Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.

Size Price Stock Quantity  
In DMSO USD 180 In stock
USD 90 In stock
USD 130 In stock
USD 170 In stock
USD 270 In stock
USD 400 In stock

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4 Customer Reviews

  • A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

    Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

Purity & Quality Control

Choose Selective Raf Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
C-Raf [1]
(Cell-free assay)
0.8 nM 3.2 nM 5.0 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NELmOnpMcW6jc3WgRZN{[Xl? M1HqUWlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDIbZMhfGGpZ3XkJGIuWmGoIG[2NFBGKG23dHHueEBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgbY5{\WO2IHPlcIx{KGOxLXX4dJJme3OrbnegR2REOzdiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[mmxdHnufYxifGWmLV3FT{Bxem:2ZXnuJJBpd3OyaH;yfYxifGmxbjDifUBCdHCqYWPjdoVmdiCjc4PhfUB4cXSqIFnDOVAhd2ZiMD6wNFA4KM7:TR?= NWjGPIN3OjR7MEC2O|M>
SK-MEL-28 NWnHS|RYU2mwYYPlJGF{e2G7 MkPnNUBp NIjKTFBKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTVKNIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xODRizszN MWSyOFkxODZ5Mx?=
HepG2 NIjrbYlMcW6jc3WgRZN{[Xl? MXTJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCHUlugdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjByNDFOwG0> NWXLUHFjOjR7MEC2O|M>
COLO205 M3y3S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfrTY5pcWKrdHnvckBw\iCqdX3hckBEV0yRMkC1JINmdGxicILvcIln\XKjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFch|ryP NEHQfIszPDlyME[3Ny=>
HepG2 MmnGSpVv[3Srb36gRZN{[Xl? NEnLblI1PSCvaX6= MnroSG1UVw>? NEHINJZKdmirYnn0bY9vKG:oIFHsb|UhcW5iVFfGMYJmfGFvc4TpcZVt[XSnZDDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCVbXHkNkBxcG:|cHjvdplt[XSrb36geJJm[XSnZDDmc5IhPDVibXnud{BxemmxcjD0c{BVT0ZvYnX0ZUB{fGmvdXzheIlwdiCvZXHzeZJm\CCjZoTldkA3OCCvaX7zJIJ6KG:meYPz[Zkh[myxdDDzZ4FvdmW{IHHuZYx6e2m|IIfpeIghUUN3MDDv[kA{NjdizszN MYWyOFkxODZ5Mx?=
HFF NH7SbVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17q[|ExKM7:TR?= MYO3NkBp M1qzPWROW09? NF7C[WdKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiaIXtZY4hUE[IIHPlcIx{KGijcnLvdolv\yC5aXzkJJR6eGViQj3SZYYhf2m2aDDJR|UxKG:oIEOg{txO MWqyN|g1PDB|OB?=
SK-MEL-28 M2TxTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHn6Vo0yOCEQvF2= M2naZ|czKGh? NH36OmlFVVOR M3LQd2lvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62LXTybZZmdiCVSz3NSWwuOjhiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjB2MzFOwG0> M2qz[|I{QDR2MEO4
A375P-F11 NUfNTINDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXi2clN3OTBizszN Mn:1O|IhcA>? MlP0SG1UVw>? Mn\KTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKEF|N{XQMWYyOSClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODdzIN88US=> Mn3zNlM5PDRyM{i=
MALME-3M Mk\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTQNVAh|ryP MUe3NkBp M1O4TGROW09? M{iwUmlEPTB;MTDuUS=> MkLENlM5PDRyM{i=
UACC-62 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XYZVExKM7:TR?= NHHNcWI4OiCq Mn7HSG1UVw>? M37TTmlEPTB;MTDuUS=> MYiyN|g1PDB|OB?=
C32TG MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe2XFdwOTBizszN NY\NXJprPzJiaB?= Mmf1SG1UVw>? MUHJR|UxRTFibl2= NXH4TG9sOjN6NESwN|g>
SK-MEL-1 MmG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LWRlExKM7:TR?= NX7MS3BoPzJiaB?= NUnEUnI6TE2VTx?= NIHtSoRKSzVyPUKgcm0> MkTkNlM5PDRyM{i=
M14 MnG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXO5RZRXOTBizszN M17Qb|czKGh? NE\3Tm5FVVOR M3XIO2lEPTB;MjDuUS=> MkfnNlM5PDRyM{i=
SK-MEL-28 Ml7IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv3SpcyOCEQvF2= NYLyZZZkPzJiaB?= NVW4W4xETE2VTx?= MXfJR|UxRTNibl2= NFGwVGkzOzh2NECzPC=>
A375 NUfXXJdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWOxNEDPxE1? MYe3NkBp NEO2bVJFVVOR NFfpOW1KSzVyPUSgcm0> NXntVmsxOjN6NESwN|g>
DU-4475 NHX3VnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjKbWEyOCEQvF2= M2[ySVczKGh? MmXiSG1UVw>? MonoTWM2OD13IH7N NUHCdY56OjN6NESwN|g>
UACC-257 Mn3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Pwb|ExKM7:TR?= MXm3NkBp MmXaSG1UVw>? M4DwT2lEPTB;NjDuUS=> NWm4VXlpOjN6NESwN|g>
Colo 205 Mo\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP3[XAyOCEQvF2= MYO3NkBp NEnpTZhFVVOR MWLJR|UxRTdibl2= M4nE[|I{QDR2MEO4
SK-MEL-3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nvSFExKM7:TR?= M2rq[VczKGh? NHj4d5FFVVOR NF;jbJBKSzVyPUegcm0> NWrScVJ7OjN6NESwN|g>
SH-4 NIDENWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r4OFExKM7:TR?= NHvKVlQ4OiCq NYC4XGdMTE2VTx?= MVTJR|UxRThibl2= NEi1ZlUzOzh2NECzPC=>
A101D NVjNZXF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3qe2IyOCEQvF2= NGi2cno4OiCq M4TlN2ROW09? MV7JR|UxRTlibl2= NXGxV5FkOjN6NESwN|g>
ES-2 NFrwcplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOzNVAh|ryP MUe3NkBp M{OxXWROW09? MY\JR|UxRTV|IH7N NXK4OG5bOjN6NESwN|g>
HT-29 M4D4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1mzW|ExKM7:TR?= M1juXVczKGh? MkPhSG1UVw>? NH73N4tKSzVyPU[2JI5O MYGyN|g1PDB|OB?=
SW1417 MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHScY1bOTBizszN MWe3NkBp MoHySG1UVw>? NID2THJKSzVyPUG1PEBvVQ>? NH\LVWQzOzh2NECzPC=>
SW872 M3fVfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXrZlcyOCEQvF2= NWj6OYhZPzJiaB?= MorESG1UVw>? NHm5U5ZKSzVyPUO3O{BvVQ>? MYeyN|g1PDB|OB?=
RKO M4rndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUWxNEDPxE1? NIrVcYo4OiCq M1[3ZWROW09? M1nVdWlEPTB;Mj61NlIh|ryP MlniNlM5PDRyM{i=
A673 NHnBXWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPjS4VSOTBizszN MW[3NkBp M13RfmROW09? NGX6ZlNKSzVyPUGwJO69VQ>? NHHXfZEzOzh2NECzPC=>
GCT MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfHPZg2OTBizszN MmjCO|IhcA>? Mn\kSG1UVw>? NVKxcJFuUUN3ME2xNEDPxE1? MWGyN|g1PDB|OB?=
WM-115 NWHhd4ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\UNVAh|ryP MoS1O|IhcA>? M3fwWWROW09? NULwc4J4UUN3ME21JI5O NUXIVXV7OjN6NESwN|g>
YUMAC NGDYRWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3faT|ExKM7:TR?= MkHZO|IhcA>? NVThco9sTE2VTx?= NHnCNmVKSzVyPUWgcm0> MkT0NlM5PDRyM{i=
OV-90 NXzyVoMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHkeZlnOTBizszN M2PNNVczKGh? NWHHXHByTE2VTx?= NYXVRWI3UUN3ME2yPUBvVQ>? MoLZNlM5PDRyM{i=
NCI-H508 M1;JOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVSxNEDPxE1? MmnYO|IhcA>? NIrkfYdFVVOR M2riUGlEPTB;MUCg{txO NFXZb5YzOzh2NECzPC=>
MDA-MB-231 MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfCNVAh|ryP NWH1NI1wPzJiaB?= NUn6Wo1nTE2VTx?= M1HMd2lEPTB;MUCg{txO MlexNlM5PDRyM{i=
SW756 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVixNEDPxE1? MXy3NkBp M3XVNWROW09? MXjJR|UxRTFyIN88US=> NELXXpYzOzh2NECzPC=>
SW-837 NVzNc41DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYmxNEDPxE1? NHf2XVg4OiCq NGn3[2lFVVOR MkDRTWM2OD1zMDFOwG0> MVOyN|g1PDB|OB?=
UMUC-3 NEnlOJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTIbGU2OTBizszN NEf3ZVE4OiCq NF7hOlVFVVOR MV3JR|UxRTFyIN88US=> M4j4d|I{QDR2MEO4
LS-174T MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPkNVAh|ryP MlPoO|IhcA>? NEnm[5pFVVOR Ml2yTWM2OD1zMDFOwG0> MWKyN|g1PDB|OB?=
A549 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXOxNEDPxE1? NUfsSmxFPzJiaB?= Mli5SG1UVw>? NVf5SmZCUUN3ME2xNEDPxE1? NYC4d2N5OjN6NESwN|g>
SHP-77 MmXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTJNVAh|ryP M1zPSlczKGh? MXnEUXNQ Mn;2TWM2OD1zMDFOwG0> M1j6VFI{QDR2MEO4
SW480 NH3BfINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;iO|cyOCEQvF2= NVuyXIZTPzJiaB?= MX7EUXNQ NUnYfXZMUUN3ME2xNEDPxE1? M2[2flI{QDR2MEO4
DLD-1 NIH5S2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTSflhUOTBizszN NXLmN41mPzJiaB?= NXe5U5k6TE2VTx?= M4HJS2lEPTB;MUCg{txO MmHaNlM5PDRyM{i=
HCT-116 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDEd2IyOCEQvF2= NWn4TJNDPzJiaB?= NUPHVW57TE2VTx?= MUTJR|UxRTFyIN88US=> NI[1XGwzOzh2NECzPC=>
NCI-H747 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:xNEDPxE1? NITmZZA4OiCq NVTuXnMyTE2VTx?= M4OweWlEPTB;MUCg{txO NGq2RlQzOzh2NECzPC=>
T-84 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPtOHA5OTBizszN NWC5dGFtPzJiaB?= MlnkSG1UVw>? NHzyPJBKSzVyPUGwJO69VQ>? NEO4enYzOzh2NECzPC=>
NCI-H460 M3rVPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zZZ|ExKM7:TR?= NV3pV4lQPzJiaB?= M3rTNGROW09? M{m4PGlEPTB;MUCg{txO MWCyN|g1PDB|OB?=
Calu-6 NEK2VWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\idlExKM7:TR?= NUGzSlZNPzJiaB?= NIrBSXFFVVOR MX\JR|UxRTFyIN88US=> NWnkZY5ROjN6NESwN|g>
HCC-2998 M2XBdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTtNVAh|ryP NITab4k4OiCq MYrEUXNQ Mn7DTWM2OD1zMDFOwG0> Mn7ZNlM5PDRyM{i=
LS1034 M1KxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi1cXE2OTBizszN NImye5I4OiCq NYXMZWtZTE2VTx?= MXfJR|UxRTFyIN88US=> MnjCNlM5PDRyM{i=
CHP-212 NUi1e2pqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoriNVAh|ryP NXLPeVJQPzJiaB?= MmHPSG1UVw>? NXO3VnVLUUN3ME2xNEDPxE1? Mmj5NlM5PDRyM{i=
SK-N-AS MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlmwNVAh|ryP M1i5ZVczKGh? NF7KR3NFVVOR MXjJR|UxRTFyIN88US=> NHT2d4czOzh2NECzPC=>
BFTC-905 Mn7yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LzN|ExKM7:TR?= NX\CPHk1PzJiaB?= M1j4UWROW09? MX7JR|UxRTFyIN88US=> NITnd3YzOzh2NECzPC=>
HuT78 NHPsNW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP4T4FZOTBizszN NIfLb3I4OiCq M1W0OWROW09? M1LwTmlEPTB;NUKgcm0> NHXEcVAzOzh2NECzPC=>
RPMI-8226 NVjLbWVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSxNEDPxE1? NX7LdINtPzJiaB?= NYriZ3I4TE2VTx?= MVjJR|UxRTJ4MzDuUS=> MnjhNlM5PDRyM{i=
BC-3 NYnJU5Q5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSxNEDPxE1? M{OwcVczKGh? Mof1SG1UVw>? NXTNPYc1UUN3ME2yO|chdk1? NVv2PWRbOjN6NESwN|g>
ACHN M3jIOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1z1blExKM7:TR?= M4HId|czKGh? NGfINFNFVVOR M164VWlEPTB;Mkm0JI5O MV:yN|g1PDB|OB?=
JRT3-T35 M3j5OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIS4U40yOCEQvF2= MX63NkBp NIjmUYhFVVOR NWP5e2RGUUN3ME2yPVUhdk1? M3fIWFI{QDR2MEO4
SK-MES-1 M2eycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULofY15OTBizszN MlfXO|IhcA>? M4DTNWROW09? NGTYRXRKSzVyPUOyPUBvVQ>? MmTUNlM5PDRyM{i=
CESS NXXKVpI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTXVGMyOCEQvF2= NGXwUHo4OiCq Mm\FSG1UVw>? M1jOXGlEPTB;NEm3JI5O NXnVZYF{OjN6NESwN|g>
H4 M1HT[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTYe4gyOCEQvF2= NX;HXXpJPzJiaB?= NH3XWGdFVVOR NWfPenJIUUN3ME22NVkhdk1? MVWyN|g1PDB|OB?=
BC-1 MljrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLLNVAh|ryP M4PJNFczKGh? NGDERVBFVVOR MUTJR|UxRTdyNDDuUS=> NGC0[YgzOzh2NECzPC=>
DB NH:xN2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInpeFYyOCEQvF2= M3fUR|czKGh? NETW[o1FVVOR MXjJR|UxRTh5MzDuUS=> NIH1NYgzOzh2NECzPC=>
RPMI-6666 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjnd|AyOCEQvF2= MVO3NkBp NY\vZXFDTE2VTx?= NXT4eWxTUUN3ME25Nlghdk1? NIfGOWIzOzh2NECzPC=>
MC/CAR NFzvR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[wOlExKM7:TR?= MUS3NkBp M2\Wd2ROW09? MYHJR|UxRTFwMECyJO69VQ>? NHXvbFYzOzh2NECzPC=>
SNU-1 M2jkVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\TNVAh|ryP NF;mW4k4OiCq MXPEUXNQ MnPOTWM2OD1zLkWwNUDPxE1? NX7wWG1UOjN6NESwN|g>
CEM/C1 NWjVbFF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNEDPxE1? NFfEdIc4OiCq MWLEUXNQ MXvJR|UxRTFwN{ezJO69VQ>? Mk\mNlM5PDRyM{i=
GDM-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYKxNEDPxE1? NYrCbmVXPzJiaB?= MVzEUXNQ M3HZ[GlEPTB;MT65PVch|ryP NGPu[oMzOzh2NECzPC=>
HT-1080 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rmN|ExKM7:TR?= M4jnUlczKGh? NHL2V3FFVVOR NEjtRZBKSzVyPUKuNFA1KM7:TR?= M3vreVI{QDR2MEO4
HL-60 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTNNVAh|ryP NWTxXlVSPzJiaB?= MknFSG1UVw>? NWTkS5d7UUN3ME2yMlE4QCEQvF2= MkHwNlM5PDRyM{i=
C3A NGSwbZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX2xNEDPxE1? M1z1SlczKGh? M{jEbmROW09? NFf2S|dKSzVyPUWuOFE1KM7:TR?= M3P5UVI{QDR2MEO4
MES-SA MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYixNEDPxE1? NUD4cI84PzJiaB?= NH;0e3pFVVOR MlrITWM2OD14Lkm4PUDPxE1? NWPWV4RZOjN6NESwN|g>
22Rv1 M1XBS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LIcVExKM7:TR?= M2nQSFczKGh? NH72c3RFVVOR MXHJR|UxRTFyIN88US=> MlH6NlM5PDRyM{i=
647-V NHv0PXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XkOVExKM7:TR?= MWW3NkBp NHXOXHFFVVOR NHHncZBKSzVyPUGwJO69VQ>? MnjqNlM5PDRyM{i=
786-O NY\tSmR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXmxNEDPxE1? M3nJTVczKGh? NEn6cItFVVOR M3zOXGlEPTB;MUCg{txO M3LHOlI{QDR2MEO4
A172 NIHxNotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvWNVAh|ryP NUjncWp{PzJiaB?= NX21ZnBzTE2VTx?= NETUXFJKSzVyPUGwJO69VQ>? M3PoOlI{QDR2MEO4
A204 NFvX[GtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nEVFExKM7:TR?= MVK3NkBp Ml7mSG1UVw>? Mn;ZTWM2OD1zMDFOwG0> NUjJdGk6OjN6NESwN|g>
A427 MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfRNVAh|ryP MYG3NkBp MYDEUXNQ MW\JR|UxRTFyIN88US=> MU[yN|g1PDB|OB?=
A431 NF63PJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\JOFExKM7:TR?= MmjaO|IhcA>? M4jTRWROW09? NUHKc2lxUUN3ME2xNEDPxE1? MkHoNlM5PDRyM{i=
A2780 MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;RS5cyOCEQvF2= NHj0W|U4OiCq M{LYSGROW09? M2nzNWlEPTB;MUCg{txO NFLKTIEzOzh2NECzPC=>
ARH-77 M{nF[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HNUlExKM7:TR?= M1LtWFczKGh? Mn;wSG1UVw>? MWHJR|UxRTFyIN88US=> MkfnNlM5PDRyM{i=
Be(2)C NFfUfFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUixNEDPxE1? Mo\MO|IhcA>? NFjNcYhFVVOR M4PP[WlEPTB;MUCg{txO Ml63NlM5PDRyM{i=
BT-20 NVfESIh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fydlExKM7:TR?= M3:zPFczKGh? MXTEUXNQ NYjBW5lkUUN3ME2xNEDPxE1? NF;Ub2wzOzh2NECzPC=>
BxPc3 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrkSJQyOCEQvF2= NFnwO4Y4OiCq M4fS[mROW09? NX\WXWxWUUN3ME2xNEDPxE1? NGKweHozOzh2NECzPC=>
C-4 I MnX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvxO3EyOCEQvF2= M{nKbVczKGh? NGn4VJRFVVOR M2nlUGlEPTB;MUCg{txO MoDDNlM5PDRyM{i=
C33A MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHL[WdSOTBizszN MWO3NkBp NGjiU4JFVVOR NUfDOFV7UUN3ME2xNEDPxE1? M3LuSFI{QDR2MEO4
CAL-27 NInmVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nnTlExKM7:TR?= M2rVWlczKGh? Moj4SG1UVw>? NX7VT|dOUUN3ME2xNEDPxE1? NV\JUZJLOjN6NESwN|g>
CAL-62 NWj4VGk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX2NVAh|ryP MmXkO|IhcA>? M4r2[GROW09? NVXoepVsUUN3ME2xNEDPxE1? NX[3PHdpOjN6NESwN|g>
Calu-3 NGDkd2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLsNVAh|ryP MYm3NkBp NUHFUZkxTE2VTx?= M2HLdmlEPTB;MUCg{txO NUHye5VQOjN6NESwN|g>
CaOV3 NXrxUo9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfSO413OTBizszN MUG3NkBp M1\YRmROW09? MWHJR|UxRTFyIN88US=> NIPJfXkzOzh2NECzPC=>
CGTHW1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3abIZWOTBizszN M1v1UlczKGh? NInz[mhFVVOR MUDJR|UxRTFyIN88US=> NWjZUIY2OjN6NESwN|g>
CHL-1 NIHjWpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rwSVExKM7:TR?= MYm3NkBp NHO1SW1FVVOR MkfOTWM2OD1zMDFOwG0> MXyyN|g1PDB|OB?=
Colo320DM MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkmwNVAh|ryP M1zaRVczKGh? NUntOpRmTE2VTx?= Mlj2TWM2OD1zMDFOwG0> MkLqNlM5PDRyM{i=
Colo704 NI\zZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLENYMyOCEQvF2= NEP4V2Y4OiCq NXLzVHh4TE2VTx?= M1rVPWlEPTB;MUCg{txO NIHPe4MzOzh2NECzPC=>
COR-L23 NVjhS3R3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkixNVAh|ryP NHfkU5g4OiCq NWrFTohqTE2VTx?= M1nKc2lEPTB;MUCg{txO MoqwNlM5PDRyM{i=
CRO-AP2 MmXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLBbZVUOTBizszN MYi3NkBp NUXOSHVuTE2VTx?= NFXtNppKSzVyPUGwJO69VQ>? NUnPTXlnOjN6NESwN|g>
Daudi MnTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXexNEDPxE1? MmHXO|IhcA>? NYLQdXFlTE2VTx?= M4\PNmlEPTB;MUCg{txO MWiyN|g1PDB|OB?=
DOTC 24510 MlPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXW4Z2FOOTBizszN NHjBNnY4OiCq M2Kw[WROW09? M3jwXWlEPTB;MUCg{txO MorsNlM5PDRyM{i=
DU-145 NEDOVWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX2xNEDPxE1? M{T5cVczKGh? MlroSG1UVw>? M{[1OmlEPTB;MUCg{txO MXuyN|g1PDB|OB?=
EB-3 NV\tcHFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPOcVVMOTBizszN M{LLNFczKGh? NFrDNm9FVVOR MnL2TWM2OD1zMDFOwG0> M3XK[lI{QDR2MEO4
EFM-19 NIPLXWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvRbVRCOTBizszN NWjvW4l{PzJiaB?= NEm5UoZFVVOR MoHNTWM2OD1zMDFOwG0> MlHhNlM5PDRyM{i=
EKVX NEjjN29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nP[lExKM7:TR?= MoS5O|IhcA>? NEGxNHJFVVOR M1PBdmlEPTB;MUCg{txO NXXac2RDOjN6NESwN|g>
FaDu NWG3N4NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXXNVAh|ryP MmPuO|IhcA>? MlTHSG1UVw>? NFPaRYlKSzVyPUGwJO69VQ>? NIHs[oQzOzh2NECzPC=>
G401 NVPGRo5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\u[IhVOTBizszN NFviS2s4OiCq MYnEUXNQ MkftTWM2OD1zMDFOwG0> NFnxNJEzOzh2NECzPC=>
HCC-70 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xNEDPxE1? NVHwUFMxPzJiaB?= M4nVZ2ROW09? NIrUfXRKSzVyPUGwJO69VQ>? NYfCRlFqOjN6NESwN|g>
HCC-1954 NWXNeXNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUOxNEDPxE1? Mk[xO|IhcA>? NGX2dllFVVOR MVvJR|UxRTFyIN88US=> NITtZnAzOzh2NECzPC=>
Hela M4\GOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEf2VYsyOCEQvF2= M{fqelczKGh? M4XaWWROW09? NGDIeZRKSzVyPUGwJO69VQ>? MkL1NlM5PDRyM{i=
Hep3B NYPaVY54T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\SNVAh|ryP MkjCO|IhcA>? NIfQU2tFVVOR NE\hd5lKSzVyPUGwJO69VQ>? NIO2ZoEzOzh2NECzPC=>
HMCB M2r1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV6xNEDPxE1? M3HHUlczKGh? M2jZWmROW09? MlP4TWM2OD1zMDFOwG0> NXnpWm8yOjN6NESwN|g>
HN5 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj4NVAh|ryP M1W0cVczKGh? MnexSG1UVw>? MV7JR|UxRTFyIN88US=> MmP5NlM5PDRyM{i=
HOS NXXKdHRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrZNVAh|ryP NGC2clc4OiCq NWX2XVI6TE2VTx?= NV[w[YJ{UUN3ME2xNEDPxE1? MUeyN|g1PDB|OB?=
HPAF-II Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvpNVAh|ryP M4nVTlczKGh? NF36NnVFVVOR NVnESW94UUN3ME2xNEDPxE1? NXXFUGF3OjN6NESwN|g>
Hs746.T NFTINGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PKcVExKM7:TR?= M2rQXFczKGh? M3jJOGROW09? NFrObXFKSzVyPUGwJO69VQ>? MmXCNlM5PDRyM{i=
HT NF[xfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\nNlMyOCEQvF2= NGTFPIE4OiCq MWLEUXNQ M4n4OWlEPTB;MUCg{txO M4n2N|I{QDR2MEO4
HT-3 Mm\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH5SGVKOTBizszN NFizSXA4OiCq MVfEUXNQ MlfDTWM2OD1zMDFOwG0> NIntOlMzOzh2NECzPC=>
HuNS-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnZbmZqOTBizszN M1vuO|czKGh? NFLMdVRFVVOR M2LGRmlEPTB;MUCg{txO NV;T[WNYOjN6NESwN|g>
IGROV1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrwSIsyOCEQvF2= MmXvO|IhcA>? NXqzNHlVTE2VTx?= MUfJR|UxRTFyIN88US=> NV;SbotXOjN6NESwN|g>
J82 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTtNVAh|ryP Ml3yO|IhcA>? MoP3SG1UVw>? MVTJR|UxRTFyIN88US=> MoDRNlM5PDRyM{i=
JM1 M1nCVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDzNVAh|ryP M{fEcFczKGh? MWfEUXNQ MVnJR|UxRTFyIN88US=> NV3YOpJyOjN6NESwN|g>
Kato III MortS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTiNVAh|ryP NWTOXoQ4PzJiaB?= MYrEUXNQ NInRVXZKSzVyPUGwJO69VQ>? MV2yN|g1PDB|OB?=
KHOS-240S M1vPdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnGXnUzOTBizszN MmDSO|IhcA>? MlPUSG1UVw>? MYLJR|UxRTFyIN88US=> M1;xO|I{QDR2MEO4
KM-12 NF:yZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LPe|ExKM7:TR?= MWe3NkBp NVXkN29sTE2VTx?= NUT6e2NEUUN3ME2xNEDPxE1? M4Cw[VI{QDR2MEO4
KPL-1 NXq4fpRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjrXZIyOCEQvF2= MWK3NkBp NFvZSpZFVVOR M{PRd2lEPTB;MUCg{txO Ml7CNlM5PDRyM{i=
KYSE-30 M{\nUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vp[VExKM7:TR?= NGD0[404OiCq M3P1XWROW09? MknYTWM2OD1zMDFOwG0> MWWyN|g1PDB|OB?=
LNCaP NEGwfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGn0[FkyOCEQvF2= NFzFPGg4OiCq NVLP[FltTE2VTx?= MlrjTWM2OD1zMDFOwG0> NHL0UY4zOzh2NECzPC=>
MCF-7 M4e2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HrcVExKM7:TR?= NWHHcoVlPzJiaB?= MW\EUXNQ NHrWTYxKSzVyPUGwJO69VQ>? MY[yN|g1PDB|OB?=
MC-IXC NE\DT4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUexNEDPxE1? MmTCO|IhcA>? NUfM[|V5TE2VTx?= M1jxW2lEPTB;MUCg{txO MlvmNlM5PDRyM{i=
MDA-MB-175 VII MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHuwbWUyOCEQvF2= NUjxPFZnPzJiaB?= NV;4VIlXTE2VTx?= NFPLR41KSzVyPUGwJO69VQ>? NIDzOlczOzh2NECzPC=>
MDA-MB-468 M3jrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HwO|ExKM7:TR?= Mk\OO|IhcA>? MlfESG1UVw>? M4jabWlEPTB;MUCg{txO MmPlNlM5PDRyM{i=
MiaPaCa MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf4fG0yOCEQvF2= NXjaem45PzJiaB?= NW\xcZpJTE2VTx?= MkHSTWM2OD1zMDFOwG0> NWP3S5k2OjN6NESwN|g>
Molt-4 NHzvT5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\3RlUyOCEQvF2= M1zqfFczKGh? NULp[2w4TE2VTx?= NXTLRnpYUUN3ME2xNEDPxE1? NWPyV41DOjN6NESwN|g>
NCI-ADR/RES NEPiU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPRWVdrOTBizszN NH2zbGk4OiCq MnfTSG1UVw>? NVuwWpJxUUN3ME2xNEDPxE1? MYWyN|g1PDB|OB?=
NCI-H69 NVvsT45rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFqxRZUyOCEQvF2= NYHQVItUPzJiaB?= NYmxVIFLTE2VTx?= MWjJR|UxRTFyIN88US=> MUGyN|g1PDB|OB?=
NCI-H82 NFniN21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHr0fmcyOCEQvF2= MVe3NkBp NHjZbXdFVVOR M1vPS2lEPTB;MUCg{txO NFTrO|AzOzh2NECzPC=>
NCI-N87 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL6NVAh|ryP NIfpVWI4OiCq NY[1N|NmTE2VTx?= MUHJR|UxRTFyIN88US=> MnXsNlM5PDRyM{i=
NCI-H146 NWjCZ2ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXRNVAh|ryP NHLqT204OiCq MnzmSG1UVw>? NETEdmJKSzVyPUGwJO69VQ>? NHXTZpAzOzh2NECzPC=>
NCI-H157 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7KNVAh|ryP NH6xc|k4OiCq MlP3SG1UVw>? NX71XIF1UUN3ME2xNEDPxE1? M1HjWVI{QDR2MEO4
NCI-H187 NY\1UYFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3Z[oR[OTBizszN NH\FVmg4OiCq MV3EUXNQ MVTJR|UxRTFyIN88US=> MXGyN|g1PDB|OB?=
NCI-H209 M1rBSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnywNVAh|ryP NEfyO2c4OiCq MXvEUXNQ NFjNdodKSzVyPUGwJO69VQ>? NGnIb24zOzh2NECzPC=>
NCI-H226 NHK3T49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWWxNEDPxE1? NWfUOXplPzJiaB?= NWjPeld7TE2VTx?= MonDTWM2OD1zMDFOwG0> MYKyN|g1PDB|OB?=
NCI-H292 M4nJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnQb5o2OTBizszN NViyb|g4PzJiaB?= NXfEfpc{TE2VTx?= NYnveFU6UUN3ME2xNEDPxE1? MojYNlM5PDRyM{i=
NCI-H322 NGjIem1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWexNEDPxE1? MXG3NkBp NEfsPYRFVVOR Ml;nTWM2OD1zMDFOwG0> NILlUZAzOzh2NECzPC=>
NCI-H358 M4e2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYexNEDPxE1? M3nDeFczKGh? Mm\kSG1UVw>? MVrJR|UxRTFyIN88US=> M4L4bVI{QDR2MEO4
NCI-H520 NXXDPGFDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHVbJkyOCEQvF2= MmrEO|IhcA>? NVe2RVA{TE2VTx?= NUe5TWo6UUN3ME2xNEDPxE1? MlzDNlM5PDRyM{i=
NCI-H526 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITwb4kyOCEQvF2= M17mbFczKGh? MXHEUXNQ M3L1emlEPTB;MUCg{txO M1vm[FI{QDR2MEO4
NCI-H630 NHnoe3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjvVYlxOTBizszN M3;iPVczKGh? M3TTNWROW09? NVTsPYVRUUN3ME2xNEDPxE1? MmTmNlM5PDRyM{i=
NCI-H661 NIHsTJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrCN3BKOTBizszN NG\KUlc4OiCq MYXEUXNQ M3nZSGlEPTB;MUCg{txO Mm[wNlM5PDRyM{i=
NCI-H716 NYf0cYV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX2xNEDPxE1? NIO5U2k4OiCq MmDrSG1UVw>? MoH3TWM2OD1zMDFOwG0> NWL6SHhVOjN6NESwN|g>
NCI-H1563 NU\UdmFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HkS|ExKM7:TR?= MmDRO|IhcA>? NEHufFlFVVOR MljxTWM2OD1zMDFOwG0> NWjLR5Z3OjN6NESwN|g>
NCI-H1792 NWnmRZZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPQeJgyOCEQvF2= MYK3NkBp NEPPOYVFVVOR M4DTdWlEPTB;MUCg{txO NVT2bJFvOjN6NESwN|g>
NCI-H2030 NGPQdlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYOxNEDPxE1? MV23NkBp NVPzOHZITE2VTx?= M3Lzc2lEPTB;MUCg{txO MYGyN|g1PDB|OB?=
NCI-H2052 MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHueZYyOCEQvF2= NHfSS3Y4OiCq M{\6eWROW09? NFrkbHlKSzVyPUGwJO69VQ>? M1n1UFI{QDR2MEO4
NCI-H2122 MmXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;tdY8yOCEQvF2= NV3t[oRrPzJiaB?= MoTTSG1UVw>? MoXqTWM2OD1zMDFOwG0> M2DZO|I{QDR2MEO4
NCI-H2228 Mkf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvIclUyOCEQvF2= NHfLbmQ4OiCq MUXEUXNQ M{C2XmlEPTB;MUCg{txO M2\3TFI{QDR2MEO4
OE-19 NHroWWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PyelExKM7:TR?= MXy3NkBp NIjEVJdFVVOR MnXKTWM2OD1zMDFOwG0> MlrRNlM5PDRyM{i=
OE-21 MlrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVGxNEDPxE1? MlTsO|IhcA>? NVnrc45JTE2VTx?= M{P0N2lEPTB;MUCg{txO MlPjNlM5PDRyM{i=
OE-33 MmfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3W3VFExKM7:TR?= NUTQNWNRPzJiaB?= MmTZSG1UVw>? MUHJR|UxRTFyIN88US=> MmPZNlM5PDRyM{i=
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SCC-9 NI\oVo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPFNVAh|ryP NUi0do46PzJiaB?= MkfqSG1UVw>? NYKwfYpSUUN3ME2xNEDPxE1? MXmyN|g1PDB|OB?=
SCC-12 M3vhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;ZVVExKM7:TR?= MX:3NkBp MXrEUXNQ MlvOTWM2OD1zMDFOwG0> NYW1XZNEOjN6NESwN|g>
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SK-N-DZ MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M320OFExKM7:TR?= M4ewbFczKGh? MkewSG1UVw>? M4CzXmlEPTB;MUCg{txO MnnnNlM5PDRyM{i=
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SW1990 NFjmbJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHzNVAh|ryP MmnaO|IhcA>? NEnk[WdFVVOR MkniTWM2OD1zMDFOwG0> NIfuNJkzOzh2NECzPC=>
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U251 Mlr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmxNEDPxE1? M3nGZVczKGh? MmPSSG1UVw>? NVjlcYlxUUN3ME2xNEDPxE1? MlW0NlM5PDRyM{i=
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YAPC NELjdWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XGbVExKM7:TR?= MX23NkBp MWHEUXNQ NGLuWVlKSzVyPUGwJO69VQ>? NWLySoRzOjN6NESwN|g>
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A375 NXrwN3A2TnWwY4Tpc44h[XO|YYm= NYHiTFdPOS5{IN88US=> NUHoUpBMPCCq NFSxUmRFVVOR MknRTY5pcWKrdHnvckBw\iCyaH;zdIhwenmuYYTpc44hd2ZiTVXLMEBGWktuIHHu[EBUPlB? NXLo[WtROjJ|OEm0O|E>
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MeWo NWjEXWZKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{XEXmROW09? NXW3fJdiUUN3MDC9JFk5PyCwTR?= NVL3Wnp6OjZyMUi1NlQ>
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LCP NIrMZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX2xNFAhdk1? NFjwRZM4OiCq NHnJO3RKdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gUGNRKGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFBTKG23dHHueIF1cW:w MWOyN|MyPzR2Nh?=
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... Click to View More Cell Line Experimental Data

In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 8 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01723202 Active, not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7, 2012 Phase 2
NCT02672358 Not yet recruiting Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis October 2017 Phase 2
NCT02447939 Withdrawn Melanoma GlaxoSmithKline May 2017 Phase 1
NCT02967692 Not yet recruiting Melanoma Novartis Pharmaceuticals|Novartis February 2017 Phase 3
NCT02858921 Not yet recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis February 2017 Phase 2
NCT03026517 Recruiting Melanoma Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Weill Medical College of Cornell University January 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID