CAS No. 666699-46-3

Batch: Purity:98.85
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TAC (TERT Activator-1) Chemical Structure
Chemical Structure
Check the TAC (TERT Activator-1) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(3-chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide
CAS Number 666699-46-3
Molecular Formula

C14H12ClF2NO2S
Molecular Weight (MW) 331.77
InChIKey JVUSVLUQMXGABO-UHFFFAOYSA-N

Ordering Information

Biological Activity

TAC (TERT Activator-1) is a small-molecule activator of telomerase reverse transcriptase (TERT). It upregulates TERT gene expression via stimulation of the MEK/ERK/AP-1 signaling cascade. Activation of this pathway leads to enhanced telomere synthesis, attenuation of cellular senescence and neuroinflammation, and reduced biological aging markers, ultimately preserving cognitive performance and neurological function in preclinical aging models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (198.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 66 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.