Catalog No.S1438 Synonyms: MCN 4853, RWJ 17021

Topiramate Chemical Structure

Molecular Weight(MW): 339.36

Topiramate is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.

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In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Topiramate is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.
sodium channel [1] Calcium Channel [1] AMPA/kainate receptor [2] Carbonic anhydrase [1]
In vitro

Topiramate slightly inhibits the persistent fraction of Na+ current in dissociated neurons and reduces the Na+-dependent long-lasting action potential shoulders, which can be evoked in layer V pyramidal neurons after Ca+ and K+ current blockade in neocortical slices. [1] Topiramate at low concentrations (IC50, approximately 0.5 mM) selectively inhibits pharmacologically isolated excitatory synaptic currents mediated by kainate receptors containing the GluR5 subunit in whole-cell voltage-clamp recordings from principal neurons of the rat basolateral amygdala. Topiramate also partially depresses predominantly AMPA-receptor-mediated EPSCs, but with lower efficacy. [2] Topiramate (TPM) suppresses voltage-sensitive Na+ channels and non-N-methyl-D-aspartate (NMDA) receptors and enhances gamma-aminobutyric acid (GABA)-mediated inhibition. [3] Topiramate selectively inhibits postsynaptic responses mediated by GluR5 kainate receptors. [4]

In vivo Topiramate (25-100 mg/kg, i.p.) produces a dose-dependent elevation in the threshold for clonic seizures induced by infusion of ATPA, a selective agonist of GluR5 kainate receptors. [4] Topiramate effectively suppresses acute seizures induced by perinatalhypoxia in a dose-related manner with a calculated ED50 of 2.1 mg/kg, i.p. [5] Topiramate (20 and 40 mg/kg i.p.) inhibits both tonic and absence-like seizures in a dose-dependent manner, whereas Phenytoin (20 mg/kg i.p.) and Zonisamide (40 mg/kg i.p.) inhibits only the tonic seizures. Topiramate inhibits sound-induced seizures in DBA/2 mice (ED50 = 8.6 mg/kg p.o.). [6]


Solubility (25°C)

In vitro DMSO 68 mg/mL (200.37 mM)
Ethanol 68 mg/mL (200.37 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 339.36


CAS No. 97240-79-4
Storage powder
in solvent
Synonyms MCN 4853, RWJ 17021

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02878798 Not yet recruiting Cryptogenic Sensory Peripheral Neuropathy University of Utah|National Institute of Neurological Disorders and Stroke (NINDS)|NeuroNEXT Network June 2017 Phase 2
NCT03018704 Not yet recruiting Alcohol Use Disorder VA Office of Research and Development March 2017 Phase 4
NCT02945839 Not yet recruiting Migraine New York University School of Medicine December 2016 --
NCT02273804 Recruiting Obese Children and Adolescents Assistance Publique - Hôpitaux de Paris June 2016 Phase 3
NCT02808533 Recruiting Schizophrenia, Schizoaffective Disorder Centre for Addiction and Mental Health|Ontario Ministry of Health and Long Term Care April 2016 --
NCT02635386 Recruiting Polycystic Ovary Syndrome|Obesity Womans|AstraZeneca March 2016 Phase 3

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Carbonic Anhydrase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID