JNJ-7777120

Catalog No.S2905

JNJ-7777120 Chemical Structure

Molecular Weight(MW): 277.75

JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.

Size Price Stock Quantity  
In DMSO USD 190 In stock
USD 147 In stock
USD 370 In stock
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Biological Activity

Description JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors.
Targets
Histamine H4 receptor [1]
4.5 nM(Ki)
In vitro

JNJ 7777120 binds with high affinity to the H4 receptor and has a greater than 1000-fold selectivity over the other histamine receptors. JNJ 7777120 is a selective and potent H4 receptor antagonist with little or no affinity for over 50 other targets. [2]

In vivo JNJ 7777120 has an oral bioavailability of ~30% in rats and 100% in dogs, with a half-life of ∼3 h in both species. JNJ 7777120 blocks histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells. JNJ 7777120 can block the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice. JNJ 7777120 significantly blocks neutrophil infiltration in a mouse zymosan-induced peritonitis model. [2]

Protocol

Animal Research:[2]
+ Expand
  • Animal Models: Female BALB/c mice
  • Formulation: 5% (w/v) dextrose in water
  • Dosages: 200 mg/kg
  • Administration: P.O.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 56 mg/mL (201.62 mM)
Ethanol 8 mg/mL (28.8 mM)
Water Insoluble
In vivo Add solvents individually and in order:
30% propylene glycol, 5% Tween 80, 65% D5W
20 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 277.75
Formula

C14H16ClN3O

CAS No. 459168-41-3
Storage powder
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Histamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID