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Telaprevir (VX-950) Chemical Structure
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Biological Activity
Telaprevir (VX-950) is an investigational oral hepatitis C virus (HCV) protease inhibitor with an IC50 of < 0.2 µM. It is an experimental treatment for hepatitis C. Specifically, it inhibits the hepatitis C virus NS3.4A serine protease. [1][2]
Chemical Information
| Molecular Weight (WM): | 679.85 |
|---|---|
| Formula: | C36H53N7O6 |
| CAS No.: | 402957-28-2 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥136mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
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The toxicity of BMS-790052 (BMS) and Telaprevir (TPV) was measured by seeding 96-well plates to 70% confluence and exposing the cells to up to 50 M of compound for 72 hours. MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] was added to each well at a final concentration of 500 μg/ml 4 h before dissolving crystals in 100 μl of DMSO and measuring at 550 nm UV wavelengths. The 50% cytotoxic concentration (CC50) was then calculation using the OD550 value and the following formula: log CC50=log concentration of HPP–[(HPP–50)/(HPP–LPP)×log d HPP: highest protective percentage closest to 50% LPP: Lowest protective percentage closest to 50% d: dilution factor
The toxicity of BMS-790052 (BMS) and Telaprevir (TPV) was measured by seeding 96-well plates to 70% confluence and exposing the cells to up to 50 M of compound for 72 hours. MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] was added to each well at a final concentration of 500 μg/ml 4 h before dissolving crystals in 100 μl of DMSO and measuring at 550 nm UV wavelengths. The 50% cytotoxic concentration (CC50) was then calculation using the OD550 value and the following formula: log CC50=log concentration of HPP–[(HPP–50)/(HPP–LPP)×log d HPP: highest protective percentage closest to 50% LPP: Lowest protective percentage closest to 50% d: dilution factor
Data independently produced by Dr Julie Sheldon,Dr Esteban Domingo and Dr Celia Perales---Telaprevir (VX-950) purchased from Selleck Telaprevir (VX-950) purchased from Selleck
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The toxicity of BMS-790052 (BMS) and Telaprevir (TPV) was measured by seeding 96-well plates to 70% confluence and exposing the cells to up to 50 M of compound for 72 hours. MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] was added to each well at a final concentration of 500 μg/ml 4 h before dissolving crystals in 100 μl of DMSO and measuring at 550 nm UV wavelengths. The 50% cytotoxic concentration (CC50) was then calculation using the OD550 value and the following formula: log CC50=log concentration of HPP–[(HPP–50)/(HPP–LPP)×log d HPP: highest protective percentage closest to 50% LPP: Lowest protective percentage closest to 50% d: dilution factor |
Data independently produced by Dr Julie Sheldon,Dr Esteban Domingo and Dr Celia Perales---Telaprevir (VX-950) purchased from Selleck
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