Levodropropizine

Catalog No.S4131

Levodropropizine possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory nerves and by modulation of neuropeptides involved in the cough reflex.

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Levodropropizine Chemical Structure

Levodropropizine Chemical Structure
Molecular Weight: 236.31

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Product Description

Biological Activity

Description Levodropropizine possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory nerves and by modulation of neuropeptides involved in the cough reflex.
Targets Histamine receptor
IC50 [1]()
In vitro Levodropropizine has affinity for H1-histaminic and alpha-adrenergic receptors. [1]
In vivo Levodropropizine has weaker central sedative effects than the racemate and it does not induce physical dependence in rats. [1] Levodropropizine (15 mg/kg, i.v.) reduces both the duration of apnoea and the response of the C-fibre to phenylbiguanide. The LVDP-induced inhibition of the C-fibre response to PBG is on average 50% in pulmonary and 25% in non-pulmonary fibres. [2] Levodropropizine is shown to have good antitussive activity in anaesthetized guinea-pigs and rabbits. Levodropropizine (i.v.) is 1/10 to 1/20 as active as codeine and comparable to dropropizine on mechanically and electrically induced coughing in rabbits and guinea-pigs. Levodropropizine (orally) is comparable with those of both dropropizine and codeine against coughing induced by irritant aerosols. [3] Levodropropizine (40 μg/50 μL i.c.v.) does not prevent electrically-induced cough, while Codeine (5 μg/50 μl i.c.v.) markedly prevents coughing in guinea-pigs. Levodropropizine has a peripheral site of action which is related to sensory neuropeptides. [4] Levodropropizine (10 mg/kg, 50 mg/kg and 200 mg/kg) reduces in a dose-dependent manner the extravasation of Evans blue dye evoked by capsaicin in the rat trachea. Levodropropizine (200 mg/kg) inhibits also substance P-evoked extravasation, whereas it does not affect the extravasation evoked by platelet activating factor. [5]
Features Demonstrates a better tolerability index than the Racemate.

Protocol(Only for Reference)

1

References

[1] Melillo G, et al. Arzneimittelforschung, 1988, 38(8), 1144-1150.

[2] Shams H, et al. Br J Pharmacol, 1996, 117(5), 853-858.

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Chemical Information

Download Levodropropizine SDF
Molecular Weight (MW) 236.31
Formula

C13H20N2O2

CAS No. 99291-25-5
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 47 mg/mL (198 mM)
Water 15 mg/mL (63 mM)
Ethanol 47 mg/mL (198 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-, (2S)-

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