Nafamostat Mesylate

Catalog No.S1386

Nafamostat Mesylate is an anticoagulant.

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In DMSO USD 130 In stock
USD 97 In stock
USD 310 In stock
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Nafamostat Mesylate Chemical Structure

Nafamostat Mesylate Chemical Structure
Molecular Weight: 539.58

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Nafamostat Mesylate is available in the following compound libraries:

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Product Description

Biological Activity

Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. [1]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Chemical Information

Download Nafamostat Mesylate SDF
Molecular Weight (MW) 539.58
Formula

C19H17N5O2.2CH4O3S

CAS No. 82956-11-4
Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms FUT-175
Solubility (25°C) * In vitro DMSO 20 mg/mL (37.06 mM)
Water 53 mg/mL (98.22 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 6-carbamimidoylnaphthalen-2-yl 4-guanidinobenzoate dimethanesulfonate

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