Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.

Size Price Stock Quantity  
In DMSO USD 180 In stock
USD 90 In stock
USD 130 In stock
USD 170 In stock
USD 270 In stock
USD 400 In stock

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5 Customer Reviews

  • A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

    Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

  • Western blot analysis of p-Erk and total ERK in A375 melanoma cell line after treatment with different doses of Dabrafenib for 48 hours (A). p-ERK signal was normalized with total ERK signal (B), SD and means of the normalized p-ERK values were reported.

    PLoS One, 2016, 11(3):e0152104. Dabrafenib (GSK2118436) purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
C-Raf [1]
(Cell-free assay)
0.8 nM 3.2 nM 5.0 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NV\ZXmNuU2mwYYPlJGF{e2G7 NIj0O2ZKdmirYnn0bY9vKG:oIF6teIVzdWmwYXygTIl{KHSjZ3fl[EBDNVKjZjDWOlAxTSCvdYThcpQh\XiycnXzd4VlKGmwIHLhZ5Vtd3[rcoXzJIlv\mWldHXkJIlve2WldDDj[YxteyClbz3lfJBz\XO|aX7nJGNFSzN5IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGKrb4Tpcplt[XSnZD3NSWsheHKxdHXpckBxcG:|cHjvdplt[XSrb36gZpkhSWyyaHHTZ5Jm\W5iYYPzZZkhf2m2aDDJR|UxKG:oIECuNFAxPyEQvF2= MXmyOFkxODZ5Mx?=
SK-MEL-28 Mnm4T4lv[XOnIFHzd4F6 MXKxJIg> NEXBWnlKdmirYnn0bY9vKG:oIFKtVoFnKFZ4MEDFJI12fGGwdDDpckBpfW2jbjDTT{1OTUxvMkigZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hTVKNIIDoc5NxcG:{eXzheIlwdiC5aYToJGlEPTBib3[gNE4xODRizszN NXjWdlJVOjR7MEC2O|M>
HepG2 M1O3eWtqdmG|ZTDBd5NigQ>? MULJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiCHUlugdIhwe3Cqb4L5cIF1cW:wIIfpeIghUUN3MDDv[kAxNjByNDFOwG0> MnzBNlQ6ODB4N{O=
COLO205 MonyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJcohq[mm2aX;uJI9nKGi3bXHuJGNQVE9{MEWgZ4VtdCCycn;sbYZmemG2aX;uJJdqfGhiSVO1NEBw\iByLkCwO{DPxE1? NYfTWVQyOjR7MEC2O|M>
HepG2 MWTGeY5kfGmxbjDBd5NigQ>? MVS0OUBucW5? NVv6[HdOTE2VTx?= MYPJcohq[mm2aX;uJI9nKEGua{WgbY4hXEeILXLleIEue3SrbYXsZZRm\CCqdX3hckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDk[YNz\WG|ZTDpckBUdWGmMjDwbI9{eGixconsZZRqd25idILlZZRm\CCob4KgOFUhdWmwczDwdolweiC2bzDUS2Yu[mW2YTDzeIlufWyjdHnvckBu\WG|dYLl[EBi\nSncjC2NEBucW6|IHL5JI9lgXO|ZYmgZoxwfCC|Y3HucoVzKGGwYXz5d4l{KHerdHigTWM2OCCxZjCzMlch|ryP NWjzZ4NkOjR7MEC2O|M>
HFF NWnLUnB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3GTI1{OTBizszN MWe3NkBp Mk\xSG1UVw>? MWLJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhcHWvYX6gTGZHKGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhSi2UYX[ge4l1cCCLQ{WwJI9nKDNizszN M173[VI{QDR2MEO4
SK-MEL-28 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PyN|ExKM7:TR?= MlLlO|IhcA>? MV3EUXNQ Mo\tTY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKFONLV3FUE0zQCClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODR|IN88US=> NV;HdIx{OjN6NESwN|g>
A375P-F11 MlzDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{W1cFExKM7:TR?= M{jSc|czKGh? NUHFTZFtTE2VTx?= M1vlWGlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62LXTybZZmdiCDM{e1VE1HOTFiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjB5MTFOwG0> M37Ie|I{QDR2MEO4
MALME-3M MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUKxNEDPxE1? NXLNPHJXPzJiaB?= M2LPTmROW09? M3fMWWlEPTB;MTDuUS=> MYeyN|g1PDB|OB?=
UACC-62 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jOPVExKM7:TR?= NYfZZm1{PzJiaB?= MYDEUXNQ NXTm[JFvUUN3ME2xJI5O NFTyW4ozOzh2NECzPC=>
C32TG NX\MVWp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV:xNEDPxE1? MYm3NkBp Mn3PSG1UVw>? M{DtPWlEPTB;MTDuUS=> MnnsNlM5PDRyM{i=
SK-MEL-1 MnvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nlO|ExKM7:TR?= M37XSlczKGh? NILBcHBFVVOR NF2zdnZKSzVyPUKgcm0> NES1PZYzOzh2NECzPC=>
M14 NE[1WJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYL4eXlLOTBizszN MXi3NkBp M1jtemROW09? M2fEfWlEPTB;MjDuUS=> M1H6UFI{QDR2MEO4
SK-MEL-28 NEHP[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1m5TlExKM7:TR?= MXy3NkBp M3LJ[GROW09? M{Wze2lEPTB;MzDuUS=> NUPpSlNOOjN6NESwN|g>
A375 NUCxeXlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfoNVAh|ryP NUT4cmlkPzJiaB?= M4ToU2ROW09? NVyxVYp5UUN3ME20JI5O M3zPTFI{QDR2MEO4
DU-4475 NWH0PW53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmexNVAh|ryP NF\LNJA4OiCq NWTT[ZBvTE2VTx?= M{PDemlEPTB;NTDuUS=> Mn7QNlM5PDRyM{i=
UACC-257 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH6UYw4OTBizszN MonkO|IhcA>? MoPaSG1UVw>? M4W5emlEPTB;NjDuUS=> NXTEeHFlOjN6NESwN|g>
Colo 205 NIjCSmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPQZZMyOCEQvF2= NYDwUpB3PzJiaB?= MVTEUXNQ M3XYSmlEPTB;NzDuUS=> MXOyN|g1PDB|OB?=
SK-MEL-3 NInaPHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmO0NVAh|ryP MV23NkBp MXjEUXNQ M4[xXGlEPTB;NzDuUS=> M1HBeVI{QDR2MEO4
SH-4 NUDUO2NHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfkdmQyOCEQvF2= NIG5VVE4OiCq NXXTb|U{TE2VTx?= MlrLTWM2OD16IH7N M{jsVFI{QDR2MEO4
A101D Mn71S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPnNVAh|ryP NEj5W3M4OiCq NF\nVHlFVVOR Ml;NTWM2OD17IH7N MUCyN|g1PDB|OB?=
ES-2 NVXCPWJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLwdoZwOTBizszN NVWzdoJbPzJiaB?= NIHUPWJFVVOR MlfLTWM2OD13MzDuUS=> MWqyN|g1PDB|OB?=
HT-29 MlWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrvTI5{OTBizszN M4LCVVczKGh? M3\Je2ROW09? MlmyTWM2OD14NjDuUS=> M4XFS|I{QDR2MEO4
SW1417 NU\FbGVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWL5[HdKOTBizszN M2S5SVczKGh? Mn32SG1UVw>? NVnEOlB6UUN3ME2xOVghdk1? MVqyN|g1PDB|OB?=
SW872 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjadYYyOCEQvF2= M3Lid|czKGh? NWDEOlF{TE2VTx?= NXTaeW5FUUN3ME2zO|chdk1? NFLFepQzOzh2NECzPC=>
RKO M3TDR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jW[|ExKM7:TR?= MXq3NkBp NWXFSYNVTE2VTx?= M3q3UmlEPTB;Mj61NlIh|ryP NUfW[HRGOjN6NESwN|g>
A673 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG1NVAh|ryP MnfsO|IhcA>? MoT1SG1UVw>? Mm\FTWM2OD1zMDFOwG0> MmTaNlM5PDRyM{i=
GCT MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWixNEDPxE1? Mm\zO|IhcA>? NILQRWlFVVOR MkTLTWM2OD1zMDFOwG0> NWLRXlZyOjN6NESwN|g>
WM-115 M2XQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXDNVAh|ryP M3rEZ|czKGh? NH\xXXVFVVOR NF:2WZVKSzVyPUWgcm0> MWOyN|g1PDB|OB?=
YUMAC NELTTHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[yfFExKM7:TR?= M4[xXlczKGh? MkH0SG1UVw>? MVnJR|UxRTVibl2= NVHST3duOjN6NESwN|g>
OV-90 NEfxTm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjTNVAh|ryP MoTEO|IhcA>? M3LzXWROW09? M4m1R2lEPTB;Mkmgcm0> M{fhflI{QDR2MEO4
NCI-H508 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULN[3A6OTBizszN NYjsdlg1PzJiaB?= NGPLUpBFVVOR M3TJ[mlEPTB;MUCg{txO M1v4SVI{QDR2MEO4
MDA-MB-231 MoHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjoXGNzOTBizszN MVi3NkBp MoLYSG1UVw>? MY\JR|UxRTFyIN88US=> M2HiSlI{QDR2MEO4
SW756 Mlv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fzTFExKM7:TR?= NFPsWoU4OiCq NUHDSnR2TE2VTx?= NUPCW4o{UUN3ME2xNEDPxE1? NE\rUYQzOzh2NECzPC=>
SW-837 NHfuVW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\lRYUyOCEQvF2= NVjyS|VbPzJiaB?= NX2yOoVKTE2VTx?= NVrlbnlRUUN3ME2xNEDPxE1? MonZNlM5PDRyM{i=
UMUC-3 Mnz0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe5e5R4OTBizszN MYW3NkBp MWTEUXNQ MXXJR|UxRTFyIN88US=> Mn3oNlM5PDRyM{i=
LS-174T M2fE[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWKxNEDPxE1? NY\T[XFzPzJiaB?= M1TKXmROW09? NEDoVldKSzVyPUGwJO69VQ>? M{Tkb|I{QDR2MEO4
A549 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;3NHMyOCEQvF2= MljCO|IhcA>? MkL4SG1UVw>? MXTJR|UxRTFyIN88US=> Mk\JNlM5PDRyM{i=
SHP-77 Mk\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYCxNEDPxE1? NGPHV2c4OiCq NUXnb4ZMTE2VTx?= NHHjTWpKSzVyPUGwJO69VQ>? M4HET|I{QDR2MEO4
SW480 NEfhNVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj5VJB1OTBizszN MnPtO|IhcA>? M2W2e2ROW09? MVvJR|UxRTFyIN88US=> MV:yN|g1PDB|OB?=
DLD-1 NF;ZdoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXpS4hPOTBizszN MUS3NkBp M3;CUmROW09? NULvbGoxUUN3ME2xNEDPxE1? MnLzNlM5PDRyM{i=
HCT-116 Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TiW|ExKM7:TR?= MnPtO|IhcA>? M3vkb2ROW09? M{fEbGlEPTB;MUCg{txO NV;2VHVCOjN6NESwN|g>
NCI-H747 NWXINGFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXYNVAh|ryP NYjCeG5VPzJiaB?= NXHVXXRSTE2VTx?= NF;6e49KSzVyPUGwJO69VQ>? M{fNOFI{QDR2MEO4
T-84 M2fTcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPnToY3OTBizszN NYfQRWtKPzJiaB?= MVTEUXNQ Mli3TWM2OD1zMDFOwG0> M2O2V|I{QDR2MEO4
NCI-H460 NUntWJZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTvNVAh|ryP NYrsUnNVPzJiaB?= M2XkdGROW09? MU\JR|UxRTFyIN88US=> M4Px[|I{QDR2MEO4
Calu-6 NEXj[IxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfGNVAh|ryP Mn3yO|IhcA>? M1;4[2ROW09? NF34eVJKSzVyPUGwJO69VQ>? NIDvSGMzOzh2NECzPC=>
HCC-2998 MofvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrKTGIyOCEQvF2= NHzm[JI4OiCq NWq0b49uTE2VTx?= NFHKVnRKSzVyPUGwJO69VQ>? MXyyN|g1PDB|OB?=
LS1034 NWjKO|VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\FbIVQOTBizszN M2TSR|czKGh? MmrPSG1UVw>? NXzRfVNOUUN3ME2xNEDPxE1? MWqyN|g1PDB|OB?=
CHP-212 NWrsc3dDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHNU|kyOCEQvF2= MUW3NkBp MVzEUXNQ NHLnTGZKSzVyPUGwJO69VQ>? M2HJVFI{QDR2MEO4
SK-N-AS Mof4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i1OVExKM7:TR?= MU[3NkBp MoXiSG1UVw>? NHLvZoNKSzVyPUGwJO69VQ>? M1qye|I{QDR2MEO4
BFTC-905 NUPBS4VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWeyO2lTOTBizszN MofQO|IhcA>? M4jXNmROW09? Mo\tTWM2OD1zMDFOwG0> MonZNlM5PDRyM{i=
HuT78 NXe3OWRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUOxNEDPxE1? M1PRRVczKGh? M{XZSmROW09? NVrPS4J1UUN3ME21NkBvVQ>? NXK0TopoOjN6NESwN|g>
RPMI-8226 NEH6WHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHhN3B7OTBizszN MVy3NkBp NELNd5lFVVOR NGT0NFdKSzVyPUK2N{BvVQ>? MV:yN|g1PDB|OB?=
BC-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXtUVUzOTBizszN MVi3NkBp MnjWSG1UVw>? NY\1S5ozUUN3ME2yO|chdk1? MmLwNlM5PDRyM{i=
ACHN M{XDWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHlZlU4OTBizszN MnL4O|IhcA>? NYSzdlc{TE2VTx?= MV3JR|UxRTJ7NDDuUS=> MU[yN|g1PDB|OB?=
JRT3-T35 M1PsVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTZW4JmOTBizszN M3TlOFczKGh? M4PLOmROW09? MVjJR|UxRTJ7NTDuUS=> NW[0[IVmOjN6NESwN|g>
SK-MES-1 Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\rNVAh|ryP MVm3NkBp NXnnN5FCTE2VTx?= NX7LT5lRUUN3ME2zNlkhdk1? MXyyN|g1PDB|OB?=
CESS MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnryNVAh|ryP NXPWeIxMPzJiaB?= MWTEUXNQ NUjFTJRXUUN3ME20PVchdk1? MY[yN|g1PDB|OB?=
H4 NHr5VmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jKNlExKM7:TR?= NI[x[VA4OiCq MUnEUXNQ MXvJR|UxRTZzOTDuUS=> NXHGNoQ1OjN6NESwN|g>
BC-1 NX3oWZZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUWxNEDPxE1? NFX5WlI4OiCq NFnVXmFFVVOR NXruOIkxUUN3ME23NFQhdk1? MmPxNlM5PDRyM{i=
DB NEj0VWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXmxNEDPxE1? MnW1O|IhcA>? Mlq4SG1UVw>? MmHSTWM2OD16N{Ogcm0> NV\IPXZrOjN6NESwN|g>
RPMI-6666 NX3z[4lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojPNVAh|ryP NVnHflZVPzJiaB?= MWHEUXNQ NF;k[Y5KSzVyPUmyPEBvVQ>? NIrldmszOzh2NECzPC=>
MC/CAR NH3MbYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnLWJBsOTBizszN MVm3NkBp NXX5Z3pYTE2VTx?= NGiyWINKSzVyPUGuNFAzKM7:TR?= NWftXGFROjN6NESwN|g>
SNU-1 MnzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf1PVQyOCEQvF2= NHz4dnQ4OiCq M4CyR2ROW09? MnrvTWM2OD1zLkWwNUDPxE1? NFjVNVAzOzh2NECzPC=>
CEM/C1 M4XYZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonONVAh|ryP MoW1O|IhcA>? M1\idWROW09? Mm[1TWM2OD1zLke3N{DPxE1? NVPBXlZYOjN6NESwN|g>
GDM-1 MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfZTYlCOTBizszN MmjUO|IhcA>? M333R2ROW09? MWfJR|UxRTFwOUm3JO69VQ>? MVGyN|g1PDB|OB?=
HT-1080 Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDofm1POTBizszN NXvGWFB4PzJiaB?= M2jFb2ROW09? NFvWbo1KSzVyPUKuNFA1KM7:TR?= NITqN28zOzh2NECzPC=>
HL-60 NYnlcJZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;jUokyOCEQvF2= NH\pZ284OiCq Mn3oSG1UVw>? NXTmXnV4UUN3ME2yMlE4QCEQvF2= MnfyNlM5PDRyM{i=
C3A MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXBUVZUOTBizszN MnTRO|IhcA>? M17VWGROW09? NEHCWmVKSzVyPUWuOFE1KM7:TR?= MkTSNlM5PDRyM{i=
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NCI-H187 MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoS4NVAh|ryP MXS3NkBp MYfEUXNQ MW\JR|UxRTFyIN88US=> M{TjfVI{QDR2MEO4
NCI-H209 NV70U5llT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3G4NVExKM7:TR?= NYnEdYtXPzJiaB?= M320PGROW09? MWnJR|UxRTFyIN88US=> M4TKV|I{QDR2MEO4
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NCI-H292 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrWTGUyOCEQvF2= NXnjTYlDPzJiaB?= NGXZcHhFVVOR M3\QPGlEPTB;MUCg{txO NG[zUWkzOzh2NECzPC=>
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NCI-H520 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYqxNEDPxE1? MVK3NkBp MYHEUXNQ M1r2fGlEPTB;MUCg{txO NVT4bG9kOjN6NESwN|g>
NCI-H526 MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3ENVAh|ryP NFTOOJI4OiCq M3qye2ROW09? MlHqTWM2OD1zMDFOwG0> NHzRTVYzOzh2NECzPC=>
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NCI-H716 M3nRXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3aWIVtOTBizszN NITHTpo4OiCq MWXEUXNQ MXrJR|UxRTFyIN88US=> NVXTNVJIOjN6NESwN|g>
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NCI-H1792 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\yXXAyOCEQvF2= MWO3NkBp NXnucoh5TE2VTx?= MUTJR|UxRTFyIN88US=> MmG5NlM5PDRyM{i=
NCI-H2030 MoPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MontNVAh|ryP NVz0Umt7PzJiaB?= NX;jXpN1TE2VTx?= MnrETWM2OD1zMDFOwG0> NGTNeIEzOzh2NECzPC=>
NCI-H2052 M3m4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXNSldoOTBizszN NH\5[Ho4OiCq MWrEUXNQ NWXRc5dJUUN3ME2xNEDPxE1? NXTrT|kxOjN6NESwN|g>
NCI-H2122 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;vN5NuOTBizszN NFK5dmc4OiCq MX\EUXNQ MXLJR|UxRTFyIN88US=> M1vPelI{QDR2MEO4
NCI-H2228 M{\Kfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU[xNEDPxE1? MljHO|IhcA>? NEfW[5hFVVOR MXLJR|UxRTFyIN88US=> M{LpR|I{QDR2MEO4
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OE-21 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X4d|ExKM7:TR?= NWfufHl1PzJiaB?= NWLWe5BvTE2VTx?= M3GweWlEPTB;MUCg{txO NUnMRXcxOjN6NESwN|g>
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RD-ES MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M324c|ExKM7:TR?= M1e4U|czKGh? Ml;1SG1UVw>? MXzJR|UxRTFyIN88US=> NEG3OWEzOzh2NECzPC=>
RL M4nUdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvjNVAh|ryP NYPXTVBtPzJiaB?= NVnKSHVCTE2VTx?= NEXOeVJKSzVyPUGwJO69VQ>? MlThNlM5PDRyM{i=
SaOS2 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfvXZoyOCEQvF2= M3XUPFczKGh? NGfCNJJFVVOR M1PabmlEPTB;MUCg{txO NWDEZXNuOjN6NESwN|g>
SCC-9 NIfPcGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVX2c3Y2OTBizszN MoPTO|IhcA>? NXzFe|J1TE2VTx?= MlLZTWM2OD1zMDFOwG0> NVnHU3JkOjN6NESwN|g>
SCC-12 NVPvb5hlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1n6NVExKM7:TR?= M2jYZVczKGh? NGXuUpJFVVOR MlmxTWM2OD1zMDFOwG0> MWiyN|g1PDB|OB?=
SCC-13 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFy1PFAyOCEQvF2= M1zKRVczKGh? NXLOUFYyTE2VTx?= MXTJR|UxRTFyIN88US=> NVPCXpRFOjN6NESwN|g>
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SCC-25 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HOW|ExKM7:TR?= NEnLRmo4OiCq M1L6PGROW09? MkHBTWM2OD1zMDFOwG0> NFjITGozOzh2NECzPC=>
SCLC-3 NF[xOnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{C5T|ExKM7:TR?= NWj6cYJ6PzJiaB?= NGnPcoRFVVOR M1fQZ2lEPTB;MUCg{txO NX3PVJF3OjN6NESwN|g>
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SK-BR-3 NGiw[3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LM[|ExKM7:TR?= NXjmeYhFPzJiaB?= M3TRW2ROW09? NVPIXpJCUUN3ME2xNEDPxE1? MkHYNlM5PDRyM{i=
SK-LMS-1 M{HrW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWSxNEDPxE1? NFP2Npk4OiCq MkP1SG1UVw>? NVrCTZBVUUN3ME2xNEDPxE1? MlPHNlM5PDRyM{i=
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SK-N-F1 NE\1dVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3MS3R2OTBizszN M4e0OVczKGh? NVTjdnBKTE2VTx?= Mki5TWM2OD1zMDFOwG0> NFLYeWEzOzh2NECzPC=>
SKOV-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PPVlExKM7:TR?= NYrqW|lYPzJiaB?= MnjwSG1UVw>? NXPofHV{UUN3ME2xNEDPxE1? NWnkPG5HOjN6NESwN|g>
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U2OS NF62eY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DKUVExKM7:TR?= MUC3NkBp MmPHSG1UVw>? MY\JR|UxRTFyIN88US=> M2XJdlI{QDR2MEO4
U251 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fO[|ExKM7:TR?= NX2wdW4yPzJiaB?= M1HSc2ROW09? NX3y[pRSUUN3ME2xNEDPxE1? NEHjVpUzOzh2NECzPC=>
UACC-812 NVPBTJhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PsVFExKM7:TR?= MlP4O|IhcA>? M4nyPGROW09? MUjJR|UxRTFyIN88US=> M1mwVFI{QDR2MEO4
YAPC M2rMPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXWxNEDPxE1? Mn[0O|IhcA>? NEjJTGhFVVOR MX7JR|UxRTFyIN88US=> M3P4clI{QDR2MEO4
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A375 NYPDc4xsTnWwY4Tpc44h[XO|YYm= MVuxMlIh|ryP MVm0JIg> NVL4UlB[TE2VTx?= NWDjU5N[UW6qaXLpeIlwdiCxZjDwbI9{eGixconsZZRqd25ib3[gUWVMNCCHUlusJIFv\CCVNmC= NX25eWg2OjJ|OEm0O|E>
YUSIT1 NXq3fHFVTnWwY4Tpc44h[XO|YYm= NGrnNWlFVVOR MoX5doVlfWOnZDDz[Y5{cXSrdnn0fUB4cXSqIFnDOVAhRiByLkWg{txO NXLKT3RPOjJ|OEm0O|E>
MeWo MoXJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn3MSG1UVw>? MXLJR|UxKD1iOUi3JI5O NFvWOZQzPjBzOEWyOC=>
WiDr MmLjS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M17WcmROW09? MWnJR|UxKD1iN{[gcm0> Mlm0NlYxOTh3MkS=
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WM266 M1flTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\3NVAxKG6P MYm3NkBp NYDk[GJQUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIGfNNlY3KGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFFFKG23dHHueIF1cW:w NWHER2IyOjN|MUe0OFY>
M257 NWrtOZd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPoNVAxKG6P MnTMO|IhcA>? MWnEc4V{KG6xdDDpcohq[mm2IFXST|EuOiCyaH;zdIhwenmuYYTpc44hcW5iTUK1O{Bk\WyuIHjhdoJwfXKrbnege4lt\CC2eYDlJGJTSUZ? M2fCcFI{OzF5NES2
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... Click to View More Cell Line Experimental Data

In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 8 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01723202 Active, not recruiting Follicular Thyroid Cancer|Insular Thyroid Cancer|Papillary Thyroid Cancer|Recurrent Thyroid Cancer Manisha Shah|National Comprehensive Cancer Network|Ohio State University Comprehensive Cancer Center November 7, 2012 Phase 2
NCT02672358 Not yet recruiting Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis October 2017 Phase 2
NCT02447939 Withdrawn Melanoma GlaxoSmithKline May 2017 Phase 1
NCT02967692 Not yet recruiting Melanoma Novartis Pharmaceuticals|Novartis February 2017 Phase 3
NCT02858921 Not yet recruiting Melanoma Melanoma Institute Australia|Merck Sharp & Dohme Corp.|Novartis February 2017 Phase 2
NCT03026517 Recruiting Melanoma Memorial Sloan Kettering Cancer Center|Massachusetts General Hospital|Weill Medical College of Cornell University January 2017 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Raf Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID