Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.

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In DMSO USD 180 In stock
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  • BRAFi/MEKi-resistant A375DR and the parental A375 cells were treated with 2 μM vorinostat and/or the combination of 0.125 μM dabrafenib and 5 nM trametinib. Protein lysates were harvested after 72 hr. Western blot analysis was carried out for p-MEK and p-P90RSK as indicators of activation of MAPK pathway, ac-H3 as indicator for levels of acetylated histone H3 and a-tubulin as a loading control.

    Cell, 2018, 173(6):1413-1425. Dabrafenib (GSK2118436) purchased from Selleck.

    A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

  • Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

    The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

  • Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

    Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [3]
(Cell-free assay)
B-Raf [3]
(Cell-free assay)
C-Raf [3]
(Cell-free assay)
0.7 nM 5.2 nM 6.3 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NXW4d|ZGU2mwYYPlJGF{e2G7 Ml;VTY5pcWKrdHnvckBw\iCQLYTldo1qdmGuIFjpd{B1[WepZXSgRk1T[WZiVk[wNGUhdXW2YX70JIV5eHKnc4Pl[EBqdiCkYXP1cI93cXK3czDpcoZm[3SnZDDpcpNm[3RiY3XscJMh[29vZYjwdoV{e2mwZzDDSGM{PyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBjcW:2aX75cIF1\WRvTVXLJJBzd3SnaX6gdIhwe3Cqb4L5cIF1cW:wIHL5JGFteGijU3Py[YVvKGG|c3H5JJdqfGhiSVO1NEBw\iByLkCwNFch|ryP MmrKNlQ6ODB4N{O=
SK-MEL-28 NUniNnBoU2mwYYPlJGF{e2G7 NETURYUyKGh? M3nVRmlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIGPLMW1GVC1{ODDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBGWkticHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxPCEQvF2= NFrncm0zPDlyME[3Ny=>
HepG2 NH\mR45McW6jc3WgRZN{[Xl? M3rKbGlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIFXST{BxcG:|cHjvdplt[XSrb36ge4l1cCCLQ{WwJI9nKDBwMEC0JO69VQ>? NGnkVVEzPDlyME[3Ny=>
COLO205 NFfDOVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1G4N2lvcGmkaYTpc44hd2ZiaIXtZY4hS0:OT{KwOUBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR|UxKG:oIECuNFA4KM7:TR?= M4rTXVI1QTByNkez
HepG2 MX3GeY5kfGmxbjDBd5NigQ>? NFLkXXA1PSCvaX6= MUHEUXNQ NFe4SmlKdmirYnn0bY9vKG:oIFHsb|UhcW5iVFfGMYJmfGFvc4TpcZVt[XSnZDDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCVbXHkNkBxcG:|cHjvdplt[XSrb36geJJm[XSnZDDmc5IhPDVibXnud{BxemmxcjD0c{BVT0ZvYnX0ZUB{fGmvdXzheIlwdiCvZXHzeZJm\CCjZoTldkA3OCCvaX7zJIJ6KG:meYPz[Zkh[myxdDDzZ4FvdmW{IHHuZYx6e2m|IIfpeIghUUN3MDDv[kA{NjdizszN MmfHNlQ6ODB4N{O=
HFF MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUexNEDPxE1? NVnzbmZTPzJiaB?= NX3ydFhzTE2VTx?= NIPjRmFKdmirYnn0bY9vKG:oIIDyc4xq\mW{YYTpc44hd2ZiaIXtZY4hUE[IIHPlcIx{KGijcnLvdolv\yC5aXzkJJR6eGViQj3SZYYhf2m2aDDJR|UxKG:oIEOg{txO MX2yN|g1PDB|OB?=
SK-MEL-28 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTST4QyOCEQvF2= NXrqdow6PzJiaB?= MmrVSG1UVw>? NGjNTYdKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iU1utUWVNNTJ6IHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yNEOg{txO MoPsNlM5PDRyM{i=
A375P-F11 MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfrUZJPOTBizszN MmjTO|IhcA>? NXfIVIFjTE2VTx?= NE\JPYhKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdD3kdol3\W5iQUO3OXAuTjFzIHPlcIwheHKxbHnm[ZJifGmxbjD3bZRpKEmFNUCgc4YhOC5yN{Gg{txO MXWyN|g1PDB|OB?=
MALME-3M NG\pd|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofLNVAh|ryP NH\JUVU4OiCq MmH0SG1UVw>? MofnTWM2OD1zIH7N MXSyN|g1PDB|OB?=
UACC-62 M3PwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV6xNEDPxE1? MoLyO|IhcA>? MXTEUXNQ NI\ZPYdKSzVyPUGgcm0> NXnXRmdsOjN6NESwN|g>
C32TG NIfDRmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\vNVAh|ryP NFTmOm84OiCq NFHielhFVVOR MULJR|UxRTFibl2= NHfLbFUzOzh2NECzPC=>
SK-MEL-1 NX;aXGZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\nTooyOCEQvF2= MV:3NkBp Mn;4SG1UVw>? NH\PTllKSzVyPUKgcm0> M4jRdFI{QDR2MEO4
M14 NF7jN3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;5NVAh|ryP MmXtO|IhcA>? MUHEUXNQ M3n5[2lEPTB;MjDuUS=> MViyN|g1PDB|OB?=
SK-MEL-28 NX;X[HJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmP2NVAh|ryP MnTRO|IhcA>? NEO0b|JFVVOR NGW2N|hKSzVyPUOgcm0> NHTzOmEzOzh2NECzPC=>
A375 NXv5[IhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PBfVExKM7:TR?= MWK3NkBp MWXEUXNQ NFWyR4dKSzVyPUSgcm0> NGj2b2czOzh2NECzPC=>
DU-4475 M1;Eemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnTUYUyOCEQvF2= MlvmO|IhcA>? MVnEUXNQ NWDBZWN6UUN3ME21JI5O NFzsXJUzOzh2NECzPC=>
UACC-257 NYf4SmhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLhNVAh|ryP NEG4c3c4OiCq MlXSSG1UVw>? NYTYbVZ{UUN3ME22JI5O NIq3bG0zOzh2NECzPC=>
Colo 205 MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnOUooyOCEQvF2= M4G5WlczKGh? MonsSG1UVw>? M3jxbGlEPTB;NzDuUS=> MWmyN|g1PDB|OB?=
SK-MEL-3 NW\ESpRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWWxNEDPxE1? MkGzO|IhcA>? MkPNSG1UVw>? M{PVTmlEPTB;NzDuUS=> MlnwNlM5PDRyM{i=
SH-4 Mn[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPMNlkyOCEQvF2= NUn6VlQ2PzJiaB?= MX\EUXNQ MoTuTWM2OD16IH7N NGTMc40zOzh2NECzPC=>
A101D M3Hlb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDkPZoyOCEQvF2= NF3MV|k4OiCq MX7EUXNQ NIjabJhKSzVyPUmgcm0> NFmyfFQzOzh2NECzPC=>
ES-2 NXPYO29DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4K4OVExKM7:TR?= MX[3NkBp MXvEUXNQ MVXJR|UxRTV|IH7N MnL1NlM5PDRyM{i=
HT-29 M3vsVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:3NVAh|ryP MoLwO|IhcA>? NHroPFBFVVOR MYfJR|UxRTZ4IH7N M1;YdVI{QDR2MEO4
SW1417 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYCxNEDPxE1? M4LiZVczKGh? NHuwPI9FVVOR Mme1TWM2OD1zNUigcm0> M12zZlI{QDR2MEO4
SW872 Mof1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\wNVAh|ryP NHTo[lE4OiCq MXvEUXNQ MXjJR|UxRTN5NzDuUS=> MlG1NlM5PDRyM{i=
RKO M33OVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDxU3MyOCEQvF2= NHvpSpM4OiCq NFTGVGNFVVOR MXrJR|UxRTJwNUKyJO69VQ>? NUHGepE{OjN6NESwN|g>
