Tretinoin

Catalog No.S1653 Synonyms: All-trans Retinoic Acid

Tretinoin Chemical Structure

Molecular Weight(MW): 300.4

Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

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Purity & Quality Control

Choose Selective Retinoid Receptor Inhibitors

Biological Activity

Description Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Targets
RAR [1] RXR [1]
In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. [1] Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse F9 cells MY\GeY5kfGmxbjDhd5NigQ>? NUfLS3pkOyCmYYnz Mnv5TY5lfWO2aX;uJI9nKHSncn3pcoFtKGSrZn\ldoVvfGmjdHnvckBqdiCvb4Xz[UBHQSClZXzsd{Bie3Onc4Pl[EBjgSCvZXHzeZJqdmdic3XjdoV1\WRicHzhd41qdm:pZX6gZYN1cX[jdH;yJIFkfGm4aYT5JIFnfGW{IEOg[IF6eyxiSVO1NF0xNjByMEGg{txO NInTWY0yPzR6OUW3PS=>
COS7 cells NV;ZT2hiTnWwY4Tpc44h[XO|YYm= MUOxOkBp MnXpRYN1cX[rdImgZZQhcHWvYX6gVmFT\2GvbXGgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDDU3M4KGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIghT2GuND3ERmQh[XO|ZYPz[YQh[XNidILhcpNkemmydHnvcoFtKGGldHn2ZZRqd25iYX\0[ZIhOTZiaILzJIJ6KEejbESgdoV{eG:wc3Wg[YxmdWWwdD3kdol3\W5ibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUCuNFAxOiEQvF2= M1vhflE6ODV6OU[1
CV-1 cells M3;yZ2Z2dmO2aX;uJIF{e2G7 M3;KZ3Rz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIlvKEOYLUGgZ4VtdHNiZYjwdoV{e2mwZzDS[ZRqdm:rYzDhZ4llKHKnY3XweI9zKFKDUjDnZY1u[SxiRVO1NF0xNjByMEeg{txO NWfUWodkPzR7MEeyOS=>
human breast cancer cell SK-BR-3 M2P2bXBzd2yrZnXyZZRqd25iYYPzZZk> M3\4TWlvcGmkaYTpc44hd2ZiRWKtcoVo[XSrdnWgbJVu[W5iYoLlZZN1KGOjbnPldkBk\WyuIGPLMWJTNTNicILvcIln\XKjdHnvckwhUUN3ME2wMlAxOTdizszN M1jqZVEzOzd{NUKw
HL-60 cells MXrGeY5kfGmxbjDhd5NigQ>? M2nWOmlv\HWldHnvckBw\iC2cnHud4dtfXSjbXnuZZNmKCiWR3Hz[Ukh[WO2aY\peJkhcW5iSFytOlAh[2WubIOsJGVEPTB;MD6wNFUh|ryP Mof3PFc5PDR3NB?=
human T47D cells MnLGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXTWOItvPiCmYYnz NWrFOIs2T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hXDR5RDDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODB4IN88US=> NITFRm8yPTZzNUWyNS=>
mouse NIH3T3 cells NX;UWmxHTnWwY4Tpc44h[XO|YYm= MVrBZ5Rqfmm2eTDheEBTSVKjbIDoZUBmgHC{ZYPz[YQhcW5ibX;1d4UhVkmKM2SzJINmdGy|IHL5JHIuW0GWIHHzd4F6NCCHQ{WwQVAvODB4M{Gg{txO NEC0UW0yQTJ|OUKzNC=>
Raji cells MkOxSpVv[3Srb36gZZN{[Xl? MXe0PEBp NHfCVIVKdmirYnn0bY9vKG:oIGTQRU1qdmS3Y3XkJGVxe3SnaX6tRoFzeiC4aYL1d{Bm[XKueTDhcpRq\2WwIHHjeIl3[XSrb36gbY4hWmGsaTDj[YxteyCjZoTldkA1QCCqcoOsJGlEPTB;MD6wNVU1KM7:TR?= MYGxO|UxOzh3MB?=
human MV-4-11 cell NYjrTYFOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYi4b2RCUW6qaXLpeIlwdiCxZjDoeY1idiCPVj20MVEyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5yMkC5PUDPxE1? M3THVXNCVkeHUh?=
human ATN-1 cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3nPTmlvcGmkaYTpc44hd2ZiaIXtZY4hSVSQLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlA{ODNizszN MnzYV2FPT0WU
HL-60 cells MXnGeY5kfGmxbjDhd5NigQ>? NYjPdI9VPCCmYYnz NHrJS2lKdmS3Y4Tpc44hd2ZiSFytOlAh[2WubIOg[Iln\mW{ZX70bYF1cW:wIH;2[ZIhPCCmYYnzMEBGTDVyPUCuNVIh|ryP MXG5OVczQDl|
human MC-IXC cell MorxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1fZW2lvcGmkaYTpc44hd2ZiaIXtZY4hVUNvSWjDJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yPTR|NjFOwG0> MVXTRW5ITVJ?
human HH cell M3PlVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NI\N[WlKdmirYnn0bY9vKG:oIHj1cYFvKEiKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xPVU2PCEQvF2= Mn\aV2FPT0WU
T-47D cells MYLQdo9tcW[ncnH0bY9vKGG|c3H5 MYPJcohq[mm2aX;uJI9nKEWUIIDvd4l1cX[nIHj1cYFvKGK{ZXHzeEBk[W6lZYKgZ4VtdCCWLUS3SEBxem:uaX\ldoF1cW:wLDDJR|UxRTBwMjFOwG0> NWf2V|U6OTJ|N{K1NlA>
human NB13 cell M3TFNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGDzfFlKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlI2PjZ2IN88US=> MnXkV2FPT0WU
human D-283MED cell M3\oemdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4HuUWlvcGmkaYTpc44hd2ZiaIXtZY4hTC1{OEPNSWQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjJ6Mk[yJO69VQ>? MmTyV2FPT0WU
human HL-60 cell NUm5cWU2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXTJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yPFQ6OSEQvF2= M{S5fXNCVkeHUh?=
human EW-3 cell NVrTN2p7T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3vF[GlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOFgxOjhizszN NXrucHpHW0GQR1XS
human LNCAP cells NHz4WZRRem:uaX\ldoF1cW:wIHHzd4F6 MV:0PEBp NVuwSW1JSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDMUmNCWCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUCuOUDPxE1? MWOxPVM4PTh{NR?=
human KU812 cell Mn3TS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGjncoRKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE42OzZyOTFOwG0> NVnRXWs{W0GQR1XS
human MCF7 cells NHT0V2FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MW[2JIRigXN? M2P2NWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlU5KM7:TR?= M3PZOlE2PjF3NUKx
NB4 cell NXnGN5VITnWwY4Tpc44h[XO|YYm= M13RdGlv\HWldHnvckBw\iCQQkSgZ4VtdCCmaX\m[ZJmdnSrYYTpc44tKEWGNUC9NE43OSEQvF2= Mlr4PVU4Ojh7Mx?=
human SK-NEP-1 cell NFzPb5FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4foS2lvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjZ4MkOxJO69VQ>? MVzTRW5ITVJ?
human HCC1806 cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFfPeodKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{G4NFYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjd{OUK5JO69VQ>? NXHtOXlRW0GQR1XS
human T47D cells MlrmR5l1d3SxeHnjxsBie3OjeR?= NHvKV5U1QCCq NHfMO21EgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBVPDeGIHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDHTVUxRTBwOEKg{txO NHXNVGIzPTdyMUK1NS=>
human HuO-3N1 cell M2m0fmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlPuTY5pcWKrdHnvckBw\iCqdX3hckBJfU9vM16xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE45OzF4IN88US=> M2HJUHNCVkeHUh?=
human RPMI-8226 cell M4f5Smdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV\Jcohq[mm2aX;uJI9nKGi3bXHuJHJRVUlvOEKyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTl|M{Sg{txO NGHMbJlUSU6JRWK=
human LAMA-84 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1PpUGlvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTl4M{Wg{txO MVTTRW5ITVJ?
human NCI-H720 cell MnXuS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3\MNGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3NlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjB{NkKxJO69VQ>? MlPuV2FPT0WU
human MOLT-13 cell NEe1THVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIXMcmdKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjF2NTFOwG0> M{PtZnNCVkeHUh?=
human JVM-2 cell MnWxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NG\4[nJKdmirYnn0bY9vKG:oIHj1cYFvKEqYTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPzNzNjFOwG0> NHTvfGdUSU6JRWK=
human NBsusSR cell NX3WT2pKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWXJcohq[mm2aX;uJI9nKGi3bXHuJG5De3W|U2KgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlQ1QTh5IN88US=> MkHQV2FPT0WU
human BV-173 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYfsVFg4UW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjV7NkK2JO69VQ>? M2nEe3NCVkeHUh?=
human CTB-1 cell Mn;xS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MojQTY5pcWKrdHnvckBw\iCqdX3hckBEXEJvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlA{QDlizszN M3LzS3NCVkeHUh?=
human ACN cell NFK2[nFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGFEViClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFwNkS5PVkh|ryP NHfRTYVUSU6JRWK=
human PC3 cells NYTt[3gzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M13ae|Yh\GG7cx?= MXPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR|Mh[2WubIOgZYZ1\XJiNjDkZZl{KGK7IF3UWEBie3OjeTygTWM2OD1{IN88US=> NF3ETZoyPTZzNUWyNS=>
human L-363 cell NXH3UWVHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M17GZmlvcGmkaYTpc44hd2ZiaIXtZY4hVC1|NkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlA3QTZ2IN88US=> M2XmdnNCVkeHUh?=
human NCI-H69 cell M13iTmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mm\aTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSE[5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4zPjV4MTFOwG0> MU\TRW5ITVJ?
human ECC10 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4CzZWlvcGmkaYTpc44hd2ZiaIXtZY4hTUOFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM5ODV{IN88US=> NWHiRW1lW0GQR1XS
human NCI-H209 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYO0SHJSUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUKxN|Ih|ryP M1LnbXNCVkeHUh?=
human KARPAS-45 cell NEPSTHdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFnKXItKdmirYnn0bY9vKG:oIHj1cYFvKEuDUmDBV{01PSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUm1PFEh|ryP MmC1V2FPT0WU
human COR-L88 cell M{DTOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3;1WGlvcGmkaYTpc44hd2ZiaIXtZY4hS0:ULVy4PEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVA{Njh3OEeyJO69VQ>? MWnTRW5ITVJ?
human ML-2 cell M2KzRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFz1R|FKdmirYnn0bY9vKG:oIHj1cYFvKE2OLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlAxPDN7IN88US=> MonZV2FPT0WU
human U-266 cell NFPpc4tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF:1bnpKdmirYnn0bY9vKG:oIHj1cYFvKFVvMk[2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4yOTh{OTFOwG0> MknUV2FPT0WU
human HT-29 cells NEf5S|REgXSxdH;4bYPDqGG|c3H5 MWm0PEBp NIjKdWFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBJXC1{OTDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVQvOyEQvF2= MWSyNFQxPTh2OR?=
human RS4-11 cell NEfTUpdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{XWW2lvcGmkaYTpc44hd2ZiaIXtZY4hWlN2LUGxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE41PDd|NzFOwG0> MUnTRW5ITVJ?
human DB cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGRDKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC55NkWxPUDPxE1? MnXXV2FPT0WU
human NB14 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4TadGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuNVI4OSEQvF2= MkHZV2FPT0WU
human BPH-1 cell Mn\YS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MofUTY5pcWKrdHnvckBw\iCqdX3hckBDWEhvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuOFM3OTFizszN MmfXV2FPT0WU
human PC3 cells MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NH\3b4s2KGSjeYO= NXrOR2tDT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWEN|IHPlcIx{KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEeLNUC9O{43KM7:TR?= MlPHNVg2PDN7MEK=
human EW-13 cell NYTEVXR{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mof0TY5pcWKrdHnvckBw\iCqdX3hckBGXy1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUeuOlExPzhizszN MU\TRW5ITVJ?
human NCI-H526 cell NEDHbpJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX3tVGx5UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFUzPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwNkiyPVEh|ryP NHvVXnZUSU6JRWK=
human NKM-1 cell NXLMc3QyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3TZU2lvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlQyODB7IN88US=> NHP5ZWxUSU6JRWK=
human MDA-MB-453 cells MYnDfZRwfG:6aXRCpIF{e2G7 MWS0PEBp MV\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvNEWzJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBIUTVyPUmuOVEh|ryP NILCXHozPTdyMUK1NS=>
human MEG-01 cell MorLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYXKO5FLUW6qaXLpeIlwdiCxZjDoeY1idiCPRVetNFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF06NjZzM{G4JO69VQ>? NYnYXoZvW0GQR1XS
human NCI-H1648 cell NIDuNnVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXLWOos{UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFE3PDhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkezOlE4KM7:TR?= MkDSV2FPT0WU
human LNCaP cells NUPkNHd3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3jGNFYh\GG7cx?= NEL6RpFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBNVkOjUDDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVExKM7:TR?= NFzmSG8yPTZzNUWyNS=>
human GP5d cell NHvH[XlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVHJcohq[mm2aX;uJI9nKGi3bXHuJGdRPWRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMD6yOlM4KM7:TR?= NGi0ZplUSU6JRWK=
human MDA-MB-231 cells M2DLfmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGrFNmQ2KGSjeYO= MVjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDViZHH5d{BjgSCPVGSgZZN{[XluIFfJOVA:OTBwOEWg{txO M1PmU|E5PTR|OUCy
human DU145 cells M{CwfWN6fG:2b4jpZ:Kh[XO|YYm= MUK0PEBp M4HmPGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDHTVUxRTFzLk[0JO69VQ>? MWKyOVcxOTJ3MR?=
human DEL cell MlXiS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2PvcWlvcGmkaYTpc44hd2ZiaIXtZY4hTEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuN|czQCEQvF2= MXPTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. [1] Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. [3] Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. [4] Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. [5]

Protocol

Solubility (25°C)

In vitro DMSO 60 mg/mL (199.73 mM)
Ethanol 6 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.4
Formula

C20H28O2

CAS No. 302-79-4
Storage powder
in solvent
Synonyms All-trans Retinoic Acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02403778 Active, not recruiting Melanoma University of Colorado, Denver September 30, 2015 Phase 2
NCT02842827 Recruiting Acute Myeloid Leukemia|Myelodysplastic Syndrome Imago BioSciences,Inc. October 2016 Phase 1
NCT02899169 Recruiting Acute Promyelocytic Leukemia First Affiliated Hospital Xian Jiaotong University|Tang-Du Hospital September 2016 Phase 3
NCT02751255 Recruiting Multiple Myeloma VU University Medical Center|EMC Rotterdam|UMC Utrecht|Vejle Hospital and University of Southern Denmark|Department of Medical Sciences, University of Torino August 2016 Phase 1|Phase 2
NCT02688140 Recruiting Acute Promyelocytic Leukemia Technische Universität Dresden|Gruppo Italiano Malattie EMatologiche dellAdulto|Groupe Francophone des Myelodysplasies|Haemato Oncology Foundation for Adults in the Netherlands|Programa para el Tratamiento de Hemopatías Malignas|German Federal Ministry of Education and Research|Teva Pharmaceuticals Europe June 2016 Phase 3
NCT03026907 Recruiting Hand Eczema University Medical Center Groningen May 2016 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID