Vilazodone

Catalog No.S5858 Synonyms: EMD-68843, SB-659746A

For research use only.

Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites.

Vilazodone Chemical Structure

CAS No. 163521-12-8

Selleck's Vilazodone has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 88 mg/mL
(199.31 mM)
Water Insoluble
Ethanol ''14 mg/mL

Chemical Information

Molecular Weight 441.52
Formula

C26H27N5O2

CAS No. 163521-12-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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