Catalog No.S1786 Synonyms: CL 318952

Verteporfin  Chemical Structure

Molecular Weight(MW): 718.79

Verteporfin is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin.

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  • Verteporfin treatment inhibits proliferation and induces apoptosis of Tsc1-null cells in vivo. Mice were administered i.p. with vehicle or verteporfin at a dose of 100 mg/kg every other day for 10 d before sacrifice. Mice were sacrificed at 6 wk of age. Three independent experiments were performed and mice in different treatments were pooled for analysis. Percentage of Ki67 and αSMA double-positive cells in α-SMA+ mesenchymal lesions in the indicated kidneys. Immunofluorescence staining and counting were performed on three sagittal sections from different kidney regions for each mouse.

    J Exp Med 2014 211(11), 2249-63. Verteporfin purchased from Selleck.

    The indicated cell lines were treated with control (Ctrl) or YAP-targeting siRNAs and growth assessed by XTT proliferation assays at the indicated time points. The mean and +SD are shown for three independent experiments. (Left panel, *, P < 0.05, significantly different from U87Rictor DMSO; Right panel, *, P < 0.05, significantly different from H4Rictor DMSO).

    J Biol Chem, 2015, 290(32): 19387-401 . Verteporfin purchased from Selleck.

  • The levels of YAP, phospho-YAP (S127), and its downstream targeted molecules CTGF and CYR61 were analyzed by Western blotting after UM cells were exposed to verteporfin for 24 hours.

    Am J Cancer Res, 2016, 6(12):2816-2830.. Verteporfin purchased from Selleck.

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Biological Activity

Description Verteporfin is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin.
VDA [1]
(Endothelial cells)
YAP/TEAD interaction [3]
In vitro

Verteporfin is about four times more efficient in absorbing light at wavelengths that penetrate tissues best (i.e., around 700 nm) and thus provides a much higher cytotoxic effect than hematoporphyrin (10 times more in human adherent cell lines). Verteporfin is lipophilic and is more readily taken up by malignant or activated cells, compared with normal or resting cells. Verteporfin binds with LDL to form a complex, which is then taken up into proliferating cells (e.g., neovascular endothelial cells) probably via LDL receptors and endocytosis. Verteporfin therapy achieves complete angiographic occlusion of the neovascular compartment by thrombosis of vascular channels, following selective endothelial damage. Verteporfin therapy selectively induces reproducible and isolated choriocapillary occlusion without alteration of overlying photoreceptors or ganglion cells, as shown by light and electron microscopy. [1] Verteporfin conbined with light rapidly exhibits apoptotic changes reflected by caspase-3 and caspase-9 activation and PARP cleavage in HL-60 cells, changes that are blocked by the general caspase inhibitor ZVAD.fmk. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HL-60 M{nDc2Z2dmO2aX;uJIF{e2G7 MmjPglExOCCwZz;tUC=> NXfRUXZPTE2VTx?= M2XX[Ilv[3KnYYPld{BFVkFiZoLh[41mdnSjdHnvckBt\X[nbIO= NV;6NHJ2OTB4MEe3NVA>
HL-60 MYHjfZRwfG:6aXPpeJkh[XO|YYm= M2fDbp4yODBibnevcWw> NUXkVpNDTE2VTx?= MUPpcohq[mm2czDj[YxtKH[rYXLpcIl1gQ>? NG\xTGoyODZyN{exNC=>
Jurkat MnvYRZBweHSxc3nzJIF{e2G7 NYr2WnJVhjJ6MDDuUS=> MYfEUXNQ Ml7RbY5lfWOnczDhJGJkdC1{LXTldIVv\GWwdDDhdI9xfG:|aYO= M1jFdVEyOjR3NEG1
RIF-1 NVvjSZA6TnWwY4Tpc44h[XO|YYm= NWLKO5JEOSEQvHevcYw> M1W5U2ROW09? MoCy[IVkemWjc3XzJI95gWenbjDjc45{fW2ydHnvci=> M4Cye|EzPjF3N{G4
RIF-1 M{fs[oN6fG:2b4jpZ4l1gSCjc4PhfS=> Mk\rNUDPxGdxbXy= NGS0fJhFVVOR NYDt[nJE\GWlcnXhd4UhfG9iMkCgxtEhPSViY3XscEB{fXK4aY\hcC=> NYT3TYRYOTJ4MUW3NVg>
SVEC4-10 MWjGeY5kfGmxbjDhd5NigQ>? M{jPW|IxOCCwZz;tcC=> NXfkT5Z[TE2VTx?= MXXpcoR2[2W|IH3pZ5JwfHWkdXzlJIRmeG:ueX3ldol7[XSrb36= NHvaSZUyPjR4N{GwOi=>
SVEC4-10 MmTnSpVv[3Srb36gZZN{[Xl? M2ixdFIxOCCwZz;tcC=> NH7xTndFVVOR M2\VTIlv\HWlZYOgd5Rz\XO|IHHjeIlvKG[rYnXyJIZwem2jdHnvci=> M4O4fVE3PDZ5MUC2
ARPE-19 M4HEeYN6fG:2b4jpZ4l1gSCjc4PhfS=> NUHlbIpnhjBwMTFOwIcwdWx? MWLEUXNQ NFHXZm5{cG:5czDhJIRwe2VvZHXw[Y5l\W62IITvfIlkcXS7 MUixOlk5PzlyNR?=
ARPE-19 Mo[0SpVv[3Srb36gZZN{[Xl? MWewMlAyKM7:Zz;tcC=> NXXqRW1zTE2VTx?= NVnI[HB3cW6lcnXhd4V{KF[HR1[gZY5lKHKnZIXj[ZMhWEWGRjDlfJBz\XO|aX;u NULlR5pXOTZ7OEe5NFU>
Y-79 NHraS2ZIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MoH4glEh|rypL33s M3TPdWROW09? NH3lVIhl\WO{ZXHz[ZMhemW2aX7vZoxie3SxbXGgZ4VtdCCycn;sbYZmemG2aX;u MWGxPFU4QTd4NB?=
WERI-Rb1 NU\kdmFXT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M{fTRp4yKM7:Zz;tcC=> MYjEUXNQ MVLk[YNz\WG|ZYOgdoV1cW6xYnzhd5RwdWFiY3XscEBxem:uaX\ldoF1cW:w MWGxPFU4QTd4NB?=
RB247C3 NIq5fI1Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NX;qZmV2hjFizsznM41t NImzZ4NFVVOR NUi3XmpC\GWlcnXhd4V{KHKndHnuc4Jt[XO2b33hJINmdGxicILvcIln\XKjdHnvci=> MlPCNVg2Pzl5NkS=
RB355 NIXqXVBIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M3;nRp4yKM7:Zz;tcC=> NX32RZpHTE2VTx?= Ml[y[IVkemWjc3XzJJJmfGmwb3LsZZN1d22jIHPlcIwheHKxbHnm[ZJifGmxbh?= Mmn2NVg2Pzl5NkS=
RB383 NUfz[VVuT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M4e5NZ4yKM7:Zz;tcC=> NV7RN4UxTE2VTx?= NGLkO|Rl\WO{ZXHz[ZMhemW2aX7vZoxie3SxbXGgZ4VtdCCycn;sbYZmemG2aX;u Mn;JNVg2Pzl5NkS=
hFibro M4ixeYN6fG:2b4jpZ4l1gSCjc4PhfS=> MorLNE42KML3Zz;tcC=> NF7wRXZFVVOR M{fnSYRm[3KnYYPld{B3cWGkaXzpeJkh[nliOE[sOUU> NFH1epIzOzR2MUGxOC=>
pTMC MkXwZ5l1d3SxeHnjbZR6KGG|c3H5 NHTO[Y8xNjViwsXnM41t NIjlO2hFVVOR M2n3bYRm[3KnYYPld{B3cWGkaXzpeJkh[nliOUKuPUU> MkLXNlM1PDFzMUS=
hTMC M2XkXIN6fG:2b4jpZ4l1gSCjc4PhfS=> M{TWR|AvPSEEtXevcYw> MWLEUXNQ M{nzSIRm[3KnYYPld{B3cWGkaXzpeJkh[nliOEiuPUU> M1PrXlI{PDRzMUG0
ARPE-19 Mk\rZ5l1d3SxeHnjbZR6KGG|c3H5 NI[zdWkxNjViwsXnM41t NFPJWJZFVVOR MVXk[YNz\WG|ZYOgeoli[mmuaYT5JIJ6KDV3LkWl MoO0NlM1PDFzMUS=
Panc-1 M3[0TGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NV;BRW55OTBizszN MVjEUXNQ NGjsb5ZqdmirYnn0d{Bk\WyuIIDyc4xq\mW{YYTpc44> MoPFNlQxPjlyNkm=
MIA PaCa-2 NELafm9Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NXHZTlJTOTBizszN MkHaSG1UVw>? NH;IVI9qdmirYnn0d{Bk\WyuIIDyc4xq\mW{YYTpc44> NV;aRotiOjRyNkmwOlk>
BxPC-3 NEe5b25Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NXPhPJJ3OTBizszN NW\TR2dYTE2VTx?= MUXpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gZ49ueGyndHXsfS=> MnX0NlQxPjlyNkm=
SU86.86 NGnlVotIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M2DF[|ExKM7:TR?= NU\O[YtTTE2VTx?= NFeycnJqdmirYnn0d{Bk\WyuIIDyc4xq\mW{YYTpc44h[2:vcHzleIVtgQ>? NEjUPXIzPDB4OUC2PS=>
MCF-7 NXf5eJJlSXW2b4DoZYd6KGG|c3H5 M3fLN|ExKM7:TR?= MY\EUXNQ MnjSbY5pcWKrdIOg[4Vu[2m2YXLpcoUucW6mdXPl[EBifXSxcHjh[5k> MkPzNlQxPjlyNkm=
WERI MUjHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NIS4eWt,OTBizsznM41t M3HHdGROW09? MUfpcohq[mm2czDndo94fGhib3[gdoV1cW6xYnzhd5RwdWFiY3XscJM> MlfjNlQ5OzdzNEK=
WERI M{DQXWZ2dmO2aX;uJIF{e2G7 NGPUdGZ,OTBizsznM41t MVXEUXNQ NGHh[m5jdG:la4OgZ4VtdCCleXPs[UBxem:pcnXzd4lwdg>? NYj4e5RnOjR6M{exOFI>
Y-79 NVz6[XZWTnWwY4Tpc44h[XO|YYm= M1PPZp4yOCEQvHevcYw> M1jEd2ROW09? NITlcGRjdG:la4OgZ4VtdCCleXPs[UBxem:pcnXzd4lwdg>? NH7sZoozPDh|N{G0Ni=>
Y-79 NI\GNoJHfW6ldHnvckBie3OjeR?= NFTzOYh,OTBizsznM41t MmrzSG1UVw>? NH3JRpRi\m[nY4TzJHlCWC2WRVHEJJBzd3SxLX;uZ49o\W6nIIDheIh4[Xl? MkWxNlQ5OzdzNEK=
Y-79 MmLjSpVv[3Srb36gZZN{[Xl? M2riU54yOCEQvHevcYw> MojZSG1UVw>? NG[4XJBld3ewLYLl[5Vt[XSnczDwcJVzcXCxdHXuZ5khdWG{a3XyJG9EXC12 MlLmNlQ5OzdzNEK=

... Click to View More Cell Line Experimental Data

In vivo Verteporfin can be used for angiographic visualization of choroidal vessels and CNV, which demonstrates that the photosensitizer accumulates rapidly in experimental CNV in monkeys. Verteporfin accumulates rapidly in the established vasculature of the choroid, RPE, and photoreceptors of rabbit eyes. Verteporfin reaches maximal tissue levels within 3 hours of intravenous injection, followed by a rapid decline within 24 hours in mice. Verteporfin is metabolized to a less active form in vivo and is cleared very rapidly, predominantly in the feces and a very small proportion excreted in urine. Verteporfin therapy effectively and selectively prevents fluorescein dye leakage from experimentally induced CNV in monkeys. [1]


Solubility (25°C)

In vitro DMSO 100 mg/mL (139.12 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 718.79


CAS No. 129497-78-5
Storage powder
in solvent
Synonyms CL 318952

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01846273 Active, not recruiting Age-related Macular Degeneration; Polypoidal Choroidal Vasculopathy (PCV) Novartis Pharmaceuticals|Novartis August 7, 2013 Phase 4
NCT03033225 Active, not recruiting Pancreatic Cancer Non-Resectable Mayo Clinic January 2017 Phase 2
NCT02939274 Recruiting Metastatic Breast Cancer Rogers Sciences Inc. October 2016 Phase 2
NCT02702700 Recruiting Pleural Effusion, Malignant Centre Hospitalier Universitaire Vaudois January 2016 Phase 1
NCT02495181 Recruiting Polypoidal Choroidal Vasculopathy Association for Innovation and Biomedical Research on Light and Image|European Vision Institute Clinical Research Network January 2016 Phase 4
NCT02457026 Withdrawn Neovascular Age-related Macular Degeneration Duke University|Bausch & Lomb Incorporated January 2016 --

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID