Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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In DMSO USD 180 In stock
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  • BRAFi/MEKi-resistant A375DR and the parental A375 cells were treated with 2 μM vorinostat and/or the combination of 0.125 μM dabrafenib and 5 nM trametinib. Protein lysates were harvested after 72 hr. Western blot analysis was carried out for p-MEK and p-P90RSK as indicators of activation of MAPK pathway, ac-H3 as indicator for levels of acetylated histone H3 and a-tubulin as a loading control.

    Cell, 2018, 173(6):1413-1425. Dabrafenib (GSK2118436) purchased from Selleck.

    A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

  • Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
M{jXbmtqdmG|ZTDBd5NigQ>? M2Da[WlvcGmkaYTpc44hd2ZiTj30[ZJucW6jbDDIbZMhfGGpZ3XkJGIuWmGoIG[2NFBGKG23dHHueEBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgbY5{\WO2IHPlcIx{KGOxLXX4dJJme3OrbnegR2REOzdiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[mmxdHnufYxifGWmLV3FT{Bxem:2ZXnuJJBpd3OyaH;yfYxifGmxbjDifUBCdHCqYWPjdoVmdiCjc4PhfUB4cXSqIFnDOVAhd2ZiMD6wNFA4KM7:TR?= M2rhT|I1QTByNkez
SK-MEL-28 NUK5TJV{U2mwYYPlJGF{e2G7 MVKxJIg> NVPk[4gyUW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSgbY4hcHWvYX6gV2suVUWOLUK4JINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKEWUSzDwbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvODB2IN88US=> NIrTVGQzPDlyME[3Ny=>
HepG2 NFrQd4ZMcW6jc3WgRZN{[Xl? MYjJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCHUlugdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjByNDFOwG0> MkDzNlQ6ODB4N{O=
COLO205 MmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vIW2lvcGmkaYTpc44hd2ZiaIXtZY4hS0:OT{KwOUBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR|UxKG:oIECuNFA4KM7:TR?= MXKyOFkxODZ5Mx?=
HepG2 MoTySpVv[3Srb36gRZN{[Xl? M3fOblQ2KG2rbh?= MVHEUXNQ MY\Jcohq[mm2aX;uJI9nKEGua{WgbY4hXEeILXLleIEue3SrbYXsZZRm\CCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBUdWGmMjDwbI9{eGixconsZZRqd25idILlZZRm\CCob4KgOFUhdWmwczDwdolweiC2bzDUS2Yu[mW2YTDzeIlufWyjdHnvckBu\WG|dYLl[EBi\nSncjC2NEBucW6|IHL5JI9lgXO|ZYmgZoxwfCC|Y3HucoVzKGGwYXz5d4l{KHerdHigTWM2OCCxZjCzMlch|ryP MoXvNlQ6ODB4N{O=
HFF M3XOdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrpUHprOTBizszN NXn1OnhjPzJiaB?= MV3EUXNQ NFf6SG1KdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiaIXtZY4hUE[IIHPlcIx{KGijcnLvdolv\yC5aXzkJJR6eGViQj3SZYYhf2m2aDDJR|UxKG:oIEOg{txO NVH6fm9tOjN6NESwN|g>
SK-MEL-28 MoTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\sbIhyOTBizszN NYr1VY1DPzJiaB?= NUG4RodFTE2VTx?= NEXGVZpKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iU1utUWVNNTJ6IHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yNEOg{txO NYGyNIxNOjN6NESwN|g>
A375P-F11 NVzBPFJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfIXGRJOTBizszN Mn:xO|IhcA>? NFPGc5dFVVOR NHr4XpdKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iQUO3OXAuTjFzIHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yN{Gg{txO NGP1doQzOzh2NECzPC=>
MALME-3M M1\t[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHtcXIyOCEQvF2= NEnZZmI4OiCq M{n5bGROW09? NV\pNIUxUUN3ME2xJI5O MmG4NlM5PDRyM{i=
UACC-62 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NISwfHgyOCEQvF2= NYKyPW9UPzJiaB?= NYfud3lWTE2VTx?= MV3JR|UxRTFibl2= MX:yN|g1PDB|OB?=
C32TG MlXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDSfWNtOTBizszN Mk\YO|IhcA>? NXPtXG1HTE2VTx?= NV7TfWg6UUN3ME2xJI5O NIfWOXMzOzh2NECzPC=>
SK-MEL-1 MoPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W4VlExKM7:TR?= NG\Nc|g4OiCq MUXEUXNQ NVfs[5hOUUN3ME2yJI5O NUKwfmtIOjN6NESwN|g>
M14 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXVTY5MOTBizszN NV3UTZpVPzJiaB?= Mk[5SG1UVw>? Ml\RTWM2OD1{IH7N MnXHNlM5PDRyM{i=
SK-MEL-28 M3G0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITGXo4yOCEQvF2= NHHoWI04OiCq MlyySG1UVw>? NV75T5o3UUN3ME2zJI5O MWqyN|g1PDB|OB?=
A375 NVWzbYtOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PGcFExKM7:TR?= NXnMeWg6PzJiaB?= MlXtSG1UVw>? MU\JR|UxRTRibl2= M4\EUVI{QDR2MEO4
DU-4475 Mki5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jyOlExKM7:TR?= M{H4[lczKGh? MV3EUXNQ M2PsV2lEPTB;NTDuUS=> NIW2[IozOzh2NECzPC=>
UACC-257 NEHCV4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEj2Vo0yOCEQvF2= M1XqWFczKGh? MXHEUXNQ M{jOd2lEPTB;NjDuUS=> MYmyN|g1PDB|OB?=
Colo 205 NITnZXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\pNZoyOCEQvF2= NHjvXJE4OiCq MWTEUXNQ NVjVXFZSUUN3ME23JI5O M2H4SVI{QDR2MEO4
SK-MEL-3 M{\yS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTiZ4dFOTBizszN MoDaO|IhcA>? NGrCdlhFVVOR NUW3PJBsUUN3ME23JI5O NXHjdVcxOjN6NESwN|g>
SH-4 Mm\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\qOph2OTBizszN MlS3O|IhcA>? MnnQSG1UVw>? MWfJR|UxRThibl2= MlvONlM5PDRyM{i=
A101D M4HC[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofINVAh|ryP NUO2S41QPzJiaB?= NVfEWXgyTE2VTx?= NFmyVmZKSzVyPUmgcm0> M3Lz[lI{QDR2MEO4
ES-2 M2jPUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfCNVAh|ryP M{DVOlczKGh? NFqzO|ZFVVOR NXzGSplmUUN3ME21N{BvVQ>? MYOyN|g1PDB|OB?=
HT-29 NHvqToFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG0NVAh|ryP NEX0dXo4OiCq NIDQN4lFVVOR MVPJR|UxRTZ4IH7N Ml3ONlM5PDRyM{i=
SW1417 NGDjNWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS3PJh[OTBizszN NUS1SW1XPzJiaB?= M3vRdGROW09? MmexTWM2OD1zNUigcm0> MUKyN|g1PDB|OB?=
SW872 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXqxNEDPxE1? NITnXFk4OiCq NEezOpVFVVOR NUW5NnlzUUN3ME2zO|chdk1? M2XMdFI{QDR2MEO4
RKO MmXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuwUXoyOCEQvF2= NYOyfJNTPzJiaB?= M3H5eGROW09? MWDJR|UxRTJwNUKyJO69VQ>? MnXLNlM5PDRyM{i=
A673 MkW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LhZ|ExKM7:TR?= NITsUJo4OiCq MmXOSG1UVw>? NVH5OoZSUUN3ME2xNEDPxE1? NWXzT4Q2OjN6NESwN|g>
GCT NEfKWZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHsNolDOTBizszN NGnXUog4OiCq M3TS[2ROW09? MmH1TWM2OD1zMDFOwG0> Mk\YNlM5PDRyM{i=
WM-115 NYG1N4szT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNEDPxE1? MVm3NkBp NX7rO|VOTE2VTx?= NHz2XJhKSzVyPUWgcm0> NGXrNo8zOzh2NECzPC=>
YUMAC MlK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUCzOXhrOTBizszN NIn2Z444OiCq MojhSG1UVw>? M{X0bGlEPTB;NTDuUS=> MX6yN|g1PDB|OB?=
OV-90 M3no[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonFNVAh|ryP MWW3NkBp MnvvSG1UVw>? M33mcmlEPTB;Mkmgcm0> MmfSNlM5PDRyM{i=
NCI-H508 NH3jPXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXQSmkyOCEQvF2= M{j2fVczKGh? Mnf3SG1UVw>? M3ftS2lEPTB;MUCg{txO MYOyN|g1PDB|OB?=
MDA-MB-231 NYrJOo1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnVfJN1OTBizszN MXi3NkBp MVvEUXNQ NHPZOYNKSzVyPUGwJO69VQ>? M3fpeFI{QDR2MEO4
SW756 NIq4SVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTYbG42OTBizszN NEfKb3Y4OiCq MnL4SG1UVw>? M2fLOGlEPTB;MUCg{txO NVHjfmNFOjN6NESwN|g>
SW-837 NIi2WWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXUXYcyOCEQvF2= MXK3NkBp NUm3VYlUTE2VTx?= NUji[ogyUUN3ME2xNEDPxE1? MUeyN|g1PDB|OB?=
UMUC-3 MnPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrzOGF{OTBizszN M1zSNFczKGh? MnzKSG1UVw>? MV;JR|UxRTFyIN88US=> Mmf5NlM5PDRyM{i=
LS-174T NHTNVG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELKXYUyOCEQvF2= M2DlVlczKGh? NVj2OIxLTE2VTx?= NG\wb5FKSzVyPUGwJO69VQ>? MUmyN|g1PDB|OB?=
A549 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYSxNEDPxE1? NVm5[nF3PzJiaB?= NHP1fZhFVVOR M3\lNWlEPTB;MUCg{txO MnrxNlM5PDRyM{i=
SHP-77 M1LFNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr1NVAh|ryP MWS3NkBp M1zJRWROW09? M13M[2lEPTB;MUCg{txO MYiyN|g1PDB|OB?=
SW480 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjs[ZRLOTBizszN MmnNO|IhcA>? M{jESmROW09? NEPKcIZKSzVyPUGwJO69VQ>? M2js[FI{QDR2MEO4
DLD-1 Mo\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rtXVExKM7:TR?= NEX5cXM4OiCq MnfsSG1UVw>? M4DLbWlEPTB;MUCg{txO NXTvdnluOjN6NESwN|g>
HCT-116 NH7UXWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVixNEDPxE1? Mn7RO|IhcA>? NVT6fVU6TE2VTx?= M1L0TWlEPTB;MUCg{txO NI\qdW0zOzh2NECzPC=>
NCI-H747 M{[3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFztOGsyOCEQvF2= M3jnXVczKGh? Ml3vSG1UVw>? MkLTTWM2OD1zMDFOwG0> MWSyN|g1PDB|OB?=
T-84 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fneFExKM7:TR?= NWfMToJtPzJiaB?= NEOxOGVFVVOR NXLTTIUyUUN3ME2xNEDPxE1? MUOyN|g1PDB|OB?=
NCI-H460 NYrUO4lCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzOXG8yOCEQvF2= NVfWdoFpPzJiaB?= MVPEUXNQ M{\kRWlEPTB;MUCg{txO NHTNeYQzOzh2NECzPC=>
Calu-6 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLLNVAh|ryP M3y0O|czKGh? M2n2VmROW09? NFTnU2tKSzVyPUGwJO69VQ>? MlzzNlM5PDRyM{i=
HCC-2998 NGHIdlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYCxNEDPxE1? MkLRO|IhcA>? MmHJSG1UVw>? M4TSXmlEPTB;MUCg{txO MlvUNlM5PDRyM{i=
LS1034 MoDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3OwbVExKM7:TR?= NITjbms4OiCq MXfEUXNQ NHnEZXRKSzVyPUGwJO69VQ>? NHfJOXozOzh2NECzPC=>
CHP-212 M33LfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1iwWlExKM7:TR?= NUHYb41RPzJiaB?= M1S0c2ROW09? MnzBTWM2OD1zMDFOwG0> NIXMT4czOzh2NECzPC=>
SK-N-AS M4DZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fGRlExKM7:TR?= M2e0NlczKGh? NYn5U3pZTE2VTx?= NHz4R5BKSzVyPUGwJO69VQ>? M4PhfVI{QDR2MEO4
BFTC-905 NUHhfYdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTHNVAh|ryP MW[3NkBp M1vzeGROW09? M4i2[GlEPTB;MUCg{txO Mo\3NlM5PDRyM{i=
HuT78 M2m0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLONVAh|ryP NWDWOok4PzJiaB?= M1;WbWROW09? M3izRWlEPTB;NUKgcm0> NVnaXnYyOjN6NESwN|g>
RPMI-8226 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYexNEDPxE1? NHj6eYI4OiCq M3X1VGROW09? MXXJR|UxRTJ4MzDuUS=> MmPWNlM5PDRyM{i=
BC-3 MoX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnGzNVAh|ryP MlPEO|IhcA>? M2\2T2ROW09? MV7JR|UxRTJ5NzDuUS=> NGSzS28zOzh2NECzPC=>
ACHN MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYKxNEDPxE1? M3nJOlczKGh? M1rkeWROW09? NUT6V3hRUUN3ME2yPVQhdk1? NGDufHMzOzh2NECzPC=>
JRT3-T35 MluxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWxNEDPxE1? MYK3NkBp MVLEUXNQ NF7Veo1KSzVyPUK5OUBvVQ>? NHrKc|czOzh2NECzPC=>
SK-MES-1 M{XwOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDa[G85OTBizszN MYi3NkBp NXvwVnBtTE2VTx?= MWrJR|UxRTN{OTDuUS=> M1HkW|I{QDR2MEO4
CESS MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILGd4oyOCEQvF2= MYi3NkBp M2Pt[mROW09? NIfCXpBKSzVyPUS5O{BvVQ>? NHf1U2wzOzh2NECzPC=>
H4 M1XNTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDNPINrOTBizszN NHq1UJg4OiCq NUXj[2VHTE2VTx?= MXjJR|UxRTZzOTDuUS=> MWKyN|g1PDB|OB?=
BC-1 NVm0fIh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7mNVAh|ryP NH3RSZc4OiCq M3vNRmROW09? Mlz4TWM2OD15MESgcm0> NIfPWVQzOzh2NECzPC=>
DB NXvKRlhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILBNlEyOCEQvF2= M{XXUlczKGh? MYDEUXNQ MUHJR|UxRTh5MzDuUS=> NWHteIViOjN6NESwN|g>
RPMI-6666 NYPnWYIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX5e243OTBizszN M{\WNVczKGh? M4S1SmROW09? NX3wXJNXUUN3ME25Nlghdk1? MmrINlM5PDRyM{i=
MC/CAR NI\oT|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTtNHZLOTBizszN NIO4SlU4OiCq NInoSHhFVVOR Mmi4TWM2OD1zLkCwNkDPxE1? NHjUPZozOzh2NECzPC=>
SNU-1 MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXWxNEDPxE1? NUXlNoJ6PzJiaB?= NFzDfVRFVVOR MmXzTWM2OD1zLkWwNUDPxE1? MUOyN|g1PDB|OB?=
CEM/C1 MmHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDsdGwyOCEQvF2= MVS3NkBp MWfEUXNQ M{TWVWlEPTB;MT63O|Mh|ryP M2XBTVI{QDR2MEO4
GDM-1 NXXrUXR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fWVVExKM7:TR?= M{PobVczKGh? NX\QT3h4TE2VTx?= NEKy[XNKSzVyPUGuPVk4KM7:TR?= MVWyN|g1PDB|OB?=
HT-1080 M4jH[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3BWXoyOCEQvF2= MnriO|IhcA>? M{\rfWROW09? MlnvTWM2OD1{LkCwOEDPxE1? Mn3xNlM5PDRyM{i=
HL-60 M{Hu[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY[xNEDPxE1? NV;POYFzPzJiaB?= NVPndlNPTE2VTx?= MkO5TWM2OD1{LkG3PEDPxE1? Mo\aNlM5PDRyM{i=
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MES-SA MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknnNVAh|ryP M{PoV|czKGh? Mm[1SG1UVw>? NVvkZYVIUUN3ME22Mlk5QSEQvF2= NFHZWVczOzh2NECzPC=>
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647-V NHrJc3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmxNEDPxE1? MYq3NkBp MnXaSG1UVw>? MnvXTWM2OD1zMDFOwG0> NEXkTY8zOzh2NECzPC=>
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A172 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF33O5EyOCEQvF2= NYrNWXU6PzJiaB?= NHjh[opFVVOR MkLwTWM2OD1zMDFOwG0> NHn0TY4zOzh2NECzPC=>
A204 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PsOVExKM7:TR?= M164eVczKGh? NHr1SopFVVOR MlHWTWM2OD1zMDFOwG0> MXeyN|g1PDB|OB?=
A427 NXHW[FRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH22dHUyOCEQvF2= MWC3NkBp M3nabGROW09? M3\Cd2lEPTB;MUCg{txO NGjTVY0zOzh2NECzPC=>
A431 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP1NVAh|ryP MXe3NkBp MYTEUXNQ MmPSTWM2OD1zMDFOwG0> MoXYNlM5PDRyM{i=
A2780 M{njfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDwNVAh|ryP M2DKUVczKGh? NF\jNGxFVVOR MoTNTWM2OD1zMDFOwG0> Mn3JNlM5PDRyM{i=
ARH-77 MlfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\wOlExKM7:TR?= NEf6bGs4OiCq NXy0TXZyTE2VTx?= M4\1fGlEPTB;MUCg{txO NX7m[GhxOjN6NESwN|g>
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BT-20 MmixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\QNVAh|ryP Mmi0O|IhcA>? NEnwfWxFVVOR NV\yNG5TUUN3ME2xNEDPxE1? NGfUOoozOzh2NECzPC=>
BxPc3 NIW0dIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq4RZMyOCEQvF2= MW[3NkBp NUHiTZljTE2VTx?= M{T1V2lEPTB;MUCg{txO NULTd3c5OjN6NESwN|g>
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C33A MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jIZlExKM7:TR?= MmPhO|IhcA>? MV\EUXNQ MkTXTWM2OD1zMDFOwG0> Ml7YNlM5PDRyM{i=
CAL-27 MkHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHoNVAh|ryP NXXFTYpzPzJiaB?= Ml3ySG1UVw>? MlzqTWM2OD1zMDFOwG0> MXuyN|g1PDB|OB?=
CAL-62 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvKdYMyOCEQvF2= NEm3VG84OiCq NGiyW|lFVVOR NWfBcJA3UUN3ME2xNEDPxE1? NYrKd21xOjN6NESwN|g>
Calu-3 M2q0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWC2UYg1OTBizszN MV[3NkBp NYrNd3dWTE2VTx?= MkCwTWM2OD1zMDFOwG0> MmfENlM5PDRyM{i=
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CGTHW1 M4f5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfmNVAh|ryP M4nRRlczKGh? MUXEUXNQ NV:yToJzUUN3ME2xNEDPxE1? MYCyN|g1PDB|OB?=
CHL-1 M2PmcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUexNEDPxE1? Mn;JO|IhcA>? M1ziWGROW09? NFrnNJVKSzVyPUGwJO69VQ>? MlPiNlM5PDRyM{i=
Colo320DM MnHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYWxNEDPxE1? NVu5NodbPzJiaB?= NXLiRYJETE2VTx?= M4q3ZWlEPTB;MUCg{txO M4f1cVI{QDR2MEO4
Colo704 MknwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVyxNEDPxE1? NVf5fHNFPzJiaB?= NFPCOIVFVVOR Mn3JTWM2OD1zMDFOwG0> MnnLNlM5PDRyM{i=
COR-L23 M2PkWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PHTlExKM7:TR?= Mmi4O|IhcA>? M1G0[WROW09? Mli2TWM2OD1zMDFOwG0> MWGyN|g1PDB|OB?=
CRO-AP2 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnmfFJUOTBizszN NEj2VVM4OiCq MlPrSG1UVw>? MkfhTWM2OD1zMDFOwG0> M4HHVVI{QDR2MEO4
Daudi NYXXeplmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjndJBrOTBizszN MVq3NkBp NWj1Vmx3TE2VTx?= NF\uZ2RKSzVyPUGwJO69VQ>? NWO5fJdrOjN6NESwN|g>
DOTC 24510 Ml34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DPO|ExKM7:TR?= M{SyVVczKGh? MW\EUXNQ M1r1cmlEPTB;MUCg{txO NWnLVXNWOjN6NESwN|g>
DU-145 M4LFO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLENVAh|ryP MYW3NkBp NX3vepN1TE2VTx?= M33VUmlEPTB;MUCg{txO M3znWVI{QDR2MEO4
EB-3 NGTkfolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHjNVAh|ryP MXu3NkBp NXvST2NITE2VTx?= NXHnN3FRUUN3ME2xNEDPxE1? MXuyN|g1PDB|OB?=
EFM-19 NIexdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G2eFExKM7:TR?= MX:3NkBp MUfEUXNQ NU\s[ZM6UUN3ME2xNEDPxE1? MU[yN|g1PDB|OB?=
EKVX NUP4OmRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M125fVExKM7:TR?= MXG3NkBp M3\kfGROW09? NHfu[W9KSzVyPUGwJO69VQ>? Mnr6NlM5PDRyM{i=
FaDu NWO0cVJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LZdFExKM7:TR?= NWP3UXR6PzJiaB?= MWfEUXNQ M{e3dGlEPTB;MUCg{txO MWOyN|g1PDB|OB?=
G401 MnTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXP[VcyOCEQvF2= MlXVO|IhcA>? NHjZZWtFVVOR NWrVcFNQUUN3ME2xNEDPxE1? MVOyN|g1PDB|OB?=
HCC-70 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrHdIFMOTBizszN M2jkNVczKGh? MX7EUXNQ NEW2[|ZKSzVyPUGwJO69VQ>? NH;jWXozOzh2NECzPC=>
HCC-1954 M1rFdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjQNVAh|ryP NEG1NFc4OiCq NXvYcWF7TE2VTx?= MmTkTWM2OD1zMDFOwG0> NV\6Z5FSOjN6NESwN|g>
Hela NHzwRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\MdGYyOCEQvF2= NInHVoM4OiCq M{DS[mROW09? M{DXemlEPTB;MUCg{txO NHT6T|IzOzh2NECzPC=>
Hep3B NEHpc4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjhOocyOCEQvF2= NIL6eW04OiCq MV3EUXNQ NInMN|VKSzVyPUGwJO69VQ>? M{nzUlI{QDR2MEO4
HMCB MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LxdFExKM7:TR?= MUe3NkBp NWLwcIp1TE2VTx?= M3frSmlEPTB;MUCg{txO MVKyN|g1PDB|OB?=
HN5 NHzhXFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH70RWMyOCEQvF2= NXLuRYZtPzJiaB?= NHjnVmZFVVOR M3\sXWlEPTB;MUCg{txO NYHhbllkOjN6NESwN|g>
HOS M2rIXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LRNVExKM7:TR?= MlvzO|IhcA>? MXLEUXNQ MVHJR|UxRTFyIN88US=> MV[yN|g1PDB|OB?=
HPAF-II NID4[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj6NVAh|ryP NXzaTnFKPzJiaB?= M{e5O2ROW09? M2r6NGlEPTB;MUCg{txO NWjieYxxOjN6NESwN|g>
Hs746.T M161cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXOxNEDPxE1? MWe3NkBp M3n3dGROW09? NEToV2ZKSzVyPUGwJO69VQ>? MUiyN|g1PDB|OB?=
HT NVnVNFlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3RNVAh|ryP NYm5T4RFPzJiaB?= Mn3CSG1UVw>? M1HKSmlEPTB;MUCg{txO MV6yN|g1PDB|OB?=
HT-3 MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTxb5VlOTBizszN NGXwN4I4OiCq NHvIW4tFVVOR NEThc|dKSzVyPUGwJO69VQ>? NFfpRYozOzh2NECzPC=>
HuNS-1 NW\5bW5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjLN5dVOTBizszN M3fpfVczKGh? MYnEUXNQ NWrkb2xyUUN3ME2xNEDPxE1? MXKyN|g1PDB|OB?=
IGROV1 MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3WzVVExKM7:TR?= MljIO|IhcA>? NInifHRFVVOR NEPmdHJKSzVyPUGwJO69VQ>? M2ex[|I{QDR2MEO4
J82 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1WyOlExKM7:TR?= M3ywZ|czKGh? MXLEUXNQ MXvJR|UxRTFyIN88US=> MlXCNlM5PDRyM{i=
JM1 Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[xNEDPxE1? MmD4O|IhcA>? NHjrNINFVVOR MXzJR|UxRTFyIN88US=> MW[yN|g1PDB|OB?=
Kato III NV;jXY9DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1O0c|ExKM7:TR?= Mn3tO|IhcA>? M2f5PGROW09? MV;JR|UxRTFyIN88US=> MYCyN|g1PDB|OB?=
KHOS-240S NH\C[5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfybFVsOTBizszN M{\UbVczKGh? MX7EUXNQ NF\XSGVKSzVyPUGwJO69VQ>? NYX1eJNrOjN6NESwN|g>
KM-12 M1GyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVGxNEDPxE1? NX65NHY4PzJiaB?= NHrmN2JFVVOR M1\HbWlEPTB;MUCg{txO MWOyN|g1PDB|OB?=
KPL-1 M1vqWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TXWlExKM7:TR?= Moj3O|IhcA>? M4TwbmROW09? MYPJR|UxRTFyIN88US=> NInjfXgzOzh2NECzPC=>
KYSE-30 NHrIeYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\CNFExKM7:TR?= MmqxO|IhcA>? M3:xeGROW09? NG[2OodKSzVyPUGwJO69VQ>? NFz0b3gzOzh2NECzPC=>
LNCaP M3LH[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfDfIoyOCEQvF2= Ml\PO|IhcA>? NE\VSGRFVVOR Mm\oTWM2OD1zMDFOwG0> NYjrSopGOjN6NESwN|g>
MCF-7 M3PJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWmwfIU5OTBizszN M3LsPVczKGh? MojUSG1UVw>? MVjJR|UxRTFyIN88US=> NG\YbIgzOzh2NECzPC=>
MC-IXC NFzWblRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1:yWFExKM7:TR?= MkHGO|IhcA>? NGKxZZhFVVOR MUHJR|UxRTFyIN88US=> NXnwcmRZOjN6NESwN|g>
MDA-MB-175 VII MkTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1y3c|ExKM7:TR?= NFmwVlE4OiCq Mn;3SG1UVw>? NHO5UopKSzVyPUGwJO69VQ>? NHn4cIQzOzh2NECzPC=>
MDA-MB-468 MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPJUooyOCEQvF2= NYT4[IxCPzJiaB?= Ml;FSG1UVw>? NGfkXIFKSzVyPUGwJO69VQ>? MXqyN|g1PDB|OB?=
MiaPaCa M2rqUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PqXFExKM7:TR?= M1nIfFczKGh? NFnBSlZFVVOR MkDGTWM2OD1zMDFOwG0> MmLjNlM5PDRyM{i=
Molt-4 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWqxNEDPxE1? MU[3NkBp NGrQ[2tFVVOR MXvJR|UxRTFyIN88US=> NVn2RVRjOjN6NESwN|g>
NCI-ADR/RES M3\KNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TCfFExKM7:TR?= NHr0[po4OiCq NIjCenBFVVOR NUW0fJdZUUN3ME2xNEDPxE1? M120TlI{QDR2MEO4
NCI-H69 M4DxPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHRW48yOCEQvF2= M1;1V|czKGh? NGfiXFlFVVOR NWDDTYNbUUN3ME2xNEDPxE1? M4X1UFI{QDR2MEO4
NCI-H82 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHQPZkyOCEQvF2= NV3LR|BLPzJiaB?= NVLSNmxvTE2VTx?= M4i2UmlEPTB;MUCg{txO M4rHdFI{QDR2MEO4
NCI-N87 NH:0e41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX:xNEDPxE1? MYS3NkBp MonhSG1UVw>? M1fKTWlEPTB;MUCg{txO MlyyNlM5PDRyM{i=
NCI-H146 M33OO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYr0fXNtOTBizszN NInDR2s4OiCq MWTEUXNQ Ml7ZTWM2OD1zMDFOwG0> MUSyN|g1PDB|OB?=
NCI-H157 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmCwNVAh|ryP MXq3NkBp NV;LW4R7TE2VTx?= NIizVXRKSzVyPUGwJO69VQ>? MmLtNlM5PDRyM{i=
NCI-H187 NHnk[IdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmxNEDPxE1? NXO2W5NJPzJiaB?= MoLGSG1UVw>? Mm\sTWM2OD1zMDFOwG0> NIPwR4YzOzh2NECzPC=>
NCI-H209 M4TuXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrPcIdtOTBizszN MorrO|IhcA>? MlrWSG1UVw>? Ml7tTWM2OD1zMDFOwG0> M130WFI{QDR2MEO4
NCI-H226 M4Pnemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnThNVAh|ryP MYm3NkBp Mly2SG1UVw>? MVHJR|UxRTFyIN88US=> Mon4NlM5PDRyM{i=
NCI-H292 NVHmZWVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPhOGE5OTBizszN NUHHNXJ3PzJiaB?= NX:wd45uTE2VTx?= NGfHNINKSzVyPUGwJO69VQ>? MkXFNlM5PDRyM{i=
NCI-H322 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETB[YcyOCEQvF2= MnHZO|IhcA>? NX63bnI1TE2VTx?= NUfCPZdqUUN3ME2xNEDPxE1? NEf5WYUzOzh2NECzPC=>
NCI-H358 NWrhd2RmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXuxNEDPxE1? NIfqfVY4OiCq NF\HfWtFVVOR Mkn2TWM2OD1zMDFOwG0> MVuyN|g1PDB|OB?=
NCI-H520 NVLRTHR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mme3NVAh|ryP M{D4RVczKGh? M4LiXmROW09? MmnzTWM2OD1zMDFOwG0> Ml3DNlM5PDRyM{i=
NCI-H526 Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e3UVExKM7:TR?= Mn;qO|IhcA>? MkfxSG1UVw>? M4nnTmlEPTB;MUCg{txO M3vsOVI{QDR2MEO4
NCI-H630 NWK1b2tVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWOxNEDPxE1? Ml\1O|IhcA>? NUXP[Wp[TE2VTx?= M17UVWlEPTB;MUCg{txO NHLHRo4zOzh2NECzPC=>
NCI-H661 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfWSGsyOCEQvF2= MmPXO|IhcA>? MmiySG1UVw>? NXTXZ2ZxUUN3ME2xNEDPxE1? NF;2cYEzOzh2NECzPC=>
NCI-H716 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XVc|ExKM7:TR?= NFPCOoY4OiCq NF3BSVRFVVOR NGjCRVNKSzVyPUGwJO69VQ>? NITa[4EzOzh2NECzPC=>
NCI-H1563 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xNEDPxE1? M4rmU|czKGh? NHzoOoxFVVOR MXXJR|UxRTFyIN88US=> MojGNlM5PDRyM{i=
NCI-H1792 NYLQVIRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj1NosyOCEQvF2= NH7RT4E4OiCq M4TyOGROW09? M4DydGlEPTB;MUCg{txO NW\Kb|huOjN6NESwN|g>
NCI-H2030 MlzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[3Z|ExKM7:TR?= M2i2WVczKGh? NWTqSZFlTE2VTx?= NEjsdVVKSzVyPUGwJO69VQ>? NXjNSppMOjN6NESwN|g>
NCI-H2052 NEfrZplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\MNVAh|ryP MnLLO|IhcA>? M3q1fWROW09? MUfJR|UxRTFyIN88US=> MVWyN|g1PDB|OB?=
NCI-H2122 M3HhWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;xc|ExKM7:TR?= MUe3NkBp M2DpZmROW09? NF;1N4lKSzVyPUGwJO69VQ>? NF\CbmgzOzh2NECzPC=>
NCI-H2228 NXrocYVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPYdVcyOCEQvF2= MoT0O|IhcA>? NUjUPW5RTE2VTx?= NVnCVmxQUUN3ME2xNEDPxE1? MUWyN|g1PDB|OB?=
OE-19 NV\5UWlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjKR5MyOCEQvF2= MorlO|IhcA>? NIHH[VZFVVOR NILvWJdKSzVyPUGwJO69VQ>? MoHqNlM5PDRyM{i=
OE-21 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXlbnBZOTBizszN M4HmPFczKGh? NXXyb2NCTE2VTx?= NW[0dnNLUUN3ME2xNEDPxE1? Mn7tNlM5PDRyM{i=
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SCC-9 M{LjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnqyNVAh|ryP NIPscII4OiCq NWjRdmlDTE2VTx?= NIXTeHBKSzVyPUGwJO69VQ>? M{T5T|I{QDR2MEO4
SCC-12 M37XeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXW3fVBwOTBizszN NGroSWo4OiCq NW[yRoFUTE2VTx?= M1ywbmlEPTB;MUCg{txO M{LKNlI{QDR2MEO4
SCC-13 M1LBW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7Nem4yOCEQvF2= M3nIVVczKGh? M3vPemROW09? MULJR|UxRTFyIN88US=> NIXNcnYzOzh2NECzPC=>
SCC-15 MnHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDoXGoyOCEQvF2= NFvxXWM4OiCq M{TwU2ROW09? Mo[2TWM2OD1zMDFOwG0> MVuyN|g1PDB|OB?=
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SF-268 M3jpeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n5WVExKM7:TR?= M37iVVczKGh? NVXkRphzTE2VTx?= M2i0Z2lEPTB;MUCg{txO Ml3WNlM5PDRyM{i=
SF-295 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY[xNEDPxE1? MkLRO|IhcA>? MUTEUXNQ M2S5[WlEPTB;MUCg{txO NGfEcJczOzh2NECzPC=>
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SK-BR-3 MlnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUP3cmJHOTBizszN NFLuRZE4OiCq MofESG1UVw>? NHuzbFVKSzVyPUGwJO69VQ>? NWXwXWZsOjN6NESwN|g>
SK-LMS-1 NFvBcGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLYR|gyOCEQvF2= NH6zRnM4OiCq M13WWWROW09? NWfMSYFPUUN3ME2xNEDPxE1? Ml;nNlM5PDRyM{i=
SK-N-DZ MmrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH6zVGgyOCEQvF2= MoTJO|IhcA>? NU[3VI51TE2VTx?= MnnhTWM2OD1zMDFOwG0> MWiyN|g1PDB|OB?=
SK-N-F1 NWL3flZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jaN|ExKM7:TR?= NWrYT|hoPzJiaB?= NX3HblJYTE2VTx?= NYfsd5R5UUN3ME2xNEDPxE1? NX36cFdWOjN6NESwN|g>
SKOV-3 NX;4PGF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnkc|gyOCEQvF2= M1\1TVczKGh? MVLEUXNQ M3rpbmlEPTB;MUCg{txO NW[2T2tIOjN6NESwN|g>
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SNU-16 MnLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\rWFExKM7:TR?= MWe3NkBp M2LoT2ROW09? NV;vWI42UUN3ME2xNEDPxE1? MoK2NlM5PDRyM{i=
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SW1990 Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;hOVExKM7:TR?= MXe3NkBp MX;EUXNQ M1O3VmlEPTB;MUCg{txO NEK3b4IzOzh2NECzPC=>
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TE381.T MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjhWVlJOTBizszN NIC5WIQ4OiCq MVLEUXNQ MofCTWM2OD1zMDFOwG0> NFzXNFMzOzh2NECzPC=>
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U251 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3yZXUyOCEQvF2= MUm3NkBp Mn\zSG1UVw>? M4n5WmlEPTB;MUCg{txO M{LlOVI{QDR2MEO4
UACC-812 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXr3VmdJOTBizszN M3fq[FczKGh? NHj3bXZFVVOR MYXJR|UxRTFyIN88US=> MkDkNlM5PDRyM{i=
YAPC M3u2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\NfGkyOCEQvF2= M1TJNlczKGh? NYPud2YxTE2VTx?= NX;IfHNsUUN3ME2xNEDPxE1? NV70OotYOjN6NESwN|g>
ZR-75-1 NFvZSppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3H0PVExKM7:TR?= M1jlZVczKGh? M3;oNWROW09? MXHJR|UxRTFyIN88US=> MYSyN|g1PDB|OB?=
A375 NHTIN4FHfW6ldHnvckBie3OjeR?= MmTDNU4zKM7:TR?= M4TaZlQhcA>? NX\5eZhmTE2VTx?= MWTJcohq[mm2aX;uJI9nKHCqb4PwbI9zgWyjdHnvckBw\iCPRVusJGVTUyxiYX7kJHM3WA>? M1jkOlIzOzh7NEex
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M257 MoH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXOxNFAhdk1? NV3NdGxwPzJiaB?= M1PiZmRw\XNibn;0JIlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= MW[yN|MyPzR2Nh?=
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... Click to View More Cell Line Experimental Data

In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
8 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01153763 Completed Melanoma GlaxoSmithKline August 9 2010 Phase 2
NCT02858921 Recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis November 8 2017 Phase 2
NCT01978236 Terminated Melanoma and Brain Metastases GlaxoSmithKline April 8 2014 Phase 2
NCT01682083 Active not recruiting Melanoma Novartis Pharmaceuticals|Novartis January 8 2013 Phase 3
NCT01340833 Completed Cancer GlaxoSmithKline June 8 2011 Phase 1
NCT01723202 Active not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID