Research Area
Product Type
United States ( Change Country )
BTZ043 racemate Chemical Structure
[Ala92]-p16 (84-103)
[Ala92]-p16 (84-103) is a CDK inhibitor with IC50 of 1.5μM for cyclin-dependent kinase-4 (cdk4)/cyclin D1
Bax inhibitor peptide,negative control
Bax inhibitor peptide,negative control is a negative control peptide for the Bax inhibitor peptides V5 and P5.
JIP-1(153-163)
JNK and p38 MAPK inhibitor
pp60 c-src (521-533)(phosphorylated)
SRC kinase inhibitor
STF-62247
Targeting VHL-deficient RCC cells, in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 μM).
GSK690693
GSK690693 is a pan-Akt kinase inhibitor,IC50 of Akt 1, 2, and 3 at 2, 13, and 9 nM respectively.
Odanacatib (MK 0822)
cathepsin K inhibitor with an IC50 of 0.2nM.
Malotilate
Malotilate is a liver protein metabolism improved compound.
PA-824
PA-824 is an experimental anti-tuberculosis drug with MIC of less than 1 μg/mL for tuberculosis.
Aprepitant (MK-0869)
Substance P antagonists (SPA).
Biological Activity
BTZ043 racemate is a decaprenylphosphoryl-b-D-ribose 2’-epimerase inhibitor with MIC of 2.3 and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively. BTZ043 racemate mainly targets the enzyme decaprenylphosphoryl-b-D-ribose 2’-epimerase. Inhibition of this enzymatic activity abolishes the formation of decaprenylphosphoryl arabinose, a key precursor that is required for the synthesis of the cell-wall arabinans, thus provoking cell lysis and bacterial death. BTZ043 racemate displayed similar activity against all clinical isolates of M. tuberculosis that were tested. The MIC ofBTZ043 racemate against M. tuberculosis H37Rv and Mycobacterium smegmatis were 1 ng/ml and 4 ng/ml, respectively, which compares favorably with those of the existing TB drugs isoniazid (INH) (0.02 to 0.2 mg/ml) and ethambutol (EMB) (1 to 5 mg/ml). [1]
References on BTZ043 racemate
- [1] Science. 2009 May 8.;324(5928):801-4.
Product Information
| Molecular Weight (WM): | 431.39 |
|---|---|
| Formula: | C17H16F3N3O5S |
| CAS No.: | 957217-65-1 |
| Synonyms: |
BTZ038, BTZ044
|
| Dissolve in (25°C): | DMSO ≥12mg/mL |
| Water <1mg/mL | |
| Ethanol ≥4mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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