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p53

p53 is a tumor suppressor protein which plays a critical role in apoptosis, Cell-cycle arrest, and DNA damage. p53 give a contribution to apoptosis with BAK, BAX and BCL-2. p53 can be phosphorylated by ATM / ATR / DNA-PK, Chk1 / Chk2, MAPK (JNK1-3, ERK1-2, p38 MAPK) and some other kinases. Cell-cycle arrest, DNA repair, Angiogenesis are related to p53 because CDKN1A, 14-3-3-σ and MMP2 are all p53-target gene which can be regulated by p53. A protein called Mdm2 which keep a continuous degradation of p53 binds to p53 to prevent p53 from transporting from nucleus to the cytosol.

Apoptosis

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  • p53 Inhibitors (12)
  • p53 Activators (22)
  • p53 Modulators (2)
  • New p53 Products
Cat.No. Product Name Information Product Use Citations Product Validations
S2929 Pifithrin-α (PFTα) Hhydrobromide Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).
J Adv Res, 2025, S2090-1232(25)00192-4
Front Pharmacol, 2025, 16:1608156
J Cell Mol Med, 2025, 29(11):e70641
Verified customer review of Pifithrin-α (PFTα) Hhydrobromide
S2930 Pifithrin-μ Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and this compound also inhibits HSP70 function and autophagy.
Cell Death Dis, 2025, 16(1):42
Front Nutr, 2025, 12:1663245
Sci Adv, 2025, 11(12):eadq9111
Verified customer review of Pifithrin-μ
S7724 Eprenetapopt (APR-246) Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. It induces apoptosis and autophagy.
Oncotarget, 2024, 15:614-633
J Cell Mol Med, 2024, 28(9):e18374
Cell Death Dis, 2023, 14(11):783
S1172 Serdemetan (JNJ-26854165) Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.
Elife, 2025, 14e75393
J Physiol, 2025, 603(19):5477-5508
Signal Transduct Target Ther, 2022, 7(1):97
Verified customer review of Serdemetan (JNJ-26854165)
S2781 RITA RITA induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and this compound also inhibits MDM2-p53 interaction by targeting p53.
Cell Death Discov, 2024, 10(1):381
J Cancer, 2023, 14(2):200-218
Theranostics, 2022, 12(9):4110-4126
Verified customer review of RITA
S8483 CBL0137 Hydrochloride CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-κB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
Oncogene, 2025, 44(13):893-908
Cancer Biol Ther, 2025, 26(1):2511301
JCI Insight, 2023, 8(4)e154120
S7723 PRIMA-1 PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
J Control Release, 2024, 371:111-125
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
J Pers Med, 2022, 12(2)258
S8000 Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. This compound is also an inhibitor of dihydroorotate dehydrogenase (DHODH).
J Pharm Biomed Anal, 2021, 201:114121
J Transl Med, 2019, 17(1):76
Int J Mol Med, 2019, 44(3):1091-1105
Verified customer review of Tenovin-1
S7149 NSC 319726 (ZMC1) NSC 319726 (ZMC1) is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Microbiol Spectr, 2021, 9(3):e0139521
Cell, 2020, 182(3):685-712.e19
S4900 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). This compound is also an inhibitor of SirT1 and SirT2.
Cell Death Dis, 2023, 14(10):667
Front Immunol, 2021, 12:685523
Biomed Pharmacother, 2020, 125:109948
S8149 NSC348884 NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.
Mol Cell, 2025, S1097-2765(25)00409-5
Front Immunol, 2022, 13:956991
Nat Commun, 2020, 3;11(1):1669
S8106 NSC59984 NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.
Cancers (Basel), 2023, 15(3)745
J Clin Med, 2023, 12(23)7491
Front Bioeng Biotechnol, 2020, 8:538663
S5791 Cyclic Pifithrin-α hydrobromide Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.
Front Pharmacol, 2022, 13:926317
Clin Transl Med, 2020, 10.1002/ctm2.41
S8580 COTI-2 COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.
Biometals, 2025, 10.1007/s10534-025-00736-z
J Cell Mol Med, 2024, 28(9):e18374
DASH, 2020, None
S5811 Kevetrin hydrochloride Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
Int J Mol Sci, 2022, 23(17)10042
S8187 ReACp53 ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).
PNAS Nexus, 2022, 1(3):pgac128
Nat Commun, 2021, 12(1):3962
S9235 Didymin Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.
E1971 Rezatapopt Rezatapopt(PC14586) is a first-in-class p53 reactivator. It selectively binds to the mutated p53 Y220C protein and restores its wild-type activity. It can also be used to inhibit solid tumor with p53 mutation.
E0935 MS7972 MS7972 is a small molecule that blocks human p53 and CREB binding protein association.
E2943 Pifithrin-β Pifithrin-β (PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide) is a potent inhibitor of p53 with an IC50 of 23 μM and is regarded as a lead compound for cancer and neurodegenerative disease therapy.
Biol Reprod, 2025, ioaf113
E0035 CP-31398 Dihydrochloride

CP-31398 Dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
E7154 C16-Ceramide C16-Ceramide (N-Palmitoylsphingosine)is a sphingolipid ligand and an activator of p53 tumor suppressor. It tightly binds within the p53 DNA-binding domain with a Kd of ~ 60 nM, in close vicinity to the Box V motif. It regulates the protein ubiquitination and proteasomal degradation and also induces apoptosis in cancer cells making it a research tool for targeting human cancers.
E1735 PK11007 PK11007 is a thiol-reactive anticancer agent that stabilizes p53 via selective alkylation of two surface cysteines without compromising its DNA binding. It induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels.
S9488 Lobetyolin Lobetyolin is one of the important active ingredients extracted from the root of Codonopsis pilosula, which has a good protective effect on gastric mucosal damage. This compound can downregulate glutamine metabolism, contribute to drug-induced apoptosis and tumor growth inhibition, and it significantly reduces the mRNA and protein expression of the amino acid transporter alanine-serine-cysteine ​​transporter 2 (ASCT2).
S8728 PK11000 PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
S2427 Triglycidyl Isocyanurate (Teroxirone) Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. This compound alkylates and cross-links DNA, thereby inhibiting DNA replication. It is also used in various polyester powder coatings in the metal finishing industry.
S8059 Nutlin-3a Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.
Nucleic Acids Res, 2025, 53(13)gkaf627
Cell Rep Med, 2025, 6(8):102284
Bone Res, 2025, 13(1):62
Verified customer review of Nutlin-3a
S7030 RG-7112 RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.
NPJ Aging, 2025, 11(1):6
Int J Mol Sci, 2024, 25(7)3948
bioRxiv, 2024, 2024.10.09.617493
S2341 (-)-Parthenolide (-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
J Adv Res, 2025, S2090-1232(25)00353-4
Biomed Pharmacother, 2025, 188:118183
Cell Death Discov, 2025, 11(1):286
Verified customer review of (-)-Parthenolide
S7649 SAR405838 SAR405838 is an orally available MDM2 antagonist with Ki of 0.88 nM. This compound is a diastereomer of MI-773 (CAS: 1303607-07-9). Phase 1.
Nat Genet, 2025, 57(1):140-153
Pharmaceutics, 2023, 15(4)1274
bioRxiv, 2023, 10.1101/2023.03.10.531074
Verified customer review of SAR405838
S2678 NSC 207895 NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
PLoS One, 2024, 19(1):e0295629
Front Oncol, 2021, 11:582511
Genes Dev, 2020, 34(7-8):526-543
Verified customer review of NSC 207895
S0507 CBL0137 CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.
Cancer Med, 2024, 13(20):e70288
STAR Protoc, 2024, 5(4):103446
JCI Insight, 2023, 8(4)e154120
E3037 Solanum lyratum Extract Solanum lyratum Extract (300 μg/ml) increases Bax levels and decreases Bcl-2 levels, which cause the loss of mitochondrial membrane potential (Δæm) followed by cytochrome C release and caspase-9 and -3 activation, finally leading to apoptosis. This compound also promotes p53 and p27, but decreases the levels of cyclin B1 thus causing S-phase arrest.
S2176 Tenovin-3 Tenovin-3 is an inhibitor of SIRT2. This compound is able to increase p53 levels in MCF-7 cells.
S6882 HI-TOPK-032 HI-TOPK-032 is a potent and specific inhibitor of TOPK. This compound also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
E0068 NiCur NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.
E0394 YK 3-237 YK-3-237, a SIRT1 activator, reduces acetylation of mutant p53 and inhibits the proliferation of triple-negative breast cancer cells.
S6851 RA-190 RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.
S2929 Pifithrin-α (PFTα) Hhydrobromide Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).
J Adv Res, 2025, S2090-1232(25)00192-4
Front Pharmacol, 2025, 16:1608156
J Cell Mol Med, 2025, 29(11):e70641
 Verified customer review of Pifithrin-α (PFTα) Hhydrobromide
S2930 Pifithrin-μ Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and this compound also inhibits HSP70 function and autophagy.
Cell Death Dis, 2025, 16(1):42
Front Nutr, 2025, 12:1663245
Sci Adv, 2025, 11(12):eadq9111
 Verified customer review of Pifithrin-μ
S5791 Cyclic Pifithrin-α hydrobromide Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.
Front Pharmacol, 2022, 13:926317
Clin Transl Med, 2020, 10.1002/ctm2.41
S8187 ReACp53 ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).
PNAS Nexus, 2022, 1(3):pgac128
Nat Commun, 2021, 12(1):3962
S9235 Didymin Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.
E0935 MS7972 MS7972 is a small molecule that blocks human p53 and CREB binding protein association.
E2943 Pifithrin-β Pifithrin-β (PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide) is a potent inhibitor of p53 with an IC50 of 23 μM and is regarded as a lead compound for cancer and neurodegenerative disease therapy.
Biol Reprod, 2025, ioaf113
E1735 PK11007 PK11007 is a thiol-reactive anticancer agent that stabilizes p53 via selective alkylation of two surface cysteines without compromising its DNA binding. It induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels.
S9488 Lobetyolin Lobetyolin is one of the important active ingredients extracted from the root of Codonopsis pilosula, which has a good protective effect on gastric mucosal damage. This compound can downregulate glutamine metabolism, contribute to drug-induced apoptosis and tumor growth inhibition, and it significantly reduces the mRNA and protein expression of the amino acid transporter alanine-serine-cysteine ​​transporter 2 (ASCT2).
S7030 RG-7112 RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.
NPJ Aging, 2025, 11(1):6
Int J Mol Sci, 2024, 25(7)3948
bioRxiv, 2024, 2024.10.09.617493
E0068 NiCur NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.
E0394 YK 3-237 YK-3-237, a SIRT1 activator, reduces acetylation of mutant p53 and inhibits the proliferation of triple-negative breast cancer cells.
S7724 Eprenetapopt (APR-246) Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. It induces apoptosis and autophagy.
Oncotarget, 2024, 15:614-633
J Cell Mol Med, 2024, 28(9):e18374
Cell Death Dis, 2023, 14(11):783
S1172 Serdemetan (JNJ-26854165) Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.
Elife, 2025, 14e75393
J Physiol, 2025, 603(19):5477-5508
Signal Transduct Target Ther, 2022, 7(1):97
 Verified customer review of Serdemetan (JNJ-26854165)
S2781 RITA RITA induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and this compound also inhibits MDM2-p53 interaction by targeting p53.
Cell Death Discov, 2024, 10(1):381
J Cancer, 2023, 14(2):200-218
Theranostics, 2022, 12(9):4110-4126
 Verified customer review of RITA
S8483 CBL0137 Hydrochloride CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-κB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
Oncogene, 2025, 44(13):893-908
Cancer Biol Ther, 2025, 26(1):2511301
JCI Insight, 2023, 8(4)e154120
S7723 PRIMA-1 PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
J Control Release, 2024, 371:111-125
Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
J Pers Med, 2022, 12(2)258
S8000 Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. This compound is also an inhibitor of dihydroorotate dehydrogenase (DHODH).
J Pharm Biomed Anal, 2021, 201:114121
J Transl Med, 2019, 17(1):76
Int J Mol Med, 2019, 44(3):1091-1105
 Verified customer review of Tenovin-1
S7149 NSC 319726 (ZMC1) NSC 319726 (ZMC1) is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Microbiol Spectr, 2021, 9(3):e0139521
Cell, 2020, 182(3):685-712.e19
S4900 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). This compound is also an inhibitor of SirT1 and SirT2.
Cell Death Dis, 2023, 14(10):667
Front Immunol, 2021, 12:685523
Biomed Pharmacother, 2020, 125:109948
S8149 NSC348884 NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.
Mol Cell, 2025, S1097-2765(25)00409-5
Front Immunol, 2022, 13:956991
Nat Commun, 2020, 3;11(1):1669
S8106 NSC59984 NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.
Cancers (Basel), 2023, 15(3)745
J Clin Med, 2023, 12(23)7491
Front Bioeng Biotechnol, 2020, 8:538663
S8580 COTI-2 COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.
Biometals, 2025, 10.1007/s10534-025-00736-z
J Cell Mol Med, 2024, 28(9):e18374
DASH, 2020, None
S5811 Kevetrin hydrochloride Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
Int J Mol Sci, 2022, 23(17)10042
E1971 Rezatapopt Rezatapopt(PC14586) is a first-in-class p53 reactivator. It selectively binds to the mutated p53 Y220C protein and restores its wild-type activity. It can also be used to inhibit solid tumor with p53 mutation.
E7154 C16-Ceramide C16-Ceramide (N-Palmitoylsphingosine)is a sphingolipid ligand and an activator of p53 tumor suppressor. It tightly binds within the p53 DNA-binding domain with a Kd of ~ 60 nM, in close vicinity to the Box V motif. It regulates the protein ubiquitination and proteasomal degradation and also induces apoptosis in cancer cells making it a research tool for targeting human cancers.
S2427 Triglycidyl Isocyanurate (Teroxirone) Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. This compound alkylates and cross-links DNA, thereby inhibiting DNA replication. It is also used in various polyester powder coatings in the metal finishing industry.
S8059 Nutlin-3a Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.
Nucleic Acids Res, 2025, 53(13)gkaf627
Cell Rep Med, 2025, 6(8):102284
Bone Res, 2025, 13(1):62
 Verified customer review of Nutlin-3a
S2341 (-)-Parthenolide (-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
J Adv Res, 2025, S2090-1232(25)00353-4
Biomed Pharmacother, 2025, 188:118183
Cell Death Discov, 2025, 11(1):286
 Verified customer review of (-)-Parthenolide
S7649 SAR405838 SAR405838 is an orally available MDM2 antagonist with Ki of 0.88 nM. This compound is a diastereomer of MI-773 (CAS: 1303607-07-9). Phase 1.
Nat Genet, 2025, 57(1):140-153
Pharmaceutics, 2023, 15(4)1274
bioRxiv, 2023, 10.1101/2023.03.10.531074
 Verified customer review of SAR405838
S2678 NSC 207895 NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
PLoS One, 2024, 19(1):e0295629
Front Oncol, 2021, 11:582511
Genes Dev, 2020, 34(7-8):526-543
 Verified customer review of NSC 207895
S0507 CBL0137 CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.
Cancer Med, 2024, 13(20):e70288
STAR Protoc, 2024, 5(4):103446
JCI Insight, 2023, 8(4)e154120
E3037 Solanum lyratum Extract Solanum lyratum Extract (300 μg/ml) increases Bax levels and decreases Bcl-2 levels, which cause the loss of mitochondrial membrane potential (Δæm) followed by cytochrome C release and caspase-9 and -3 activation, finally leading to apoptosis. This compound also promotes p53 and p27, but decreases the levels of cyclin B1 thus causing S-phase arrest.
S2176 Tenovin-3 Tenovin-3 is an inhibitor of SIRT2. This compound is able to increase p53 levels in MCF-7 cells.
S6882 HI-TOPK-032 HI-TOPK-032 is a potent and specific inhibitor of TOPK. This compound also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
S6851 RA-190 RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.

Signaling Pathway Map