Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.

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In DMSO USD 180 In stock
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USD 130 In stock
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5 Customer Reviews

  • A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

    Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

  • Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

Purity & Quality Control

Choose Selective Raf Inhibitors

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
C-Raf [1]
(Cell-free assay)
0.8 nM 3.2 nM 5.0 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NEPNdFZMcW6jc3WgRZN{[Xl? NInGeWdKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygTIl{KHSjZ3fl[EBDNVKjZjDWOlAxTSCvdYThcpQh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJIlve2WldDDj[YxteyClbz3lfJBz\XO|aX7nJGNFSzN5IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGKrb4Tpcplt[XSnZD3NSWsheHKxdHXpckBxcG:|cHjvdplt[XSrb36gZpkhSWyyaHHTZ5Jm\W5iYYPzZZkhf2m2aDDJR|UxKG:oIECuNFAxPyEQvF2= MmHJNlQ6ODB4N{O=
SK-MEL-28 NHXhXINMcW6jc3WgRZN{[Xl? MVmxJIg> M{nQO2lvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62IHnuJIh2dWGwIGPLMW1GVC1{ODDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBGWkticHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxPCEQvF2= MUeyOFkxODZ5Mx?=
HepG2 NETmVIFMcW6jc3WgRZN{[Xl? NVL4NFg2UW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSgbY4hcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP NWrsfHhNOjR7MEC2O|M>
COLO205 NFvkOGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nicmlvcGmkaYTpc44hd2ZiaIXtZY4hS0:OT{KwOUBk\WyuIIDyc4xq\mW{YYTpc44hf2m2aDDJR|UxKG:oIECuNFA4KM7:TR?= NE\GVFMzPDlyME[3Ny=>
HepG2 NXPsOYV[TnWwY4Tpc44hSXO|YYm= M4HwXVQ2KG2rbh?= NUTBUHB3TE2VTx?= Mki5TY5pcWKrdHnvckBw\iCDbHu1JIlvKFSJRj3i[ZRiNXO2aX31cIF1\WRiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hW22jZEKgdIhwe3Cqb4L5cIF1cW:wIITy[YF1\WRiZn;yJFQ2KG2rboOgdJJqd3JidH:gWGdHNWKndHGgd5RqdXWuYYTpc44hdWWjc4Xy[YQh[W[2ZYKgOlAhdWmwczDifUBw\Hm|c3X5JIJtd3Ric3Phco5meiCjbnHsfZNqeyC5aYToJGlEPTBib3[gN{44KM7:TR?= NYPVSYtDOjR7MEC2O|M>
HFF NYDJUoQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYexNEDPxE1? NHPZZYU4OiCq MoTSSG1UVw>? NXGye3lsUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIHj1cYFvKEiIRjDj[YxteyCqYYLic5Jqdmdid3ns[EB1gXCnIFKtVoFnKHerdHigTWM2OCCxZjCzJO69VQ>? M4\OXFI{QDR2MEO4
SK-MEL-28 NFnPO5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\0eWgyOCEQvF2= NYfIT4xNPzJiaB?= M2njOmROW09? NWG1S45sUW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSt[JJqfmWwIGPLMW1GVC1{ODDj[YxtKHC{b3zp[oVz[XSrb36ge4l1cCCLQ{WwJI9nKDBwMESzJO69VQ>? NIrZbW4zOzh2NECzPC=>
A375P-F11 NWS2UmFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3r1W|ExKM7:TR?= MU[3NkBp NITLV21FVVOR MYnJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfC2mcnn2[Y4hSTN5NWCtSlEyKGOnbHygdJJwdGmoZYLheIlwdiC5aYToJGlEPTBib3[gNE4xPzFizszN NIjKO4MzOzh2NECzPC=>
MALME-3M NG[4eY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:0cncyOCEQvF2= NYXLRZEzPzJiaB?= MoO5SG1UVw>? M2WxZ2lEPTB;MTDuUS=> NFLnc|UzOzh2NECzPC=>
UACC-62 NX3tOFFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnThNVAh|ryP MkTpO|IhcA>? MYjEUXNQ NFjHe5hKSzVyPUGgcm0> NUm1UpBCOjN6NESwN|g>
C32TG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEL5XmkyOCEQvF2= NUTGN4twPzJiaB?= M{\wT2ROW09? NHz1cFBKSzVyPUGgcm0> MoXtNlM5PDRyM{i=
SK-MEL-1 M4LJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfrTJRjOTBizszN MoXYO|IhcA>? MWrEUXNQ NXfzbZpTUUN3ME2yJI5O NYLReZpSOjN6NESwN|g>
M14 MmPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXOxNEDPxE1? NVfPbXhqPzJiaB?= NV:0WFVZTE2VTx?= NF7DU5dKSzVyPUKgcm0> MVuyN|g1PDB|OB?=
SK-MEL-28 NIPFd4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XzblExKM7:TR?= M4n3SVczKGh? M3n2O2ROW09? MUnJR|UxRTNibl2= NEPIWm8zOzh2NECzPC=>
A375 NHm4flVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rtSFExKM7:TR?= M{\pd|czKGh? M3O4SmROW09? NEG4dXdKSzVyPUSgcm0> NIHSWlYzOzh2NECzPC=>
DU-4475 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoO2NVAh|ryP M3\yZlczKGh? Mn7uSG1UVw>? NWPXWmxGUUN3ME21JI5O MoKyNlM5PDRyM{i=
UACC-257 M3f1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX6xNEDPxE1? M{XHc|czKGh? MW\EUXNQ M{TScmlEPTB;NjDuUS=> M{TQTlI{QDR2MEO4
Colo 205 NWXvRVE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVuxNEDPxE1? M3W0e|czKGh? NIDOOINFVVOR MWnJR|UxRTdibl2= MlHCNlM5PDRyM{i=
SK-MEL-3 NXjBRnFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHmwTIwyOCEQvF2= NFfHdmY4OiCq MojvSG1UVw>? NVXFW3BmUUN3ME23JI5O Mk\BNlM5PDRyM{i=
SH-4 NITWXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUmycGZbOTBizszN MUS3NkBp MXzEUXNQ NXHVUIlGUUN3ME24JI5O MXOyN|g1PDB|OB?=
A101D MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX[xNEDPxE1? NXTXWIVEPzJiaB?= NWjCWHRUTE2VTx?= NUfX[IxqUUN3ME25JI5O NY[1R2R6OjN6NESwN|g>
ES-2 MofTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXmxNEDPxE1? MWG3NkBp MUfEUXNQ MmW0TWM2OD13MzDuUS=> NHTFeGIzOzh2NECzPC=>
HT-29 NVzvdXRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSxNEDPxE1? NH\4Ook4OiCq M1e1dWROW09? MYfJR|UxRTZ4IH7N M1XLRlI{QDR2MEO4
SW1417 M4rIemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HyfVExKM7:TR?= M1vjRlczKGh? MVXEUXNQ MUPJR|UxRTF3ODDuUS=> M2HMdFI{QDR2MEO4
SW872 NVPhSlV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSxNEDPxE1? NFX6cmI4OiCq NVPDZ4ExTE2VTx?= NXHZUoFVUUN3ME2zO|chdk1? NFnXSokzOzh2NECzPC=>
RKO NWHjXWN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWqwfGxMOTBizszN M4P0PVczKGh? NHn5TY9FVVOR NHXGO3JKSzVyPUKuOVIzKM7:TR?= M4D0S|I{QDR2MEO4
A673 NVvLcGQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXuxNEDPxE1? M3L1T|czKGh? NGjFXmFFVVOR Ml31TWM2OD1zMDFOwG0> M2q0[FI{QDR2MEO4
GCT M2m4UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknYNVAh|ryP M4HLdFczKGh? M2WwNGROW09? MlvUTWM2OD1zMDFOwG0> M1\Qb|I{QDR2MEO4
WM-115 MoH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3frblExKM7:TR?= MWi3NkBp NHzqbZdFVVOR MkH2TWM2OD13IH7N MmDINlM5PDRyM{i=
YUMAC NYDu[HE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXV[ngyOCEQvF2= M376TlczKGh? NHvCS5FFVVOR Mm\KTWM2OD13IH7N NI\yPJUzOzh2NECzPC=>
OV-90 NXLZfoRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrYNVAh|ryP MXu3NkBp M3;vXmROW09? Ml\XTWM2OD1{OTDuUS=> NWGxU4VkOjN6NESwN|g>
NCI-H508 NXH1UG1RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nIV|ExKM7:TR?= M4\TU|czKGh? NWK2ZYs2TE2VTx?= NFf0bVZKSzVyPUGwJO69VQ>? M1z3SlI{QDR2MEO4
MDA-MB-231 NF7UO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIS3NpoyOCEQvF2= MXG3NkBp NX;5[ll[TE2VTx?= MXfJR|UxRTFyIN88US=> NVXmT2ViOjN6NESwN|g>
SW756 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fkW|ExKM7:TR?= NXfrcVdLPzJiaB?= NF\6UJhFVVOR Moj5TWM2OD1zMDFOwG0> NVriRllqOjN6NESwN|g>
SW-837 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUixNEDPxE1? NWfKdnpDPzJiaB?= Mn3GSG1UVw>? MknmTWM2OD1zMDFOwG0> MV[yN|g1PDB|OB?=
UMUC-3 NVz2OVVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV31OWlKOTBizszN MlrmO|IhcA>? NUPXPYV3TE2VTx?= M13GbGlEPTB;MUCg{txO MoHoNlM5PDRyM{i=
LS-174T MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXqxNEDPxE1? M1fBO|czKGh? NUDHSJB[TE2VTx?= NE\6NmlKSzVyPUGwJO69VQ>? NIH4TogzOzh2NECzPC=>
A549 MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYexNEDPxE1? NYDHe5VEPzJiaB?= M3excWROW09? NXnsT|JOUUN3ME2xNEDPxE1? NVzDOIJ6OjN6NESwN|g>
SHP-77 M{DWVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELlO44yOCEQvF2= NYrrZWdDPzJiaB?= NITQWVVFVVOR MU\JR|UxRTFyIN88US=> MljVNlM5PDRyM{i=
SW480 MoOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYD3NWhiOTBizszN MljpO|IhcA>? NXjVRpoxTE2VTx?= NVP0UWlrUUN3ME2xNEDPxE1? NHLvNmkzOzh2NECzPC=>
DLD-1 MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU[xNEDPxE1? MlXXO|IhcA>? NGnrVppFVVOR MXfJR|UxRTFyIN88US=> NX;WdWh7OjN6NESwN|g>
HCT-116 NHLWN5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy3TJY6OTBizszN M{P2NVczKGh? M3Lqc2ROW09? NIDJVWFKSzVyPUGwJO69VQ>? Ml6xNlM5PDRyM{i=
NCI-H747 MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG4S5AyOCEQvF2= NXf3e3IzPzJiaB?= NIj1T5pFVVOR M1PRe2lEPTB;MUCg{txO MVGyN|g1PDB|OB?=
T-84 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkS1NVAh|ryP MUC3NkBp MlfsSG1UVw>? MUHJR|UxRTFyIN88US=> NYWyZnp[OjN6NESwN|g>
NCI-H460 NF2yVmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV:xNEDPxE1? NInr[XQ4OiCq MmSxSG1UVw>? M2rPbGlEPTB;MUCg{txO NGnTWpkzOzh2NECzPC=>
Calu-6 NGLHRZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\YeFcyOCEQvF2= MXS3NkBp NXLiT4pPTE2VTx?= M4TvUWlEPTB;MUCg{txO NITJcZEzOzh2NECzPC=>
HCC-2998 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHHOFJNOTBizszN M1S2dlczKGh? NVTjfpB{TE2VTx?= M2\WPGlEPTB;MUCg{txO MkniNlM5PDRyM{i=
LS1034 NGfVZYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PkN|ExKM7:TR?= MYW3NkBp M{j2eGROW09? NInSWVRKSzVyPUGwJO69VQ>? MUKyN|g1PDB|OB?=
CHP-212 NXPoeJY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3vNVAh|ryP NFPCVnY4OiCq M{PPUWROW09? MWPJR|UxRTFyIN88US=> MXSyN|g1PDB|OB?=
SK-N-AS NYDXcJNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;rO|AyOCEQvF2= NGTJTZE4OiCq MVnEUXNQ NUe0O2JNUUN3ME2xNEDPxE1? MnG5NlM5PDRyM{i=
BFTC-905 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjPPIFiOTBizszN M1rFeFczKGh? NELYbFBFVVOR MWrJR|UxRTFyIN88US=> MlnuNlM5PDRyM{i=
HuT78 NXPHbIJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XBSlExKM7:TR?= NV3X[4VCPzJiaB?= MoL6SG1UVw>? MoHwTWM2OD13MjDuUS=> NXvMRYFwOjN6NESwN|g>
RPMI-8226 M3eyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHSSYoyOCEQvF2= NX;OVm06PzJiaB?= NHzndFJFVVOR NWH2WFJlUUN3ME2yOlMhdk1? MWOyN|g1PDB|OB?=
BC-3 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e4U|ExKM7:TR?= MnH5O|IhcA>? M3vxTWROW09? NIT0OldKSzVyPUK3O{BvVQ>? NV62d|JQOjN6NESwN|g>
ACHN MoKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkKzNVAh|ryP MVi3NkBp NIX5XWZFVVOR NYrydXMxUUN3ME2yPVQhdk1? NGPjWXQzOzh2NECzPC=>
JRT3-T35 MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXmxNEDPxE1? NYHwZpo{PzJiaB?= M1XmcGROW09? MVPJR|UxRTJ7NTDuUS=> M4fFTFI{QDR2MEO4
SK-MES-1 M2mwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknqNVAh|ryP M3HQU|czKGh? MXfEUXNQ M2jCcGlEPTB;M{K5JI5O MnPhNlM5PDRyM{i=
CESS M{\QWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjKTIF3OTBizszN NUHyT201PzJiaB?= M{H0S2ROW09? MXPJR|UxRTR7NzDuUS=> M2LTWVI{QDR2MEO4
H4 MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzp[nU1OTBizszN MmnBO|IhcA>? M{S3PWROW09? M{X5XGlEPTB;NkG5JI5O NIS0SJQzOzh2NECzPC=>
BC-1 MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\aNVAh|ryP MVW3NkBp MmezSG1UVw>? NXX2c3JtUUN3ME23NFQhdk1? MUKyN|g1PDB|OB?=
DB M{jGbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYCxNEDPxE1? M4fiSFczKGh? M4LMUWROW09? NGrxTlNKSzVyPUi3N{BvVQ>? NIrSXG0zOzh2NECzPC=>
RPMI-6666 M2LJWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LwPVExKM7:TR?= M2DzUlczKGh? NUC4WVB[TE2VTx?= MV;JR|UxRTl{ODDuUS=> NG[2ZokzOzh2NECzPC=>
MC/CAR MlnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDJNVAh|ryP NYnPTnRZPzJiaB?= MVLEUXNQ NF23eXVKSzVyPUGuNFAzKM7:TR?= M2jDeFI{QDR2MEO4
SNU-1 M2PNeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HQbVExKM7:TR?= MXK3NkBp NVXyS4VwTE2VTx?= M2nyU2lEPTB;MT61NFEh|ryP MnXvNlM5PDRyM{i=
CEM/C1 M1vLUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYi4SIZkOTBizszN MWS3NkBp NESxU2pFVVOR M3nnemlEPTB;MT63O|Mh|ryP NVHmUmRuOjN6NESwN|g>
GDM-1 M1fXZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nKeVExKM7:TR?= MnvPO|IhcA>? MXnEUXNQ NEGxZ2NKSzVyPUGuPVk4KM7:TR?= NHi3PXYzOzh2NECzPC=>
HT-1080 M2PubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYOxNEDPxE1? MXm3NkBp MlzSSG1UVw>? MVPJR|UxRTJwMEC0JO69VQ>? M2TSUFI{QDR2MEO4
HL-60 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;Ib3cyOCEQvF2= NYPIVY9oPzJiaB?= NWnQR3JsTE2VTx?= NXPOUVdGUUN3ME2yMlE4QCEQvF2= M4\FWlI{QDR2MEO4
C3A M{DPXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;VZ5VROTBizszN NFrs[Ik4OiCq NYOxbI9[TE2VTx?= M3PocGlEPTB;NT60NVQh|ryP NXf3WVl1OjN6NESwN|g>
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A2780 Ml3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoGzNVAh|ryP MnjvO|IhcA>? MV;EUXNQ NXrPXmhxUUN3ME2xNEDPxE1? MV6yN|g1PDB|OB?=
ARH-77 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DYbVExKM7:TR?= Ml21O|IhcA>? MV3EUXNQ MV3JR|UxRTFyIN88US=> NH3DeWEzOzh2NECzPC=>
Be(2)C MkjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnuc4RKOTBizszN M1[xb|czKGh? NVL3S3UyTE2VTx?= MlnVTWM2OD1zMDFOwG0> MVmyN|g1PDB|OB?=
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Colo704 MlKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn2fpQ1OTBizszN NV;yfItKPzJiaB?= MmDpSG1UVw>? MlvhTWM2OD1zMDFOwG0> MUOyN|g1PDB|OB?=
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DOTC 24510 NEfn[JlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{C3UlExKM7:TR?= NFTudmE4OiCq NH7aSW1FVVOR NX;mU4xbUUN3ME2xNEDPxE1? MV[yN|g1PDB|OB?=
DU-145 M{TqTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHWWlQyOCEQvF2= M4TFfVczKGh? MUnEUXNQ MoTRTWM2OD1zMDFOwG0> MUSyN|g1PDB|OB?=
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Hep3B MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIe4TlkyOCEQvF2= NWjBSGhsPzJiaB?= M1fzVGROW09? MmHYTWM2OD1zMDFOwG0> MkTtNlM5PDRyM{i=
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Kato III NHjUSmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH71ZZIyOCEQvF2= NVfvZ2pqPzJiaB?= Mo\xSG1UVw>? NEflPWNKSzVyPUGwJO69VQ>? M2\Le|I{QDR2MEO4
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NCI-H69 NYH4XZJlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWSxNEDPxE1? M3nWUFczKGh? NYW5b|VzTE2VTx?= M13WNmlEPTB;MUCg{txO MmjDNlM5PDRyM{i=
NCI-H82 NXTiWnN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWCxNEDPxE1? M4fyeFczKGh? MUjEUXNQ NYXSR|hKUUN3ME2xNEDPxE1? MoT5NlM5PDRyM{i=
NCI-N87 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnuV2JNOTBizszN M2T6eFczKGh? NXjqZnczTE2VTx?= Mln5TWM2OD1zMDFOwG0> NH2zRXczOzh2NECzPC=>
NCI-H146 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHac24yOCEQvF2= MoTvO|IhcA>? NHzLbYhFVVOR NX3CbnRJUUN3ME2xNEDPxE1? MViyN|g1PDB|OB?=
NCI-H157 Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYCxNEDPxE1? MXW3NkBp MYrEUXNQ M{HMXmlEPTB;MUCg{txO NVXxVGl5OjN6NESwN|g>
NCI-H187 Mkf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2H2UFExKM7:TR?= NFL1cFg4OiCq NXvQdGxxTE2VTx?= MWfJR|UxRTFyIN88US=> M2S1RVI{QDR2MEO4
NCI-H209 NFjWW|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWKxNEDPxE1? NFvkcZc4OiCq MnTGSG1UVw>? NIrJeVFKSzVyPUGwJO69VQ>? NFjIVWozOzh2NECzPC=>
NCI-H226 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4eyZVExKM7:TR?= NIG3PHQ4OiCq MmPKSG1UVw>? M3PXeGlEPTB;MUCg{txO NU\QXlB3OjN6NESwN|g>
NCI-H292 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVixNEDPxE1? NVXofWVLPzJiaB?= M4G1SWROW09? NEHSTGtKSzVyPUGwJO69VQ>? M{\IdlI{QDR2MEO4
NCI-H322 MlW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYSxNEDPxE1? MlyzO|IhcA>? NXfSXIhzTE2VTx?= MYrJR|UxRTFyIN88US=> MViyN|g1PDB|OB?=
NCI-H358 NHzwbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfuNVAh|ryP MVK3NkBp M4HadmROW09? MYPJR|UxRTFyIN88US=> MoLSNlM5PDRyM{i=
NCI-H520 NIjuOoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonNNVAh|ryP MWm3NkBp M2jyWmROW09? M2\NWmlEPTB;MUCg{txO NFP1cG4zOzh2NECzPC=>
NCI-H526 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TuTVExKM7:TR?= MV63NkBp MkXsSG1UVw>? MUXJR|UxRTFyIN88US=> NFPsSY4zOzh2NECzPC=>
NCI-H630 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnm5NVAh|ryP M{TzblczKGh? M2CwbmROW09? M1Ln[GlEPTB;MUCg{txO NGTNc5IzOzh2NECzPC=>
NCI-H661 M3mwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HqXlExKM7:TR?= MUO3NkBp MlnXSG1UVw>? M{nyfWlEPTB;MUCg{txO M{\tfVI{QDR2MEO4
NCI-H716 NXnIU5VjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HzS|ExKM7:TR?= NWPmUVB{PzJiaB?= NHz2dHNFVVOR NUfCemdkUUN3ME2xNEDPxE1? MmrHNlM5PDRyM{i=
NCI-H1563 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGyRVdyOTBizszN M3jLU|czKGh? NWjzcVI{TE2VTx?= NVfJT48{UUN3ME2xNEDPxE1? M3u2OVI{QDR2MEO4
NCI-H1792 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2i5PVExKM7:TR?= NV6xPVlQPzJiaB?= NV7SO4Q{TE2VTx?= NIDB[GFKSzVyPUGwJO69VQ>? MXyyN|g1PDB|OB?=
NCI-H2030 Mo\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M375blExKM7:TR?= MXO3NkBp M2HU[2ROW09? NF2zSG1KSzVyPUGwJO69VQ>? MXyyN|g1PDB|OB?=
NCI-H2052 MlzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXTZ4oyOCEQvF2= NYHuXGVzPzJiaB?= MnzWSG1UVw>? M3;ySGlEPTB;MUCg{txO NXPNUohwOjN6NESwN|g>
NCI-H2122 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TNZlExKM7:TR?= MUO3NkBp NGHCSWVFVVOR M3G0NGlEPTB;MUCg{txO MkDrNlM5PDRyM{i=
NCI-H2228 M4D2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq0bXAyOCEQvF2= M1HORlczKGh? MY\EUXNQ MXnJR|UxRTFyIN88US=> NIfxOHYzOzh2NECzPC=>
OE-19 MofWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfDdo0yOCEQvF2= NXO1ToxnPzJiaB?= MXjEUXNQ M1\i[2lEPTB;MUCg{txO NYPKXZd[OjN6NESwN|g>
OE-21 MonzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFywR4MyOCEQvF2= M1S3fVczKGh? NVrNbYJzTE2VTx?= M4HjdmlEPTB;MUCg{txO MVyyN|g1PDB|OB?=
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SK-LMS-1 M1f3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXv3Z2xIOTBizszN NV3xU5prPzJiaB?= M3L3V2ROW09? NITCeGxKSzVyPUGwJO69VQ>? NF62W4szOzh2NECzPC=>
SK-N-DZ M{fUZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYSxNEDPxE1? NUTHOXZkPzJiaB?= NYjORoJUTE2VTx?= MWrJR|UxRTFyIN88US=> NGXZeYUzOzh2NECzPC=>
SK-N-F1 NUXKS4NTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrze4syOCEQvF2= NVrSNVM4PzJiaB?= NWfreJF6TE2VTx?= M1nzdWlEPTB;MUCg{txO NEmzOpIzOzh2NECzPC=>
SKOV-3 Mm\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzoSGUyOCEQvF2= NVi2XnRiPzJiaB?= NXj1TXRVTE2VTx?= M3LwbWlEPTB;MUCg{txO MYSyN|g1PDB|OB?=
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SW684 M13mXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;sVm13OTBizszN NYfaWlA6PzJiaB?= M37RPGROW09? MnfkTWM2OD1zMDFOwG0> MWWyN|g1PDB|OB?=
SW-780 M3v2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LGXlExKM7:TR?= NEHBeGo4OiCq Ml3WSG1UVw>? NGSy[GZKSzVyPUGwJO69VQ>? NFfOdHEzOzh2NECzPC=>
SW900 MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETETGcyOCEQvF2= NFrUbY44OiCq MnLrSG1UVw>? Ml[1TWM2OD1zMDFOwG0> MV2yN|g1PDB|OB?=
SW1088 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3n3VVExKM7:TR?= Mn7qO|IhcA>? NYPse2lQTE2VTx?= MkP2TWM2OD1zMDFOwG0> MVOyN|g1PDB|OB?=
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SW1990 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LtblExKM7:TR?= NGLjbYI4OiCq MWDEUXNQ M3\KT2lEPTB;MUCg{txO MX[yN|g1PDB|OB?=
T47D MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXwXmEyOCEQvF2= MYS3NkBp M4rESmROW09? M3PHdGlEPTB;MUCg{txO M1[z[lI{QDR2MEO4
TE381.T M3PpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\LeokyOCEQvF2= M4PXT|czKGh? M4OwbGROW09? NXXTW|czUUN3ME2xNEDPxE1? NGmySpYzOzh2NECzPC=>
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U2OS MlXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPGNVAh|ryP NVnkW5l2PzJiaB?= MUTEUXNQ M3\wVmlEPTB;MUCg{txO MonsNlM5PDRyM{i=
U251 NHnnZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjDV4lNOTBizszN MnjZO|IhcA>? NWra[ldkTE2VTx?= NX7wOG1DUUN3ME2xNEDPxE1? NWPmSIJLOjN6NESwN|g>
UACC-812 NHHJOJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmi2NVAh|ryP NVXNXVBWPzJiaB?= NH:zSFhFVVOR MknLTWM2OD1zMDFOwG0> NX3N[FR[OjN6NESwN|g>
YAPC NFnjVYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzkNGwyOCEQvF2= MmPIO|IhcA>? MW\EUXNQ NHfLPIJKSzVyPUGwJO69VQ>? MmHFNlM5PDRyM{i=
ZR-75-1 MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M364S|ExKM7:TR?= MUi3NkBp MYfEUXNQ NXjye5BCUUN3ME2xNEDPxE1? M{jlT|I{QDR2MEO4
A375 MYjGeY5kfGmxbjDhd5NigQ>? NVm3SYhWOS5{IN88US=> M1TIT|QhcA>? MmW5SG1UVw>? MmDWTY5pcWKrdHnvckBw\iCyaH;zdIhwenmuYYTpc44hd2ZiTVXLMEBGWktuIHHu[EBUPlB? NIHS[GgzOjN6OUS3NS=>
YUSIT1 MnSySpVv[3Srb36gZZN{[Xl? Mn;hSG1UVw>? MYTy[YR2[2WmIIPlcpNqfGm4aYT5JJdqfGhiSVO1NEA,KDBwNTFOwG0> MnXyNlI{QDl2N{G=
MeWo NVXBWVNGT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYP3[mVjTE2VTx?= M{XqZ2lEPTBiPTC5PFchdk1? MljmNlYxOTh3MkS=
WiDr NGTXcJlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmPQSG1UVw>? NY\JTYRSUUN3MDC9JFc3KG6P M{nFN|I3ODF6NUK0
Colo-205 MV7GeY5kfGmxbjDhd5NigQ>? M1XDeFEh|ryP NFPvPFY1KGR? MkjmSG1UVw>? MojlTY5lfWOnZDDhJIhq\2iueTDjc41x[XKjYnzlJINwdXCjY4Tpc44heGinbn;0fZBm NYnNVHJwOjV|OEGxOVI>
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RBOW M3PoV2Z2dmO2aX;uJIF{e2G7 NFvTdW8yKM7:TR?= NFrr[mxFVVOR M1f3cmlvcGmkaYTpc44hd2ZiIF3lb{AyNzJicHjvd5Bpd3K7bHH0bY9v M4TKVlI1QDh3Nkmw
M257 MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fBWVExOCCwTR?= MUG3NkBp MnHTSI9meyCwb4SgbY5pcWKrdDDwdo9tcW[ncnH0bY9vKG:oIF2yOVch[2WubDDoZZJjd3W{aX7nJJdqdGRidInw[UBDWkGI M{XBZlI{OzF5NES2
LCP MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELvXlMyODBibl2= NH\uTm44OiCq MX3Jcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhVEOSIHPlcIwhcGG{Yn;1dolv\yCEUlHGJHY3ODCUIH31eIFvfGG2aX;u NVfiUpVvOjN|MUe0OFY>
WM266 M2nVUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLuN|AyODBibl2= M1Xae|czKGh? MWjJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhX01{Nk[gZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMVSgcZV1[W62YYTpc44> NXjxPGNXOjN|MUe0OFY>
M257 NIjZfoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonNNVAxKG6P MX:3NkBp NIrYVZNFd2W|IH7veEBqdmirYnn0JGVTUzFvMjDwbI9{eGixconsZZRqd25iaX6gUVI2PyClZXzsJIhiemKxdYLpcochf2muZDD0fZBmKEKUQV[= MYqyN|MyPzR2Nh?=
LCP MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2CwblExOCCwTR?= M1LiSlczKGh? NVP0NYJoUW6qaXLpeEBGWktzLUKgdIhwe3Cqb4L5cIF1cW:wIHnuJGxEWCClZXzsJIhiemKxdYLpcochSlKDRjDWOlAxWiCvdYThcpRifGmxbh?= MnOwNlM{OTd2NE[=
WM266 NH7BR2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:1NmRQOTByIH7N M3W2N|czKGh? M3TVT2lvcGmkaYSgSXJMOS1{IIDoc5NxcG:{eXzheIlwdiCrbjDXUVI3PiClZXzsJIhiemKxdYLpcochSlKDRjDWOlAxTCCvdYThcpRifGmxbh?= NULTRYtqOjN|MUe0OFY>

... Click to View More Cell Line Experimental Data

In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 8 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01723202 Active, not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7, 2012 Phase 2
NCT02672358 Not yet recruiting Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis October 2017 Phase 2
NCT02447939 Withdrawn Melanoma GlaxoSmithKline May 2017 Phase 1
NCT02967692 Not yet recruiting Melanoma Novartis Pharmaceuticals|Novartis February 2017 Phase 3
NCT02858921 Not yet recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis February 2017 Phase 2
NCT03026517 Recruiting Melanoma Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Weill Medical College of Cornell University January 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID