Dabrafenib (GSK2118436)

Catalog No.S2807

Dabrafenib (GSK2118436) Chemical Structure

Molecular Weight(MW): 519.56

Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.

Size Price Stock Quantity  
In DMSO USD 180 In stock
USD 90 In stock
USD 130 In stock
USD 170 In stock
USD 270 In stock
USD 400 In stock

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4 Customer Reviews

  • A375P cells were treated with vehicle, the BRAF inhibitor GSK2118436, the MEK inhibitor GSK1120212, 10 uM HCQ, or the indicated combinations. Shown are 48-hour immunoblots directed against the indicated proteins.

    J Clin Invest 2014 24(3), 1406-17. Dabrafenib (GSK2118436) purchased from Selleck.

    Levels of pERK and tERK in the CLL cells derived from PBMC were measured by Western blot. We used vemurafenib, dabrafenib, and trametinib (0.07 uM) as indicated. One of 3 independent experiments with similar results is shown. CLL cells exposed to dabrafenib or vemurafenib had an elevated pERK/tERK ratio as compared with vehicle (P < 0.01).

    J Clin Invest 2014 124(11), 5074-84. Dabrafenib (GSK2118436) purchased from Selleck.

  • The effects of inhibitors of mutant BRAFV600 inhibitor dabrafenib on cancer cell growth were evaluated by the MTT assay. Cell growth inhibition of FRO and SW1736 cell lines induced by dabrafenib.

    Transl Res 2014 10.1016/j.trsl.2014.06.005. Dabrafenib (GSK2118436) purchased from Selleck.

    Dabrafenib alleviates acetaminophen-induced hepatotoxicity in mice. Mice were treated with 300 mg/kg acetaminophen (i.p.), with or without pretreatment with 300 mg/kg or 100 mg/kg dabrafenib (p.o.).TUNEL staining for nuclear DNA fragmentation in mouse liver cells.

    Cell Death Dis 2014 5, e1278. Dabrafenib (GSK2118436) purchased from Selleck.

Purity & Quality Control

Choose Selective Raf Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM in cell-free assays, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.
Targets
B-Raf (V600E) [1]
(Cell-free assay)
B-Raf [1]
(Cell-free assay)
C-Raf [1]
(Cell-free assay)
0.8 nM 3.2 nM 5.0 nM
In vitro

Dabrafenib is selective for Raf kinase, with 400 fold selectivity towards B-Raf over 91% of the other kinases tested. Dabrafenib inhibits B-RafV600E kinase, leading to decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle in cancer cells that specifically encode the mutation for B-RafV600E. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV\LbY5ie2ViQYPzZZk> MYfJcohq[mm2aX;uJI9nKE5vdHXycYlv[WxiSHnzJJRi\2enZDDCMXJi\iCYNkCwSUBufXSjboSg[ZhxemW|c3XkJIlvKGKjY4Xsc5ZqenW|IHnu[oVkfGWmIHnud4VkfCClZXzsd{Bkdy2neIDy[ZN{cW6pIFPER|M4KGG|c3Xzd4VlKGG|IHTlZ5Jm[XOnIHnuJIJqd3SrbonsZZRm\C2PRVugdJJwfGWrbjDwbI9{eGixconsZZRqd25iYomgRYxxcGGVY4Ll[Y4h[XO|YYmge4l1cCCLQ{WwJI9nKDBwMECwO{DPxE1? NGL4Zm8zPDlyME[3Ny=>
SK-MEL-28 Mn\XT4lv[XOnIFHzd4F6 MoWwNUBp MULJcohq[mm2aX;uJI9nKEJvUnHmJHY3ODCHIH31eIFvfCCrbjDoeY1idiCVSz3NSWwuOjhiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP M3\INVI1QTByNkez
HepG2 M3vMOWtqdmG|ZTDBd5NigQ>? NWLyUW95UW6qaXLpeIlwdiCxZjDCMXJi\iCYNkCwSUBufXSjboSgbY4hcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gSXJMKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFQh|ryP NGfwe20zPDlyME[3Ny=>
COLO205 M{TvSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJcohq[mm2aX;uJI9nKGi3bXHuJGNQVE9{MEWgZ4VtdCCycn;sbYZmemG2aX;uJJdqfGhiSVO1NEBw\iByLkCwO{DPxE1? M{HMOVI1QTByNkez
HepG2 NX\QU40zTnWwY4Tpc44hSXO|YYm= NWfXfXdiPDVibXnu MmPCSG1UVw>? Mn3qTY5pcWKrdHnvckBw\iCDbHu1JIlvKFSJRj3i[ZRiNXO2aX31cIF1\WRiaIXtZY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4hW22jZEKgdIhwe3Cqb4L5cIF1cW:wIITy[YF1\WRiZn;yJFQ2KG2rboOgdJJqd3JidH:gWGdHNWKndHGgd5RqdXWuYYTpc44hdWWjc4Xy[YQh[W[2ZYKgOlAhdWmwczDifUBw\Hm|c3X5JIJtd3Ric3Phco5meiCjbnHsfZNqeyC5aYToJGlEPTBib3[gN{44KM7:TR?= MnWxNlQ6ODB4N{O=
HFF MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[xUpoyOCEQvF2= NXf6OoQxPzJiaB?= NXPJSWQxTE2VTx?= MULJcohq[mm2aX;uJI9nKHC{b3zp[oVz[XSrb36gc4YhcHWvYX6gTGZHKGOnbHzzJIhiemKxcnnu[{B4cWymIIT5dIUhSi2UYX[ge4l1cCCLQ{WwJI9nKDNizszN MWeyN|g1PDB|OB?=
SK-MEL-28 NF\HenlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1niS|ExKM7:TR?= MoHIO|IhcA>? NF3FfIRFVVOR Mnf0TY5pcWKrdHnvckBw\iCELWLh[kBXPjByRTDteZRidnRvZILpeoVvKFONLV3FUE0zQCClZXzsJJBzd2yrZnXyZZRqd25id3n0bEBKSzVyIH;mJFAvODR|IN88US=> MluyNlM5PDRyM{i=
A375P-F11 NGrYRpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHrNVAh|ryP NGCwVms4OiCq MVjEUXNQ M{DvUmlvcGmkaYTpc44hd2ZiQj3SZYYhXjZyMFWgcZV1[W62LXTybZZmdiCDM{e1VE1HOTFiY3XscEBxem:uaX\ldoF1cW:wIIfpeIghUUN3MDDv[kAxNjB5MTFOwG0> MYKyN|g1PDB|OB?=
MALME-3M M{DlRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu3dVIyOCEQvF2= M{LTTFczKGh? NYq0e4JNTE2VTx?= MVjJR|UxRTFibl2= NUnjc29wOjN6NESwN|g>
UACC-62 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTFNVAh|ryP NHvaO3Q4OiCq MoHDSG1UVw>? Mke4TWM2OD1zIH7N MUOyN|g1PDB|OB?=
C32TG NYm4cZVJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG2WlVVOTBizszN MoHwO|IhcA>? M1P0SmROW09? NEW3VnZKSzVyPUGgcm0> M4LNflI{QDR2MEO4
SK-MEL-1 MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPvPYtOOTBizszN MnfoO|IhcA>? NGntbJJFVVOR MoHMTWM2OD1{IH7N MYKyN|g1PDB|OB?=
M14 NV3yfmh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rRO|ExKM7:TR?= NFPXVlg4OiCq NFnUW5NFVVOR MYXJR|UxRTJibl2= MoXhNlM5PDRyM{i=
SK-MEL-28 NFPpbmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDaeWF{OTBizszN NYDpZ45PPzJiaB?= MkPXSG1UVw>? NIXENm1KSzVyPUOgcm0> MUmyN|g1PDB|OB?=
A375 NIKyPIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTiUoZyOTBizszN M12zT|czKGh? MnLQSG1UVw>? M3XPeGlEPTB;NDDuUS=> NYKxcHlZOjN6NESwN|g>
DU-4475 NXOxdoF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4POU|ExKM7:TR?= NFvw[pM4OiCq NESxUZpFVVOR NI\TVYJKSzVyPUWgcm0> MUOyN|g1PDB|OB?=
UACC-257 NEPYXo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX6xNEDPxE1? NYXmb4dJPzJiaB?= MWXEUXNQ NUDY[otNUUN3ME22JI5O NV6wcIMzOjN6NESwN|g>
Colo 205 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvBOWoyOCEQvF2= NUPQXW1nPzJiaB?= NXT0XWxuTE2VTx?= MULJR|UxRTdibl2= NGLIdo8zOzh2NECzPC=>
SK-MEL-3 NWX3N2xiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXtR49FOTBizszN M4LBUlczKGh? M2myV2ROW09? MV3JR|UxRTdibl2= M4DvSlI{QDR2MEO4
SH-4 MnjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW[xNEDPxE1? M4LrbFczKGh? NHPGVJRFVVOR MYjJR|UxRThibl2= M2r3eVI{QDR2MEO4
A101D M2fsNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmzXXgyOCEQvF2= NVn6[pRCPzJiaB?= NVqyUXlSTE2VTx?= MnrNTWM2OD17IH7N NH3TdZozOzh2NECzPC=>
ES-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\iNVAh|ryP MX[3NkBp NVW3NZJmTE2VTx?= MWTJR|UxRTV|IH7N NVn6Z29UOjN6NESwN|g>
HT-29 M1zPPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPXNVAh|ryP NHfTc5I4OiCq NYPp[nk{TE2VTx?= NYPkfIFFUUN3ME22OkBvVQ>? M13tWFI{QDR2MEO4
SW1417 M33K[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIi2fGkyOCEQvF2= NGHtPZA4OiCq M{njPGROW09? M3fqOGlEPTB;MUW4JI5O MlewNlM5PDRyM{i=
SW872 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT3NVAh|ryP MW[3NkBp Mn;xSG1UVw>? MVrJR|UxRTN5NzDuUS=> NWn1[VhuOjN6NESwN|g>
RKO MmO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:wNVAh|ryP MnXRO|IhcA>? MlHYSG1UVw>? NXztOoNTUUN3ME2yMlUzOiEQvF2= NIXM[YYzOzh2NECzPC=>
A673 NIH4c4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzkVIwyOCEQvF2= M{nJdlczKGh? NXjpOWRPTE2VTx?= NHLXSYdKSzVyPUGwJO69VQ>? NUK3fWRTOjN6NESwN|g>
GCT NV\zVGNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDDPYMyOCEQvF2= MWC3NkBp MVrEUXNQ MmnNTWM2OD1zMDFOwG0> MWKyN|g1PDB|OB?=
WM-115 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXezfGQ3OTBizszN MVO3NkBp Mn7zSG1UVw>? MUnJR|UxRTVibl2= NXjGRYxSOjN6NESwN|g>
YUMAC Mlr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVexNEDPxE1? MkO3O|IhcA>? NWjGO3M4TE2VTx?= NXnNU|JxUUN3ME21JI5O M1fPT|I{QDR2MEO4
OV-90 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon1NVAh|ryP MmPvO|IhcA>? MojySG1UVw>? MnjwTWM2OD1{OTDuUS=> NHfDdFEzOzh2NECzPC=>
NCI-H508 NHXKN3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFG5bG8yOCEQvF2= MVG3NkBp NVLRWYs6TE2VTx?= MVPJR|UxRTFyIN88US=> MWmyN|g1PDB|OB?=
MDA-MB-231 NXXOc2Y1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\lNVAh|ryP MkfWO|IhcA>? MUDEUXNQ NIfkZZlKSzVyPUGwJO69VQ>? MUCyN|g1PDB|OB?=
SW756 NX3lTZU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWq4c5d[OTBizszN NXXBUZoxPzJiaB?= M1\0fmROW09? NVnXPG9GUUN3ME2xNEDPxE1? NHvuZY4zOzh2NECzPC=>
SW-837 Mor6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3XNVAh|ryP MUK3NkBp NWTubGxbTE2VTx?= MYjJR|UxRTFyIN88US=> MlPTNlM5PDRyM{i=
UMUC-3 M{PSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXVXGNPOTBizszN MYG3NkBp MY\EUXNQ MoLjTWM2OD1zMDFOwG0> MW[yN|g1PDB|OB?=
LS-174T NXjOVXo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlO5NVAh|ryP NXvucIU4PzJiaB?= M{K2OGROW09? MXLJR|UxRTFyIN88US=> M4jI[FI{QDR2MEO4
A549 MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\tXlExKM7:TR?= MoCwO|IhcA>? MljBSG1UVw>? MVTJR|UxRTFyIN88US=> M{\FcFI{QDR2MEO4
SHP-77 NGS4RWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrVZWkyOCEQvF2= MV23NkBp M3rWcWROW09? NYLPfJBbUUN3ME2xNEDPxE1? NXricolsOjN6NESwN|g>
SW480 NUPhZWYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUmxNEDPxE1? M4P6e|czKGh? M2rxXWROW09? NVTReYYxUUN3ME2xNEDPxE1? Mn[0NlM5PDRyM{i=
DLD-1 M{HJ[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO4VXMyOCEQvF2= NEPmWVY4OiCq M1jrWGROW09? M4fZ[mlEPTB;MUCg{txO NHry[YszOzh2NECzPC=>
HCT-116 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV[xNEDPxE1? MWi3NkBp NGezWGNFVVOR MXrJR|UxRTFyIN88US=> NX3ZZmRWOjN6NESwN|g>
NCI-H747 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrQNVAh|ryP NV3tPFdZPzJiaB?= NVf2RmxsTE2VTx?= M1zBPGlEPTB;MUCg{txO NY\MN|YyOjN6NESwN|g>
T-84 NU\pTpY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYexNEDPxE1? NULTNVR2PzJiaB?= NVPvZ2N2TE2VTx?= M4rtUGlEPTB;MUCg{txO MY[yN|g1PDB|OB?=
NCI-H460 M1Ptcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljwNVAh|ryP MXS3NkBp NHvoeGRFVVOR NWDBXXRPUUN3ME2xNEDPxE1? MkHZNlM5PDRyM{i=
Calu-6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHtNVAh|ryP NVTYU2Y5PzJiaB?= MmDESG1UVw>? MYDJR|UxRTFyIN88US=> NFnlRmozOzh2NECzPC=>
HCC-2998 MoLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\3d286OTBizszN M4TvSlczKGh? MnHiSG1UVw>? M{TRWmlEPTB;MUCg{txO M1WzSVI{QDR2MEO4
LS1034 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETT[YoyOCEQvF2= Mne5O|IhcA>? Mk[3SG1UVw>? NWDWfoNPUUN3ME2xNEDPxE1? M4nHV|I{QDR2MEO4
CHP-212 Ml;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfmNVAh|ryP MnfxO|IhcA>? NFrNbmZFVVOR NYL3SoJjUUN3ME2xNEDPxE1? NXPwWHhGOjN6NESwN|g>
SK-N-AS NFf5OnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfzNVAh|ryP Mnv4O|IhcA>? NV;qUmw{TE2VTx?= NULsXHh3UUN3ME2xNEDPxE1? MWKyN|g1PDB|OB?=
BFTC-905 M2rKT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWqxNEDPxE1? M1LZeVczKGh? MXHEUXNQ NFuwN4pKSzVyPUGwJO69VQ>? NWDDVWo3OjN6NESwN|g>
HuT78 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\TXZIyOCEQvF2= NGHwe4U4OiCq MYDEUXNQ NYSyRYh2UUN3ME21NkBvVQ>? NVOxO5JyOjN6NESwN|g>
RPMI-8226 MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn0NVAh|ryP NFL5WFg4OiCq M37NbmROW09? Mkf6TWM2OD1{NkOgcm0> MlT1NlM5PDRyM{i=
BC-3 M17EXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfM[m5YOTBizszN MYS3NkBp NWT4fmRtTE2VTx?= MoDUTWM2OD1{N{egcm0> M3XrR|I{QDR2MEO4
ACHN MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnr3NVAh|ryP MYO3NkBp NHjKN4lFVVOR NXTzPGNHUUN3ME2yPVQhdk1? NF7HNYQzOzh2NECzPC=>
JRT3-T35 NG\WTVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDneFg{OTBizszN MlnLO|IhcA>? M1zwPWROW09? MmjiTWM2OD1{OUWgcm0> MXiyN|g1PDB|OB?=
SK-MES-1 NGjSWHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPZcWRtOTBizszN NGjB[Is4OiCq NWT5fnZ4TE2VTx?= MkLITWM2OD1|Mkmgcm0> NXnnTIc{OjN6NESwN|g>
CESS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVSxNEDPxE1? NGftUok4OiCq MnPnSG1UVw>? NVnGTolLUUN3ME20PVchdk1? NFnrWoszOzh2NECzPC=>
H4 MnrQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX2ZlU2OTBizszN NXLqbG46PzJiaB?= M3fCSGROW09? NH\DWXBKSzVyPU[xPUBvVQ>? MnnPNlM5PDRyM{i=
BC-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\0[2MyOCEQvF2= NWPrNIp1PzJiaB?= NXW1fGtbTE2VTx?= M{\SUWlEPTB;N{C0JI5O MlTzNlM5PDRyM{i=
DB MlL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\2N|ExKM7:TR?= NIrmXFE4OiCq M1HwXWROW09? Ml20TWM2OD16N{Ogcm0> MXKyN|g1PDB|OB?=
RPMI-6666 MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVn0No8zOTBizszN MVy3NkBp NUHhSlh4TE2VTx?= NIHuepVKSzVyPUmyPEBvVQ>? NH3lZ4UzOzh2NECzPC=>
MC/CAR NXnCb4FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe2TZRNOTBizszN M{LDO|czKGh? NV6zSlVrTE2VTx?= NIXo[4RKSzVyPUGuNFAzKM7:TR?= NVTNcYYxOjN6NESwN|g>
SNU-1 MoLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYqxNEDPxE1? NEWxNlY4OiCq NFH1eZZFVVOR NVvJeGl4UUN3ME2xMlUxOSEQvF2= MnjUNlM5PDRyM{i=
CEM/C1 Mn\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYmxNEDPxE1? NGe2UG84OiCq M4fEVWROW09? M1LmcWlEPTB;MT63O|Mh|ryP MV6yN|g1PDB|OB?=
GDM-1 M13mOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYCwenY1OTBizszN M2jMbVczKGh? NY\UeY5iTE2VTx?= MnrpTWM2OD1zLkm5O{DPxE1? NWe5NFVFOjN6NESwN|g>
HT-1080 Mnr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWizd|BKOTBizszN NF6xZ2U4OiCq M1ftcmROW09? NUjDPIxJUUN3ME2yMlAxPCEQvF2= NXHSfJR1OjN6NESwN|g>
HL-60 M3HVNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PHSlExKM7:TR?= NYK0Uod3PzJiaB?= Ml;ESG1UVw>? NH\rVpVKSzVyPUKuNVc5KM7:TR?= M2\RcVI{QDR2MEO4
C3A NEnOdmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHXNVAh|ryP NH;XUGU4OiCq MYrEUXNQ M{fPRWlEPTB;NT60NVQh|ryP NYf1fWk5OjN6NESwN|g>
MES-SA NVjEXY12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PzVFExKM7:TR?= M1vjUFczKGh? NWL3fGNDTE2VTx?= NGDOOJdKSzVyPU[uPVg6KM7:TR?= MYqyN|g1PDB|OB?=
22Rv1 M1\ZVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImyR2YyOCEQvF2= NYHhcHU3PzJiaB?= M3rOb2ROW09? MWPJR|UxRTFyIN88US=> NXnITHZYOjN6NESwN|g>
647-V MnjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrKe5kyOCEQvF2= M3Xad|czKGh? Mn;vSG1UVw>? NV;j[2c3UUN3ME2xNEDPxE1? NFrhcIUzOzh2NECzPC=>
786-O NFfXXoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVyxNEDPxE1? M2C4R|czKGh? MlPESG1UVw>? NW\md5VqUUN3ME2xNEDPxE1? NXvEe4hVOjN6NESwN|g>
A172 MlvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjyNVAh|ryP M1\sUlczKGh? Mk\ISG1UVw>? NIjnWG9KSzVyPUGwJO69VQ>? MmLlNlM5PDRyM{i=
A204 M1LtRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;LNVAh|ryP M4H1N|czKGh? NUjBNmxwTE2VTx?= NFPOR3JKSzVyPUGwJO69VQ>? M1nNRlI{QDR2MEO4
A427 NFLH[4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TSZVExKM7:TR?= NXXifIdIPzJiaB?= NV;zTnBKTE2VTx?= NV\6W|Z{UUN3ME2xNEDPxE1? MV:yN|g1PDB|OB?=
A431 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjxWIFUOTBizszN M3TENVczKGh? M1j4cmROW09? M2jCNWlEPTB;MUCg{txO NHfKdZozOzh2NECzPC=>
A2780 NHrFfnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjRO4IyOCEQvF2= Mn7JO|IhcA>? NYS3c2dETE2VTx?= NHG2V|VKSzVyPUGwJO69VQ>? MVqyN|g1PDB|OB?=
ARH-77 M3z6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfZbZEyOCEQvF2= Mn[1O|IhcA>? NEXiNmdFVVOR M3TWW2lEPTB;MUCg{txO MUOyN|g1PDB|OB?=
Be(2)C MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:xNEDPxE1? NYXm[HpJPzJiaB?= MnWxSG1UVw>? MlfjTWM2OD1zMDFOwG0> MmDDNlM5PDRyM{i=
BT-20 NWOyO3RWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HuUVExKM7:TR?= M3nLcVczKGh? NF7GPWRFVVOR NUPKT|lIUUN3ME2xNEDPxE1? NEKyOGczOzh2NECzPC=>
BxPc3 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmm1NVAh|ryP M3OzUlczKGh? M3;zZWROW09? M2LkXWlEPTB;MUCg{txO MmTONlM5PDRyM{i=
C-4 I Mlr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDZNVAh|ryP MXu3NkBp NV7WboNDTE2VTx?= MonhTWM2OD1zMDFOwG0> Mny2NlM5PDRyM{i=
C33A M2PwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPZNHIyOCEQvF2= MmjLO|IhcA>? M{HRd2ROW09? NWT2e4pKUUN3ME2xNEDPxE1? NHm2XZMzOzh2NECzPC=>
CAL-27 MomzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnuxNVAh|ryP NIn5S|k4OiCq MlrSSG1UVw>? NIfOSYlKSzVyPUGwJO69VQ>? Mly4NlM5PDRyM{i=
CAL-62 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILubJYyOCEQvF2= M2nSb|czKGh? M4mxS2ROW09? NF;1NllKSzVyPUGwJO69VQ>? MmTUNlM5PDRyM{i=
Calu-3 M4H2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorKNVAh|ryP M1zt[|czKGh? NGjPT5RFVVOR MWXJR|UxRTFyIN88US=> M2[zNlI{QDR2MEO4
CaOV3 NGnzenpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LTZ|ExKM7:TR?= NXPm[IM3PzJiaB?= MU\EUXNQ MVvJR|UxRTFyIN88US=> MUGyN|g1PDB|OB?=
CGTHW1 NIHSTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3MNVAh|ryP MU[3NkBp M2m5OGROW09? MXHJR|UxRTFyIN88US=> MkHXNlM5PDRyM{i=
CHL-1 M4S5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPnNVAh|ryP NUHBVosxPzJiaB?= NHrPTZZFVVOR NHvPUmNKSzVyPUGwJO69VQ>? NVS2OVVNOjN6NESwN|g>
Colo320DM NHLlNlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO3dGxyOTBizszN NGj2dHc4OiCq NV3xWY43TE2VTx?= NXO4TYRDUUN3ME2xNEDPxE1? MYWyN|g1PDB|OB?=
Colo704 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX6xNEDPxE1? NUHH[JAyPzJiaB?= M3vRdmROW09? NYK2TnlKUUN3ME2xNEDPxE1? M2jNclI{QDR2MEO4
COR-L23 M2C4dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PicVExKM7:TR?= NWT5S2ttPzJiaB?= MmG0SG1UVw>? NYPvfnlZUUN3ME2xNEDPxE1? NVPBe3B1OjN6NESwN|g>
CRO-AP2 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HsU|ExKM7:TR?= M4PiZlczKGh? NVfNV5poTE2VTx?= NX;PZlRWUUN3ME2xNEDPxE1? NGDrS5MzOzh2NECzPC=>
Daudi MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH65e4QyOCEQvF2= NUnZe4ozPzJiaB?= M1zTRmROW09? NWrkO486UUN3ME2xNEDPxE1? M4XxNFI{QDR2MEO4
DOTC 24510 M1\5VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\acGdsOTBizszN M13iR|czKGh? MmfiSG1UVw>? MlfGTWM2OD1zMDFOwG0> NGnTU|AzOzh2NECzPC=>
DU-145 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX6xNEDPxE1? MofMO|IhcA>? MmTOSG1UVw>? MVzJR|UxRTFyIN88US=> NYTFflF3OjN6NESwN|g>
EB-3 MlP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYSxNEDPxE1? MWG3NkBp NHzydoFFVVOR Ml32TWM2OD1zMDFOwG0> M3L2UVI{QDR2MEO4
EFM-19 M2\1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\PPZEyOCEQvF2= NFv6Z3U4OiCq M2frdWROW09? NYDMUZVsUUN3ME2xNEDPxE1? Mo\tNlM5PDRyM{i=
EKVX NV\3SYF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3tTIRVOTBizszN NEWySFc4OiCq NHTGPHhFVVOR MVvJR|UxRTFyIN88US=> Mlf1NlM5PDRyM{i=
FaDu MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXIU2MyOCEQvF2= Mo\oO|IhcA>? MkfySG1UVw>? MVHJR|UxRTFyIN88US=> Mnu2NlM5PDRyM{i=
G401 NXfxdW5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;FNVAh|ryP M1G2b|czKGh? MYrEUXNQ MW\JR|UxRTFyIN88US=> NGDnZXczOzh2NECzPC=>
HCC-70 NILIT|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVGxNEDPxE1? NUL5TlRlPzJiaB?= MUnEUXNQ M37m[2lEPTB;MUCg{txO NETnXIYzOzh2NECzPC=>
HCC-1954 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rvUlExKM7:TR?= NH6yO5I4OiCq Mor4SG1UVw>? M4GxUmlEPTB;MUCg{txO MmjMNlM5PDRyM{i=
Hela M3KxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXWxNEDPxE1? NIrGVHE4OiCq M4LTV2ROW09? NEDYeGdKSzVyPUGwJO69VQ>? MVmyN|g1PDB|OB?=
Hep3B M4PFTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTUNVAh|ryP M{T1clczKGh? M323NWROW09? MmjxTWM2OD1zMDFOwG0> MkfGNlM5PDRyM{i=
HMCB M3W3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHsUYRMOTBizszN M1PjdFczKGh? M3T2bWROW09? NFLHVpVKSzVyPUGwJO69VQ>? NXLMSYc2OjN6NESwN|g>
HN5 NGHVeIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\L[pgyOCEQvF2= NV\tb5FMPzJiaB?= M2XGdGROW09? NWDIb5pQUUN3ME2xNEDPxE1? NFjDS40zOzh2NECzPC=>
HOS MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXGxNEDPxE1? NV\aToVJPzJiaB?= M4j4RWROW09? NV3xdHd2UUN3ME2xNEDPxE1? NXLVRpBpOjN6NESwN|g>
HPAF-II NUXSb5dGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnKwNVAh|ryP MlvYO|IhcA>? NGHKPG1FVVOR NVLHdmdoUUN3ME2xNEDPxE1? NE[wOIgzOzh2NECzPC=>
Hs746.T NWTNZZU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXLNVAh|ryP M4rPTlczKGh? M3OxRmROW09? NVvxOG9ZUUN3ME2xNEDPxE1? M2S4RlI{QDR2MEO4
HT MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPpXW0yOCEQvF2= M33yTFczKGh? M4XvSmROW09? NFLzSlhKSzVyPUGwJO69VQ>? M1fydFI{QDR2MEO4
HT-3 M1fyOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ywN|ExKM7:TR?= MnTXO|IhcA>? NWWyS2QzTE2VTx?= NGHtVFZKSzVyPUGwJO69VQ>? MUCyN|g1PDB|OB?=
HuNS-1 NHi5W2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq5SpkyOCEQvF2= NF7EZpA4OiCq NEL0eVNFVVOR MkT6TWM2OD1zMDFOwG0> NETJV4MzOzh2NECzPC=>
IGROV1 NFzWTHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXTfoIyOCEQvF2= MV23NkBp NX:4TIFGTE2VTx?= M3P5fWlEPTB;MUCg{txO NIDrdG8zOzh2NECzPC=>
J82 Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj2NVAh|ryP MVy3NkBp M2HxemROW09? NXG0e|E{UUN3ME2xNEDPxE1? MkTyNlM5PDRyM{i=
JM1 NULwNXcyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTtNVAh|ryP M4DVfFczKGh? NXLFcZBHTE2VTx?= NUHsOYl4UUN3ME2xNEDPxE1? M1PDPFI{QDR2MEO4
Kato III NVr3OJhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTRfGcyOCEQvF2= NYXZWmliPzJiaB?= M4roe2ROW09? M4LsVWlEPTB;MUCg{txO MlewNlM5PDRyM{i=
KHOS-240S NI\WTmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;pO2JnOTBizszN M2fFR|czKGh? NHjtU4hFVVOR NYDkV3FqUUN3ME2xNEDPxE1? NFroRmszOzh2NECzPC=>
KM-12 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHQNVAh|ryP NVfBdFdZPzJiaB?= NX3zNZNWTE2VTx?= MV\JR|UxRTFyIN88US=> NV62V2dVOjN6NESwN|g>
KPL-1 NVfw[5hZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIj3S|AyOCEQvF2= MkPsO|IhcA>? Ml;OSG1UVw>? NF\uZWZKSzVyPUGwJO69VQ>? NHrtfGczOzh2NECzPC=>
KYSE-30 M4H5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLuNVAh|ryP MYW3NkBp NHe4RnFFVVOR M4CwfGlEPTB;MUCg{txO M1fESlI{QDR2MEO4
LNCaP NIHmToxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLoNVAh|ryP NYS1dHR6PzJiaB?= NVjydlJuTE2VTx?= MVHJR|UxRTFyIN88US=> MYWyN|g1PDB|OB?=
MCF-7 NH\OO5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUT5U|JVOTBizszN NWDlem1TPzJiaB?= M3vsNmROW09? NGG1NWVKSzVyPUGwJO69VQ>? MkfHNlM5PDRyM{i=
MC-IXC MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:xNEDPxE1? NXTzXnFWPzJiaB?= NVPxTYFqTE2VTx?= M4r0WWlEPTB;MUCg{txO NGLyeXUzOzh2NECzPC=>
MDA-MB-175 VII MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XpVFExKM7:TR?= NGi5dpg4OiCq MnuxSG1UVw>? MojRTWM2OD1zMDFOwG0> NIfh[JEzOzh2NECzPC=>
MDA-MB-468 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXZXm8yOCEQvF2= MV[3NkBp M4LIbWROW09? MVfJR|UxRTFyIN88US=> Mon6NlM5PDRyM{i=
MiaPaCa M{\UZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP1NVAh|ryP NHXIW2E4OiCq MWLEUXNQ Mn2zTWM2OD1zMDFOwG0> MkX5NlM5PDRyM{i=
Molt-4 NF;iWHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;ufFExKM7:TR?= NYDPemNvPzJiaB?= MVLEUXNQ NF\aN5JKSzVyPUGwJO69VQ>? M4PQSFI{QDR2MEO4
NCI-ADR/RES MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGqwVHIyOCEQvF2= NF2xclY4OiCq NXPsUZFKTE2VTx?= MWTJR|UxRTFyIN88US=> Mn65NlM5PDRyM{i=
NCI-H69 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3y4bVExKM7:TR?= NFu4ZlQ4OiCq MmLwSG1UVw>? NWXsNItTUUN3ME2xNEDPxE1? NXy2T3V1OjN6NESwN|g>
NCI-H82 NVvJ[GE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUGxNEDPxE1? NVTMdY5YPzJiaB?= NYHYZ4FmTE2VTx?= MnTZTWM2OD1zMDFOwG0> M3;TVVI{QDR2MEO4
NCI-N87 MnzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn2NVAh|ryP NX3CNWRQPzJiaB?= NWrEZo44TE2VTx?= MXPJR|UxRTFyIN88US=> M2[1dVI{QDR2MEO4
NCI-H146 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xNEDPxE1? Mk\HO|IhcA>? M1jRb2ROW09? NF3EdWZKSzVyPUGwJO69VQ>? NXfWdZBUOjN6NESwN|g>
NCI-H157 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlL4NVAh|ryP NFHUfnA4OiCq MWXEUXNQ MoWzTWM2OD1zMDFOwG0> NX3ZNWp[OjN6NESwN|g>
NCI-H187 M{jWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nnTFExKM7:TR?= MVW3NkBp NH;RTWdFVVOR MYfJR|UxRTFyIN88US=> M4K5VlI{QDR2MEO4
NCI-H209 NYXqd3pXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWWxNEDPxE1? MV:3NkBp NIPUPWRFVVOR MlrSTWM2OD1zMDFOwG0> MV[yN|g1PDB|OB?=
NCI-H226 NX25UZVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX2xNEDPxE1? MUW3NkBp NILBS3NFVVOR MnvrTWM2OD1zMDFOwG0> MkLQNlM5PDRyM{i=
NCI-H292 NHThUWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\sblExKM7:TR?= NYPqOHhzPzJiaB?= MoPnSG1UVw>? MoqzTWM2OD1zMDFOwG0> NH7E[|MzOzh2NECzPC=>
NCI-H322 M2LnVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi0PGc1OTBizszN NVLhZYlVPzJiaB?= NYPic4ljTE2VTx?= MVHJR|UxRTFyIN88US=> M3m1ZVI{QDR2MEO4
NCI-H358 MlvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFWzPVEyOCEQvF2= M4nOc|czKGh? NIHwcmRFVVOR NUPucWs3UUN3ME2xNEDPxE1? NF;2RoczOzh2NECzPC=>
NCI-H520 M3rIdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHq3bpYyOCEQvF2= M4Lv[lczKGh? MlnKSG1UVw>? MoPOTWM2OD1zMDFOwG0> NFPiOnIzOzh2NECzPC=>
NCI-H526 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDpU2Y3OTBizszN M1noWlczKGh? MXfEUXNQ NV;hT4h6UUN3ME2xNEDPxE1? NWTPToczOjN6NESwN|g>
NCI-H630 NE\zR2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXWxNEDPxE1? NUnKWmtrPzJiaB?= NHyyPWZFVVOR NVPTUIxPUUN3ME2xNEDPxE1? NXX0WGZ[OjN6NESwN|g>
NCI-H661 M3y3ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnLcI8yOCEQvF2= MYK3NkBp MkXTSG1UVw>? NYH2S5RUUUN3ME2xNEDPxE1? NUPKXoJDOjN6NESwN|g>
NCI-H716 NESwOpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jj[FExKM7:TR?= M1rRdlczKGh? MkP1SG1UVw>? MVLJR|UxRTFyIN88US=> M3nvblI{QDR2MEO4
NCI-H1563 M1Tkfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\NRlExKM7:TR?= NXvDcoc3PzJiaB?= MWjEUXNQ MYnJR|UxRTFyIN88US=> NXPD[ZNQOjN6NESwN|g>
NCI-H1792 MlLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvqNXoyOCEQvF2= Mlq5O|IhcA>? NUHBOolkTE2VTx?= MoGwTWM2OD1zMDFOwG0> NFnr[GgzOzh2NECzPC=>
NCI-H2030 NIPKOWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3m3UFExKM7:TR?= MV:3NkBp MVHEUXNQ NIT6dVFKSzVyPUGwJO69VQ>? MkW2NlM5PDRyM{i=
NCI-H2052 NE\3Z|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;heFExKM7:TR?= Mo[zO|IhcA>? NHjoTlRFVVOR MnXpTWM2OD1zMDFOwG0> MWeyN|g1PDB|OB?=
NCI-H2122 MkLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrYbFF1OTBizszN Mnv2O|IhcA>? MXPEUXNQ NHPMU2NKSzVyPUGwJO69VQ>? NWPxOZl6OjN6NESwN|g>
NCI-H2228 NWfNU4YxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;EfZcyOCEQvF2= NX33Onk2PzJiaB?= NES4XmJFVVOR MYTJR|UxRTFyIN88US=> MUOyN|g1PDB|OB?=
OE-19 NU\SNGxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDKd4UyOCEQvF2= MUe3NkBp MX\EUXNQ Mk\hTWM2OD1zMDFOwG0> M{PhbVI{QDR2MEO4
OE-21 NUPpUVhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nwcFExKM7:TR?= MXW3NkBp NH\xe3RFVVOR MUXJR|UxRTFyIN88US=> MoXuNlM5PDRyM{i=
OE-33 M3XjXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUexNEDPxE1? NUHKTFQ4PzJiaB?= MoWzSG1UVw>? NWXCR3g3UUN3ME2xNEDPxE1? NFnOWlEzOzh2NECzPC=>
OVCAR-3 NHOwT3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHONVAh|ryP M4DONVczKGh? NGPpW5dFVVOR NHnyUZVKSzVyPUGwJO69VQ>? M1nyd|I{QDR2MEO4
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PC-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYOxNEDPxE1? NVzjNWk3PzJiaB?= MWDEUXNQ MVnJR|UxRTFyIN88US=> M2[wflI{QDR2MEO4
Raji M3vZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nzVlExKM7:TR?= Mmf3O|IhcA>? NWjQNFE5TE2VTx?= NHj4copKSzVyPUGwJO69VQ>? NWroS|JXOjN6NESwN|g>
RD NYrhN49WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fqV|ExKM7:TR?= MXO3NkBp M2HxU2ROW09? MkKxTWM2OD1zMDFOwG0> MljpNlM5PDRyM{i=
RD-ES NF7rT3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVqxNEDPxE1? NYS1d5JzPzJiaB?= NIHhV|FFVVOR M{fNb2lEPTB;MUCg{txO NXz3N29OOjN6NESwN|g>
RL NYnXXYtVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj5OlBsOTBizszN Ml3ZO|IhcA>? M3jYR2ROW09? NWqwU|k3UUN3ME2xNEDPxE1? NXrCfXA2OjN6NESwN|g>
SaOS2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfaZpU6OTBizszN MXO3NkBp MnnzSG1UVw>? MYHJR|UxRTFyIN88US=> NVrRd5l3OjN6NESwN|g>
SCC-9 MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXlVZAyOCEQvF2= NU\HRolzPzJiaB?= MVrEUXNQ M3zYcGlEPTB;MUCg{txO MkXENlM5PDRyM{i=
SCC-12 NEDkd5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXoNVAh|ryP MkjaO|IhcA>? M2Ph[GROW09? NEPIbnNKSzVyPUGwJO69VQ>? MnnDNlM5PDRyM{i=
SCC-13 Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDnNVAh|ryP NGXUbXI4OiCq M1e1N2ROW09? NVjuTGJ{UUN3ME2xNEDPxE1? MYCyN|g1PDB|OB?=
SCC-15 Mo[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HwUVExKM7:TR?= NFvMco84OiCq MY\EUXNQ NH34PFlKSzVyPUGwJO69VQ>? MmC0NlM5PDRyM{i=
SCC-25 NV3WXJMyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\1PFExKM7:TR?= NV7pR3Q5PzJiaB?= NFHlOo1FVVOR MVXJR|UxRTFyIN88US=> MVmyN|g1PDB|OB?=
SCLC-3 NEW3TXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWqxNEDPxE1? NUD6dGFIPzJiaB?= MUjEUXNQ MX7JR|UxRTFyIN88US=> NXvQZpQ3OjN6NESwN|g>
SF-268 NFjGfmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\aOFExKM7:TR?= MUK3NkBp NGjDVIpFVVOR MWDJR|UxRTFyIN88US=> NVTkN5BLOjN6NESwN|g>
SF-295 MmfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlOxNVAh|ryP MVK3NkBp MnHzSG1UVw>? NVqyUllmUUN3ME2xNEDPxE1? MX6yN|g1PDB|OB?=
SJRH30 NIW4blFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TOWVExKM7:TR?= M2HrS|czKGh? NHnUbFRFVVOR MWXJR|UxRTFyIN88US=> NF\6Z5UzOzh2NECzPC=>
SK-BR-3 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X0VVExKM7:TR?= NIm5UVc4OiCq M2LxOGROW09? NV\UOFU2UUN3ME2xNEDPxE1? NYK1SmM1OjN6NESwN|g>
SK-LMS-1 NEDJUohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWexNEDPxE1? NU\rO|ZWPzJiaB?= MV7EUXNQ MYDJR|UxRTFyIN88US=> M{LWSlI{QDR2MEO4
SK-N-DZ M2r6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnENVAh|ryP NE\INVE4OiCq NIjpbXVFVVOR NY[zfoRmUUN3ME2xNEDPxE1? MUSyN|g1PDB|OB?=
SK-N-F1 MkXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;PNWcyOCEQvF2= MXq3NkBp M4D6XWROW09? NVS4bHI6UUN3ME2xNEDPxE1? M3;USlI{QDR2MEO4
SKOV-3 NV33WVZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFe2UlYyOCEQvF2= MWG3NkBp M4rVU2ROW09? NF\nUIpKSzVyPUGwJO69VQ>? Ml3UNlM5PDRyM{i=
SK-UT-1 Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrDfVEyOCEQvF2= MYG3NkBp NX2xZ|FtTE2VTx?= M1jZUWlEPTB;MUCg{txO MlniNlM5PDRyM{i=
SN12C NEDhSpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDWNVAh|ryP MorpO|IhcA>? M1zIbmROW09? NYPQbGJMUUN3ME2xNEDPxE1? NHfvcGIzOzh2NECzPC=>
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SNU-16 NUHZUFJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzzcJloOTBizszN NXrtZXZuPzJiaB?= MVzEUXNQ NIrSNoxKSzVyPUGwJO69VQ>? NW\telNSOjN6NESwN|g>
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SNU-449 M3zrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDsNVAh|ryP MVW3NkBp MXfEUXNQ MoDNTWM2OD1zMDFOwG0> M4q2XFI{QDR2MEO4
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ST486 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVWxNEDPxE1? NHTRUmc4OiCq MVzEUXNQ NYS4SnBsUUN3ME2xNEDPxE1? MYCyN|g1PDB|OB?=
SW579 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHSeHAyOCEQvF2= NVHIUnRLPzJiaB?= MnrPSG1UVw>? M17aOGlEPTB;MUCg{txO NXTKVmVLOjN6NESwN|g>
SW684 NVvQV|dLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzFN4wyOCEQvF2= NWqwR|JzPzJiaB?= MVXEUXNQ MlzLTWM2OD1zMDFOwG0> MXqyN|g1PDB|OB?=
SW-780 M3vUVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37oT|ExKM7:TR?= NVHZSXRDPzJiaB?= MmnNSG1UVw>? NH3iVlBKSzVyPUGwJO69VQ>? MlTINlM5PDRyM{i=
SW900 Mk\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH3RZoyOCEQvF2= MoGyO|IhcA>? MorvSG1UVw>? MVnJR|UxRTFyIN88US=> NXrYR3RrOjN6NESwN|g>
SW1088 M1XJfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUWxNEDPxE1? M1PTZlczKGh? NVfrSFVrTE2VTx?= Mn3QTWM2OD1zMDFOwG0> M3rDVVI{QDR2MEO4
SW1463 NV;2fVVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3DNVAh|ryP M4\wNlczKGh? NE\5SJBFVVOR NIHTNZNKSzVyPUGwJO69VQ>? M17kNlI{QDR2MEO4
SW1990 MkDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVqxNEDPxE1? MVy3NkBp M1PKcWROW09? M1X3SWlEPTB;MUCg{txO Mo\VNlM5PDRyM{i=
T47D MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlr3NVAh|ryP M2KyVlczKGh? NG\0eZdFVVOR M1rneWlEPTB;MUCg{txO M3HtcVI{QDR2MEO4
TE381.T MnjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjCNVAh|ryP NX7ZUIJ6PzJiaB?= NHvtbVVFVVOR Mn;XTWM2OD1zMDFOwG0> MUmyN|g1PDB|OB?=
TK-10 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX6xNEDPxE1? Ml7GO|IhcA>? NHvwOIdFVVOR NEPkVmJKSzVyPUGwJO69VQ>? M{XyR|I{QDR2MEO4
U2OS NEHQ[oxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVyxNEDPxE1? MlTYO|IhcA>? NYHzUFRqTE2VTx?= NWr4TWw2UUN3ME2xNEDPxE1? MUOyN|g1PDB|OB?=
U251 M{jv[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTNdHdTOTBizszN NFr5No44OiCq NFjqTlhFVVOR MmnLTWM2OD1zMDFOwG0> NULBcYpYOjN6NESwN|g>
UACC-812 NH;3RYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zIVVExKM7:TR?= MYe3NkBp M17S[mROW09? M2CyfmlEPTB;MUCg{txO MWGyN|g1PDB|OB?=
YAPC NUGxdoZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXuxNEDPxE1? NE\sdHI4OiCq M4LZcmROW09? NUPHdFNLUUN3ME2xNEDPxE1? M3niTlI{QDR2MEO4
ZR-75-1 NYjxfmVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPVe3YyOCEQvF2= MWi3NkBp MY\EUXNQ NELFSGRKSzVyPUGwJO69VQ>? NFvYcpgzOzh2NECzPC=>
A375 MX7GeY5kfGmxbjDhd5NigQ>? MUGxMlIh|ryP Mn;wOEBp M{T5TWROW09? NV;RR49lUW6qaXLpeIlwdiCxZjDwbI9{eGixconsZZRqd25ib3[gUWVMNCCHUlusJIFv\CCVNmC= M4jBXFIzOzh7NEex
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MeWo NGSx[GNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mlu3SG1UVw>? NEPjcFFKSzVyIE2gPVg4KG6P M17RfFI3ODF6NUK0
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Colo-205 Ml64SpVv[3Srb36gZZN{[Xl? NGXxWmUyKM7:TR?= NY\4NI9sPCCm MkTXSG1UVw>? M{ezfmlv\HWlZXSgZUBpcWeqbImgZ49ueGG{YXLs[UBkd22yYXP0bY9vKHCqZX7veJlx\Q>? NVLzNYVsOjV|OEGxOVI>
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LCP NUK0WZJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrnOoFVOTByIH7N NUnNcmRLPzJiaB?= M3;oR2lvcGmkaYTpc44hd2ZicILvcIln\XKjdHnvckBw\iCOQ2CgZ4VtdCCqYYLic5VzcW6pIFLSRWYhXjZyMGKgcZV1[W62YYTpc44> M3T0NFI{OzF5NES2
WM266 NFXpfG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoD4NVAxKG6P M3LicVczKGh? NWfhdpZLUW6qaXLpeIlwdiCxZjDwdo9tcW[ncnH0bY9vKG:oIGfNNlY3KGOnbHygbIFz[m:3cnnu[{BDWkGIIG[2NFFFKG23dHHueIF1cW:w NVLWN5VHOjN|MUe0OFY>
M257 NH[3PGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3KcWsyODBibl2= Mn\sO|IhcA>? MnezSI9meyCwb4SgbY5pcWKrdDDFVmsyNTJicHjvd5Bpd3K7bHH0bY9vKGmwIF2yOVch[2WubDDoZZJjd3W{aX7nJJdqdGRidInw[UBDWkGI M{j0U|I{OzF5NES2
LCP MoTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLPeXAyODBibl2= MXm3NkBp MYDJcohq[mm2IFXST|EuOiCyaH;zdIhwenmuYYTpc44hcW5iTFPQJINmdGxiaHHyZo92emmwZzDCVmFHKFZ4MEDSJI12fGGwdHH0bY9v M2PtU|I{OzF5NES2
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... Click to View More Cell Line Experimental Data

In vivo Dabrafenib (orally administrated) inhibits the growth of B-RafV600E mutant melanoma (A375P) and colon cancer (Colo205) human tumor xenografts, growing subcutaneously in immuno-compromised mice. [1]

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 8 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 519.56
Formula

C23H20F3N5O2S2

CAS No. 1195765-45-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02447939 Not yet recruiting Melanoma GlaxoSmithKline September 2016 Phase 1
NCT02672358 Not yet recruiting Non-Small-Cell Lung Cancer Novartis Pharmaceuticals|Novartis July 2016 Phase 2
NCT02684058 Not yet recruiting Anaplastic Astrocytoma|Glioblastoma|Giant Cell Glioblastoma|Gliosarcoma|Anaplastic Oligodendroglioma|Anaplastic Oligoastrocytoma|Anaplastic Ependymoma|Choroid Plexus Carcinoma|Anaplastic Ganglioglioma|Pineal Parenchymal Tumor|Pineoblastoma|Medulloblastoma|PNET|Rhabdoid Tumor|Perineurioma|MPNST|Malignant Meningloma|Anaplastic Hemangiopericytoma Novartis Pharmaceuticals|Novartis May 2016 Phase 2
NCT02700763 Not yet recruiting Melanoma University Medical Center Groningen April 2016 Phase 1
NCT02382549 Recruiting Melanoma Craig L Slingluff, Jr|National Cancer Institute (NCI)|University of Virginia April 2016 Phase 1|Phase 2
NCT02196181 Recruiting BRAF V600E Mutation Present|BRAF V600K Mutation Present|Recurrent Melanoma|Stage IIIA Skin Melanoma|Stage IIIB Skin Melanoma|Stage IIIC Skin Melanoma|Stage IV Skin Melanoma National Cancer Institute (NCI) April 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Raf Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID