Vilazodone

Catalog No.S5858 Synonyms: EMD-68843, SB-659746A

Vilazodone Chemical Structure

Molecular Weight(MW): 441.52

Vilazodone is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites.

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Biological Activity

Description Vilazodone is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites.

Protocol

References

Solubility (25°C)

In vitro DMSO 88 mg/mL (199.31 mM)
Ethanol 14 mg/mL (31.7 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 441.52
Formula

C26H27N5O2

CAS No. 163521-12-8
Storage powder
in solvent
Synonyms EMD-68843, SB-659746A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02893371 Enrolling by invitation Bipolar Disorder University of New Mexico|Patient-Centered Outcomes Research Institute|Montana State University|National Alliance on Mental Illness|CGStat LLC|Risk Benefit Statistics LLC September 2016 --
NCT02893371 Enrolling by invitation Bipolar Disorder University of New Mexico|Patient-Centered Outcomes Research Institute|Montana State University|National Alliance on Mental Illness|CGStat LLC|Risk Benefit Statistics LLC September 2016 --
NCT02436239 Completed Major Depressive Disorder Forest Laboratories May 2 2015 Phase 3
NCT02436239 Completed Major Depressive Disorder Forest Laboratories May 2 2015 Phase 3
NCT02372799 Completed Major Depressive Disorder Forest Laboratories February 28 2015 Phase 3
NCT02372799 Completed Major Depressive Disorder Forest Laboratories February 28 2015 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID