Praziquantel

Catalog No.S1691

Praziquantel is an anthelmintic effective against flatworms.

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Praziquantel Chemical Structure

Praziquantel Chemical Structure
Molecular Weight: 312.41

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Praziquantel is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Description Praziquantel is an anthelmintic effective against flatworms.
In vitro
In vivo
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-23)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02806232 Not yet recruiting Schistosomiasis Merck KGaA June 2016 Phase 2
NCT02734186 Recruiting Schistosomiasis National Institute of Allergy and Infectious Diseases (NI  ...more National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) March 2016 Phase 4
NCT02612896 Recruiting Tenia Solium Infection Institute of Tropical Medicine, Belgium|University of Zam  ...more Institute of Tropical Medicine, Belgium|University of Zambia|Ministry of Health, Zambia|Université Catholique de Louvain|University Ghent March 2016 --
NCT02144389 Completed Schistosomiasis|Bilharzia DSM Nutritional Products, Inc.|National Liver Institute,  ...more DSM Nutritional Products, Inc.|National Liver Institute, Egypt|Cairo University|High Institute of Public Health, Egypt January 2013 --
NCT01901484 Completed Intestinal Schistosomiasis Makerere University|University of Copenhagen December 2012 Phase 2

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Chemical Information

Download Praziquantel SDF
Molecular Weight (MW) 312.41
Formula

C19H24N2O2

CAS No. 55268-74-1
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 63 mg/mL (201.65 mM)
Ethanol 63 mg/mL (201.65 mM)
Water <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 2-​(cyclohexylcarbonyl)​-​1,​2,​3,​6,​7,​11b-​hexahydro-4H-​pyrazino[2,​1-​a]​isoquinolin-​4-​one

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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