LY2940680 Chemical Structure
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
XAV-939 is a small molecule and selective Wnt pathway transcription factor β-catenin-mediated transcription inhibitor to TNKS1 and TNKS2 with IC50 of 11 nM and 4 nM, respectively.
DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 of 0.12 and 0.2 μM for total Aβ and Aβ42 levels, respectively.
ICG-001 is a selective Wnt/β-catenin signalling inhibitor with an IC50 of 3μM.
LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor with an IC50 of 0.1 nM for APP23 and APP51/16 primary neurons.
LY2940680 is a potent agent used to treat cancer. A study will explore the changes in a cancer marker level in skin, hair follicles and tumor cells. Finally, the study will help document any antitumor activity this drug may have. [1]
| Molecular Weight (WM): | 512.5 |
|---|---|
| Formula: | C26H24F4N6O |
| CAS No.: | 1258861-20-9 |
| Synonyms: |
N/A
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| Dissolve in (25°C): | DMSO ≥1mg/mL |
| Water <1mg/mL | |
| Ethanol ≥2mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
A collection of 864 bioactive compounds
A collection of 481 inhibitors
A collection of 194 kinase inhibitors
A collection of 85 tyrosine kinase inhibitors.
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A unique collection of 17 small molecule modulators
A unique collection of 47 small molecule inhibitors
A unique collection of 63 GPCR small molecules
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