Sodium Phenylbutyrate

Catalog No.S4125

Sodium Phenylbutyrate Chemical Structure

Molecular Weight(MW): 186.18

Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
USD 970 In stock

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1 Customer Review

  • Representative images and quantitative analysis results of the transwell experiment. Notes: (A) Results of migration assay for DU145. (B) Results of invasion assay for DU145. (C) Results of migration assay for PC3. (D) Results of invasion assay for PC3. “*” Means significantly different from control group, P<0.05. Abbreviation: SPB, sodium phenylbutyrate.

    OncoTargets and Therapy, 2016, 9:2825-2833.. Sodium Phenylbutyrate purchased from Selleck.

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.
Targets
HDAC [1]
In vitro

Phenylbutyrate is a well-known HDAC inhibitor, which increases gene transcription of a number of genes, and also exerts neuroprotective effects. Phenylbutyrate significantly attenuates MPTP-induced depletion of striatal dopamine and loss of tyrosine hydroxylase-positive neurons in the substantia nigra. [1] Phenylbutyrate attenuates the expression of the apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker caveolin-1, and the pro-angiogenic vascular endothelial growth factor in prostate cancer cells. Phenylbutyrate is found to act in synergy with ionizing radiation to induce apoptosis in prostate cancer cells. [2]

In vivo Phenylbutyrate significantly extends survival and improved both the clinical and neuropathological phenotypes in G93A transgenic ALS mice. Phenylbutyrate administration ameliorates histone hypoacetylation observed in G93A mice and induced expression of nuclear factor-kappaB (NF-kappaB) p50, the phosphorylated inhibitory subunit of NF-kappaB (pIkappaB) and beta cell lymphoma 2 (bcl-2), but reduced cytochrome c and caspase expression. Phenylbutyrate acts to phosphorylate IkappaB, translocating NF-kappaB p50 to the nucleus, or to directly acetylate NF-kappaB p50. [3] Phenylbutyrate increases brain histone acetylation and decreased histone methylation levels as assessed by both immunocytochemistry and Western blots in a transgenic mousemodel of Huntington's disease (HD). Phenylbutyrate increases mRNA for components of the ubiquitin-proteosomal pathway and down-regulated caspases implicated in apoptotic cell death, and active caspase 3 immunoreactivity in the striatum. [4]

Protocol

Solubility (25°C)

In vitro Water 30 mg/mL (161.13 mM)
DMSO 8 mg/mL (42.96 mM)
Ethanol <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 186.18
Formula

C10H11O2.Na

CAS No. 1716-12-7
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02111200 Completed UCDs (The Data May be Helpful in the Treatment of UCDs.) Baylor College of Medicine September 2014 --
NCT02046434 Active, not recruiting Parkinsons Disease University of Colorado, Denver January 2014 Phase 1
NCT01529060 Active, not recruiting Maple Syrup Urine Disease Brendan Lee|Baylor College of Medicine February 2013 Phase 2|Phase 3
NCT01698476 Completed Pulmonary Tuberculosis (TB) Karolinska Institutet|Addis Ababa University|Armauer Hansen Research Institute, Ethiopia September 2012 Phase 2
NCT01702974 Completed HIV Infection Karolinska Institutet|Addis Ababa University|Armauer Hansen Research Institute, Ethiopia September 2012 Phase 2
NCT01580007 Completed Pulmonary Tuberculosis International Centre for Diarrhoeal Disease Research, Bangladesh|Karolinska Institutet|National Tuberculosis Reference Laboratory, National Institute of Diseases of Chest and Hospital (NIDCH), Dhaka, Bangladesh|University of Iceland December 2010 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID