Moxifloxacin HCl

Catalog No.S1465 Synonyms: BAY12-8039 HCl

Moxifloxacin HCl Chemical Structure

Molecular Weight(MW): 437.89

Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.

Size Price Stock Quantity  
In DMSO USD 160 In stock
USD 97 In stock
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Purity & Quality Control

Choose Selective Topoisomerase Inhibitors

Biological Activity

Description Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.
Targets
Topoisomerase II [1] Topoisomerase IV [1]
In vitro

Moxifloxacin exerts its effects by trapping a DNA drug enzyme complex and specifically inhibiting ATP-dependent enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. Moxifloxacin shows in-vitro potency against M. tuberculosis H37Rv with MIC of 0.177 μg/mL. Moxifloxacin has broad Grampositive and Gram-negative activity. Moxifloxacin shows in vitro and clinical efficacy against Staphylococcus aureus, Streptococcus pneumoniae, Str. pyogenes, Haemophilus influenzae, H. parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneumoniae and Mycoplasma pneumoniae. Moxifloxacin has activity against mycobacteria in addition to M. tuberculosis; Moxifloxacin is more active against M. kansasii than M. avium complex: specifically MIC90 for M. avium > M. intracellulare > M. kansasii at 4, 2 and 2 μg/mL, respectively. MIC90 for M. chelonae > M. fortuitum at 16 and 0.5 μg/mL, respectively. [1]

In vivo Moxifloxacin combined with RIF/pyrazinamide (PZA) reduces treatment time by up to 2 months compared to regimens with isoniazid (INH)/RIF/PZA in a mouse model designed to mimic human disease. Similar results with a stable cure are reached after 4 months in mice treated twice weekly with RIF/Moxifloxacin/PZA compared to cure in 6 months when daily treated with RIF/INH/PZA. 100 mg/kg Moxifloxacin in mice gives activity comparable to INH; increased dose in mice to 400 mg/kg Moxifloxacin daily results in spleen CFU counts lower than for INH 25 mg/kg although the differences are not statistically significant. AUC/MIC ratio correlates best with in-vivo efficacy for the fluoroquinolones in a mouse model of tuberculosis. [1]

Protocol

Solubility (25°C)

In vitro DMSO 87 mg/mL (198.68 mM)
Water 60 mg/mL (137.02 mM)
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 437.89
Formula

C21H24FN3O4.HCl

CAS No. 186826-86-8
Storage powder
Synonyms BAY12-8039 HCl

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00816426 Completed Tuberculosis National Institute of Allergy and Infectious Diseases (NIAID)|Korean Center for Disease Control and Prevention|International Tuberculosis Research Center|Novartis Institute for Tropical Medicine|Asian Medical Center|National Institutes of Health Clinical Center (CC) December 29, 2008 Phase 1
NCT03021616 Not yet recruiting Cardiovascular Diseases David Grant U.S. Air Force Medical Center January 2017 --
NCT02589782 Recruiting Tuberculosis, Multidrug-Resistant|Extensively Drug-Resistant Tuberculosis|Tuberculosis, Pulmonary Medecins Sans Frontieres, Netherlands|London School of Hygiene and Tropical Medicine|Global Alliance for TB Drug Development|University College, London|Drugs for Neglected Diseases|Swiss Tropical & Public Health Institute|eResearch Technology, Inc.|Ministry of Health, Republic of Uzbekistan|World Health Organization|Ministry of Health, Belarus|TB & HIV Investigative Network (THINK) January 2017 Phase 2|Phase 3
NCT02680080 Not yet recruiting Long QT Syndrome Tel-Aviv Sourasky Medical Center|Tel Aviv Medical Center December 2016 --
NCT02754765 Recruiting Tuberculosis, Multidrug-Resistant Médecins Sans Frontières France|Partners in Health|Harvard Medical School|Epicentre|Institute of Tropical Medicine, Belgium|Ministry of Health, Kyrgyzstan|National Center for Tuberculosis Problems, Kazakhstan|Ministry of Health, Lesotho|National Center for Tuberculosis and Lung Diseases, Georgia|Socios En Salud, Peru December 2016 Phase 3
NCT02903836 Recruiting Community-Acquired Bacterial Pneumonia (CABP) Wockhardt|ACM September 2016 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Topoisomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID