phosphatase
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S1949 | Menadione | <1 mg/mL | 34 mg/mL | 34 mg/mL |
| S1857 | Etidronate | 41 mg/mL | <1 mg/mL | <1 mg/mL |
| S1514 | Cyclosporine | <1 mg/mL | 100 mg/mL | 100 mg/mL |
| S4007 | Pentamidine isethionate | 100 mg/mL | 100 mg/mL | <1 mg/mL |
| S7437 | Sal003 | <1 mg/mL | 93 mg/mL | <1 mg/mL |
| S8278 | SHP099 dihydrochloride | 77 mg/mL | 2 mg/mL | <1 mg/mL |
| S8182 | NSC87877 | 100 mg/mL | 100 mg/mL | <1 mg/mL |
| S4013 | Sodium Monofluorophosphate | 29 mg/mL | <1 mg/mL | <1 mg/mL |
| S7485 | CCT007093 | <1 mg/mL | 1 mg/mL | <1 mg/mL |
| S7537 | LB-100 | 53 mg/mL | <1 mg/mL | <1 mg/mL |
| S7383 | (-)-p-Bromotetramisole Oxalate | 30 mg/mL | 74 mg/mL | <1 mg/mL |
| S7573 | GSK2830371 | <1 mg/mL | 92 mg/mL | 92 mg/mL |
- phosphatase Inhibitors (12)
- New phosphatase Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1949 |
MenadioneMenadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
||
| S1857 |
EtidronateEtidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification. |
||
| S1514 |
CyclosporineCyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. |
||
| S4007 |
Pentamidine isethionatePentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein. |
||
| S7437 |
Sal003Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. |
||
| S8278New |
SHP099 dihydrochlorideSHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1. |
||
| S8182New |
NSC87877NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. |
||
| S4013 |
Sodium MonofluorophosphateSodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM. |
||
| S7485 |
CCT007093CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. |
(A-B)Twenty-four hours after plating 1×105 shh-EGFP cells, media was changed to serum-free media containing vehicle (Vh), DMSO, CCT007093 (CCT, 5µM), and/or Shh (3µg/mL). Cells were also transduced with LentiORF-RFP-CTRL or LentiORF-YFP-WIP1 lentivirus. 48 hours later, cells were fixed in 4% paraformaldehyde, permeabilized, incubated with α-WIP1 or α-Ki-67 antibody, and mounted using media containing DAPI (left-hand panels). Quantification of cells, per high power field (HPF), that express green fluorescent protein (GFP) or Ki-67 (right-hand panels). Bars, mean of cell counts from 10 representative fields for each experimental condition.
|
|
| S7537 |
LB-100LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. |
||
| S7383 |
(-)-p-Bromotetramisole Oxalate(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor. |
||
| S7573 |
GSK2830371GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1949 |
MenadioneMenadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
||
| S1857 |
EtidronateEtidronate is a non-aminobisphosphonate, show protein tyrosine phosphatase (PTP) inhibitory activity, used for the treatment of Paget's disease and the prevention of heterotopic ossification. |
||
| S1514 |
CyclosporineCyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. |
||
| S4007 |
Pentamidine isethionatePentamidine is an inhibitor of PRL Phosphatases and also inhibits synthesis of DNA, RNA and protein. |
||
| S7437 |
Sal003Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. |
||
| S8278New |
SHP099 dihydrochlorideSHP099 is a highly potent, selective and orally bioavailable small-molecule SHP2 inhibitor with an IC50 value of 0.071 μM and shows no activity against SHP1. |
||
| S8182New |
NSC87877NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. |
||
| S4013 |
Sodium MonofluorophosphateSodium Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM. |
||
| S7485 |
CCT007093CCT007093 is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM. |
(A-B)Twenty-four hours after plating 1×105 shh-EGFP cells, media was changed to serum-free media containing vehicle (Vh), DMSO, CCT007093 (CCT, 5µM), and/or Shh (3µg/mL). Cells were also transduced with LentiORF-RFP-CTRL or LentiORF-YFP-WIP1 lentivirus. 48 hours later, cells were fixed in 4% paraformaldehyde, permeabilized, incubated with α-WIP1 or α-Ki-67 antibody, and mounted using media containing DAPI (left-hand panels). Quantification of cells, per high power field (HPF), that express green fluorescent protein (GFP) or Ki-67 (right-hand panels). Bars, mean of cell counts from 10 representative fields for each experimental condition.
|
|
| S7537 |
LB-100LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. |
||
| S7383 |
(-)-p-Bromotetramisole Oxalate(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor. |
||
| S7573 |
GSK2830371GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM. |
