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p53 Inhibitors | Activators (8)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1172 JNJ-26854165 (Serdemetan) JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.
  • Sci Rep, 2014, 4:4664
  • Head Neck, 2014, 10.1002/hed.23822
S2929 Pifithrin-α (PFTα) Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
  • Int J Radiat Oncol Biol Phys, 2014, 88(2):385-94
  • Exp Cell Res, 2014, 330(2):346-57
  • Leuk Lymphoma, 2015, 10.3109/10428194.2014.976819
S2678 NSC 207895 NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
S2781 RITA (NSC 652287) RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.
  • Oncogene, 2014, 10.1038/onc.2014.37
S8000 Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.
S4900 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity.
  • Nat Biotechnol, 2015, 10.1038/nbt.3130
S7149 NSC 319726 NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.
S2930 Pifithrin-μ Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
  • Biochim Biophys Acta, 2014, 1842(11):2204-15

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