Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.

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In DMSO USD 180 In stock
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5 Customer Reviews

  • A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

    Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

  • Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
C-Raf [1]
(Cell-free assay)
0.8 nM 3.2 nM 5.0 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NFm0O|RMcW6jc3WgRZN{[Xl? M3Hnc2lvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDIbZMhfGGpZ3XkJGIuWmGoIG[2NFBGKG23dHHueEBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgbY5{\WO2IHPlcIx{KGOxLXX4dJJme3OrbnegR2REOzdiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[mmxdHnufYxifGWmLV3FT{Bxem:2ZXnuJJBpd3OyaH;yfYxifGmxbjDifUBCdHCqYWPjdoVmdiCjc4PhfUB4cXSqIFnDOVAhd2ZiMD6wNFA4KM7:TR?= MVyyOFkxODZ5Mx?=
SK-MEL-28 NFTte5lMcW6jc3WgRZN{[Xl? MnfsNUBp MYXJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCVSz3NSWwuOjhiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP NFXlUWgzPDlyME[3Ny=>
HepG2 NXTDVVR[U2mwYYPlJGF{e2G7 M4nxOWlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFXST{BxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC0JO69VQ>? M2jBblI1QTByNkez
COLO205 NXnNeY1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnoXldFUW6qaXLpeIlwdiCxZjDoeY1idiCFT1zPNlA2KGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xODdizszN MYiyOFkxODZ5Mx?=
HepG2 MnKxSpVv[3Srb36gRZN{[Xl? MVO0OUBucW5? MlPKSG1UVw>? M{Pr[GlvcGmkaYTpc44hd2ZiQXzrOUBqdiCWR1[tZoV1[S2|dHnteYxifGWmIHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKFOvYXSyJJBpd3OyaH;yfYxifGmxbjD0doVifGWmIH\vdkA1PSCvaX7zJJBzcW:{IITvJHRITi2kZYThJJN1cW23bHH0bY9vKG2nYYP1doVlKGGodHXyJFYxKG2rboOgZpkhd2S7c4PlfUBjdG:2IIPjZY5v\XJiYX7hcJl{cXNid3n0bEBKSzVyIH;mJFMvPyEQvF2= NIq3R3czPDlyME[3Ny=>
HFF MnzIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrLeIhYOTBizszN M3O3c|czKGh? NF7pdJlFVVOR M2P1bGlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCqdX3hckBJTkZiY3XscJMhcGG{Yn;ybY5oKHerbHSgeJlx\SCELWLh[kB4cXSqIFnDOVAhd2ZiMzFOwG0> MoPONlM5PDRyM{i=
SK-MEL-28 NWHLPZp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\2cY95OTBizszN NVvPbW1iPzJiaB?= M{PqZ2ROW09? NIDpbplKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iU1utUWVNNTJ6IHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yNEOg{txO M1LIfFI{QDR2MEO4
A375P-F11 NVf4Wmt4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[xNEDPxE1? MmLnO|IhcA>? NGDWT5NFVVOR MknwTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKEF|N{XQMWYyOSClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODdzIN88US=> MnXtNlM5PDRyM{i=
MALME-3M NVzofJJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjje3NrOTBizszN M{\sZ|czKGh? NHrVWHJFVVOR M1fPRmlEPTB;MTDuUS=> MWqyN|g1PDB|OB?=
UACC-62 Ml7GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPKNVAh|ryP MUS3NkBp NXK1dVRKTE2VTx?= NIH4SmRKSzVyPUGgcm0> NXfCUHBXOjN6NESwN|g>
C32TG NUfDbolqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jUflExKM7:TR?= NUjoOlAyPzJiaB?= M4C1NWROW09? MnTmTWM2OD1zIH7N M2HxblI{QDR2MEO4
SK-MEL-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;rNI56OTBizszN NX3reWFZPzJiaB?= MmjrSG1UVw>? MmT3TWM2OD1{IH7N NUjTUVd[OjN6NESwN|g>
