Tezacaftor (VX-661)

Catalog No.S7059

Tezacaftor (VX-661) Chemical Structure

Molecular Weight(MW): 520.5

Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.

Size Price Stock Quantity  
In DMSO USD 560 In stock
USD 270 In stock
USD 970 In stock
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2 Customer Reviews

  • (B)ΔISC response to forskolin observed in VX-661-treated CF HBE cells (*P = 0.0021, VX661 vs. vehicle) was prevented by chronic VX-770 treatment and significantly different from VX-661-treated cells (#P=0.0126, VX661 vs. VX661+VX770). (C) The response to CFTR inh-172 that was observed in VX-661-treated cells (*P = 0.0111, VX661 vs. vehicle) was significantly decreased in VX809+VX770 treated cells (#P = 0.0038, VX661 vs. VX661+VX770). Primary CF HBE cultures (ΔF508/ΔF508) were derived from 3 different patients, and 3-4 replicates were performed per patient.

    Sci Transl Med 2014 6(246), 246ra96. Tezacaftor (VX-661) purchased from Selleck.

    Bar graphs represent maximum percentage change in fluorescence (ΔF) after addition of CFTR agonist, relative to baseline (F0) measurements prior to agonist addition (time = 10 min). Asterisks indicate statistical significance using one-way ANOVA and Tukey’s multiple comparison tests for the three distinct differentiations (*p < 0.05, **p < 0.01, ***p < 0.001).

    NPJ Genom Med. 2017, 2:12. Tezacaftor (VX-661) purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.
Targets
F508del-CFTR [1]
(Cell-free assay)
In vitro

VX-661, known as a CTFR corrector, allows F508del mutant channels to escape degradation and transit to the cell membrane.

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (192.12 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 520.5
Formula

C26H27F3N2O6

CAS No. 1152311-62-0
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02953314 Recruiting Cystic Fibrosis Vertex Pharmaceuticals Incorporated October 2016 Phase 3
NCT02730208 Recruiting Cystic Fibrosis Vertex Pharmaceuticals Incorporated September 2016 Phase 2
NCT02508207 Recruiting Cystic Fibrosis Vertex Pharmaceuticals Incorporated February 2016 Phase 2
NCT02565914 Enrolling by invitation Cystic Fibrosis Vertex Pharmaceuticals Incorporated August 2015 Phase 3
NCT02516410 Completed Cystic Fibrosis Vertex Pharmaceuticals Incorporated August 2015 Phase 3
NCT02412111 Recruiting Cystic Fibrosis Vertex Pharmaceuticals Incorporated June 2015 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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CFTR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID