Research Area
Product Type
United States ( Change Country )
PTC124 (Ataluren) Chemical Structure
Recommended Products
[Ala92]-p16 (84-103)
[Ala92]-p16 (84-103) is a CDK inhibitor with IC50 of 1.5μM for cyclin-dependent kinase-4 (cdk4)/cyclin D1
Bax inhibitor peptide,negative control
Bax inhibitor peptide,negative control is a negative control peptide for the Bax inhibitor peptides V5 and P5.
JIP-1(153-163)
JNK and p38 MAPK inhibitor
pp60 c-src (521-533)(phosphorylated)
SRC kinase inhibitor
STF-62247
Targeting VHL-deficient RCC cells, in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 μM).
BTZ043 racemate
BTZ043 racemate is a decaprenylphosphoryl-b-D-ribose 2’-epimerase inhibitor with MIC of 2.3 and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.
GSK690693
GSK690693 is a pan-Akt kinase inhibitor,IC50 of Akt 1, 2, and 3 at 2, 13, and 9 nM respectively.
Odanacatib (MK 0822)
cathepsin K inhibitor with an IC50 of 0.2nM.
Malotilate
Malotilate is a liver protein metabolism improved compound.
PA-824
PA-824 is an experimental anti-tuberculosis drug with MIC of less than 1 μg/mL for tuberculosis.
Biological Activity
PTC124 targets genetic disorders caused by nonsense mutations. [1] PTC124 is an orally bioavailable compound that promotes of the human CFTR-G542X nonsense allele in a CF mouse model. [2] Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective phase II trial. [3]
PTC124 induces dose-dependent suppression of premature translational termination without concomitant effects on normal termination or mRNA decay. [1]
In safety pharmacology studies in rats and dogs, oral administration of PTC124 induces no adverse neurological, pulmonary, or cardiovascular effects at doses through 1500 mg/kg. In toxicology studies in rats and dogs at oral doses through 1500 mg/kg for 28 days, PTC124 has shown good tolerability. [1]
The minimal concentration of PTC124 showing discernable readthrough was 0.01–0.1 mM (2.8–28 ng ml-1), whereas the concentration promoting maximal activity was approximately 3 mM(852 ng ml-1). [1]
Chemical Information
| Molecular Weight (WM): | 284.24 |
|---|---|
| Formula: | C15H9FN2O3 |
| CAS No.: | 775304-57-9 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥57mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Related Inhibitors
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Selleck's high quality products have been used in several published research findings, including the following:
PTC124 improves readthrough and increases enzymatic activity of the CPT1A R160X nonsense mutation.
We have 2 customer reviews of PTC124 (Ataluren).
- (0)
- (2)
- (0)
- (0)
- (0)
- (0)
- (0)
- (0)
- (0)
Average Customer Review
(2 customer reviews)
-
Click to enlarge
Quantitative RT-PCR analysis of CPT1A in normal and patient fibroblasts treated with various concentration of PTC124 (0, 1, 3 and 5 μm) for 72 hours. The relative contents of mRNA were calculated by using the ΔΔCt method. Expression was normalized to human GAPDH and no significant fold difference was observed in the patient mRNA levels after treatment with PTC124. The normal control cells showed approximately 10-fold higher expression than patient cells. Data are presented as mean; Error bar indicates SEM
Quantitative RT-PCR analysis of CPT1A in normal and patient fibroblasts treated with various concentration of PTC124 (0, 1, 3 and 5 μm) for 72 hours. The relative contents of mRNA were calculated by using the ΔΔCt method. Expression was normalized to human GAPDH and no significant fold difference was observed in the patient mRNA levels after treatment with PTC124. The normal control cells showed approximately 10-fold higher expression than patient cells. Data are presented as mean; Error bar indicates SEM
Data independently produced by Dr Lu Tan of Children’s Hospital of Philadelphia PTC124 (Ataluren) purchased from Selleck
- I have used the chemical that I bought from you(Selleck, PTC-124) and it worked well.So we will eventually be ordering more.
R.B.Cambridge
This product has been referenced in
Check our customer reviews
Quantitative RT-PCR analysis of CPT1A in normal and patient fibroblasts treated with various concentration of PTC124 (0, 1, 3 and 5 μm) for 72 hours. The relative contents of mRNA were calculated by using the ΔΔCt method. Expression was normalized to human GAPDH and no significant fold difference was observed in the patient mRNA levels after treatment with PTC124. The normal control cells showed approximately 10-fold higher expression than patient cells. Data are presented as mean; Error bar indicates SEM |
Data independently produced by Dr Lu Tan of Children’s Hospital of Philadelphia
We give free samples and rewards to people who would like to provide us useful scientific data(western blot, etc.) > See Details
Recently Viewed Items
Keywords:buy PTC124 (Ataluren) | PTC124 (Ataluren) supplier | purchase PTC124 (Ataluren) | PTC124 (Ataluren) cost | PTC124 (Ataluren) manufacturer | order PTC124 (Ataluren) | PTC124 (Ataluren) distributor