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p53 Inhibitors | Activators (10)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1172 JNJ-26854165 (Serdemetan) JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.
  • Sci Rep, 2014, 4:4664
  • Mol Ther, 2015, 23(5):857-65
  • Head Neck, 2014, 10.1002/hed.23822
S2929 Pifithrin-α (PFTα) Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
  • Am J Transplant, 2015, 15(12):3095-111
  • Int J Radiat Oncol Biol Phys, 2014, 88(2):385-94
  • Apoptosis, 2015, 20(6):787-95
S2678 NSC 207895 NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
S2781 RITA (NSC 652287) RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.
  • Nat Chem Biol, 2015, 10.1038/nchembio.1986
  • Oncogene, 2014, 10.1038/onc.2014.37
S8000 Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.
S8106 NSC59984 NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.
S7149 NSC 319726 NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.
S2930 Pifithrin-μ Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
  • J Leukoc Biol, 2016, 10.1189/jlb.2AB0715-301R
  • Biochim Biophys Acta, 2014, 1842(11):2204-15
S7649 MI-773 (SAR405838) MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
S4900 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity.
  • Nat Biotechnol, 2015, 10.1038/nbt.3130

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1172 JNJ-26854165 (Serdemetan) <1 mg/mL 66 mg/mL 2 mg/mL
S2929 Pifithrin-α (PFTα) <1 mg/mL 67 mg/mL <1 mg/mL
S2678 NSC 207895 <1 mg/mL 0.4 mg/mL <1 mg/mL
S2781 RITA (NSC 652287) <1 mg/mL 58 mg/mL 8 mg/mL
S8000 Tenovin-1 <1 mg/mL 74 mg/mL <1 mg/mL
S8106 NSC59984 <1 mg/mL 53 mg/mL 53 mg/mL
S7149 NSC 319726 <1 mg/mL 19 mg/mL <1 mg/mL
S2930 Pifithrin-μ <1 mg/mL 36 mg/mL 36 mg/mL
S7649 MI-773 (SAR405838) <1 mg/mL 100 mg/mL 31 mg/mL
S4900 Tenovin-6 98 mg/mL 98 mg/mL <1 mg/mL
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