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Taurolidine

Synonyms: Taurolin, Tauroline, Tauroflex

Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.

Taurolidine Chemical Structure

Taurolidine Chemical Structure

CAS: 19388-87-5

Purity & Quality Control

Batch: S488501 DMSO] 56 mg/mL] false] ] ] false] ] ] false Purity: 98%
98

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Biological Activity

Description Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.
In vitro
In vitro Taurolidine inhibits the growth of a rat metastatic colorectal tumor cell line in vitro[1]. Taurolidine possesses antineoplastic activity. The antiproliferative IC50 of taurolidine is in the 10-50 μM range, approximately 100-fold lower that that required for its antibiotic effects. Exposure to taurolidine induces apoptosis in SKOV-3 and PA-1 human tumor cells but apparently not in NIH-3T3 fibroblasts[2]. Taurolidine causes significant in vitro growth inhibition and cytotoxicity of human MM cells, which appears to be due, at least in part, to apoptosis[3].
Cell Research Cell lines a rat metastatic colorectal tumor cell line (DHD/K12/TRb)
Concentrations 5, 10, 15, 25 mg/ml
Incubation Time 14 h
Method DHD/K12/TRb cells (1×105 cells/ml) are cultured in 24-well plates and incubated for 6 hours at 37°C in humidified 5% CO2 conditions to allow the cells to adhere. Culture medium is then removed and fresh culture medium alone (control) or culture medium with 5, 10, 15, and 25 mg/ml of Taurolidine is added. Cells are then incubated at 37°C in humidified 5% CO2 conditions for a further 14 hours followed by addition of 10 ml of BrdU labeling solution.
In Vivo
In vivo In BD IX rats that underwent laparotomy, intraperitoneal instillation of DHD/K12/TRb tumor cells, local/intraperitoneal administration of taurolidine results in a marked decrease in tumor burden compared with control animals[1]. The i.p. administration of taurolidine effectively inhibits the development and growth of ovarian tumors when therapy is initiated on the day of tumor cell injection[2]. i.p. taurolidine inhibits adherence of colon tumor cells injected into the peritoneal cavity of rats[3].
Animal Research Animal Models Adult male syngenic BD IX rats, aged 8-10 weeks
Dosages 100 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02279121 Completed
Catheter-Related Infections
Centre Hospitalier Régional Metz-Thionville|centre régional de pharmacovigilance de Nancy|Theradial
 November 2014 Not Applicable

Chemical Information & Solubility

Molecular Weight 284.36 Formula

C7H16N4O4S2
CAS No. 19388-87-5 SDF --
Smiles C1CS(=O)(=O)NCN1CN2CCS(=O)(=O)NC2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 56 mg/mL ( (196.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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