Vecuronium Bromide

Synonyms: ORG NC45

Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.

Vecuronium Bromide Chemical Structure

Vecuronium Bromide Chemical Structure

CAS: 50700-72-6

Purity & Quality Control

Batch: Purity: 99.35%
99.35

Vecuronium Bromide Related Products

Signaling Pathway

Choose Selective AChR Inhibitors

Biological Activity

Description Vecuronium Bromide (ORG NC45) is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.
In vitro
In vitro Vecuronium inhibits both forms of the muscle-type acetylcholine receptor with IC50 of 1-2 nM. Vecuronium combined with methylprednisolone shows additive effects on both receptor forms, which is best described by a two-site model, with each site independent. [1] Vecuronium interferes with nicotinic processes in the carotid body and inhibits the chemoreceptor neural response to hypoxia. Vecuronium significantly attenuates the increase in CSNA (DeltaCSNA) in response to hypoxia in the carotid body. [2]
In Vivo
In vivo Vecuronium (a monoquaternary ammonium compound) has a higher biliary clearance than pancuronium (a bisquaternary ammonium compound) in the rats. [3]

Chemical Information & Solubility

Molecular Weight 637.73 Formula

C34H57N2O4.Br

CAS No. 50700-72-6 SDF Download Vecuronium Bromide SDF
Smiles CC(=O)OC1CC2CCC3C(C2(CC1N4CCCCC4)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (156.8 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : 21 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Vecuronium Bromide | Vecuronium Bromide ic50 | Vecuronium Bromide price | Vecuronium Bromide cost | Vecuronium Bromide solubility dmso | Vecuronium Bromide purchase | Vecuronium Bromide manufacturer | Vecuronium Bromide research buy | Vecuronium Bromide order | Vecuronium Bromide mouse | Vecuronium Bromide chemical structure | Vecuronium Bromide mw | Vecuronium Bromide molecular weight | Vecuronium Bromide datasheet | Vecuronium Bromide supplier | Vecuronium Bromide in vitro | Vecuronium Bromide cell line | Vecuronium Bromide concentration | Vecuronium Bromide nmr