Calcitriol

Catalog No.S1466 Synonyms: RO215535, Topitriol

Calcitriol Chemical Structure

Molecular Weight(MW): 416.64

Calcitriol is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol.

Size Price Stock Quantity  
In DMSO USD 500 In stock
USD 120 In stock
USD 270 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

1 Customer Review

  • Mireia Vila Gasull University of Porto. 2011;Mireia Vila Gasull . Calcitriol purchased from Selleck.

Purity & Quality Control

Choose Selective Vitamin Inhibitors

Biological Activity

Description Calcitriol is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol.
Targets
vitamin D receptor [1]
(Cell-free assay)
In vitro

Calcitriol is a potent inhibitor of PHA-induced lymphocyte proliferation, achieving 70% inhibition of tritiated thymidine incorporation after 72 h in culture. Calcitriol suppresses interleukin-2 (IL-2) production by PHA-stimulated peripheral blood mononuclear cells in a concentration-dependent fashion. [1] Calcitriol increases the concentration of intracellular calcium ([Ca2+]i) within 5 s by mobilizing calcium from the endoplasmic reticulum and the formation of inositol 1,4, 5-trisphosphate and diacylglycerol. [2] Calcitriol can inhibit the proliferation and promote the differentiation of human prostate adenocarcinoma cells. Calcitriol causes a selective decrease in the secreted levels of type IV collagenases (MMP-2 and MMP-9). [3] Calcitriol has antiproliferative activity in squamous cell carcinoma and prostatic adenocarcinoma and enhances the antitumor activity of platinum-based agents. Calcitriol prior to paclitaxel significantly reduces clonogenic survival compared with either agent alone in the murine squamous cell carcinoma and PC-3 cells. [4] Calcitriol is a potent anti-proliferative agent in a wide variety of malignant cell types. Calcitriol effects are associated with an increase in G0/G1 arrest, induction of apoptosis and differentiation, modulation of expression of growth factor receptors. Calcitriol potentiates the antitumor effects of many cytotoxic agents and inhibits motility and invasiveness of tumor cells and formation of new blood vessels. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HCT116 NXW3UJdtS3m2b4TvfIlkyqCjc4PhfS=> Mo\qNVIxKGh? MWXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDIR3QyOTZiYYPz[ZN{\WRiYYOg[IVkemWjc3WgbY4h[2WubDDjc5VvfCCjZoTldkAyOjBiaILzMEBKSzVyPUHlMVA2KM7:TR?= MkLsNlI6OjZyNki=
human HOS cells MomxSpVv[3Srb36gZZN{[Xl? NV;kXZRuOjRiaB?= M3jPUmFkfGm4aYT5JIF1KGi3bXHuJHZFWiCneIDy[ZN{\WRiaX6gbJVu[W5iSF;TJINmdGy|IITyZY5{\mWldHXkJJdqfGhicFfMN{1pV2NuIIDDSG5CNWiYRGKgZY5lKHCqUlytWGsh[XO|ZYPz[YQh[XNiYYPz[ZN{\WRiYYOgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gcYVie3W{ZXSgNlQhcHK|IIDvd5QhcW6oZXP0bY9vKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2x[U0xPSEQvF2= MmGyNlE5QDl|M{S=
human HOS/SF cells MVvGeY5kfGmxbjDhd5NigQ>? NYfqTpNwOjRiaB?= NX3reoFkXHKjboPhZ5RqfmG2aX;uJI9nKF[GUj3t[YRq[XSnZDDvd5Rmd2OjbHPpckBxem:vb4TldkBqdiCqdX3hckBJV1NxU1[gZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1{Lk\lMVA2KM7:TR?= MYqyOFkxODd{OB?=
human PBMC MYjGeY5kfGmxbjDhd5NigQ>? M2izZ|I1KGh? NYf5NpFkUW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBVVk[jbIDoZUBxem:mdXP0bY9vKGmwIHj1cYFvKFCETVOgZYZ1\XJiMkSgbJJ{KGK7IFXMTXNCNCCLQ{W9Nk46\S1yNTFOwG0> NG\5ZpQyQTNyOUG1OS=>
mouse LM05e cells M4LkW3Bzd2yrZnXyZZRqd25iYYPzZZk> NF:zNGM4OiCq NHrKc41CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFzNNFVmKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhdnWvYnXyJIFnfGW{IEeyJIhzeyCkeTDXV3Qh[XO|YYmsJGlEPTB;M3WtNFUh|ryP MkLVNlQ6ODB|M{m=
rat osteosarcoma cells NIP0TYhHfW6ldHnvckBie3OjeR?= M2Pqemlv\HWldHnvckBw\iCYRGKtcYVlcWG2ZXSgNlQucHmmcn;4fYxie2VidILhcpNkemmydHnvckBqdiC{YYSgc5N1\W:|YYLjc41iKGOnbHzzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWQ2OD1yLkKgcm0> MYCyNVkxOjJ|NR?=
rat ROS 17/2.8 cells NUfhXmxoTnWwY4Tpc44h[XO|YYm= NFjvN3EyPiCq MYTBZ5Rqfmm2eTDheEBXTFJiaX6gdoF1KFKRUzCxO{8zNjhiY3XscJMh[XO|ZYPz[YQh[XNidILhcpNkemmydHnvcoFtKGGldHn2ZZRqd25ib3[gNlQucHmmcn;4fYxie2ViZ3Xu[UBxem:vb4TldkBi\nSncjCxOkBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvOiCwTR?= MV[xPVE3Pzh7Mx?=
COS7 cells NYXPO3VoTnWwY4Tpc44h[XO|YYm= Ml;YNlQhcA>? NXyx[ItbSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBXTFJiaX6gR29UPyClZXzsd{Bie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[geJJidnOlcnnweIlwdmGuIITyZY5{[WO2aY\heIlwdiCjZoTldkAzPCCqcoOgZpkhdW:3c3Wgc5N1\W:yb370bY4hdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTBwNTDuUS=> M1G1TlE4QTB2M{ew
mouse SVEC cells M1iwPXBzd2yrZnXyZZRqd25iYYPzZZk> MlHCO|IhcA>? NIjGRmpCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIGPWSWMh[2WubIOgZZN{\XO|ZXSgZZMh\GWlcnXhd4UhcW5iY3XscEBvfW2kZYKgZYZ1\XJiN{KgbJJ{KGK7IGfTWEBie3OjeTygTWM2OD1yLkWyJI5O NHHPOpMzPDlyMEOzPS=>
CV1 cells MXnGeY5kfGmxbjDhd5NigQ>? NEHHV45C[3Srdnn0fUBwdiCqdX3hckBXTFJvbXXkbYF1\WRidILhcpNkemmydHnvckBw\iCxc4Tlc4NidGOrbjDWSHJGKG[3c3XkJJRwKHSqeX3p[Ilv\SCtaX7hd4UheHKxbX;0[ZIw\3Kxd4ToJIhwem2xbnWgdoVxd3K2ZYKg[4Vv\SCrbjDDWlEh[2WubIOsJGVFPTB;MD63JI5O M{DEZ|E4OTR7OEiw
COS1 cells M2O2UWZ2dmO2aX;uJIF{e2G7 M{H5c2Rqe3CuYXPlcYVvfCCxZjCxMYFteGijLDCyOU0pV0hrW{PIYWQ{KG[{b32gbJVu[W5iVlTSJIV5eHKnc4Pl[EBqdiCFT2OxJINmdGy|LDDJR|UxRTBwODDuUS=> NITJXGgyPzl{NE[xOi=>
human PBMC NWnHVYo2TnWwY4Tpc44h[XO|YYm= NIXqN48zPCCq NYHtNZhOUW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBKVDF{L{KzdFQxKHC{b3T1Z5Rqd25iaX6gbJVu[W5iUFLNR{Bi\nSncjCyOEBpenNiYomgSWxKW0FuIFnDOVA:OSCwTR?= MYKxPVMxQTF3NR?=
HEK293 cells NVzXWJlOTnWwY4Tpc44h[XO|YYm= M2TLTVI1KGh? M4LwcGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gWmRTKGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[geJJidnOlcnnweIlwdmGuIITyZY5{[WO2aY\heIlwdiCjZoTldkAzPCCqcoOgZpkhdW:3c3Wgc5N1\W:yb370bY4hdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTFibl2= MljVNVc6ODR|N{C=
human HL60 cells M2rwZ2Z2dmO2aX;uJIF{e2G7 MVHJcoR2[3Srb36gc4YhcHWvYX6gTGw3OCCmaX\m[ZJmdnSrYYTpc44h[XO|ZYPz[YQh[XNiY3XscJMhemWmdXPpcochdmm2cn:gZox2\SC2ZYTyZZpwdGm3bTygSWQ2OD1zIH7N MoW4NlE6ODJ{M{W=
human HeLa cells M1q0eGZ2dmO2aX;uJIF{e2G7 NFXVOo8yPiCq M321U3Rz[W6|YXP0bZZifGmxbjDv[kBISUx2LX\1d4VlKF[GUjDsbYdidmRiYnnu[Ilv\yCmb33hbY4h\XiycnXzd4VlKGmwIHj1cYFvKEinTHGgZ4VtdHNiYX\0[ZIhOTZiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1zIH7N MWGyNlk2Pzh|NB?=
