Clinical Trials

Tetracycline has been evaluated across numerous clinical trials spanning early phase 1 through phase 4 investigations. Research primarily focuses on infectious and dermatological conditions—such as *Helicobacter pylori* eradication, acne vulgaris, and antibiotic-resistant infections—while also exploring applications in non-Hodgkin lymphoma, ocular adnexal lymphoma, and breast cancer. Sponsored by academic medical centers and international research networks including Shandong University, the Medical University of South Carolina, and the International Extranodal Lymphoma Study Group, these active, recruiting, and completed studies evaluate diverse therapeutic regimens.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06509139 ENROLLING_BY_INVITATION
Helicobacter Pylori Infection; Sex; Bismuth Quadruple Therapy
National Cheng-Kung University Hospital
 2024-07-09 PHASE4
NCT07144657 NOT_YET_RECRUITING
MALT Lymphoma of Stomach
National Taiwan University Hospital
 2025-09-01 PHASE2
NCT07788053 NOT_YET_RECRUITING
Helicobatcer Pylori; First-Line Eradication
Chih-An Shih, MD
 2026-09-01
NCT04527055 ENROLLING_BY_INVITATION
Helicobacter Pylori Infection; Dysbiosis; Probiotics
National Cheng-Kung University Hospital
 2020-05-06 PHASE4
NCT07542639 NOT_YET_RECRUITING
Pulp Disease, Dental; Pulp Necrosis; Pulp Therapy in Primary Molars; Primary Teeth; Pulpectomy; Endodontics; Dental Care for Children; Treatment Outcome; Quality of Life; Health Services Accessibility
University of Sao Paulo
 2026-06-08 EARLY_PHASE1
NCT07757919 NOT_YET_RECRUITING
HELICOBACTER PYLORI INFECTIONS
Qilu Hospital of Shandong University
 2026-09-01 PHASE4
NCT07358130 RECRUITING
Helicobacter Pylori Infection
Kaohsiung Medical University
 2025-10-21
NCT07729293 NOT_YET_RECRUITING
Helicobacter Pylori Infection; Dyspepsia; Gastrointestinal Adverse Effects
Gala Servicios Clinicos S.L.
 2026-08-31
NCT06225570 RECRUITING
Acne Vulgaris
Medical University of South Carolina
 2025-02-01 EARLY_PHASE1
NCT05821478 RECRUITING
Hidradenitis Suppurativa
Institut Pasteur
 2025-05-22 PHASE3
NCT07139366 RECRUITING
Gastritis; Dyspepsia; Helicobacter Pylori Infection; Gastric Cancer; Peptic Ulcer
Yongquan Shi
 2025-10-28 PHASE4
NCT07320001 NOT_YET_RECRUITING
Lymphatic Abnormality
Basharat Hussain
 2026-01-26 PHASE2
NCT05061732 UNKNOWN
Helicobacter Pylori Infection
Shanghai Zhongshan Hospital
 2021-09-30 PHASE4
NCT05219929 COMPLETED
Post-Treatment Lyme Disease
Johns Hopkins University
 2022-11-02 PHASE2
NCT06977841 COMPLETED
Helicobacter Pylori Eradication; Adverse Reaction
Zhongshan Hospital (Xiamen), Fudan University
 2025-06-10
NCT06561711 COMPLETED
Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2024-08-21 PHASE4
NCT07738861 COMPLETED
Postoperative Pain; Mandibular Molar Extraction; Tooth Extraction
CMH Lahore Medical College and Institute of Dentistry
 2026-01-10 PHASE4
NCT07487142 COMPLETED
H Pylori Infection
Beni-Suef University
 2024-06-10 PHASE3
NCT05874570 RECRUITING
Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2023-06-20 PHASE4
NCT07068607 RECRUITING
Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer
Yongquan Shi
 2025-04-01 PHASE4
NCT06299605 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2024-11-27
NCT06723197 RECRUITING
HELICOBACTER PYLORI INFECTIONS
Shandong University
 2024-12-10 PHASE4
NCT06695559 COMPLETED
Periimplantitis; Periimplant Diseases
Aristotle University Of Thessaloniki
 2024-02-05 PHASE4
NCT05874544 COMPLETED
Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2023-05-16 PHASE4
NCT06225570 Not yet recruiting
Acne Vulgaris
Medical University of South Carolina
 2025-01 Early Phase 1
NCT05850117 UNKNOWN
Helicobacter Pylori Eradication
Kaohsiung Medical University
 2020-02-10
NCT02754583 COMPLETED
Trachoma
University of California, San Francisco
 2015-12-05 PHASE3
NCT06351891 UNKNOWN
Helicobacter Pylori Infection
Qilu Hospital of Shandong University
 2024-04 PHASE4
NCT06168214 UNKNOWN
the Eradication Rates of Helicobacter Pylori
Xijing Hospital of Digestive Diseases
 2023-09-04 PHASE4
NCT06759610 COMPLETED
Ameloblastoma
Minia University
 2024-02-10
NCT06372925 Not yet recruiting
Plaque Atherosclerotic
Novartis Pharmaceuticals|Novartis
 2024-07-23 Phase 4
NCT06402760 Not yet recruiting
Psoriasis|Diabetes
Shanghai Yueyang Integrated Medicine Hospital|Shanghai Hongkou District Center for Disease Control And Prevention
 2024-07-01 Early Phase 1
NCT05802888 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2023-03-12 PHASE4
NCT06085274 Recruiting
Breast Cancer
University Health Network Toronto
 2024-06-01 Not Applicable
NCT06168084 COMPLETED
Gastritis Dyspepsia Helicobacter Pylori Infection Gastric Cancer Peptic Ulcer
Yongquan Shi
 2023-06-06 PHASE4
NCT05431075 COMPLETED
Helicobacter Pylori Infection
Shandong University
 2022-07-01 PHASE4
NCT05432115 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2022-06-25 PHASE4
NCT04901117 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2021-06 PHASE4
NCT05049902 COMPLETED
Helicobacter Pylori Infection
Shandong University
 2021-09-21 PHASE4
NCT05345210 UNKNOWN
Helicobacter Pylori
Xijing Hospital of Digestive Diseases
 2022-04-25 PHASE4
NCT05250050 WITHDRAWN
Helicobacter Pylori Infection
Shanghai Zhongshan Hospital
 2022-03-25 PHASE4
NCT05018923 UNKNOWN
Helicobacter Pylori Infection
Shanghai Zhongshan Hospital
 2021-08-24 PHASE4
NCT04531059 COMPLETED
Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2020-10-15 PHASE4
NCT02359331 TERMINATED
Helicobacter Infection
Seoul National University Bundang Hospital
 2014-08
NCT03908892 UNKNOWN
Paronychia
Guangzhou University of Traditional Chinese Medicine
 2019-06-12
NCT04264663 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2019-11-01 PHASE4
NCT04879992 COMPLETED
Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2021-05-07
NCT05135182 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2021-11-28 PHASE4
NCT04122287 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2019-11-01 PHASE4
NCT04853875 COMPLETED
Helicobacter Pylori Infection
Mackay Memorial Hospital
 2021-04-19 PHASE4
NCT05129176 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2021-11-23 PHASE4
NCT04991584 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2021-08-04
NCT05126121 UNKNOWN
Helicobacter Pylori Infection
Xiuli Zuo
 2021-11-20
NCT03779074 COMPLETED
Helicobacter Pylori Infection
Kaohsiung Veterans General Hospital.
 2018-09-03 PHASE3
NCT04678492 COMPLETED
Gastritis; Dyspepsia; Helicobacter Pylori Infection; Gastric Cancer; Peptic Ulcer
Xijing Hospital of Digestive Diseases
 2020-12-20 PHASE4
NCT03555526 UNKNOWN
H Pylori Infection
National Taiwan University Hospital
 2017-12-15 PHASE4
NCT04716426 COMPLETED
COVID-19
University of Nove de Julho
 2021-01-28
NCT04107194 UNKNOWN
Helicobacter Pylori Infection; Antibiotic Resistant Infection; Antibiotic Resistant Strain
University of Bari
 2020-01-14 PHASE3
NCT03892330 NOT_YET_RECRUITING
0.5-14 Year Old Children With Nephroblastoma
Shengjing Hospital
 2019-06-01 PHASE4
NCT04039126 UNKNOWN
Malignant Pleural Effusion
University College Hospital, Ibadan
 2019-06-20 PHASE1
NCT04730674 COMPLETED
Post-mastectomty Seroma
Zagazig University
 2020-01-01
NCT03726099 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2019-03-15 PHASE4
NCT03377933 UNKNOWN
Efficacy; Gastric Microbiota; Safety
Yiqi Du
 2019-03-15
NCT03208426 UNKNOWN
Helicobacter Pylori Infection
National Taiwan University Hospital
 2017-10-01 PHASE4
NCT03658746 COMPLETED
Helicobacter Pylori Infection
Shandong University
 2019-01-01 PHASE4
NCT03571230 UNKNOWN
Helicobacter Pylori Infection; Antimicrobial Susceptibility Testing
Shandong University
 2018-07-01 PHASE4
NCT03656484 COMPLETED
Chronic Periodontitis
Concordia Dent Srl
 2019-01-15 PHASE2
NCT03616405 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2019-04-01 PHASE4
NCT03708848 COMPLETED
Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2018-12-05 PHASE4
NCT03658733 UNKNOWN
Helicobacter Pylori Infection
Shandong University
 2018-12-15 PHASE4
NCT03609892 COMPLETED
Gastric Ulcer; Chronic Gastritis; Gastric Cancer; Helicobacter Pylori Infection; Gastritis
Xijing Hospital of Digestive Diseases
 2018-08-01 PHASE4
NCT04066257 COMPLETED
Healthy
HK inno.N Corporation
 2019-01-17 PHASE1
NCT03925818 TERMINATED
Helicobacter Pylori Infection
Università degli Studi di Sassari
 2017-08-29
NCT02490839 COMPLETED
Helicobacter Pylori Infection
National Taiwan University Hospital
 2015-07 PHASE4
NCT03632733 UNKNOWN
Keratotic Nodular Size
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2018-01-21 PHASE2
NCT02741414 UNKNOWN
Gastritis
Taizhou Hospital
 2016-06
NCT02483715 COMPLETED
Helicobacter Pylori Infection
National Taiwan University Hospital
 2015-07 PHASE4
NCT02576652 COMPLETED
Osteoporosis
Amgen
 2015-12-22 PHASE4
NCT02978157 COMPLETED
Helicobacter Pylori Infection
Kaohsiung Veterans General Hospital.
 2015-02
NCT02988089 UNKNOWN
Helicobacter Pylori Infection; Antimicrobial Susceptibility Testing
Shandong University
 2017-04-20 PHASE4
NCT03139253 UNKNOWN
Antimicrobial Susceptibility Testing; Triple Therapy
Yanqing Li
 2017-05-30 PHASE4
NCT03494972 COMPLETED
Post-Operative Wound Infection
University of Oslo
 2016-01-02
NCT03095378 COMPLETED
Gingival Recession
University of Sao Paulo
 2014-03-10
NCT03634605 COMPLETED
Primary Spontaneous Pneumothorax
Isfahan University of Medical Sciences
 2015-05-05
NCT02045251 WITHDRAWN
Treatment of H. Pylori Infection
American University of Beirut Medical Center
 2013-06 PHASE4
NCT03146325 WITHDRAWN
Helicobacter Pylori Infection
The University of Texas Health Science Center, Houston
 2012-11 PHASE4
NCT02175927 COMPLETED
Helicobacter Pylori Treatment Failure
Shanghai Jiao Tong University School of Medicine
 2014-07 PHASE4
NCT02159976 COMPLETED
Helicobacter Pylori Infection
Seoul National University Bundang Hospital
 2014-07
NCT01763437 WITHDRAWN
Chalazia; Chalazion
The Cleveland Clinic
 2014-03 EARLY_PHASE1
NCT01481844 COMPLETED
Optimization of Second Line Treatment Protocol for H Pylori Eradication
Soroka University Medical Center
 2011-11 PHASE3
NCT01880515 COMPLETED
Skin Rash; Lung Cancer
Instituto Nacional de Cancerologia de Mexico
 2010-12 PHASE2
NCT01753856 COMPLETED
Osteoporosis
Eli Lilly and Company
 2013-01 PHASE4
NCT01742429 COMPLETED
Cure Rate of Helicobacter Pylori Infection
Shanghai Jiao Tong University School of Medicine
 2012-11 PHASE4
NCT02259543 COMPLETED
Gingival Recession
University of Sao Paulo
 2011-08
NCT01628549 COMPLETED
Acne Vulgaris
Almirall, S.A.
 2012-06-30 PHASE2
NCT01863823 COMPLETED
Oral Helicobacter Pylori
Ameritek USA
 2011-08 PHASE1; PHASE2
NCT01668927 COMPLETED
Functional Dyspepsia; Scarred Peptic Ulcer
Shanghai Jiao Tong University School of Medicine
 2012-07 PHASE4
NCT01010295 COMPLETED
Non-Hodgkin Lymphoma
International Extranodal Lymphoma Study Group (IELSG)
 2006-09 PHASE2
NCT02057926 COMPLETED
Ridge Preservation Technique
Universitat Internacional de Catalunya
 2009-11 PHASE2
NCT00469261 COMPLETED
Myocardial Infarction; Left Ventricular Remodeling
Careggi Hospital
 2007-05 PHASE2
NCT01335334 UNKNOWN
H. Pylori Infection
The University of Texas Health Science Center, Houston
 2011-03 PHASE4
NCT01573975 COMPLETED
Helicobacter Pylori Infection
Buddhist Tzu Chi General Hospital
 2009-01 PHASE4
NCT01293643 COMPLETED
Vaginosis, Bacterial; Candidiasis, Vulvovaginal
Merck Sharp & Dohme LLC
 2010-05 PHASE3
NCT01792700 COMPLETED
Helicobacter Infections
Seoul National University Bundang Hospital
 2003-01 PHASE4
NCT01032499 UNKNOWN
Acne Vulgaris II or III Degree; Boils
Laboratorios Goulart S.A.
 2010-05 PHASE3
NCT00841854 COMPLETED
Helicobacter Infection
Asan Medical Center
 2008-06 PHASE4
NCT00889356 UNKNOWN
Candidiasis; Bacterial Vaginosis
Zodiac Produtos Farmaceuticos S.A.
 2009-09 PHASE3
NCT00361257 TERMINATED
HIV Infections
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2007-03 PHASE2
NCT00669955 COMPLETED
Helicobacter Infections
Forest Laboratories
 2008-06 PHASE3
NCT00243893 COMPLETED
Aneurysms; Arteriovenous Malformations
University of California, San Francisco
 2004-07 PHASE1
NCT00591162 TERMINATED
Burn
The University of Texas Medical Branch, Galveston
 1992-10 PHASE2; PHASE3
NCT00336154 WITHDRAWN
Epidermolysis Bullosa
Rambam Health Care Campus
 PHASE4
NCT00091247 COMPLETED
Unspecified Adult Solid Tumor, Protocol Specific
Alliance for Clinical Trials in Oncology
 2004-12
NCT01098448 COMPLETED
Periodontitis
The Forsyth Institute
 1999-09 PHASE3
NCT00347776 COMPLETED
Trichiasis
Johns Hopkins University
 2001-08 PHASE4
NCT00002682 COMPLETED
Lymphoma
M.D. Anderson Cancer Center
 1995-08-10 PHASE2
NCT00003151 COMPLETED
Lymphoma
European Organisation for Research and Treatment of Cancer - EORTC
 1997-09 PHASE2
NCT00355459 WITHDRAWN
Dry Eye Syndrome
University of Texas Southwestern Medical Center
 2005-08

(data from https://clinicaltrials.gov, updated on 2024-11-07)

Check the Tetracycline product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Tetracycline reversibly binds to the 30S ribosomal subunit of susceptible microorganisms, thereby blocking the attachment of aminoacyl-tRNA to the ribosomal acceptor site and halting protein synthesis. This arrest of translational elongation suppresses pathogen proliferation, providing therapeutic utility in clinical trial conditions such as Helicobacter pylori infections and acne vulgaris.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.