Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1172 JNJ-26854165 (Serdemetan) <1 mg/mL 66 mg/mL 2 mg/mL
S2929 Pifithrin-α (PFTα) HBr <1 mg/mL 67 mg/mL <1 mg/mL
S2678 NSC 207895 <1 mg/mL 0.4 mg/mL <1 mg/mL
S2781 RITA (NSC 652287) <1 mg/mL 58 mg/mL 8 mg/mL
S8000 Tenovin-1 <1 mg/mL 74 mg/mL <1 mg/mL
S8483 CBL0137 (CBL-0137) 24 mg/mL 38 mg/mL <1 mg/mL
S8580 COTI-2 <1 mg/mL 73 mg/mL <1 mg/mL
S7149 NSC 319726 <1 mg/mL 19 mg/mL <1 mg/mL
S2930 Pifithrin-μ <1 mg/mL 36 mg/mL 36 mg/mL
S7649 MI-773 (SAR405838) <1 mg/mL 100 mg/mL 31 mg/mL
S4900 Tenovin-6 98 mg/mL 98 mg/mL <1 mg/mL
S7724 APR-246 (PRIMA-1MET) 40 mg/mL
S8106 NSC59984 <1 mg/mL 53 mg/mL 53 mg/mL
S8149 NSC348884 <1 mg/mL 100 mg/mL 100 mg/mL
S7723 PRIMA-1 37 mg/mL 37 mg/mL 37 mg/mL
S2341 (-)-Parthenolide <1 mg/mL 49 mg/mL 49 mg/mL
S8187 ReACp53 100 mg/mL -1 mg/mL -1 mg/mL
Catalog No. Information Product Use Citations Product Validations

JNJ-26854165 (Serdemetan)

JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.


Pifithrin-α (PFTα) HBr

Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.


NSC 207895

NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.


RITA (NSC 652287)

RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.



Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.


CBL0137 (CBL-0137)

CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).



COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.


NSC 319726

NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.



Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.


MI-773 (SAR405838)

MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.



Tenovin-6 is a small molecule activator of p53 transcriptional activity.



APR-246, also known as PRIMA-1MET, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types.



NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.



NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.



PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.



(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.



ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).

Tags: p53 apoptosis | p53 inhibition | p53 cancer | p53 mutation | p53 protein | p53 pathway | p53 activation | p53 phosphorylation | p53 activity | p53-dependent apoptosis | p53 apoptosis pathway | p53 cancer therapy | p53-independent apoptosis | p53-mdm2 interaction | p53-p21 pathway | p53-mdm2 pathway | p53 protein structure | p53 protein function | p53 cleavage | p53 inhibitor review