human T47D cells MYjQdo9tcW[ncnH0bY9vKGG|c3H5 MkL0O|IhcA>? MoLYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCWNEfEJINmdGy|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKGOnbHygcpVu[mW{IHHmeIVzKDd{IHjyd{BjgSCZU2SgZZN{[XluIFnDOVA:OS5|IH7N NHPseYYzPDlyMEOzPS=>
human peripheral blood mononuclear cells NWfaZYMxWHKxbHnm[ZJifGmxbjDhd5NigQ>? NVHyblRNUW5idnn0do8hcW6qaXLpeIlwdiCxZjDwbJl1d2inbXHn[4x2fGmwaX7pck1qdmS3Y3XkJJN1cW23bHH0bY9vKG:oIHj1cYFvKHCncnnwbIVz[WxiYnzvc4QhdW:wb371Z4xm[XJiY3XscJMheHKxbHnm[ZJifGmxbjygSWQ2OD1{Lkegcm0> MlroNVExODByMUS=
human Caco-2 cells MnG5SpVv[3Srb36gZZN{[Xl? M3rp[mVn\mWldDDvckBXTFJidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGmwIHj1cYFvKEOjY3:tNkBk\WyuczDpckBxemW|ZX7j[UBw\iB3JTDm[ZRidCClYXzmJJNmenWvLDDFR|UxRTNwNUKgcm0> Mmq1NVgxPTR{M{C=
human MCF7 cells MmrVSpVv[3Srb36gZZN{[Xl? MmW5RYdwdmm|dDDhZ5Rqfmm2eTDheEB7\WK{YX\pd4gh\2GuND3WSHIhVEKGIHX4dJJme3OnZDDpckBpfW2jbjDNR2Y4KGOnbHzzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBj[XOnZDD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9OU42KG6P NI\lSGUzOjF6MEizOy=>
human THP1 cells M2POU2Z2dmO2aX;uJIF{e2G7 MX7BZ5RqfmG2aX;uJI9nKF[GUjDpckBpfW2jbjDUTHAyKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHPheIhmdGmlaXTpckBidnSrbXnjdo9jcWGuIIDldJRq\GVibWLORUBmgHC{ZYPzbY9vKGK7IGLUMXBEWixiRVO1NF0yOCCwTR?= MWGxPVMxQTF3NR?=
human HaCaT cells NIGwR29HfW6ldHnvckBie3OjeR?= M{\ad|I1KGh? MoL0WJJidnOjY4TpeoF1cW:wIH;mJHZFWiCrbjDoeY1idiCKYVPhWEBk\WyuczDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUCuN|IyPSEQvF2= MmHiNlY{PjdyMUm=
human HN12 cells M3yzZXBzd2yrZnXyZZRqd25iYYPzZZk> NIj1XJo4OiCq NWfYdo9ZSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUlEzKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhdnWvYnXyJIFnfGW{IEeyJIhzeyCkeTDXV3Qh[XO|YYmsJGlEPTB;MD61OVMh|ryP M1G5clI1QTByM{O5
human HaCaT cells NXXIOpllTnWwY4Tpc44h[XO|YYm= NYnxd3dbUW6qaXLpeIlwdiCxZjDjc4xwdnliZn;ycYF1cW:wIH;mJIh2dWGwIFjhR4FVKGOnbHzz MX6yNlQxPDN{Nh?=
human HCT116 cells M1Xw[2Z2dmO2aX;uJIF{e2G7 MX[yNE01OCEQvF2= Ml\GNlQhcA>? MlTBRYdwdmm|dDDhZ5Rqfmm2eTDheEBTSVJiKIXub45wf25ib4Lp[4lvMSCneIDy[ZN{\WRiaX6gbJVu[W5iSFPUNVE3KGOnbHzzJINwNWW6cILld5NqdmdiUlHSSUBifCB{MDD0c{A1OCC3TTDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 MlT6NlMzPzZ2NEm=
mouse C3H10T1/2 cells MnzOSpVv[3Srb36gZZN{[Xl? MnS0NE42NTVizszN NGTRT2QzPCCq NHLRT2tKdmirYnn0bY9vKG:oIFjl[IdmcG:pIIPp[45idGmwZzDwZZRpf2G7IHnuJI1wfXOnIFOzTFExXDFxMjDj[YxteyCjc4Pld5Nm\CCjczDkc5dvKHKnZ4XsZZRqd25ib3[gS4xqOSCjdDCwMlUhfG9iNTD1UUBi\nSncjCyOEBpenNiYomgVnQuWEOUIHHuZYx6e2m| MXGyNlIzPjZ3Nx?=
human A498 cells Ml\qSpVv[3Srb36gZZN{[Xl? NIfuRXMxNjBzIN88US=> Ml\2OEBp NHjLVlBKdmS3Y4Tpc44hd2ZiQ2nQNlQhdVKQQTDlfJBz\XO|aX;uJIlvKGi3bXHuJGE1QThiY3XscJMh[XRiMD6wNUDPxE1iYX\0[ZIhPCCqcoOgZpkhWlRvUFPSJIFv[Wy7c3nz NHzRTIEzOTN7Mkm4Ny=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 83 mg/mL (199.21 mM)
Ethanol 83 mg/mL (199.21 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 416.64
Formula

C27H44O3

CAS No. 32222-06-3
Storage powder
in solvent
Synonyms RO215535, Topitriol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02962102 Not yet recruiting Critically Ill|Acute Kidney Injury David Leaf|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Brigham and Womens Hospital February 2017 Phase 2
NCT01561222 Not yet recruiting Chronic Kidney Disease Stage 1|Chronic Kidney Disease Stage 2 Taixing Peoples Hospital July 2015 Phase 4
NCT02410005 Active, not recruiting Diabetic Nephropathies Weill Cornell Medical College in Qatar|Weill Medical College of Cornell University|Hamad Medical Corporation October 2014 Phase 2|Phase 3
NCT02224144 Active, not recruiting End Stage Renal Disease|Kidney Transplantation|Bone Loss|Fractures|Vascular Calcifications Columbia University|Satellite Healthcare August 2014 Phase 2
NCT02061384 Active, not recruiting Male Infertility|Klinefelters Syndrome|Y-chromosome Microdeletions University of Washington August 2014 Phase 2
NCT02186665 Completed Plaque Psoriasis Galderma July 2014 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy Calcitriol | Calcitriol ic50 | Calcitriol price | Calcitriol cost | Calcitriol solubility dmso | Calcitriol purchase | Calcitriol manufacturer | Calcitriol research buy | Calcitriol order | Calcitriol mouse | Calcitriol chemical structure | Calcitriol mw | Calcitriol molecular weight | Calcitriol datasheet | Calcitriol supplier | Calcitriol in vitro | Calcitriol cell line | Calcitriol concentration | Calcitriol nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID