Home Neuronal Signaling 5-HT Receptor antagonist Trazodone

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Trazodone 5-HT Receptor antagonist

Cat.No.S5857

Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.
Trazodone 5-HT Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 371.86

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Quality Control

Batch: S585701 DMSO]45 mg/mL]false]Ethanol]17 mg/mL]false]Water]Insoluble]false Purity: 98.98%
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98.98

Solubility

In vitro
Batch:

DMSO : 45 mg/mL (121.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 17 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 371.86 Formula

C19H22ClN5O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 19794-93-5 -- Storage of Stock Solutions

Synonyms AF-1161 Smiles C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl

Mechanism of Action

Targets/IC50/Ki
5-HT2A
5-HT2C

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06286189 Recruiting
Obstructive Sleep Apnea
Brigham and Women''s Hospital
 January 1 2024 Phase 1|Phase 2
NCT02086929 Completed
Major Depressive Disorder
Aziende Chimiche Riunite Angelini Francesco S.p.A
 December 2012 Phase 3
NCT01097980 Completed
Sexual Dysfunction
Beitou Armed Forces Hospital Taipei Taiwan
 April 2010 Not Applicable

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