Home Neuronal Signaling 5-HT Receptor antagonist Trazodone

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Trazodone 5-HT Receptor antagonist

Cat.No.S5857

Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.
Trazodone 5-HT Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 371.86

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Quality Control

Batch: S585701 DMSO]45 mg/mL]false]Ethanol]17 mg/mL]false]Water]Insoluble]false Purity: 98.98%
98.98

Solubility

In vitro
Batch:

DMSO : 45 mg/mL (121.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 17 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 371.86 Formula

C19H22ClN5O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 19794-93-5 -- Storage of Stock Solutions

Synonyms AF-1161 SMILES C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC50/Ki
5-HT2A
5-HT2C

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-06-05)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07542756 RECRUITING
Insomnia; Insomnia Disorder; Chronic Insomnia; Chronic Insomnia Disorder
University of Pennsylvania
 2026-05-01 PHASE4
NCT07136415 RECRUITING
Menopausal Women; Insomnia
Brigham and Women's Hospital
 2026-02-13 PHASE4
NCT04302870 RECRUITING
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
University of Edinburgh
 2020-02-27 PHASE2; PHASE3
NCT07210606 NOT_YET_RECRUITING
Sleep Disordered Breathing; Able Bodied
VA Office of Research and Development
 2026-10-01 PHASE4
NCT07210112 NOT_YET_RECRUITING
Depression - Major Depressive Disorder; Treatment-resistant Depression (TRD)
Centre Hospitalier St Anne
 2025-10-08 PHASE2
NCT05085808 WITHDRAWN
Delirium; Morality; Quality of Life; Psych; Treatment Side Effects
University of Southern California
 2028-03-01 PHASE4

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