Divalproex Sodium

Catalog No.S1703

Divalproex Sodium Chemical Structure

Molecular Weight(MW): 310.41

Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.

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Biological Activity

Description Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.
In vitro

Divalproex sodium enhances IM-induced cell growth inhibition, apoptosis and cell cycle arrest in K562-S and K562-G cells. Divalproex sodium enhances the inhibitory effects of IM on SIRT1 expression in K562-S and K562-G cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1. [1] Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas a lower dose of Divalproex, 50 mg/kg, has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC. [2]

Protocol

Solubility (25°C)

In vitro DMSO 62 mg/mL (199.73 mM)
Water 62 mg/mL (199.73 mM)
Ethanol 62 mg/mL (199.73 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 310.41
Formula

C8H16O2.C8H15O2.Na

CAS No. 76584-70-8
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01170325 Withdrawn Autism|Autism Spectrum Disorders National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) June 30, 2010 Phase 2
NCT03012815 Not yet recruiting Alcohol Withdrawal Syndrome Mayo Clinic March 2017 Phase 4
NCT02707965 Not yet recruiting Epilepsy Food and Drug Administration (FDA)|University of Maryland March 2016 --
NCT02166229 Withdrawn Scleroderma|Systemic Sclerosis Yale University June 2014 Phase 1|Phase 2
NCT02094651 Withdrawn Autism Boston Children’s Hospital|University of Louisville April 2014 Phase 2
NCT01898676 Unknown status Epilepsy Vince & Associates Clinical Research, Inc.|Food and Drug Administration (FDA) July 2013 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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HDAC Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID