CAS No. 11088-09-8
Chemical Structure
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Wilforine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | [(1S,3R,15S,18S,19R,20R,21R,22S,23R,24R,25R,26S)-20,22,23,25-tetraacetyloxy-21-(acetyloxymethyl)-26-hydroxy-3,15,26-trimethyl-6,16-dioxo-2,5,17-trioxa-11-azapentacyclo[16.7.1.01,21.03,24.07,12]hexacosa-7(12),8,10-trien-19-yl] benzoate | |
|---|---|---|
| CAS Number | 11088-09-8 | |
| Molecular Formula |
C43H49NO18 |
|
| Molecular Weight (MW) | 867.85 | |
| SMILES | CC1CCC2=C(C=CC=N2)C(=O)OCC3(C4C(C(C5(C(C(C(C(C5(C4OC(=O)C)O3)(C)O)OC1=O)OC(=O)C6=CC=CC=C6)OC(=O)C)COC(=O)C)OC(=O)C)OC(=O)C)C | |
| InChIKey | ZOCKGJZEUVPPPI-QSNSFFMXSA-N |
Biological Activity
Wilforine is a sesquiterpene pyridine alkaloid derived from Tripterygium wilfordii that acts as a P-glycoprotein (P-gp) efflux pump inhibitor. By suppressing P-gp transport activity, wilforine increases the intracellular accumulation of substrate drugs and restores sensitivity in multidrug-resistant cells. Additionally, it downregulates pro-inflammatory signaling pathways, attenuating inflammatory responses and modulating cell viability in preclinical models.
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Note: Technical data last updated: Sep 1, 2026.