Carbonic Anhydrase

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S1375

Dorzolamide HCl

Dorzolamide HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.

S1438

Topiramate

Topiramate is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.

S2866

U-104

U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.

S2603

Tioxolone

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.

S1736

Methocarbamol

Methocarbamol is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.

S4725New

Benzenesulfonamide

Benzenesulfonamide ia an inhibitor of carbonic anhydrases.

S4506New

Acetazolamide

Acetazolamide, a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).

S2177

Dichlorphenamide

Dichlorphenamide is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.

S3178

Brinzolamide

Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.

S4039

Methazolamide

Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.

Catalog No. Information Product Use Citations Product Validations
S1375

Dorzolamide HCl

Dorzolamide HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.

S1438

Topiramate

Topiramate is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.

S2866

U-104

U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II.

S2603

Tioxolone

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.

S1736

Methocarbamol

Methocarbamol is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.

S4725New

Benzenesulfonamide

Benzenesulfonamide ia an inhibitor of carbonic anhydrases.

S4506New

Acetazolamide

Acetazolamide, a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).

S2177

Dichlorphenamide

Dichlorphenamide is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class.

S3178

Brinzolamide

Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.

S4039

Methazolamide

Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.