A673 MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHiNVAh|ryP NYDw[ZZQPzJiaB?= NHj2NmlFVVOR NYH5TmJVUUN3ME2xNEDPxE1? Mn\aNlM5PDRyM{i=
GCT MnHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XROFExKM7:TR?= MnL4O|IhcA>? MVjEUXNQ M1fPZmlEPTB;MUCg{txO NUDsUmE{OjN6NESwN|g>
WM-115 NHfqflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWK4ZpdJOTBizszN NXP3VI1kPzJiaB?= NES5fplFVVOR MmewTWM2OD13IH7N M1LvNFI{QDR2MEO4
YUMAC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfxOnMyOCEQvF2= M3\0R|czKGh? NUXtXZlpTE2VTx?= MY\JR|UxRTVibl2= M4DDRVI{QDR2MEO4
OV-90 NIPycFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfneWh4OTBizszN MnHkO|IhcA>? NFG0NYxFVVOR MoLjTWM2OD1{OTDuUS=> MkfoNlM5PDRyM{i=
NCI-H508 NW\VTWl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTFNVAh|ryP MY[3NkBp NHnSUVNFVVOR MlOxTWM2OD1zMDFOwG0> NHKzfYgzOzh2NECzPC=>
MDA-MB-231 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\VXFExKM7:TR?= MUe3NkBp NFrOc5dFVVOR M2mydmlEPTB;MUCg{txO MWqyN|g1PDB|OB?=
SW756 NIn1W3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTlZ4E2OTBizszN NHLCO3E4OiCq NYjoNmNjTE2VTx?= MXTJR|UxRTFyIN88US=> MWGyN|g1PDB|OB?=
SW-837 NFjlOZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjiVnNvOTBizszN M4XkPVczKGh? NXXENYNDTE2VTx?= NVL5W4tvUUN3ME2xNEDPxE1? NIHxRokzOzh2NECzPC=>
UMUC-3 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUOxNEDPxE1? NET1[m44OiCq M1zHWWROW09? M3HUfmlEPTB;MUCg{txO NGq3b24zOzh2NECzPC=>
LS-174T NIDIdmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7UNlEyOCEQvF2= MXm3NkBp M2CxWGROW09? M4DMUmlEPTB;MUCg{txO MliwNlM5PDRyM{i=
A549 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHaSnpMOTBizszN NFTvRm44OiCq MkjJSG1UVw>? MmO4TWM2OD1zMDFOwG0> MlW5NlM5PDRyM{i=
SHP-77 MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfRRpJGOTBizszN MYS3NkBp MYnEUXNQ NUjWPW13UUN3ME2xNEDPxE1? NFHVb4UzOzh2NECzPC=>
SW480 M4TFU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWGxNEDPxE1? Mkj2O|IhcA>? MmP0SG1UVw>? NXTZSHZtUUN3ME2xNEDPxE1? M3XvPVI{QDR2MEO4
DLD-1 NXLxUG9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i3NVExKM7:TR?= MYm3NkBp MUXEUXNQ MVLJR|UxRTFyIN88US=> NHr6ZlIzOzh2NECzPC=>
HCT-116 MnH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHzNVAh|ryP M17vRVczKGh? MoPlSG1UVw>? M3LWSmlEPTB;MUCg{txO NHrTeFgzOzh2NECzPC=>
NCI-H747 MonRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnUNVAh|ryP NFLiXlA4OiCq NH3PSpZFVVOR NInuVY9KSzVyPUGwJO69VQ>? MnjaNlM5PDRyM{i=
T-84 M{j3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETyemYyOCEQvF2= M{XZcVczKGh? MV\EUXNQ NHPZOVNKSzVyPUGwJO69VQ>? NH;tT40zOzh2NECzPC=>
NCI-H460 MmXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LpN|ExKM7:TR?= NHjZbGU4OiCq M4XmWGROW09? MoXiTWM2OD1zMDFOwG0> Ml\YNlM5PDRyM{i=
Calu-6 NVjUSYtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLuSIRjOTBizszN MXW3NkBp M{LJRWROW09? MVrJR|UxRTFyIN88US=> MYOyN|g1PDB|OB?=
HCC-2998 MmHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml76NVAh|ryP M2CwS|czKGh? NIXac3NFVVOR NFvOUlBKSzVyPUGwJO69VQ>? NXHpXYlPOjN6NESwN|g>
LS1034 NYDQcVhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLRO2w4OTBizszN MUe3NkBp NEDGV49FVVOR NEPae2xKSzVyPUGwJO69VQ>? NVrRWVhkOjN6NESwN|g>
CHP-212 NInjb|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\MdlExKM7:TR?= M{TXRVczKGh? NF2xeWpFVVOR MofPTWM2OD1zMDFOwG0> NGrYflIzOzh2NECzPC=>
SK-N-AS M1TSeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnOzNVAh|ryP MVm3NkBp NYLUV3p6TE2VTx?= NVOzNHVpUUN3ME2xNEDPxE1? NIKwc4UzOzh2NECzPC=>
BFTC-905 Ml\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVqxNEDPxE1? MUi3NkBp NF:zNJFFVVOR MUTJR|UxRTFyIN88US=> M1v3OlI{QDR2MEO4
HuT78 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f2dFExKM7:TR?= NV\NcnpYPzJiaB?= MlvHSG1UVw>? NGfRdG5KSzVyPUWyJI5O MmrRNlM5PDRyM{i=
RPMI-8226 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HmWlExKM7:TR?= MY[3NkBp M3nJfWROW09? M1jHe2lEPTB;Mk[zJI5O MYGyN|g1PDB|OB?=
BC-3 NH3S[nlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnhdY0yOCEQvF2= NFXS[mI4OiCq M{CzRmROW09? NFqweIVKSzVyPUK3O{BvVQ>? NVm3eWlSOjN6NESwN|g>
ACHN NGK5WJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnyNVAh|ryP Mmq0O|IhcA>? MX7EUXNQ NUDDW4FOUUN3ME2yPVQhdk1? NUjHRWprOjN6NESwN|g>
JRT3-T35 Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHMN3RqOTBizszN NWLH[XJvPzJiaB?= M2DWcGROW09? MkPDTWM2OD1{OUWgcm0> MV:yN|g1PDB|OB?=
SK-MES-1 NGXJeY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HHdFExKM7:TR?= MoPqO|IhcA>? M1nv[2ROW09? NIX6NnVKSzVyPUOyPUBvVQ>? NHfXSJQzOzh2NECzPC=>
CESS MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\VXVExKM7:TR?= M4fyOFczKGh? MX\EUXNQ MV\JR|UxRTR7NzDuUS=> NHPtU2szOzh2NECzPC=>
H4 NWmzXHNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWixNEDPxE1? M3XTe|czKGh? MoDBSG1UVw>? M2TXT2lEPTB;NkG5JI5O NFzxXGEzOzh2NECzPC=>
BC-1 MnixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PKSlExKM7:TR?= NGTTSWI4OiCq NHjsVXhFVVOR NIL4d4hKSzVyPUewOEBvVQ>? MmruNlM5PDRyM{i=
DB NFXLTJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoG5NVAh|ryP MnjvO|IhcA>? M3j5bGROW09? MV;JR|UxRTh5MzDuUS=> MUSyN|g1PDB|OB?=
RPMI-6666 M4HkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknRNVAh|ryP MVe3NkBp MUjEUXNQ MmLrTWM2OD17Mkigcm0> MkTaNlM5PDRyM{i=
MC/CAR MmT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DnXFExKM7:TR?= MmT0O|IhcA>? M{fJdGROW09? M375NGlEPTB;MT6wNFIh|ryP MmHGNlM5PDRyM{i=
SNU-1 NVO3c4dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzaUlIyOCEQvF2= NEn0Oo04OiCq NVn3PFk{TE2VTx?= M4KxcGlEPTB;MT61NFEh|ryP NYjvSIp7OjN6NESwN|g>
CEM/C1 NYTBT4dkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3S4[lExKM7:TR?= M33SVFczKGh? M1HvV2ROW09? NEnsfphKSzVyPUGuO|c{KM7:TR?= MViyN|g1PDB|OB?=
GDM-1 NUfyZW1QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3S2e|ExKM7:TR?= MUS3NkBp MkfRSG1UVw>? MXTJR|UxRTFwOUm3JO69VQ>? MYWyN|g1PDB|OB?=
HT-1080 NUj6dZJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjINVAh|ryP MUO3NkBp MWPEUXNQ MY\JR|UxRTJwMEC0JO69VQ>? NWrhPGdjOjN6NESwN|g>
HL-60 NH\2W45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFn4N5IyOCEQvF2= NWmySoNpPzJiaB?= NUmzS5N2TE2VTx?= NX;ndFFkUUN3ME2yMlE4QCEQvF2= Ml7hNlM5PDRyM{i=
C3A MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2S0d|ExKM7:TR?= M4O0VlczKGh? MoX4SG1UVw>? NWf1[2RQUUN3ME21MlQyPCEQvF2= NHHkU3YzOzh2NECzPC=>
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SaOS2 NIXq[4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\ONVAh|ryP M1:zWFczKGh? MUPEUXNQ M2DDdmlEPTB;MUCg{txO NEPtSYEzOzh2NECzPC=>
SCC-9 NUTzeIlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTsTWVIOTBizszN MmP0O|IhcA>? M3j0RmROW09? M1rIZ2lEPTB;MUCg{txO MYmyN|g1PDB|OB?=
SCC-12 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfFW|kyOCEQvF2= M1HQ[VczKGh? NUHuNohZTE2VTx?= Mme2TWM2OD1zMDFOwG0> M3G3[|I{QDR2MEO4
SCC-13 NFTtWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnGNVAh|ryP NWXDUZRGPzJiaB?= M2rSVGROW09? NV\3U3hFUUN3ME2xNEDPxE1? MXOyN|g1PDB|OB?=
SCC-15 M1XTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPxNVAh|ryP MkLqO|IhcA>? NIrETmVFVVOR NUDH[HBzUUN3ME2xNEDPxE1? MW[yN|g1PDB|OB?=
SCC-25 NEjiTVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUexNEDPxE1? MVS3NkBp NYrlbppRTE2VTx?= MlPmTWM2OD1zMDFOwG0> MoXtNlM5PDRyM{i=
SCLC-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13nW|ExKM7:TR?= M{X3WlczKGh? M2TDS2ROW09? MoLrTWM2OD1zMDFOwG0> MYKyN|g1PDB|OB?=
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SK-N-F1 NHHn[JVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDx[GFwOTBizszN Mn24O|IhcA>? MoC1SG1UVw>? NIXz[WdKSzVyPUGwJO69VQ>? M3fsW|I{QDR2MEO4
SKOV-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;V[IQyOCEQvF2= NX71PIJHPzJiaB?= NHTiW5JFVVOR M2Htb2lEPTB;MUCg{txO NIXrS4MzOzh2NECzPC=>
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SW1088 MlHPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nEflExKM7:TR?= MoTJO|IhcA>? MWrEUXNQ NEL5OFJKSzVyPUGwJO69VQ>? NEHMSnczOzh2NECzPC=>
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SW1990 NGfLR|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrTT2MyOCEQvF2= MVW3NkBp M1nSSmROW09? NEXpXGRKSzVyPUGwJO69VQ>? MU[yN|g1PDB|OB?=
T47D NILhU4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH4NVAh|ryP M4L1WlczKGh? M3j6SGROW09? M1jKbmlEPTB;MUCg{txO MUSyN|g1PDB|OB?=
TE381.T NUfMR5k2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jlRlExKM7:TR?= M4TvclczKGh? NEn4VG1FVVOR M2DRO2lEPTB;MUCg{txO MoDpNlM5PDRyM{i=
TK-10 NUPsbFRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILIOoYyOCEQvF2= M3K1OFczKGh? NWnJTmU1TE2VTx?= NUDpTmtpUUN3ME2xNEDPxE1? NIG4O3ozOzh2NECzPC=>
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U251 M4jJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PpdVExKM7:TR?= NWL3UmozPzJiaB?= NHHPd4lFVVOR NGX4WGpKSzVyPUGwJO69VQ>? NV;2NZRUOjN6NESwN|g>
UACC-812 NXfhTmNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX:xNEDPxE1? MlKwO|IhcA>? NV7mO3NMTE2VTx?= M4DEcmlEPTB;MUCg{txO NWHuPGJzOjN6NESwN|g>
YAPC MmnWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\LNVAh|ryP M2mxUVczKGh? M37qSmROW09? M4L2WGlEPTB;MUCg{txO M4njR|I{QDR2MEO4
ZR-75-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4r6TVExKM7:TR?= NF3hNHQ4OiCq MWrEUXNQ NVfwdZZGUUN3ME2xNEDPxE1? NYLLNYxbOjN6NESwN|g>
A375 M3[4NmZ2dmO2aX;uJIF{e2G7 NYD6SlF4OS5{IN88US=> Ml\KOEBp M3XrZWROW09? M2D3bmlvcGmkaYTpc44hd2ZicHjvd5Bpd3K7bHH0bY9vKG:oIF3FT{whTVKNLDDhcoQhWz[S M4LYflIzOzh7NEex
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WiDr MnrES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mlz2SG1UVw>? MnXITWM2OCB;IEe2JI5O NVPqeXY{OjZyMUi1NlQ>
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M257 M33DVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDNNVAxKG6P M{fme|czKGh? MWDEc4V{KG6xdDDpcohq[mm2IIDyc4xq\mW{YYTpc44hd2ZiTUK1O{Bk\WyuIHjhdoJwfXKrbnege4lt\CC2eYDlJGJTSUZ? NHHze2ozOzNzN{S0Oi=>
LCP NHXIOY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3jXIYzOTByIH7N NHW0TlI4OiCq M{PIPWlvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCOQ2CgZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMGKgcZV1[W62YYTpc44> NI\KR|gzOzNzN{S0Oi=>
WM266 M{\EbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;tNFExOCCwTR?= MWe3NkBp MWrJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhX01{Nk[gZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMVSgcZV1[W62YYTpc44> MorwNlM{OTd2NE[=
M257 M1fkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjSe3MyODBibl2= M{PJbFczKGh? M{W0dWRw\XNibn;0JIlvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDNNlU4KGOnbHygbIFz[m:3cnnu[{B4cWymIIT5dIUhSlKDRh?= MYKyN|MyPzR2Nh?=
LCP NIXi[ItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmzfVRLOTByIH7N Moj2O|IhcA>? NVzlfIxWUW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJGxEWCClZXzsJIhiemKxdYLpcochSlKDRjDWOlAxWiCvdYThcpRifGmxbh?= MmmwNlM{OTd2NE[=
WM266 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDsSYQyODBibl2= Mn;NO|IhcA>? MXPJcohq[mm2IFXST|EuOiCyaH;zdIhwenmuYYTpc44hcW5iV12yOlYh[2WubDDoZZJjd3W{aX7nJGJTSUZiVk[wNGQhdXW2YX70ZZRqd25? MYCyN|MyPzR2Nh?=

... Click to View More Cell Line Experimental Data

In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
8 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01723202 Active, not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7, 2012 Phase 2
NCT02672358 Not yet recruiting Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis October 2017 Phase 2
NCT02447939 Withdrawn Melanoma GlaxoSmithKline May 2017 Phase 1
NCT02967692 Not yet recruiting Melanoma Novartis Pharmaceuticals|Novartis February 2017 Phase 3
NCT02858921 Not yet recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis February 2017 Phase 2
NCT03026517 Recruiting Melanoma Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Weill Medical College of Cornell University January 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Raf Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID