VDA

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VDA Chemicals (3)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1537 DMXAA (Vadimezan) DMXAA (Vadimezan) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. Phase 3.
S1786 Verteporfin Verteporfin is a potent second-generation photosensitizing agent derived from porphyrin in endothelial cells.
  • J Exp Med, 2014, 211(11):2249-63
  • J Clin Endocrinol Metab, 2016, 10.1210/jc.2016-1120
  • J Biol Chem, 2015, 290(32):19387-401
S1176 Plinabulin (NPI-2358) Plinabulin (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 of 9.8~18 nM in tumor cells. Phase 1/2.
  • Curr Protoc Chem Biol, 2013, 5(3):195-212

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1537 DMXAA (Vadimezan) <1 mg/mL 7 mg/mL <1 mg/mL
S1786 Verteporfin <1 mg/mL 100 mg/mL <1 mg/mL
S1176 Plinabulin (NPI-2358) <1 mg/mL 54 mg/mL <1 mg/mL
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