvF2= Mk\QV2FPT0WU
human NBsusSR cell NGDyb5lIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3f6T2lvcGmkaYTpc44hd2ZiaIXtZY4hVkK|dYPTVkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEvPDR7OEeg{txO NFr4N4lUSU6JRWK=
human BV-173 cell NXTLcHB[T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3PZeWlvcGmkaYTpc44hd2ZiaIXtZY4hSlZvMUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU42QTZ{NjFOwG0> MVjTRW5ITVJ?
human CTB-1 cell NUW1ZWJDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlLuTY5pcWKrdHnvckBw\iCqdX3hckBEXEJvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlA{QDlizszN M{DuRnNCVkeHUh?=
human ACN cell NInDNoFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIflUpdKdmirYnn0bY9vKG:oIHj1cYFvKEGFTjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlQ6QTlizszN MWjTRW5ITVJ?
human PC3 cells Ml75S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn72OkBl[Xm| M3i1c2dzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHBEOyClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBKSzVyPUKg{txO NGnZU|cyPTZzNUWyNS=>
human L-363 cell NV7me4c6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUXJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mj6wOlk3PCEQvF2= NV7EN2lrW0GQR1XS
human NCI-H69 cell MnTrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnSyTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSE[5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPjV4MTFOwG0> MXrTRW5ITVJ?
human ECC10 cell M3S4OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1nCUWlvcGmkaYTpc44hd2ZiaIXtZY4hTUOFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM5ODV{IN88US=> MUHTRW5ITVJ?
human NCI-H209 cell M33hbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MW\Jcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkC5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk42OjF|MjFOwG0> MnvoV2FPT0WU
human KARPAS-45 cell NUXR[YFnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV7LOXRmUW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW5OVgyKM7:TR?= NX\QR25DW0GQR1XS
human COR-L88 cell NYHrcYdHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWHJcohq[mm2aX;uJI9nKGi3bXHuJGNQWi2OOEigZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wN{45PTh5MjFOwG0> NHT1fIdUSU6JRWK=
human ML-2 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXLJcohq[mm2aX;uJI9nKGi3bXHuJG1NNTJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12LkCwOFM6KM7:TR?= M1njN3NCVkeHUh?=
human U-266 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGHSSY1KdmirYnn0bY9vKG:oIHj1cYFvKFVvMk[2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yOTh{OTFOwG0> NWruc2s3W0GQR1XS
human HT-29 cells NWnUd5ZOS3m2b4TvfIlkyqCjc4PhfS=> MmjYOFghcA>? MofYR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTHQuOjliY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME20MlMh|ryP NWjI[2FnOjB2MEW4OFk>
human RS4-11 cell M2SxfWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NUXEV2I1UW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjR2N{O3JO69VQ>? NW\OTHk3W0GQR1XS
human DB cell NXfKPXB5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWnJcohq[mm2aX;uJI9nKGi3bXHuJGRDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC55NkWxPUDPxE1? NHjLXJlUSU6JRWK=
human NB14 cell M{e3VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEHQUGlKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlEzPzFizszN M1;zWHNCVkeHUh?=
human BPH-1 cell MlXLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWfJcohq[mm2aX;uJI9nKGi3bXHuJGJRUC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz60N|YyOSEQvF2= MlHKV2FPT0WU
human PC3 cells NXPoTWJHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVjlcVBxPSCmYYnz NY\lRnJwT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWEN|IHPlcIx{KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEeLNUC9O{43KM7:TR?= MUixPFU1OzlyMh?=
human EW-13 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXnF[pNNUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xN{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPjFyN{ig{txO MUHTRW5ITVJ?
human NCI-H526 cell NY\CWW9kT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NED3TZdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py54OEK5NUDPxE1? NGTTWoZUSU6JRWK=
human NKM-1 cell M1\QNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH7IZXhKdmirYnn0bY9vKG:oIHj1cYFvKE6NTT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE41OTByOTFOwG0> M2TqSnNCVkeHUh?=
human MDA-MB-453 cells M361VGN6fG:2b4jpZ:Kh[XO|YYm= NGjPXIU1QCCq NWqyelhXS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hVUSDLV3CMVQ2OyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF06NjVzIN88US=> NFzYSG8zPTdyMUK1NS=>
human MEG-01 cell MmfGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4LYO2lvcGmkaYTpc44hd2ZiaIXtZY4hVUWJLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU43OTNzODFOwG0> NW\EV|lEW0GQR1XS
human NCI-H1648 cell MkXoS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVn6UXJ1UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3PDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkezOlE4KM7:TR?= MXHTRW5ITVJ?
human LNCaP cells MoPlS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml7HOkBl[Xm| MnLGS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUG5E[VBiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2xNEDPxE1? Mn\qNVU3OTV3MkG=
human GP5d cell MlrhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFTJRXFKdmirYnn0bY9vKG:oIHj1cYFvKEeSNXSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE4zPjN5IN88US=> NGT6bXNUSU6JRWK=
human MDA-MB-231 cells Mn;rS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnqxOUBl[Xm| NF73NppIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIFnfGW{IEWg[IF6eyCkeTDNWHQh[XO|YYmsJGdKPTB;MUCuPFUh|ryP NVfLS41JOTh3NEO5NFI>
human DU145 cells MVvDfZRwfG:6aXRCpIF{e2G7 Mn7lOFghcA>? MWDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF0yOS54NDFOwG0> Mm[4NlU4ODF{NUG=
human DEL cell M4iyd2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH3ZZW5KdmirYnn0bY9vKG:oIHj1cYFvKESHTDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlM4OjhizszN NG[xbHhUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. [1] Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. [3] Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. [4] Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. [5]

Protocol

Solubility (25°C)

In vitro DMSO 60 mg/mL (199.73 mM)
Ethanol 6 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.4
Formula

C20H28O2

CAS No. 302-79-4
Storage powder
Synonyms All-trans Retinoic Acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02403778 Active, not recruiting Melanoma University of Colorado, Denver September 30, 2015 Phase 2
NCT02842827 Recruiting Acute Myeloid Leukemia|Myelodysplastic Syndrome Imago BioSciences,Inc. October 2016 Phase 1
NCT02899169 Recruiting Acute Promyelocytic Leukemia First Affiliated Hospital Xian Jiaotong University|Tang-Du Hospital September 2016 Phase 3
NCT02751255 Recruiting Multiple Myeloma VU University Medical Center|EMC Rotterdam|UMC Utrecht|Vejle Hospital and University of Southern Denmark|Department of Medical Sciences, University of Torino August 2016 Phase 1|Phase 2
NCT02688140 Recruiting Acute Promyelocytic Leukemia Technische Universität Dresden|Gruppo Italiano Malattie EMatologiche dellAdulto|Groupe Francophone des Myelodysplasies|Haemato Oncology Foundation for Adults in the Netherlands|Programa para el Tratamiento de Hemopatías Malignas|German Federal Ministry of Education and Research|Teva Pharmaceuticals Europe June 2016 Phase 3
NCT03026907 Recruiting Hand Eczema University Medical Center Groningen May 2016 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID