Catalog No.S1691 1 Product Use Citation

Praziquantel is an anthelmintic effective against flatworms.

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In DMSO USD 130 In stock
USD 97 In stock
USD 970 In stock
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Praziquantel Chemical Structure

Praziquantel Chemical Structure
Molecular Weight: 312.41

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Praziquantel is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Praziquantel(Biltricide, Droncit) is an anthelmintic effective against flatworms. It increases the permeability of the membranes of schistosome cells towards calcium ions. The drug, thereby induces contraction of the parasites, resulting in paralysis in the contracted state. The dying parasites are dislodged from their site of action in the host organism and may enter systemic circulation or may be destroyed by host immune reaction (phagocytosis). Additional mechanisms including focal disintegrations and disturbances of oviposition (laying of eggs) are seen in other types of sensitive parasites. [1]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.
Body Surface Area (m2)
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from, updated on 2015-04-11)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT02144389 Completed Schistosomiasis|Bilharzia DSM Nutritional Products, Inc.|National Liver Institute,  ...more DSM Nutritional Products, Inc.|National Liver Institute, Egypt|Cairo University|High Institute of Public Health, Egypt January 2013 --
NCT01901484 Completed Intestinal Schistosomiasis Makerere University|University of Copenhagen December 2012 Phase 2
NCT01722539 Completed Healthy Universiteit Antwerpen|Fund for Scientific Research, Flan  ...more Universiteit Antwerpen|Fund for Scientific Research, Flanders, Belgium|University of Kinshasa November 2012 Phase 3
NCT01541631 Not yet recruiting Anemia|Intestinal Helminthiasis|Intestinal Schistosomiasis|Human Immunodeficiency Virus I Infection|Hematologic Diseases|Opportunistic Infections Catholic University of Health and Allied Sciences|Nationa  ...more Catholic University of Health and Allied Sciences|National Institute for Medical Research, Tanzania|University of Cambridge May 2012 --
NCT01288872 Completed Schistosomiasis [Bilharziasis] National Institute of Allergy and Infectious Diseases (NI  ...more National Institute of Allergy and Infectious Diseases (NIAID) January 2012 Phase 1

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Chemical Information

Download Praziquantel SDF
Molecular Weight (MW) 312.41


CAS No. 55268-74-1
Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Solubility (25°C) * In vitro DMSO 63 mg/mL (201.65 mM)
Water <1 mg/mL (<1 mM)
Ethanol 63 mg/mL (201.65 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 2-​(cyclohexylcarbonyl)​-​1,​2,​3,​6,​7,​11b-​hexahydro-4H-​pyrazino[2,​1-​a]​isoquinolin-​4-​one

Research Area

Product Use Citation (1)

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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