Nafamostat Mesylate

Catalog No.S1386

Nafamostat Mesylate is an anticoagulant.

Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
USD 310 In stock
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Nafamostat Mesylate Chemical Structure

Nafamostat Mesylate Chemical Structure
Molecular Weight: 539.58

Validation & Quality Control

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Related Compound Libraries

Nafamostat Mesylate is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. [1]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Chemical Information

Download Nafamostat Mesylate SDF
Molecular Weight (MW) 539.58
Formula

C19H17N5O2.2CH4O3S

CAS No. 82956-11-4
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms FUT-175
Solubility (25°C) * In vitro DMSO 20 mg/mL (37 mM)
Water 53 mg/mL (98 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 6-carbamimidoylnaphthalen-2-yl 4-guanidinobenzoate dimethanesulfonate

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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