Home Neuronal Signaling AChR agonist Varenicline Hydrochloride

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Varenicline Hydrochloride AChR agonist

Cat.No.S5022

Varenicline (CP 526555) Hydrochloride is a partial agonist of α4β2 nicotine acetylcholine receptor (nAChR) and α6β2 nicotine acetylcholine receptor (nAChR), with a Ki value of 0.12 nM and 0.14 nM for α6β2 nAChR and α4β2 nAChR, respectively, in the striatum of rats.
Varenicline Hydrochloride AChR agonist Chemical Structure

Chemical Structure

Molecular Weight: 247.72

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Quality Control

Batch: S502201 Water]50 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.95%
99.95

Solubility

In vitro
Batch:

Water : 50 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 247.72 Formula

C13H14ClN3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 230615-23-3 -- Storage of Stock Solutions

Synonyms CP 526555 hydrochloride Smiles Cl.C1NCC2CC1C3=CC4=NC=CN=C4C=C23

Mechanism of Action

Targets/IC50/Ki
α6β2 nAChR
(Cell-free assay)
0.12 nM(Ki)
α4β2 nAChR
(Cell-free assay)
0.14 nM(Ki)
References

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