VX-661

Catalog No.S7059

VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.

Price Stock Quantity  
In DMSO USD 560 In stock
USD 270 In stock
USD 970 In stock
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VX-661 Chemical Structure

VX-661 Chemical Structure
Molecular Weight: 520.5

Validation & Quality Control

Quality Control & MSDS

Product Information

  • Compare CFTR Chemicals
    Compare CFTR Chemicals
  • Research Area
  • Combination Therapy
    Combination Therapy

Product Description

Biological Activity

Description VX-661 is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.
Targets F508del CFTR
IC50
In vitro VX-661, known as a CTFR corrector, allows F508del mutant channels to escape degradation and transit to the cell membrane.
In vivo
Features

Protocol(Only for Reference)

1

References

Clinical Trial Information( data from http://clinicaltrials.gov)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT01531673 Recruiting Cystic Fibrosis Vertex Pharmaceuticals Incorporated 2012-02 Phase 2

Chemical Information

Molecular Weight (MW) 520.5
Formula

C26H27F3N2O6

CAS No. 1152311-62-0
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Syonnyms N/A
Solubility (25°C) * In vitro DMSO 100 mg/mL (192 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-

Preparing Stock Solutions

Stock Solution (1ml DMSO) 1mM 10mM 20mM 30mM
Mass(mg) 0.5205 5.205 10.41 15.615

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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