CAS No. 6138-41-6

Batch: Purity:99.99
Check CoA
Trigonelline Hydrochloride Chemical Structure
Chemical Structure
Check the Trigonelline Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 6138-41-6
Molecular Formula

C7H8NO2.Cl
Molecular Weight (MW) 173.6
SMILES C[N+]1=CC=CC(=C1)C(=O)O.[Cl-]

Ordering Information

Biological Activity

Trigonelline Hydrochloride is a naturally occurring plant alkaloid that acts as an inhibitor of Nrf2 signaling. By blocking Nrf2 nuclear translocation, it downregulates Nrf2-dependent antioxidant gene expression, thereby dampening cellular defense mechanisms and restoring sensitivity to apoptosis in resistant cancer cells. Additionally, trigonelline demonstrates diverse pharmacological activities, including hypoglycemic, hypolipidemic, and neuroprotective effects in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 18 mg/mL (103.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.