Moxifloxacin HCl

Catalog No.S1465 1 Product Citations

Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.

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In DMSO USD 160 In stock
USD 97 In stock
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Moxifloxacin HCl Chemical Structure

Moxifloxacin HCl Chemical Structure
Molecular Weight: 437.89

Validation & Quality Control

Quality Control & MSDS

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Product Description

Biological Activity

Description Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
Targets Topoisomerase II Topoisomerase IV
IC50 [1]() [1]()
In vitro Moxifloxacin exerts its effects by trapping a DNA drug enzyme complex and specifically inhibiting ATP-dependent enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. Moxifloxacin shows in-vitro potency against M. tuberculosis H37Rv with MIC of 0.177 μg/mL. Moxifloxacin has broad Grampositive and Gram-negative activity. Moxifloxacin shows in vitro and clinical efficacy against Staphylococcus aureus, Streptococcus pneumoniae, Str. pyogenes, Haemophilus influenzae, H. parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneumoniae and Mycoplasma pneumoniae. Moxifloxacin has activity against mycobacteria in addition to M. tuberculosis; Moxifloxacin is more active against M. kansasii than M. avium complex: specifically MIC90 for M. avium > M. intracellulare > M. kansasii at 4, 2 and 2 μg/mL, respectively. MIC90 for M. chelonae > M. fortuitum at 16 and 0.5 μg/mL, respectively. [1]
In vivo Moxifloxacin combined with RIF/pyrazinamide (PZA) reduces treatment time by up to 2 months compared to regimens with isoniazid (INH)/RIF/PZA in a mouse model designed to mimic human disease. Similar results with a stable cure are reached after 4 months in mice treated twice weekly with RIF/Moxifloxacin/PZA compared to cure in 6 months when daily treated with RIF/INH/PZA. 100 mg/kg Moxifloxacin in mice gives activity comparable to INH; increased dose in mice to 400 mg/kg Moxifloxacin daily results in spleen CFU counts lower than for INH 25 mg/kg although the differences are not statistically significant. AUC/MIC ratio correlates best with in-vivo efficacy for the fluoroquinolones in a mouse model of tuberculosis. [1]
Features

Protocol(Only for Reference)

1

References

[1] Tuberculosis (Edinb), 2008, 88(2):127-131.

Clinical Trial Information( data from http://clinicaltrials.gov)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02098486 Not yet recruiting Cholangitis Kangbuk Samsung Hospital 2014-04 Phase 2
NCT02119091 Recruiting Cardiac Toxicity Peking University Third Hospital|Haiyan Li|Food and Drug Administration (FDA)|Spaulding Clinical Research LLC|BioClinica, Inc.|Peking University 2014-04 Phase 1
NCT01589497 Not yet recruiting Tuberculosis AIDS Clinical Trials Group|National Institute of Allergy and Infectious Diseases (NIAID) 2014-04 Phase 2
NCT02127593 Not yet recruiting Healthy Janssen Research & Development, LLC 2014-06 Phase 1
NCT01803399 Not yet recruiting Infections, Bacterial GlaxoSmithKline 2014-08 Phase 1

Chemical Information

Download Moxifloxacin HCl SDF
Molecular Weight (MW) 437.89
Formula

C21H24FN3O4.HCl

CAS No. 186826-86-8
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms BAY12-8039 HCl
Solubility (25°C) * In vitro DMSO 88 mg/mL (200 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1-cyclopropyl-6-fluoro-8-methoxy-7-((4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride

Research Area

Product Citations (1)

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