M14 M4XjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zWUVExKM7:TR?= M4TUNFczKGh? NFPmUVhFVVOR M4jQTWlEPTB;MjDuUS=> NGjkZ4IzOzh2NECzPC=>
SK-MEL-28 M{XJV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2faS|ExKM7:TR?= MVe3NkBp MlzhSG1UVw>? NXS4PZZTUUN3ME2zJI5O MkKxNlM5PDRyM{i=
A375 M3fy[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYT5dmdpOTBizszN NHKzTWc4OiCq MWTEUXNQ NVPLWYlrUUN3ME20JI5O MV:yN|g1PDB|OB?=
DU-4475 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWixNEDPxE1? NWW4OHo2PzJiaB?= NITmeIVFVVOR MYDJR|UxRTVibl2= MWOyN|g1PDB|OB?=
UACC-257 M{HUXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrpU5FpOTBizszN M4GyWVczKGh? MmTHSG1UVw>? NYjIW3pRUUN3ME22JI5O NELoZoIzOzh2NECzPC=>
Colo 205 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULWT|NbOTBizszN NYrMbYpbPzJiaB?= NHnCc45FVVOR M2fUVmlEPTB;NzDuUS=> NGmwc5ozOzh2NECzPC=>
SK-MEL-3 NWnQW2NCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[3e|ExKM7:TR?= M3\mNVczKGh? MkKySG1UVw>? Ml;LTWM2OD15IH7N MVyyN|g1PDB|OB?=
SH-4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHESo4yOCEQvF2= NW\HVYg5PzJiaB?= NVzYcJk{TE2VTx?= MonuTWM2OD16IH7N MoHrNlM5PDRyM{i=
A101D MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHUNVAh|ryP NVHWeVlyPzJiaB?= MX;EUXNQ NVnDdYtrUUN3ME25JI5O M2j1TlI{QDR2MEO4
ES-2 NWDmb3M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNEDPxE1? NGHOelY4OiCq NVf6fIZzTE2VTx?= MY\JR|UxRTV|IH7N NF24cGwzOzh2NECzPC=>
HT-29 NIHLR5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXtfJYyOCEQvF2= NFOwR3E4OiCq NGfFeGpFVVOR NYTEcXZ1UUN3ME22OkBvVQ>? MXmyN|g1PDB|OB?=
SW1417 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPtNVAh|ryP NIPmPJU4OiCq MVTEUXNQ NYTGSJdyUUN3ME2xOVghdk1? MmnENlM5PDRyM{i=
SW872 M1robGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjzN5FqOTBizszN NIjq[JM4OiCq MkO3SG1UVw>? MUTJR|UxRTN5NzDuUS=> NUDWTYhJOjN6NESwN|g>
RKO NX60OHRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWWxNEDPxE1? NEf4PHk4OiCq MUXEUXNQ NInleYRKSzVyPUKuOVIzKM7:TR?= NWC0cohEOjN6NESwN|g>
A673 NWLJVZhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:2b|IyOCEQvF2= MlfuO|IhcA>? M2DTSWROW09? MYLJR|UxRTFyIN88US=> NHe2[FkzOzh2NECzPC=>
GCT NGXZ[|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P6SVExKM7:TR?= MnHWO|IhcA>? NICwN5ZFVVOR MmDjTWM2OD1zMDFOwG0> MUSyN|g1PDB|OB?=
WM-115 NFzNdY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkOxNVAh|ryP M3HVW|czKGh? MkLQSG1UVw>? NWn1VIlpUUN3ME21JI5O MkXyNlM5PDRyM{i=
YUMAC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLYNVAh|ryP M3LoSFczKGh? NEjU[GVFVVOR NHe3eJpKSzVyPUWgcm0> MVOyN|g1PDB|OB?=
OV-90 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTOXZg5OTBizszN Mm[0O|IhcA>? NGXyNI5FVVOR NYP1cGN5UUN3ME2yPUBvVQ>? NUXXPG5MOjN6NESwN|g>
NCI-H508 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrudXFmOTBizszN MX[3NkBp MlzkSG1UVw>? MkDzTWM2OD1zMDFOwG0> M3;5RlI{QDR2MEO4
MDA-MB-231 NH7nWY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzxXo5UOTBizszN MYC3NkBp Mmf6SG1UVw>? NIjNR3FKSzVyPUGwJO69VQ>? M2C0XlI{QDR2MEO4
SW756 NUTiUoc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[4WGdCOTBizszN M3ewOlczKGh? NV\sWVB[TE2VTx?= Mn;zTWM2OD1zMDFOwG0> M2P5dFI{QDR2MEO4
SW-837 M{XoR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\vb2JtOTBizszN M4rhUlczKGh? MVLEUXNQ MmXSTWM2OD1zMDFOwG0> NWDHbopFOjN6NESwN|g>
UMUC-3 M1LNc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;nbYcyOCEQvF2= Ml[xO|IhcA>? NFjjbpJFVVOR MWTJR|UxRTFyIN88US=> MWiyN|g1PDB|OB?=
LS-174T NVjGWHJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXPNVAh|ryP MXu3NkBp M1XnSWROW09? M4S0RmlEPTB;MUCg{txO MYGyN|g1PDB|OB?=
A549 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn72NVAh|ryP Mkm3O|IhcA>? NYfLd4ZlTE2VTx?= MmjBTWM2OD1zMDFOwG0> MXOyN|g1PDB|OB?=
SHP-77 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvzNVAh|ryP M3izUVczKGh? MW\EUXNQ M2TXOGlEPTB;MUCg{txO M4HwfVI{QDR2MEO4
SW480 NUTPfnlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjWWHhoOTBizszN NX76O3poPzJiaB?= M{PtWGROW09? NHO0eYxKSzVyPUGwJO69VQ>? MVuyN|g1PDB|OB?=
DLD-1 NWS1clRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYexNEDPxE1? M{fCSlczKGh? NI\IVWRFVVOR MkPDTWM2OD1zMDFOwG0> NXPwRmU4OjN6NESwN|g>
HCT-116 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fVO|ExKM7:TR?= M1nXeFczKGh? NUO5dFRNTE2VTx?= NXPuRWs5UUN3ME2xNEDPxE1? MlTrNlM5PDRyM{i=
NCI-H747 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Pj[lExKM7:TR?= NYLoOm5UPzJiaB?= MUDEUXNQ NF7ONZhKSzVyPUGwJO69VQ>? NFq3fVIzOzh2NECzPC=>
T-84 NV3nVXRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLHc4NZOTBizszN NXfZbFNPPzJiaB?= M1nCZWROW09? MUPJR|UxRTFyIN88US=> NWX1R|ZVOjN6NESwN|g>
NCI-H460 M2PCdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUGxNEDPxE1? MmWxO|IhcA>? MnvFSG1UVw>? MkWxTWM2OD1zMDFOwG0> MY[yN|g1PDB|OB?=
Calu-6 M2j2dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUniOnJyOTBizszN M1T3VFczKGh? NVLBe5NITE2VTx?= NHPFWHBKSzVyPUGwJO69VQ>? MU[yN|g1PDB|OB?=
HCC-2998 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzTNVAh|ryP M4T3d|czKGh? NILyW2xFVVOR MlvJTWM2OD1zMDFOwG0> M1zHO|I{QDR2MEO4
LS1034 MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVOxNEDPxE1? NXrzT2w3PzJiaB?= M{myWWROW09? NV\wWVFkUUN3ME2xNEDPxE1? NYTZdJMxOjN6NESwN|g>
CHP-212 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPNOY55OTBizszN MYm3NkBp MmHySG1UVw>? MnvsTWM2OD1zMDFOwG0> NVzxUWI3OjN6NESwN|g>
SK-N-AS NGH1OVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWOxNEDPxE1? M3m4flczKGh? MYfEUXNQ NFXqbINKSzVyPUGwJO69VQ>? MV:yN|g1PDB|OB?=
BFTC-905 MnnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzkb4QyOCEQvF2= MVi3NkBp NEPMUXFFVVOR M1f6SmlEPTB;MUCg{txO NWDFO4hpOjN6NESwN|g>
HuT78 NEW1b3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEOwVlkyOCEQvF2= NEL1eXk4OiCq NH\3SlRFVVOR NH6xfJVKSzVyPUWyJI5O MmjKNlM5PDRyM{i=
RPMI-8226 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;BOlExKM7:TR?= NU\2dmFzPzJiaB?= NITKT3BFVVOR NFPVU5FKSzVyPUK2N{BvVQ>? NVvvZ3lsOjN6NESwN|g>
BC-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTzNIh{OTBizszN NXzL[HM1PzJiaB?= M3LVfWROW09? NUfPdmhoUUN3ME2yO|chdk1? MXGyN|g1PDB|OB?=
ACHN M{nHSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWexNEDPxE1? MnjIO|IhcA>? M4KxRmROW09? NHj0SohKSzVyPUK5OEBvVQ>? NIW4SHczOzh2NECzPC=>
JRT3-T35 NXfzPW9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PRTlExKM7:TR?= NYX5doxHPzJiaB?= MYTEUXNQ MWLJR|UxRTJ7NTDuUS=> MlfNNlM5PDRyM{i=
SK-MES-1 NVPXfW1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLpN4dGOTBizszN NUTpVGl1PzJiaB?= MUDEUXNQ NUXwOIF6UUN3ME2zNlkhdk1? M1LUbVI{QDR2MEO4
CESS M{LXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13qXVExKM7:TR?= NHHxSGk4OiCq MmPVSG1UVw>? NXe4VlVzUUN3ME20PVchdk1? NWmzVFA{OjN6NESwN|g>
H4 NGnyOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml32NVAh|ryP MXm3NkBp MVnEUXNQ NIHkUZBKSzVyPU[xPUBvVQ>? MUiyN|g1PDB|OB?=
BC-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\2NVAh|ryP NXe5OY5sPzJiaB?= NH7iPHlFVVOR NGTMepVKSzVyPUewOEBvVQ>? NHTMT2gzOzh2NECzPC=>
DB MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\LWYdFOTBizszN NEDQ[YQ4OiCq NXq2e2RSTE2VTx?= NGTwdIdKSzVyPUi3N{BvVQ>? MkW5NlM5PDRyM{i=
RPMI-6666 MlTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofuNVAh|ryP M2CxW|czKGh? NWPUXlFnTE2VTx?= MXfJR|UxRTl{ODDuUS=> M3rU[VI{QDR2MEO4
MC/CAR MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWGxNEDPxE1? MWO3NkBp MX7EUXNQ NWHlPGtNUUN3ME2xMlAxOiEQvF2= NIm1T28zOzh2NECzPC=>
SNU-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj2O5FJOTBizszN Mn6xO|IhcA>? NVW2XYxSTE2VTx?= MoC5TWM2OD1zLkWwNUDPxE1? MmfNNlM5PDRyM{i=
CEM/C1 NG\HXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37xVVExKM7:TR?= M3rSZ|czKGh? M{X5PGROW09? NFvlSnhKSzVyPUGuO|c{KM7:TR?= NUPubJBbOjN6NESwN|g>
GDM-1 M2rtO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DhclExKM7:TR?= NVnyO3g5PzJiaB?= M3Owb2ROW09? NV[2eopkUUN3ME2xMlk6PyEQvF2= M3LoeVI{QDR2MEO4
HT-1080 MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfTSngxOTBizszN NV;RXJdkPzJiaB?= NX;lT5JHTE2VTx?= NGnXcHhKSzVyPUKuNFA1KM7:TR?= NHPjO4szOzh2NECzPC=>
HL-60 M4LZVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TrXVExKM7:TR?= M2Xhc|czKGh? NXvEc3FOTE2VTx?= MnPsTWM2OD1{LkG3PEDPxE1? M4P4TlI{QDR2MEO4
C3A NEDado1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fLPFExKM7:TR?= MVO3NkBp NHnNfJVFVVOR Moq3TWM2OD13LkSxOEDPxE1? MlzFNlM5PDRyM{i=
MES-SA NF7jV5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\SflhzOTBizszN M2fxW|czKGh? Mm\HSG1UVw>? MY\JR|UxRTZwOUi5JO69VQ>? M3Li[|I{QDR2MEO4
22Rv1 NIDpZYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLoNVAh|ryP NEXudmw4OiCq MYnEUXNQ NHTKR2NKSzVyPUGwJO69VQ>? MnnINlM5PDRyM{i=
647-V MofUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrFd21QOTBizszN MkXBO|IhcA>? M4nmWmROW09? MVXJR|UxRTFyIN88US=> NGe5N5kzOzh2NECzPC=>
786-O NW\TNpdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUCxNEDPxE1? MmL6O|IhcA>? M3;QPWROW09? MnnTTWM2OD1zMDFOwG0> M{\PbVI{QDR2MEO4
A172 NETTcphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\uNVAh|ryP NFm3Zmg4OiCq M1T1ZWROW09? NF\GO2pKSzVyPUGwJO69VQ>? MlvYNlM5PDRyM{i=
A204 NHLScFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PxOVExKM7:TR?= MVm3NkBp NX;SOphRTE2VTx?= NYnaTpZuUUN3ME2xNEDPxE1? NHjH[FYzOzh2NECzPC=>
A427 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7QNVAh|ryP NXvKeJg{PzJiaB?= M131V2ROW09? NUfkfZY5UUN3ME2xNEDPxE1? Mmj5NlM5PDRyM{i=
A431 NH62c2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjENVAh|ryP MVe3NkBp NIrpdo5FVVOR MXTJR|UxRTFyIN88US=> Ml7YNlM5PDRyM{i=
A2780 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HkXVExKM7:TR?= MkjkO|IhcA>? NY\6bHU1TE2VTx?= M3:zRWlEPTB;MUCg{txO Mor3NlM5PDRyM{i=
ARH-77 NGP0eZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\vXGUyOCEQvF2= MnzSO|IhcA>? NGrXcnhFVVOR NITP[IlKSzVyPUGwJO69VQ>? MV:yN|g1PDB|OB?=
Be(2)C NGSwUodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljhNVAh|ryP NYW0fogxPzJiaB?= M1TkTWROW09? NWX1PZltUUN3ME2xNEDPxE1? NGHKPFkzOzh2NECzPC=>
BT-20 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LBe|ExKM7:TR?= MlHmO|IhcA>? M3z4NmROW09? MYTJR|UxRTFyIN88US=> NVz0V3I4OjN6NESwN|g>
BxPc3 Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj5NVAh|ryP M4PTO|czKGh? MoGxSG1UVw>? NIrsPG5KSzVyPUGwJO69VQ>? NFfQZnMzOzh2NECzPC=>
C-4 I NWXaXFFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDJRXoyOCEQvF2= NESwUZY4OiCq NIrPSWZFVVOR NVT4c5hXUUN3ME2xNEDPxE1? Mly4NlM5PDRyM{i=
C33A NWPHNIdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm3NVAh|ryP NVj2TVhGPzJiaB?= Mn\NSG1UVw>? NU\Qe3BXUUN3ME2xNEDPxE1? M131ZlI{QDR2MEO4
CAL-27 NVzOb2ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHLUHYyOCEQvF2= NXPvdnp4PzJiaB?= MYjEUXNQ MkXvTWM2OD1zMDFOwG0> NHXKZlgzOzh2NECzPC=>
CAL-62 MkTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVuxNEDPxE1? MXi3NkBp MYHEUXNQ M3z5U2lEPTB;MUCg{txO NWTXeFB6OjN6NESwN|g>
Calu-3 Ml3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTHNVAh|ryP M3fCS|czKGh? MnrYSG1UVw>? NGmzd2tKSzVyPUGwJO69VQ>? MXqyN|g1PDB|OB?=
CaOV3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PyRVExKM7:TR?= M3fnUFczKGh? NXHPb3QzTE2VTx?= MlLCTWM2OD1zMDFOwG0> M4jvOlI{QDR2MEO4
CGTHW1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILWUGIyOCEQvF2= MkTBO|IhcA>? MofoSG1UVw>? MX3JR|UxRTFyIN88US=> M2PPdlI{QDR2MEO4
CHL-1 NWfHUlZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXURnhHOTBizszN MW[3NkBp NFHWeFlFVVOR NGOzTIpKSzVyPUGwJO69VQ>? NYn1XplDOjN6NESwN|g>
Colo320DM MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFqxboQyOCEQvF2= MnjqO|IhcA>? NXr1[4JSTE2VTx?= NXn4cI9uUUN3ME2xNEDPxE1? NGPIc4EzOzh2NECzPC=>
Colo704 M{XXeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUixNEDPxE1? MX23NkBp NITzOXlFVVOR MYfJR|UxRTFyIN88US=> NYD1PXNUOjN6NESwN|g>
COR-L23 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\mVVFTOTBizszN NYDHTYJYPzJiaB?= M{\xb2ROW09? NIq1O3VKSzVyPUGwJO69VQ>? MX2yN|g1PDB|OB?=
CRO-AP2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\JNVAh|ryP NI\NNmc4OiCq NEfIT4xFVVOR NXz3emExUUN3ME2xNEDPxE1? NUPLfWRXOjN6NESwN|g>
Daudi M4W0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHMeJF2OTBizszN NXGzNXhIPzJiaB?= NEXSTYNFVVOR NH;oOZNKSzVyPUGwJO69VQ>? NF7ZcYkzOzh2NECzPC=>
DOTC 24510 NEHsT4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVOxNEDPxE1? NH\QOoo4OiCq M3Hn[GROW09? MmHFTWM2OD1zMDFOwG0> M4fkNlI{QDR2MEO4
DU-145 MoLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTNNVAh|ryP MnfEO|IhcA>? MWHEUXNQ MlPGTWM2OD1zMDFOwG0> M{C1bVI{QDR2MEO4
EB-3 NYfXTGc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYWxNEDPxE1? MmDIO|IhcA>? M3\MO2ROW09? MWLJR|UxRTFyIN88US=> NYHRVnY6OjN6NESwN|g>
EFM-19 NFHBXHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLkNVAh|ryP NXT6R|dZPzJiaB?= M1j0PGROW09? M2fQVWlEPTB;MUCg{txO MVyyN|g1PDB|OB?=
EKVX NXXwTIhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVOxNEDPxE1? M3fRfVczKGh? MUfEUXNQ MU\JR|UxRTFyIN88US=> MV6yN|g1PDB|OB?=
FaDu MnPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHZN2MyOCEQvF2= M1POcVczKGh? M33SfGROW09? M3S3U2lEPTB;MUCg{txO NFHaUG8zOzh2NECzPC=>
G401 NHiyO|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUmxNEDPxE1? MW[3NkBp M{O0TmROW09? M37XR2lEPTB;MUCg{txO MmqxNlM5PDRyM{i=
HCC-70 MoS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlviNVAh|ryP MWi3NkBp NInGOZpFVVOR MWXJR|UxRTFyIN88US=> MnT2NlM5PDRyM{i=
HCC-1954 MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorLNVAh|ryP MXm3NkBp M3XIXmROW09? MlrZTWM2OD1zMDFOwG0> MlHZNlM5PDRyM{i=
Hela M33sNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfi[IQ{OTBizszN MkfYO|IhcA>? MVnEUXNQ NYjwSYJuUUN3ME2xNEDPxE1? NYfE[HRCOjN6NESwN|g>
Hep3B NVTvN3BFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUmxNEDPxE1? M1zaVVczKGh? MlXYSG1UVw>? MUnJR|UxRTFyIN88US=> MkPDNlM5PDRyM{i=
HMCB MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[wNVAh|ryP Moi3O|IhcA>? MVzEUXNQ NYPqPJJ4UUN3ME2xNEDPxE1? MYiyN|g1PDB|OB?=
HN5 MnL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY[xNEDPxE1? MWi3NkBp MnT4SG1UVw>? NHzzfYFKSzVyPUGwJO69VQ>? MUKyN|g1PDB|OB?=
HOS NWiyS2FnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX[xNEDPxE1? NH\pNYw4OiCq NFnEOXNFVVOR NEPIRlRKSzVyPUGwJO69VQ>? NFroRpgzOzh2NECzPC=>
HPAF-II MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOxNEDPxE1? MUK3NkBp NHnCTo5FVVOR Mo[yTWM2OD1zMDFOwG0> NHTHemozOzh2NECzPC=>
Hs746.T NWHNflFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWi0cGx5OTBizszN MlTQO|IhcA>? M4PFemROW09? M2TCc2lEPTB;MUCg{txO MVeyN|g1PDB|OB?=
HT NXvUcpU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDLRmIyOCEQvF2= MoS2O|IhcA>? M{i3S2ROW09? M{W1WmlEPTB;MUCg{txO NUjQWXV3OjN6NESwN|g>
HT-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVixNEDPxE1? NY\JW3lXPzJiaB?= MoG0SG1UVw>? MX3JR|UxRTFyIN88US=> NUPKPZRSOjN6NESwN|g>
HuNS-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLoNVAh|ryP Ml;OO|IhcA>? NUjZ[nJmTE2VTx?= MVjJR|UxRTFyIN88US=> NXPzPHFCOjN6NESwN|g>
IGROV1 NGfMO3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnONVAh|ryP NIXZWpI4OiCq Ml\rSG1UVw>? NFXITmxKSzVyPUGwJO69VQ>? NG[wT2UzOzh2NECzPC=>
J82 NEjNfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWmxNEDPxE1? MVe3NkBp MlyxSG1UVw>? MV\JR|UxRTFyIN88US=> NX34PXhyOjN6NESwN|g>
JM1 NETM[ZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEX3eHIyOCEQvF2= M3j0WlczKGh? M1r0VmROW09? NHvLPXFKSzVyPUGwJO69VQ>? NIXpXIQzOzh2NECzPC=>
Kato III MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzLZm9WOTBizszN MkL5O|IhcA>? M2i2TmROW09? M{S1VWlEPTB;MUCg{txO MV:yN|g1PDB|OB?=
KHOS-240S NYThXph{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13Ib|ExKM7:TR?= MYW3NkBp MkLISG1UVw>? MVTJR|UxRTFyIN88US=> M1Pw[|I{QDR2MEO4
KM-12 M2\yO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNEDPxE1? MY[3NkBp M1TZc2ROW09? NVGwb4s1UUN3ME2xNEDPxE1? M3;aV|I{QDR2MEO4
KPL-1 NH;CU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVOxNEDPxE1? NHrqNFQ4OiCq MnXNSG1UVw>? NFPJSZlKSzVyPUGwJO69VQ>? NYjyfJVROjN6NESwN|g>
KYSE-30 NVr2eY1NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTLfGYyOCEQvF2= NXf4ZmRoPzJiaB?= MVHEUXNQ M4e2e2lEPTB;MUCg{txO NVrNe3dqOjN6NESwN|g>
LNCaP M364NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S0elExKM7:TR?= MojsO|IhcA>? MWHEUXNQ MXjJR|UxRTFyIN88US=> NWKyN5pTOjN6NESwN|g>
MCF-7 NFLlXHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPEflZOOTBizszN Mn;uO|IhcA>? NH\qfohFVVOR NVjMU3NKUUN3ME2xNEDPxE1? NHT0cHczOzh2NECzPC=>
MC-IXC M3LJR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PPXVExKM7:TR?= M4nBWlczKGh? Mlz5SG1UVw>? MYPJR|UxRTFyIN88US=> M2nZfFI{QDR2MEO4
MDA-MB-175 VII M4fTPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHzNVAh|ryP NYG4OZhuPzJiaB?= NHOwdXpFVVOR NHiz[4xKSzVyPUGwJO69VQ>? MnqwNlM5PDRyM{i=
MDA-MB-468 NVPsSoZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rFc|ExKM7:TR?= M370UVczKGh? M3O5VmROW09? M2j4RmlEPTB;MUCg{txO NUjCd3VxOjN6NESwN|g>
MiaPaCa NEjZcXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;Hc|ExKM7:TR?= NX7zN45uPzJiaB?= M2rlS2ROW09? MXPJR|UxRTFyIN88US=> MYeyN|g1PDB|OB?=
Molt-4 MmHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mke2NVAh|ryP NFPVc2I4OiCq MoizSG1UVw>? Mk[3TWM2OD1zMDFOwG0> MUeyN|g1PDB|OB?=
NCI-ADR/RES NGHmcVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT2VlIyOCEQvF2= MVS3NkBp NVPl[VJxTE2VTx?= NHHPPYpKSzVyPUGwJO69VQ>? M4GwTVI{QDR2MEO4
NCI-H69 NEH1cnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XhRlExKM7:TR?= NHThfpI4OiCq M1q1WWROW09? NY\OZWttUUN3ME2xNEDPxE1? MUCyN|g1PDB|OB?=
NCI-H82 Ml;XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrKdY44OTBizszN NFT4blA4OiCq M{DEeWROW09? NWDOS4dOUUN3ME2xNEDPxE1? MkXnNlM5PDRyM{i=
NCI-N87 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXlUnkyOCEQvF2= M2T3eFczKGh? NXO4OHRLTE2VTx?= NWCzUJNmUUN3ME2xNEDPxE1? M{f6TlI{QDR2MEO4
NCI-H146 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fD[VExKM7:TR?= MmrGO|IhcA>? MlmwSG1UVw>? MkntTWM2OD1zMDFOwG0> NXrkcJY4OjN6NESwN|g>
NCI-H157 NYnhUpF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfiZWEyOCEQvF2= NWLxUWxIPzJiaB?= NXjHU4ROTE2VTx?= MlPiTWM2OD1zMDFOwG0> NF\GSHczOzh2NECzPC=>
NCI-H187 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXriWZdjOTBizszN MVe3NkBp MnXKSG1UVw>? M{KwbGlEPTB;MUCg{txO M2Prb|I{QDR2MEO4
NCI-H209 NEnzcWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLCNVAh|ryP Mn;kO|IhcA>? M4P0N2ROW09? M4fwOWlEPTB;MUCg{txO MXOyN|g1PDB|OB?=
NCI-H226 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonkNVAh|ryP MUO3NkBp MUDEUXNQ NFHyWJdKSzVyPUGwJO69VQ>? NGOzRVMzOzh2NECzPC=>
NCI-H292 NU\me|Z5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrpb3gyOCEQvF2= M1W5SVczKGh? NYXVPYk3TE2VTx?= NIjBcYpKSzVyPUGwJO69VQ>? MY[yN|g1PDB|OB?=
NCI-H322 M{noRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTORWQyOCEQvF2= MoTmO|IhcA>? NInXdlNFVVOR NH3MPIRKSzVyPUGwJO69VQ>? M2jCdVI{QDR2MEO4
NCI-H358 M3rFPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHZNVAh|ryP NV7qU5RoPzJiaB?= NGLMPJZFVVOR M4LYVmlEPTB;MUCg{txO M2Xw[FI{QDR2MEO4
NCI-H520 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXjNVAh|ryP MW[3NkBp M2TkSGROW09? MULJR|UxRTFyIN88US=> MWGyN|g1PDB|OB?=
NCI-H526 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYqxNEDPxE1? NV21U3lpPzJiaB?= NInGSJJFVVOR Mo\NTWM2OD1zMDFOwG0> NGHITIgzOzh2NECzPC=>
NCI-H630 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXHVmFqOTBizszN MkHmO|IhcA>? NEfJNVJFVVOR MULJR|UxRTFyIN88US=> MoD2NlM5PDRyM{i=
NCI-H661 NFz3emxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m4WVExKM7:TR?= NH2yem44OiCq NYLyeoRHTE2VTx?= MkPYTWM2OD1zMDFOwG0> NH;ncWwzOzh2NECzPC=>
NCI-H716 NUn3VlVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7GVI8yOCEQvF2= M1GxdlczKGh? MWfEUXNQ MnHPTWM2OD1zMDFOwG0> MlmzNlM5PDRyM{i=
NCI-H1563 MlL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3TNVAh|ryP MnTkO|IhcA>? M1jJb2ROW09? MX7JR|UxRTFyIN88US=> M33RV|I{QDR2MEO4
NCI-H1792 NHPHWZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYKxNEDPxE1? M1jONlczKGh? M4LhUGROW09? MVLJR|UxRTFyIN88US=> MXGyN|g1PDB|OB?=
NCI-H2030 MkLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXrTpRCOTBizszN MoniO|IhcA>? NFToWpdFVVOR M37abGlEPTB;MUCg{txO MoPvNlM5PDRyM{i=
NCI-H2052 M1\xc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV6xNEDPxE1? MnrQO|IhcA>? NVzoT|ZmTE2VTx?= MXHJR|UxRTFyIN88US=> M12wSVI{QDR2MEO4
NCI-H2122 NVX0fXNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjIUWp1OTBizszN MWm3NkBp M4DCVGROW09? NXrST|YzUUN3ME2xNEDPxE1? MWCyN|g1PDB|OB?=
NCI-H2228 NES1O3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PLR|ExKM7:TR?= Mlz1O|IhcA>? M4m2R2ROW09? NFTucJJKSzVyPUGwJO69VQ>? NUT2fZBrOjN6NESwN|g>
OE-19 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvOW5QyOCEQvF2= M1XINlczKGh? NX\4UlhRTE2VTx?= NXLaSItrUUN3ME2xNEDPxE1? MU[yN|g1PDB|OB?=
OE-21 M2q0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWWxNEDPxE1? NYDObYo4PzJiaB?= NFXUS3pFVVOR MoTMTWM2OD1zMDFOwG0> MljJNlM5PDRyM{i=
OE-33 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDQSI5jOTBizszN MmPhO|IhcA>? M33vemROW09? NHfLWGpKSzVyPUGwJO69VQ>? MofqNlM5PDRyM{i=
OVCAR-3 NEG3WJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HzRlExKM7:TR?= NUK3TodsPzJiaB?= NFjtfGZFVVOR MlzYTWM2OD1zMDFOwG0> NXz4NmZlOjN6NESwN|g>
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SCC-12 M{LndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\JXoIyOCEQvF2= NXr5eIRUPzJiaB?= Mk\4SG1UVw>? M3npV2lEPTB;MUCg{txO M2jvXFI{QDR2MEO4
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UACC-812 NFiyeYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY[xNEDPxE1? NYLnNWhyPzJiaB?= M16weWROW09? MV7JR|UxRTFyIN88US=> M4C3PFI{QDR2MEO4
YAPC NUf1T4Q5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILvbpAyOCEQvF2= NX;QSFNGPzJiaB?= NGTab3lFVVOR MUfJR|UxRTFyIN88US=> NWrlWGpwOjN6NESwN|g>
ZR-75-1 MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjk[mwyOCEQvF2= MmPUO|IhcA>? M1rPUGROW09? NV;nWoxJUUN3ME2xNEDPxE1? NU[3V21SOjN6NESwN|g>
A375 MlzHSpVv[3Srb36gZZN{[Xl? MVqxMlIh|ryP NInXNmw1KGh? MoLtSG1UVw>? NWrKN3h1UW6qaXLpeIlwdiCxZjDwbI9{eGixconsZZRqd25ib3[gUWVMNCCHUlusJIFv\CCVNmC= MVeyNlM5QTR5MR?=
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... Click to View More Cell Line Experimental Data

In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
8 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01723202 Active, not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7, 2012 Phase 2
NCT02672358 Not yet recruiting Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis October 2017 Phase 2
NCT02447939 Withdrawn Melanoma GlaxoSmithKline May 2017 Phase 1
NCT02967692 Not yet recruiting Melanoma Novartis Pharmaceuticals|Novartis February 2017 Phase 3
NCT02858921 Not yet recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis February 2017 Phase 2
NCT03026517 Recruiting Melanoma Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Weill Medical College of Cornell University January 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Raf Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID