Smoothened Agonist (SAG) HCl
Molecular Weight(MW): 526.52
Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
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|Description||Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.|
SAG regulates Smo activity by binding directly to the Smo heptahelical bundle.  SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way.  SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells. 
|In vivo||In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells.  In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities. |
|In vitro||Water||100 mg/mL (189.92 mM)|
|DMSO||71 mg/mL warmed (134.84 mM)|
|Ethanol||40 mg/mL warmed (75.97 mM)|
|In vivo||Add solvents to the product individually and in order:
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|CAS No.||912545-86-9(free base)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT00990574||Withdrawn||Hypotension|Headache||Stanford University||October 2009||--|
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