Tertiapin-Q

For research use only.

Catalog No.E0016 Synonyms: TPNQ

Tertiapin-Q Chemical Structure

CAS No. 910044-56-3

Tertiapin-Q (TPNQ) is a derivative of tertiapin and inhibits BK-type K+ channels in a use- and concentration-dependent manner. Tertiapin-Q also binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with Ki values of 1.3 nM and 13.3 nM respectively.

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Description

Tertiapin-Q (TPNQ) is a derivative of tertiapin and inhibits BK-type K+ channels in a use- and concentration-dependent manner. Tertiapin-Q also binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with Ki values of 1.3 nM and 13.3 nM respectively.

Targets
ROMK1 [2]
()
GIRK1/4 [2]
()
1.3 nM(Ki) 13.3 nM(Ki)

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (40.78 mM)
Ethanol '-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 2452.00
Formula

C106H175N35O24S4

CAS No. 910044-56-3
Storage powder
in solvent
Synonyms TPNQ

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID