CAS No. 923262-96-8

Batch: Purity:98.7
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SAR407899 hydrochloride Chemical Structure
Chemical Structure
Check the SAR407899 hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 923262-96-8
Molecular Formula

C14H16N2O2.ClH
Molecular Weight (MW) 280.75
SMILES Cl.O=C1NC=CC2=C1C=CC(=C2)OC3CCNCC3

Ordering Information

Biological Activity

SAR407899 hydrochloride is an ATP-competitive Rho kinase (ROCK) inhibitor, exhibiting inhibition constant (Ki) values of 36 nM for human ROCK-2 and 41 nM for rat ROCK-2. By suppressing ROCK-mediated phosphorylation of myosin phosphatase, it inhibits thrombin-induced stress fiber formation, platelet-derived growth factor-induced cellular proliferation, and monocyte chemotactic protein-1-stimulated chemotaxis, ultimately resulting in concentration-dependent relaxation of precontracted vascular smooth muscle tissue.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 56 mg/mL
DMSO 28 mg/mL (99.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 1 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.