- Topo I
- Topo II
- Topo IV
Topo I Selective Inhibitors
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
Topotecan (NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.
|Selective||Topo I (DU-145 Luc cells), IC50: 2 nM; Topo I (MCF-7 Luc cells), IC50: 13 nM|
Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM. Phase 2.
|Selective||Topo I, IC50: 0.68 μM|
Betulinic acid, a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. Phase 1/2.
|Selective||Eukaryotic topoisomerase I, IC50: 5 μM|
10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
|S2217||Irinotecan HCl Trihydrate||
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.
Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.
Ellagic acid has antiproliferative and antioxidant property.
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