UK-371804 HCl

Catalog No.S8457 Synonyms: UK-371804 HCl

UK-371804 HCl Chemical Structure

Molecular Weight(MW): 422.29

UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

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Choose Selective Serine Protease Inhibitors

Biological Activity

Description UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
Targets
uPA [1]
(Cell-free assay)
10 nM(Ki)
In vitro

In Vitro, UK-3718046 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 µM)[1].

In vivo In Vivo, in a porcine acute excisional wound model, following topical delivery, UK-3718046 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters[1].

Protocol

Animal Research:[1]
+ Expand
  • Animal Models: A porcine acute excisional wound model
  • Formulation: hydrogel vehicle
  • Dosages: 10 mg/mL
  • Administration: topical delivery
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 30 mg/mL warmed (71.04 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 422.29
Formula

C14H16ClN5O4S.HCl

CAS No. 256476-36-5
Storage powder
Synonyms UK-371804 HCl

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID