Tretinoin

Catalog No.S1653 Synonyms: All-trans Retinoic Acid

Tretinoin Chemical Structure

Molecular Weight(MW): 300.4

Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

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Purity & Quality Control

Choose Selective Retinoid Receptor Inhibitors

Biological Activity

Description Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.
Targets
RAR [1] RXR [1]
In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. [1] Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
mouse F9 cells NGn4[HhHfW6ldHnvckBie3OjeR?= NX3rZ2F7OyCmYYnz Mnu1TY5lfWO2aX;uJI9nKHSncn3pcoFtKGSrZn\ldoVvfGmjdHnvckBqdiCvb4Xz[UBHQSClZXzsd{Bie3Onc4Pl[EBjgSCvZXHzeZJqdmdic3XjdoV1\WRicHzhd41qdm:pZX6gZYN1cX[jdH;yJIFkfGm4aYT5JIFnfGW{IEOg[IF6eyxiSVO1NF0xNjByMEGg{txO NVHvdmdsOTd2OEm1O|k>
COS7 cells M{DYXmZ2dmO2aX;uJIF{e2G7 MVqxOkBp MWnBZ5Rqfmm2eTDheEBpfW2jbjDSRXJo[W2vYTDsbYdidmRiYnnu[Ilv\yCmb33hbY4h\XiycnXzd4VlKGmwIFPPV|ch[2WubIOgZ48ufHKjboPm[YN1\WRid3n0bEBI[Wx2LVTCSEBie3Onc4Pl[EBieyC2cnHud4NzcXC2aX;uZYwh[WO2aY\heIlwdiCjZoTldkAyPiCqcoOgZpkhT2GuNDDy[ZNxd26|ZTDlcIVu\W62LXTybZZmdiCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6wNFAzKM7:TR?= NFrhRoEyQTB3OEm2OS=>
CV-1 cells NH3KT|BHfW6ldHnvckBie3OjeR?= NUXre25KXHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44hcW5iQ2[tNUBk\WyuczDlfJBz\XO|aX7nJHJmfGmwb3njJIFkcWRicnXj[ZB1d3JiUlHSJIdidW2jLDDFR|UxRTBwMECwO{DPxE1? NHfROWY4PDlyN{K1
human breast cancer cell SK-BR-3 MX;Qdo9tcW[ncnH0bY9vKGG|c3H5 M3jUOGlvcGmkaYTpc44hd2ZiRWKtcoVo[XSrdnWgbJVu[W5iYoLlZZN1KGOjbnPldkBk\WyuIGPLMWJTNTNicILvcIln\XKjdHnvckwhUUN3ME2wMlAxOTdizszN MV[xNlM4OjV{MB?=
HL-60 cells MYXGeY5kfGmxbjDhd5NigQ>? NXX1WFYxUW6mdXP0bY9vKG:oIITyZY5{\2y3dHHtbY5ie2ViKGTHZZNmMSCjY4Tpeol1gSCrbjDIUE03OCClZXzsd{whTUN3ME2wMlAxPSEQvF2= NH7OdHo5Pzh2NEW0
human T47D cells NF76[WlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYi2JIRigXN? NV:5OI9pT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hXDR5RDDj[YxteyCjZoTldkA3KGSjeYOgZpkhVVSWIHHzd4F6NCCLQ{WwQVAvODB4IN88US=> MV[xOVYyPTV{MR?=
mouse NIH3T3 cells NIfYXoRHfW6ldHnvckBie3OjeR?= NF3QW3JC[3Srdnn0fUBifCCUQWLhcJBp[SCneIDy[ZN{\WRiaX6gcY92e2ViTlnIN3Q{KGOnbHzzJIJ6KFJvU1HUJIF{e2G7LDDFR|UxRTBwMEC2N|Eh|ryP M1nqV|E6OjN7MkOw
Raji cells NFnFU2FHfW6ldHnvckBie3OjeR?= M3jIbFQ5KGh? MXrJcohq[mm2aX;uJI9nKFSSQT3pcoR2[2WmIFXwd5RmcW5vQnHydkB3cXK3czDlZZJtgSCjboTp[4VvKGGldHn2ZZRqd25iaX6gVoFrcSClZXzsd{Bi\nSncjC0PEBpenNuIFnDOVA:OC5yMUW0JO69VQ>? MX6xO|UxOzh3MB?=
human MV-4-11 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGrIWVhKdmirYnn0bY9vKG:oIHj1cYFvKE2YLUStNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjB{MEm5JO69VQ>? NIPlW4xUSU6JRWK=
human ATN-1 cell NW\OUpJuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUHJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6wN|A{KM7:TR?= MUTTRW5ITVJ?
HL-60 cells NYLWSIZbTnWwY4Tpc44h[XO|YYm= MWG0JIRigXN? MVHJcoR2[3Srb36gc4YhUExvNkCgZ4VtdHNiZHnm[oVz\W62aXH0bY9vKG:4ZYKgOEBl[Xm|LDDFSFUxRTBwMUKg{txO NF7MZ3E6PTd{OEmz
human MC-IXC cell NIfBPFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYGxPVRuUW6qaXLpeIlwdiCxZjDoeY1idiCPQz3JXGMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF3NEO2JO69VQ>? MYPTRW5ITVJ?
human HH cell NYPzd4NYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFXYO25KdmirYnn0bY9vKG:oIHj1cYFvKEiKIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xPVU2PCEQvF2= MYfTRW5ITVJ?
T-47D cells M3LzUHBzd2yrZnXyZZRqd25iYYPzZZk> M3jIT2lvcGmkaYTpc44hd2ZiRWKgdI9{cXSrdnWgbJVu[W5iYoLlZZN1KGOjbnPldkBk\WyuIGStOFdFKHC{b3zp[oVz[XSrb36sJGlEPTB;MD6yJO69VQ>? MkH0NVI{PzJ3MkC=
human NB13 cell MnfvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlTTTY5pcWKrdHnvckBw\iCqdX3hckBPSjF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yOVY3PCEQvF2= MoHvV2FPT0WU
human D-283MED cell NGjMNXpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGm1S2hKdmirYnn0bY9vKG:oIHj1cYFvKERvMkizUWVFKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5{OEK2NkDPxE1? Mm\nV2FPT0WU
human HL-60 cell Mn7kS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NWrnfG1nUW6qaXLpeIlwdiCxZjDoeY1idiCKTD22NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOjh2OUGg{txO NEDyVZpUSU6JRWK=
human EW-3 cell NGj2VpNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3nT[2lvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuOFgxOjhizszN MljOV2FPT0WU
human LNCAP cells NX\2dmk1WHKxbHnm[ZJifGmxbjDhd5NigQ>? M4LMPFQ5KGh? MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEyQQ1HQJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OC53IN88US=> NHHsTFIyQTN5NUiyOS=>
human KU812 cell MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGfVWFhKdmirYnn0bY9vKG:oIHj1cYFvKEuXOEGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE42OzZyOTFOwG0> NVTYTVZpW0GQR1XS
human MCF7 cells NXHvfpVoT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkHWOkBl[Xm| M4TJ[Gdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2wMlU5KM7:TR?= MlfvNVU3OTV3MkG=
NB4 cell MU\GeY5kfGmxbjDhd5NigQ>? M4\JTWlv\HWldHnvckBw\iCQQkSgZ4VtdCCmaX\m[ZJmdnSrYYTpc44tKEWGNUC9NE43OSEQvF2= MnrPPVU4Ojh7Mx?=
human SK-NEP-1 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4K4O2lvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTlXQMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjZ4MkOxJO69VQ>? NYLyPYxoW0GQR1XS
human HCC1806 cell NEf3VllIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4PSfWlvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUiwOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvPzJ7Mkmg{txO NULUPWF7W0GQR1XS
human T47D cells M2P1fmN6fG:2b4jpZ:Kh[XO|YYm= NUPYUnNsPDhiaB?= Mk\wR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gWFQ4TCClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPDhiaILzJIJ6KE2WVDDhd5NigSxiR1m1NF0xNjh{IN88US=> M33scFI2PzBzMkWx
human HuO-3N1 cell NIXyfGJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFnJR|ZKdmirYnn0bY9vKG:oIHj1cYFvKEi3Tz2zUlEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjh|MU[g{txO M2XYVXNCVkeHUh?=
human RPMI-8226 cell NU\NZ3NrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NU\udIxCUW6qaXLpeIlwdiCxZjDoeY1idiCUUF3JMVgzOjZiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkm5N|M1KM7:TR?= MWTTRW5ITVJ?
human LAMA-84 cell MkK1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2jpR2lvcGmkaYTpc44hd2ZiaIXtZY4hVEGPQT24OEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvQTl4M{Wg{txO M{TzO3NCVkeHUh?=
human NCI-H720 cell NUftXHV6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHfVcJdKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO|IxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5yMk[yNUDPxE1? M2jyR3NCVkeHUh?=
human MOLT-13 cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVnx[|lEUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE{KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OS5zNEWg{txO M3nMVHNCVkeHUh?=
human JVM-2 cell MlnMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGPZOZdKdmirYnn0bY9vKG:oIHj1cYFvKEqYTT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU4yPzNzNjFOwG0> NFvrNVlUSU6JRWK=
human NBsusSR cell M4P0[Wdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmWxTY5pcWKrdHnvckBw\iCqdX3hckBPSnO3c2PSJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NU41PDl6NzFOwG0> MXrTRW5ITVJ?
human BV-173 cell NEHkN49Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWjmd|hOUW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yNjV7NkK2JO69VQ>? NWK2[lluW0GQR1XS
human CTB-1 cell NVHyfXdXT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mn3iTY5pcWKrdHnvckBw\iCqdX3hckBEXEJvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGuOlA{QDlizszN M4fo[nNCVkeHUh?=
human ACN cell Mn6wS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoO3TY5pcWKrdHnvckBw\iCqdX3hckBCS05iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLk[0PVk6KM7:TR?= M2DFXHNCVkeHUh?=
human PC3 cells M{Dq[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M361fFYh\GG7cx?= M2OwOWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJHBEOyClZXzsd{Bi\nSncjC2JIRigXNiYomgUXRVKGG|c3H5MEBKSzVyPUKg{txO NGL6[HkyPTZzNUWyNS=>
human L-363 cell NFHZVW1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHfTW3VKdmirYnn0bY9vKG:oIHj1cYFvKExvM{[zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Nk4xPjl4NDFOwG0> M3TaSXNCVkeHUh?=
human NCI-H69 cell NWWxS2tqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUDMS5R7UW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFY6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Oi5{NkW2NUDPxE1? NVj6dWFHW0GQR1XS
human ECC10 cell NHHzeYNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3nmbWlvcGmkaYTpc44hd2ZiaIXtZY4hTUOFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yMlM5ODV{IN88US=> NX2y[WZLW0GQR1XS
human NCI-H209 cell NVfJTVFyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWfxZYVwUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1mtTFIxQSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNUKxN|Ih|ryP NYnwcIZoW0GQR1XS
human KARPAS-45 cell Ml3QS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXvFd5VbUW6qaXLpeIlwdiCxZjDoeY1idiCNQWLQRXMuPDViY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{LkW5OVgyKM7:TR?= NYX2V|ByW0GQR1XS
human COR-L88 cell NWfQNW9yT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmS4TY5pcWKrdHnvckBw\iCqdX3hckBEV1JvTEi4JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NFMvQDV6N{Kg{txO MV;TRW5ITVJ?
human ML-2 cell MoTNS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFr5SGVKdmirYnn0bY9vKG:oIHj1cYFvKE2OLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlAxPDN7IN88US=> NHP2NHVUSU6JRWK=
human U-266 cell M3fmcmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV\Jcohq[mm2aX;uJI9nKGi3bXHuJHUuOjZ4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND6xNVgzQSEQvF2= NInrUlBUSU6JRWK=
human HT-29 cells MX7DfZRwfG:6aXRCpIF{e2G7 NHTHT4k1QCCq MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIWE0zQSClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUSuN{DPxE1? M{HoW|IxPDB3OES5
human RS4-11 cell M{W2cGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVrkfG1VUW6qaXLpeIlwdiCxZjDoeY1idiCUU{StNVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF01NjR2N{O3JO69VQ>? M3fnWXNCVkeHUh?=
human DB cell NFK2cZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVPOeZlKUW6qaXLpeIlwdiCxZjDoeY1idiCGQjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuO|Y2OTlizszN MkLpV2FPT0WU
human NB14 cell MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MUXJcohq[mm2aX;uJI9nKGi3bXHuJG5DOTRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD15LkGyO|Eh|ryP M4flNHNCVkeHUh?=
human BPH-1 cell NVviTHFwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{TFeWlvcGmkaYTpc44hd2ZiaIXtZY4hSlCKLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlQ{PjFzIN88US=> MlTrV2FPT0WU
human PC3 cells NX7Fe4ZvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXq3UnpwPSCmYYnz NYnW[nNKT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWEN|IHPlcIx{KGGodHXyJFUh\GG7czDifUBOXFRiYYPzZZktKEeLNUC9O{43KM7:TR?= MUCxPFU1OzlyMh?=
human EW-13 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3nSfmlvcGmkaYTpc44hd2ZiaIXtZY4hTVdvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23MlYyODd6IN88US=> Ml;jV2FPT0WU
human NCI-H526 cell NEK5U4VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEf0[25KdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVI3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py54OEK5NUDPxE1? M3y0eHNCVkeHUh?=
human NKM-1 cell MmnaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWDJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD60NVAxQSEQvF2= MknXV2FPT0WU
human MDA-MB-453 cells MV3DfZRwfG:6aXRCpIF{e2G7 M2XGd|Q5KGh? NGLuNYVEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOTEFvTVKtOFU{KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCJSUWwQVkvPTFizszN Ml\4NlU4ODF{NUG=
human MEG-01 cell NEjqRXdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{XzN2lvcGmkaYTpc44hd2ZiaIXtZY4hVUWJLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU43OTNzODFOwG0> NFfhd2pUSU6JRWK=
human NCI-H1648 cell NV\CNWlOT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFT4foZKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVY1QCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTlwN{O2NVch|ryP MVvTRW5ITVJ?
human LNCaP cells Mon2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NY\4TFA2PiCmYYnz MnK5S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUG5E[VBiY3XscJMh[W[2ZYKgOkBl[Xm|IHL5JG1VXCCjc4PhfUwhUUN3ME2xNEDPxE1? NUjQSIhtOTV4MUW1NlE>
human GP5d cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYHiUo5QUW6qaXLpeIlwdiCxZjDoeY1idiCJUEXkJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvOjZ|NzFOwG0> MnjmV2FPT0WU
human MDA-MB-231 cells MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHvaPGY2KGSjeYO= MoHDS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDh[pRmeiB3IHThfZMh[nliTWTUJIF{e2G7LDDHTVUxRTFyLki1JO69VQ>? NEnZW2YyQDV2M{mwNi=>
human DU145 cells NWOxZpY4S3m2b4TvfIlkyqCjc4PhfS=> MYq0PEBp M1vRdWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGRWOTR3IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDh[pRmeiB2ODDodpMh[nliTWTUJIF{e2G7LDDHTVUxRTFzLk[0JO69VQ>? MWCyOVcxOTJ3MR?=
human DEL cell M{\ZVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWnJcohq[mm2aX;uJI9nKGi3bXHuJGRGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF3LkO3Nlgh|ryP NWLnbmlPW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Tretinoin-treated old male Fischer 344 rats have 30% lower protein content in the renal cortex than control old rats, this effect may depend on the inhibition of the expression of tumor necrosis factor-beta1, a matrigenic cytokine, and osteopontin, a protein with cell adhesive and chemotactic properties. [1] Tretinoin has the ability to prevent the major steroid-induced biomechanical changes in hairless mouse dermal connective tissue that contribute to atrophy. [3] Tretinoin combined with imiquimod leads to faded tattoos and moderate clearance of pigment on histopathology in the guinea pig. [4] Tretinoin increases fibroplastic proliferation in the Skin incisions were made in 45 CD-1 mice, but the production of collagen was diminished. [5]

Protocol

Solubility (25°C)

In vitro DMSO 60 mg/mL (199.73 mM)
Ethanol 6 mg/mL (19.97 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 300.4
Formula

C20H28O2

CAS No. 302-79-4
Storage powder
Synonyms All-trans Retinoic Acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02403778 Active, not recruiting Melanoma University of Colorado, Denver September 30, 2015 Phase 2
NCT02842827 Recruiting Acute Myeloid Leukemia|Myelodysplastic Syndrome Imago BioSciences,Inc. October 2016 Phase 1
NCT02899169 Recruiting Acute Promyelocytic Leukemia First Affiliated Hospital Xian Jiaotong University|Tang-Du Hospital September 2016 Phase 3
NCT02751255 Recruiting Multiple Myeloma VU University Medical Center|EMC Rotterdam|UMC Utrecht|Vejle Hospital and University of Southern Denmark|Department of Medical Sciences, University of Torino August 2016 Phase 1|Phase 2
NCT02688140 Recruiting Acute Promyelocytic Leukemia Technische Universität Dresden|Gruppo Italiano Malattie EMatologiche dellAdulto|Groupe Francophone des Myelodysplasies|Haemato Oncology Foundation for Adults in the Netherlands|Programa para el Tratamiento de Hemopatías Malignas|German Federal Ministry of Education and Research|Teva Pharmaceuticals Europe June 2016 Phase 3
NCT03026907 Recruiting Hand Eczema University Medical Center Groningen May 2016 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID